Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

Journal of Medicinal Chemistry

Volumn 59, Issue 12, 2016, Pages 5706-5720

  Amato, Jussara ^a   Morigi, Rita ^b   Pagano, Bruno ^a   Pagano, Alessia ^a   Ohnmacht, Stephan ^c   De Magis, Alessio ^b   Tiang, Yee Peng ^b   Capranico, Giovanni ^b   Locatelli, Alessandra ^b   Graziadio, Alessandra ^b   Leoni, Alberto ^b   Rambaldi, Mirella ^b   Novellino, Ettore ^a   Neidle, Stephen ^c   Randazzo, Antonio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; GUANINE QUADRUPLEX; HYDRAZONE DERIVATIVE; DNA;

ARTICLE; BINDING KINETICS; CANCER CELL; CARCINOMA CELL; CELL NUCLEUS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; MELTING POINT; ONCOGENE; OSTEOSARCOMA CELL; PROMOTER REGION; SYNTHESIS; TELOMERE; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; G-QUADRUPLEXES; HUMANS; HYDRAZONES; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84975894188     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00129     Document Type: Article

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