Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes

Biochimica et Biophysica Acta - General Subjects

Volumn 1861, Issue 5, 2017, Pages 1341-1352

  Musumeci, Domenica ^a   Amato, Jussara ^a   Zizza, Pasquale ^b   Platella, Chiara ^a   Cosconati, Sandro ^c   Cingolani, Chiara ^b   Biroccio, Annamaria ^b   Novellino, Ettore ^a   Randazzo, Antonio ^a   Giancola, Concetta ^a   Pagano, Bruno ^a   Montesarchio, Daniela ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Anticancer agents; Drug discovery; G quadruplex; Virtual screening

Indexed keywords

DNA; GUANINE QUADRUPLEX; LIGAND; OLIGODEOXYRIBONUCLEOTIDE; ANTINEOPLASTIC AGENT; GUANOSINE; MOLECULAR LIBRARY;

AFFINITY CHROMATOGRAPHY; ARTICLE; ASSAY; BIOPHYSICS; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; G QUADRUPLEX ON OLIGO AFFINITY SUPPORT ASSAY; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIGAND BASED VIRTUAL SCREENING; MELANOMA CELL LINE; MTT ASSAY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCREENING; SOLID PHASE SYNTHESIS; TUMOR CELL; U2OS CELL LINE; ULTRAVIOLET SPECTROSCOPY; BINDING SITE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR LIBRARY; MOLECULAR MODEL; NEOPLASMS; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TELOMERE; TIME FACTOR; TRANSFORMED CELL LINE;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL SURVIVAL; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; G-QUADRUPLEXES; GUANOSINE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MODELS, MOLECULAR; NEOPLASMS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERE; TIME FACTORS;

EID: 85010957504     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2017.01.024     Document Type: Article

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