Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 9785-9792

  Cosconati, Sandro ^a   Rizzo, Angela ^b   Trotta, Roberta ^c   Pagano, Bruno ^c   Iachettini, Sara ^b   De Tito, Stefano ^c   Lauri, Ilaria ^c   Fotticchia, Iolanda ^c   Giustiniano, Mariateresa ^c   Marinelli, Luciana ^c   Giancola, Concetta ^c   Novellino, Ettore ^c   Biroccio, Annamaria ^b   Randazzo, Antonio ^c  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE QUADRUPLEX;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DEATH; DNA DAMAGE; DRUG ACTIVITY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULE; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; SENESCENCE; STRUCTURE ANALYSIS; TELOMERE; TUMOR CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL AGING; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; CIRCULAR DICHROISM; DNA DAMAGE; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; G-QUADRUPLEXES; HELA CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERE;

EID: 84869996732     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301019w     Document Type: Article

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