메뉴 건너뛰기




Volumn 61, Issue 4, 2017, Pages

Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay

Author keywords

8 Prenylnaringenin; Angiogenesis; Bifunctional enzyme; Lipid uptake; Xanthohumol

Indexed keywords

8-PRENYLNARINGENIN; ANGIOGENIC FACTOR; FLAVANONE DERIVATIVE; FLAVONOID; FLT1 PROTEIN, HUMAN; POLYPHENOL; PROPIOPHENONE DERIVATIVE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; XANTHOHUMOL;

EID: 85011031752     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201600488     Document Type: Article
Times cited : (16)

References (60)
  • 1
    • 84895544715 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and complications associated with diabetes
    • Blake, R., Trounce, I. A., Mitochondrial dysfunction and complications associated with diabetes. Biochim. Biophys. Acta. 2014, 1840, 1404–1412.
    • (2014) Biochim. Biophys. Acta. , vol.1840 , pp. 1404-1412
    • Blake, R.1    Trounce, I.A.2
  • 2
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee, M., Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414, 813–820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 3
    • 79251508353 scopus 로고    scopus 로고
    • Erythropoietin in kidney disease and type 2 diabetes
    • author reply 385–386
    • Schnuelle, P., Benck, U., Kramer, B. K., Erythropoietin in kidney disease and type 2 diabetes. N. Engl. J. Med. 2011, 364, 384; author reply 385–386.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 384
    • Schnuelle, P.1    Benck, U.2    Kramer, B.K.3
  • 5
    • 84881119066 scopus 로고    scopus 로고
    • Role of PFKFB3-driven glycolysis in vessel sprouting
    • De Bock, K., Georgiadou, M., Schoors, S., Kuchnio, A. et al., Role of PFKFB3-driven glycolysis in vessel sprouting. Cell 2013, 154, 651–663.
    • (2013) Cell , vol.154 , pp. 651-663
    • De Bock, K.1    Georgiadou, M.2    Schoors, S.3    Kuchnio, A.4
  • 6
    • 84916618642 scopus 로고    scopus 로고
    • Metabolic pathway compartmentalization: an underappreciated opportunity?
    • Zecchin, A., Stapor, P. C., Goveia, J., Carmeliet, P., Metabolic pathway compartmentalization: an underappreciated opportunity? Curr. Opin. Biotechnol. 2015, 34, 73–81.
    • (2015) Curr. Opin. Biotechnol. , vol.34 , pp. 73-81
    • Zecchin, A.1    Stapor, P.C.2    Goveia, J.3    Carmeliet, P.4
  • 7
    • 84884916443 scopus 로고    scopus 로고
    • Need glucose to sprout: local metabolic control of angiogenesis
    • Eichmann, A., Simons, M., Need glucose to sprout: local metabolic control of angiogenesis. EMBO Mol. Med. 2013, 5, 1459–1461.
    • (2013) EMBO Mol. Med. , vol.5 , pp. 1459-1461
    • Eichmann, A.1    Simons, M.2
  • 8
    • 0020438908 scopus 로고
    • A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate
    • Van Schaftingen, E., Lederer, B., Bartrons, R., Hers, H. G., A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur. J. Biochem. 1982, 129, 191–195.
    • (1982) Eur. J. Biochem. , vol.129 , pp. 191-195
    • Van Schaftingen, E.1    Lederer, B.2    Bartrons, R.3    Hers, H.G.4
  • 9
    • 84891841003 scopus 로고    scopus 로고
    • Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis
    • Schoors, S., De Bock, K., Cantelmo, A. R., Georgiadou, M. et al., Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014, 19, 37–48.
    • (2014) Cell Metab. , vol.19 , pp. 37-48
    • Schoors, S.1    De Bock, K.2    Cantelmo, A.R.3    Georgiadou, M.4
  • 10
    • 33947370773 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) signaling in tumor progression
    • Roskoski, R., Jr., Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit. Rev. Oncol. Hematol. 2007, 62, 179–213.
    • (2007) Crit. Rev. Oncol. Hematol. , vol.62 , pp. 179-213
    • Roskoski, R.1
  • 11
    • 79957902010 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch, S., Tugues, S., Li, X., Gualandi, L. et al., Signal transduction by vascular endothelial growth factor receptors. Biochem. J. 2011, 437, 169–183.
    • (2011) Biochem. J. , vol.437 , pp. 169-183
    • Koch, S.1    Tugues, S.2    Li, X.3    Gualandi, L.4
  • 12
    • 70450174366 scopus 로고    scopus 로고
    • VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
    • Waltenberger, J., VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus. Biochem. Soc. Trans. 2009, 37, 1167–1170.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 1167-1170
    • Waltenberger, J.1
  • 13
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara, N., Kerbel, R. S., Angiogenesis as a therapeutic target. Nature 2005, 438, 967–974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 14
    • 0035062394 scopus 로고    scopus 로고
    • The splice variants of vascular endothelial growth factor (VEGF) and their receptors
    • Robinson, C. J., Stringer, S. E., The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J. Cell Sci. 2001, 114, 853–865.
    • (2001) J. Cell Sci. , vol.114 , pp. 853-865
    • Robinson, C.J.1    Stringer, S.E.2
  • 15
    • 33748683966 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials
    • Rahimi, N., Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp. Eye. Res. 2006, 83, 1005–1016.
    • (2006) Exp. Eye. Res. , vol.83 , pp. 1005-1016
    • Rahimi, N.1
  • 16
    • 77955713744 scopus 로고    scopus 로고
    • VEGF-B: a thing of beauty
    • Li, X., VEGF-B: a thing of beauty. Cell. Res. 2010, 20, 741–744.
    • (2010) Cell. Res. , vol.20 , pp. 741-744
    • Li, X.1
  • 17
    • 78149281188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
    • Bry, M., Kivela, R., Holopainen, T., Anisimov, A. et al., Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation 2010, 122, 1725–1733.
    • (2010) Circulation , vol.122 , pp. 1725-1733
    • Bry, M.1    Kivela, R.2    Holopainen, T.3    Anisimov, A.4
  • 18
    • 77950865464 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B controls endothelial fatty acid uptake
    • Hagberg, C. E., Falkevall, A., Wang, X., Larsson, E. et al., Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 2010, 464, 917–921.
    • (2010) Nature , vol.464 , pp. 917-921
    • Hagberg, C.E.1    Falkevall, A.2    Wang, X.3    Larsson, E.4
  • 19
    • 84874641178 scopus 로고    scopus 로고
    • Endothelial fatty acid transport: role of vascular endothelial growth factor B
    • Hagberg, C., Mehlem, A., Falkevall, A., Muhl, L. et al., Endothelial fatty acid transport: role of vascular endothelial growth factor B. Physiology (Bethesda) 2013, 28, 125–134.
    • (2013) Physiology (Bethesda) , vol.28 , pp. 125-134
    • Hagberg, C.1    Mehlem, A.2    Falkevall, A.3    Muhl, L.4
  • 20
    • 84959353857 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
    • Muhl, L., Moessinger, C., Adzemovic, M. Z., Dijkstra, M. H. et al., Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney. Cell Tissue Res. 2016, 365, 51–63.
    • (2016) Cell Tissue Res. , vol.365 , pp. 51-63
    • Muhl, L.1    Moessinger, C.2    Adzemovic, M.Z.3    Dijkstra, M.H.4
  • 21
    • 84871402833 scopus 로고    scopus 로고
    • Treating diabetes by blocking a vascular growth factor
    • Carmeliet, P., Wong, B. W., De Bock, K., Treating diabetes by blocking a vascular growth factor. Cell Metab. 2012, 16, 553–555.
    • (2012) Cell Metab. , vol.16 , pp. 553-555
    • Carmeliet, P.1    Wong, B.W.2    De Bock, K.3
  • 22
    • 9644296035 scopus 로고    scopus 로고
    • Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille)
    • Imhof, A., Woodward, M., Doering, A., Helbecque, N. et al., Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille). Eur. Heart. J. 2004, 25, 2092–2100.
    • (2004) Eur. Heart. J. , vol.25 , pp. 2092-2100
    • Imhof, A.1    Woodward, M.2    Doering, A.3    Helbecque, N.4
  • 23
    • 0043014626 scopus 로고    scopus 로고
    • Phenol antioxidant quantity and quality in foods: beers and the effect of two types of beer on an animal model of atherosclerosis
    • Vinson, J. A., Mandarano, M., Hirst, M., Trevithick, J. R. et al., Phenol antioxidant quantity and quality in foods: beers and the effect of two types of beer on an animal model of atherosclerosis. J. Agric. Food Chem. 2003, 51, 5528–5533.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 5528-5533
    • Vinson, J.A.1    Mandarano, M.2    Hirst, M.3    Trevithick, J.R.4
  • 24
    • 25144446897 scopus 로고    scopus 로고
    • Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice
    • Nozawa, H., Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem. Biophys. Res. Commun. 2005, 336, 754–761.
    • (2005) Biochem. Biophys. Res. Commun. , vol.336 , pp. 754-761
    • Nozawa, H.1
  • 25
    • 26244450830 scopus 로고    scopus 로고
    • Beer constituents as potential cancer chemopreventive agents
    • Gerhauser, C., Beer constituents as potential cancer chemopreventive agents. Eur. J. Cancer. 2005, 41, 1941–1954.
    • (2005) Eur. J. Cancer. , vol.41 , pp. 1941-1954
    • Gerhauser, C.1
  • 26
    • 84859175244 scopus 로고    scopus 로고
    • Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration
    • Legette, L., Ma, L., Reed, R. L., Miranda, C. L. et al., Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol. Nutr. Food Res. 2012, 56, 466–474.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 466-474
    • Legette, L.1    Ma, L.2    Reed, R.L.3    Miranda, C.L.4
  • 27
    • 0037830987 scopus 로고    scopus 로고
    • Associations between diet and the metabolic syndrome vary with the validity of dietary intake data
    • Rosell, M. S., Hellenius, M. L., de Faire, U. H., Johansson, G. K., Associations between diet and the metabolic syndrome vary with the validity of dietary intake data. Am. J. Clin. Nutr. 2003, 78, 84–90.
    • (2003) Am. J. Clin. Nutr. , vol.78 , pp. 84-90
    • Rosell, M.S.1    Hellenius, M.L.2    de Faire, U.H.3    Johansson, G.K.4
  • 28
    • 84867101055 scopus 로고    scopus 로고
    • Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer
    • Scoditti, E., Calabriso, N., Massaro, M., Pellegrino, M. et al., Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch. Biochem. Biophys. 2012, 527, 81–89.
    • (2012) Arch. Biochem. Biophys. , vol.527 , pp. 81-89
    • Scoditti, E.1    Calabriso, N.2    Massaro, M.3    Pellegrino, M.4
  • 29
    • 33646855791 scopus 로고    scopus 로고
    • In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.)
    • Nikolic, D., Li, Y., Chadwick, L. R., van Breemen, R. B., In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm. Res. 2006, 23, 864–872.
    • (2006) Pharm. Res. , vol.23 , pp. 864-872
    • Nikolic, D.1    Li, Y.2    Chadwick, L.R.3    van Breemen, R.B.4
  • 30
    • 46249120181 scopus 로고    scopus 로고
    • Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine
    • Possemiers, S., Rabot, S., Espin, J. C., Bruneau, A. et al., Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine. J. Nutr. 2008, 138, 1310–1316.
    • (2008) J. Nutr. , vol.138 , pp. 1310-1316
    • Possemiers, S.1    Rabot, S.2    Espin, J.C.3    Bruneau, A.4
  • 31
    • 78649691087 scopus 로고    scopus 로고
    • Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria
    • Possemiers, S., Verstraete, W., Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria. Environ Microbiol Rep 2009, 1, 100–109.
    • (2009) Environ Microbiol Rep , vol.1 , pp. 100-109
    • Possemiers, S.1    Verstraete, W.2
  • 32
    • 78649890064 scopus 로고    scopus 로고
    • Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells
    • Negrao, R., Costa, R., Duarte, D., Taveira Gomes, T. et al., Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells. J. Cell. Biochem. 2010, 111, 1270–1279.
    • (2010) J. Cell. Biochem. , vol.111 , pp. 1270-1279
    • Negrao, R.1    Costa, R.2    Duarte, D.3    Taveira Gomes, T.4
  • 33
    • 0141960048 scopus 로고    scopus 로고
    • Beer and obesity: a cross-sectional study
    • Bobak, M., Skodova, Z., Marmot, M., Beer and obesity: a cross-sectional study. Eur. J. Clin. Nutr. 2003, 57, 1250–1253.
    • (2003) Eur. J. Clin. Nutr. , vol.57 , pp. 1250-1253
    • Bobak, M.1    Skodova, Z.2    Marmot, M.3
  • 34
    • 84901722389 scopus 로고    scopus 로고
    • Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes
    • Kiyofuji, A., Yui, K., Takahashi, K., Osada, K., Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes. J. Oleo Sci. 2014, 63, 593–597.
    • (2014) J. Oleo Sci. , vol.63 , pp. 593-597
    • Kiyofuji, A.1    Yui, K.2    Takahashi, K.3    Osada, K.4
  • 35
    • 84893397732 scopus 로고    scopus 로고
    • Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops
    • Legette, L., Karnpracha, C., Reed, R. L., Choi, J. et al., Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol. Nutr. Food Res. 2014, 58, 248–255.
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 248-255
    • Legette, L.1    Karnpracha, C.2    Reed, R.L.3    Choi, J.4
  • 36
    • 84893279481 scopus 로고    scopus 로고
    • Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet
    • Yui, K., Kiyofuji, A., Osada, K., Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet. J. Oleo Sci. 2014, 63, 159–168.
    • (2014) J. Oleo Sci. , vol.63 , pp. 159-168
    • Yui, K.1    Kiyofuji, A.2    Osada, K.3
  • 37
    • 84961223392 scopus 로고    scopus 로고
    • Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice
    • Miranda, C. L., Elias, V. D., Hay, J. J., Choi, J. et al., Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Arch. Biochem. Biophys. 2016, 599, 22–30.
    • (2016) Arch. Biochem. Biophys. , vol.599 , pp. 22-30
    • Miranda, C.L.1    Elias, V.D.2    Hay, J.J.3    Choi, J.4
  • 38
    • 84872037445 scopus 로고    scopus 로고
    • Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term
    • Sumiyoshi, M., Kimura, Y., Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term. Br. J. Nutr. 2013, 109, 162–172.
    • (2013) Br. J. Nutr. , vol.109 , pp. 162-172
    • Sumiyoshi, M.1    Kimura, Y.2
  • 40
    • 67349280310 scopus 로고    scopus 로고
    • Soy, phytoestrogens and metabolism: a review
    • Cederroth, C. R., Nef, S., Soy, phytoestrogens and metabolism: a review. Mol. Cell Endocrinol. 2009, 304, 30–42.
    • (2009) Mol. Cell Endocrinol. , vol.304 , pp. 30-42
    • Cederroth, C.R.1    Nef, S.2
  • 41
    • 84919950459 scopus 로고    scopus 로고
    • Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
    • Andreoli, M. F., Stoker, C., Rossetti, M. F., Alzamendi, A. et al., Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism. Mol. Cell Endocrinol. 2015, 401, 111–119.
    • (2015) Mol. Cell Endocrinol. , vol.401 , pp. 111-119
    • Andreoli, M.F.1    Stoker, C.2    Rossetti, M.F.3    Alzamendi, A.4
  • 42
    • 77949382900 scopus 로고    scopus 로고
    • Soy isoflavones, Mediterranean diet, and physical exercise in postmenopausal women with insulin resistance
    • Llaneza, P., Gonzalez, C., Fernandez-Inarrea, J., Alonso, A. et al., Soy isoflavones, Mediterranean diet, and physical exercise in postmenopausal women with insulin resistance. Menopause 2010, 17, 372–378.
    • (2010) Menopause , vol.17 , pp. 372-378
    • Llaneza, P.1    Gonzalez, C.2    Fernandez-Inarrea, J.3    Alonso, A.4
  • 43
    • 0036274089 scopus 로고    scopus 로고
    • Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin
    • Zierau, O., Gester, S., Schwab, P., Metz, P. et al., Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin. Planta Med. 2002, 68, 449–451.
    • (2002) Planta Med. , vol.68 , pp. 449-451
    • Zierau, O.1    Gester, S.2    Schwab, P.3    Metz, P.4
  • 44
    • 84888385770 scopus 로고    scopus 로고
    • Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing
    • Costa, R., Negrao, R., Valente, I., Castela, A. et al., Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing. J. Nat. Prod. 2013, 76, 2047–2053.
    • (2013) J. Nat. Prod. , vol.76 , pp. 2047-2053
    • Costa, R.1    Negrao, R.2    Valente, I.3    Castela, A.4
  • 45
    • 84055177148 scopus 로고    scopus 로고
    • Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes
    • Negrao, R., Costa, R., Duarte, D., Gomes, T. T. et al., Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes. J. Cell. Biochem. 2012, 113, 100–109.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 100-109
    • Negrao, R.1    Costa, R.2    Duarte, D.3    Gomes, T.T.4
  • 46
    • 42649104331 scopus 로고    scopus 로고
    • The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice
    • Cong, W. N., Tao, R. Y., Tian, J. Y., Liu, G. T. et al., The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. Life Sci. 2008, 82, 983–990.
    • (2008) Life Sci. , vol.82 , pp. 983-990
    • Cong, W.N.1    Tao, R.Y.2    Tian, J.Y.3    Liu, G.T.4
  • 47
    • 84878890534 scopus 로고    scopus 로고
    • Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats
    • Legette, L. L., Luna, A. Y., Reed, R. L., Miranda, C. L. et al., Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochemistry 2013, 91, 236–241.
    • (2013) Phytochemistry , vol.91 , pp. 236-241
    • Legette, L.L.1    Luna, A.Y.2    Reed, R.L.3    Miranda, C.L.4
  • 48
    • 55849126672 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic complications
    • Wirostko, B., Wong, T. Y., Simo, R., Vascular endothelial growth factor and diabetic complications. Prog. Retin. Eye Res. 2008, 27, 608–621.
    • (2008) Prog. Retin. Eye Res. , vol.27 , pp. 608-621
    • Wirostko, B.1    Wong, T.Y.2    Simo, R.3
  • 49
    • 85027935272 scopus 로고    scopus 로고
    • At the interface of antioxidant signalling and cellular function: key polyphenol effects
    • Kerimi, A., Williamson, G., At the interface of antioxidant signalling and cellular function: key polyphenol effects. Mol. Nutr. Food Res. 2016, 60, 1770–1788.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 1770-1788
    • Kerimi, A.1    Williamson, G.2
  • 50
    • 84856539058 scopus 로고    scopus 로고
    • Vascular endothelial growth factor plasma levels before and after treatment of neovascular age-related macular degeneration with bevacizumab or ranibizumab
    • Carneiro, A. M., Costa, R., Falcao, M. S., Barthelmes, D. et al., Vascular endothelial growth factor plasma levels before and after treatment of neovascular age-related macular degeneration with bevacizumab or ranibizumab. Acta Ophthalmol. 2012, 90, e25–30.
    • (2012) Acta Ophthalmol. , vol.90 , pp. e25-30
    • Carneiro, A.M.1    Costa, R.2    Falcao, M.S.3    Barthelmes, D.4
  • 51
    • 84856603282 scopus 로고    scopus 로고
    • Correlation of peripheral arterial blood flow with plasma chemerin and VEGF in diabetic peripheral vascular disease
    • Zakareia, F. A., Correlation of peripheral arterial blood flow with plasma chemerin and VEGF in diabetic peripheral vascular disease. Biomark. Med. 2012, 6, 81–87.
    • (2012) Biomark. Med. , vol.6 , pp. 81-87
    • Zakareia, F.A.1
  • 52
    • 20244378531 scopus 로고    scopus 로고
    • Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor
    • Yoon, Y. S., Uchida, S., Masuo, O., Cejna, M. et al., Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 2005, 111, 2073–2085.
    • (2005) Circulation , vol.111 , pp. 2073-2085
    • Yoon, Y.S.1    Uchida, S.2    Masuo, O.3    Cejna, M.4
  • 53
    • 3342952964 scopus 로고    scopus 로고
    • 17 beta -estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk
    • Soares, R., Guo, S., Gartner, F., Schmitt, F. C. et al., 17 beta -estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk. Angiogenesis 2003, 6, 271–281.
    • (2003) Angiogenesis , vol.6 , pp. 271-281
    • Soares, R.1    Guo, S.2    Gartner, F.3    Schmitt, F.C.4
  • 54
    • 0037220125 scopus 로고    scopus 로고
    • Role of the estrogen antagonist ICI 182,780 in vessel assembly and apoptosis of endothelial cells
    • Soares, R., Guo, S., Russo, J., Schmitt, F., Role of the estrogen antagonist ICI 182,780 in vessel assembly and apoptosis of endothelial cells. Ultrastruct. Pathol. 2003, 27, 33–39.
    • (2003) Ultrastruct. Pathol. , vol.27 , pp. 33-39
    • Soares, R.1    Guo, S.2    Russo, J.3    Schmitt, F.4
  • 55
    • 84864710223 scopus 로고    scopus 로고
    • Selective insulin and leptin resistance in metabolic disorders
    • Konner, A. C., Bruning, J. C., Selective insulin and leptin resistance in metabolic disorders. Cell Metab. 2012, 16, 144–152.
    • (2012) Cell Metab. , vol.16 , pp. 144-152
    • Konner, A.C.1    Bruning, J.C.2
  • 56
    • 84941125412 scopus 로고    scopus 로고
    • Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity
    • Cerezo, A. B., Winterbone, M. S., Moyle, C. W., Needs, P. W. et al., Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity. Mol. Nutr. Food Res. 2015, 59, 2119–2131.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 2119-2131
    • Cerezo, A.B.1    Winterbone, M.S.2    Moyle, C.W.3    Needs, P.W.4
  • 57
    • 84923967518 scopus 로고    scopus 로고
    • Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis
    • Moyle, C. W., Cerezo, A. B., Winterbone, M. S., Hollands, W. J. et al., Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis. Mol. Nutr. Food Res. 2015, 59, 401–412.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 401-412
    • Moyle, C.W.1    Cerezo, A.B.2    Winterbone, M.S.3    Hollands, W.J.4
  • 58
    • 12444296524 scopus 로고    scopus 로고
    • Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
    • Heilbronn, L., Smith, S. R., Ravussin, E., Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int. J. Obes. Relat. Metab. Disord. 2004, 28(Suppl 4), S12–21.
    • (2004) Int. J. Obes. Relat. Metab. Disord. , vol.28 , pp. S12-21
    • Heilbronn, L.1    Smith, S.R.2    Ravussin, E.3
  • 59
    • 84925431240 scopus 로고    scopus 로고
    • Obesity impairs gammadelta T cell homeostasis and antiviral function in humans
    • Costanzo, A. E., Taylor, K. R., Dutt, S., Han, P. P. et al., Obesity impairs gammadelta T cell homeostasis and antiviral function in humans. PLoS One 2015, 10, e0120918.
    • (2015) PLoS One , vol.10
    • Costanzo, A.E.1    Taylor, K.R.2    Dutt, S.3    Han, P.P.4
  • 60
    • 52249090234 scopus 로고    scopus 로고
    • ERRalpha: a metabolic function for the oldest orphan
    • Villena, J. A., Kralli, A., ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol. Metab. 2008, 19, 269–276.
    • (2008) Trends Endocrinol. Metab. , vol.19 , pp. 269-276
    • Villena, J.A.1    Kralli, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.