Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways

Oncotarget

Volumn 8, Issue 4, 2017, Pages 5800-5813

  Yang, Tai ^a   Liu, Jin ^a   Yang, Mali ^a   Huang, Ning ^b   Zhong, Yueling ^a   Zeng, Ting ^a   Wei, Rong ^a   Wu, Zhongjun ^a   Xiao, Cui ^a   Cao, Xiaohua ^a   Li, Minhui ^a   Li, Limei ^a   Han, Bin ^a   Yu, Xiaoping ^a   Li, Hua ^c   Zou, Qiang ^a  

^a CHENGDU MEDICAL COLLEGE   (China)

^b SICHUAN UNIVERSITY   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Aurora A kinase; Cucurbitacin B; Multiple cellular pathways; Multiple myeloma; Xenograft

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; CASPASE 8; COFILIN; CUCURBITACIN B; CYTOCHROME C; DOXORUBICIN; INTERLEUKIN 10; PHOSPHOTRANSFERASE INHIBITOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; AURKA PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; STAT3 GENE; ANIMAL; CELL CYCLE; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AURORA KINASE A; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-10; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MULTIPLE MYELOMA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85010755887     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10584     Document Type: Article

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