Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes

Journal of Oleo Science

Volumn 63, Issue 6, 2014, Pages 593-597

  Kiyofuji, Ayane ^a   Yui, Kazuki ^a   Takahashi, Koki ^a   Osada, Kyoichi ^a  

^a MEIJI UNIVERSITY   (Japan)

Author keywords

Adipocytes; Hop; Xanthohumol

Indexed keywords

ANTIOBESITY AGENT; CCAAT ENHANCER BINDING PROTEIN ALPHA; FABP4 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; FLAVONOID; ISOXANTHOHUMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; PROPIOPHENONE DERIVATIVE; XANTHOHUMOL; XANTHONE DERIVATIVE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENETICS; HUMULUS; ISOLATION AND PURIFICATION; LIPID METABOLISM; METABOLISM; MOUSE;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTI-OBESITY AGENTS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINE; FATTY ACID-BINDING PROTEINS; FIBROBLASTS; FLAVONOIDS; HUMULUS; LIPID METABOLISM; MICE; PLANT EXTRACTS; PPAR GAMMA; PROPIOPHENONES; XANTHONES;

EID: 84901722389     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.ess14009     Document Type: Note

References (14)

1. Magrone T.; Perez de Heredia F.; Jirillo E.; Morabito G.; Marcos A.; Serafini M. Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases. Can. J. Physiol. Pharmacol. 91, 387-396 (2013).
2. Yui K.; Kiyofuji A.; Osada K. Effects of xanthohumolrich extract from the hop on fatty acid metabolism in rats fed a high-fat diet. J. Oleo Sci. 63, 159-168 (2014).
3. Pinto, C.; Duque, A. L.; Rodríguez-Galdón, B.; Cestero, J. J.; Macías, P. Xanthohumol prevents carbon tetrachloride-induced acute liver injury in rats. Food Chem. Toxicol. 50, 3405-3412 (2012).
4. Miranda, C. L.; Stevens, J. F.; Helmrich, A.; Henderson, M. C. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus)in human cancer cell lines. Food Chem. Toxicol. 37, 271-285 (1999).
5. Monteiro, R.; Calhau, C.; Silva, A. O; Pinheiro-Silva, S.; Guerreiro, S.; Gartner, F.; Azevedo, I.; Soares, R. Xan-thohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts. J. Cell Biochem. 104, 1699-1707 (2008).
6. Yang, J. Y.; Della-Fera, M. A.; Rayalam, S.; Baile, C. A. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis 12, 1953-1963 (2007).
7. Dudhia, Z.; Louw, J.; Muller, C.; Joubert, E.; de Beer, D.; Kinnear, C.; Pheiffer, C. Cyclopia maculate and Cyclopia subternata (honeybush tea)inhibits adipogenesis in 3T3L1 pre-adipocytes. Phytomedicine 20, 401-408 (2013).
8. Siersbaek, R.; Nielsen, R.; Mandrup, S. PPARgamma in adipocyte differentiation and metabolism-novel insights from genome-wide studies. FEBS Lett. 584, 3242-3249 (2010).
9. Chawla, A.; Schwarz, E. J.; Dimaculangan D. D.; Lazar, M. A. Peroxisome proliferator-activated receptor (PPAR)gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135, 798-800 (1994).
10. Wu, Z.; Rosen, E. D.; Brun, R.; Hauser, S.; Adelmant, G.; Troy, A. E.; McKeon, C.; Darlington, G. J.; Spiegelman, B. M. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell 3, 151-158 (1999).
11. Coe, N. R.; Bernlohr, D. A. Physiological properties and functions of intracellular fattyacid-binding proteins. Biochim. Biophys. Acta 391, 287-306 (1998).
12. Makowski, L.; Brittingham, K. C.; Reynolds, J. M.; Suttles, J.; Hotamisligil, G. S. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J. Biol. Chem. 280, 12888-12895 (2005).
13. Crespy, V.; Aprikian, O.; Besson, C.; Manach, C.; Demigné, C.; Rémésy, C. Bioavailability of phloretin and phloridzin in rats. J. Nutr. 131, 3227-3230 (2001).
14. Xiao, H. B.; Fang, J.; Lu, X. Y.; Sun, Z. L. Kaempferol inproves carcase characteristics in broiler chikens by regulating ANGPL3 gene expression. Br. Poult. Sci. 53, 836-842 (2012).