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Volumn 292, Issue 3, 2017, Pages 762-770

The translational significance of the neurovascular unit

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS;

EID: 85010665781     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R116.760215     Document Type: Review
Times cited : (220)

References (101)
  • 1
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci. 5, 347-360
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 2
    • 53249138093 scopus 로고    scopus 로고
    • Brain endothelial cell-cell junctions: How to "open" the blood brain barrier
    • Stamatovic, S. M., Keep, R. F., and Andjelkovic, A. V. (2008) Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr. Neuropharmacol. 6, 179-192
    • (2008) Curr. Neuropharmacol. , vol.6 , pp. 179-192
    • Stamatovic, S.M.1    Keep, R.F.2    Andjelkovic, A.V.3
  • 3
    • 0025048342 scopus 로고
    • Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study
    • Butt, A. M., Jones, H. C., and Abbott, N. J. (1990) Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J. Physiol. 429, 47-62
    • (1990) J. Physiol. , vol.429 , pp. 47-62
    • Butt, A.M.1    Jones, H.C.2    Abbott, N.J.3
  • 4
    • 0018855966 scopus 로고
    • Polarity of the bloodbrain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells
    • Betz, A. L., Firth, J. A., and Goldstein, G. W. (1980) Polarity of the bloodbrain barrier: distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res. 192, 17-28
    • (1980) Brain Res. , vol.192 , pp. 17-28
    • Betz, A.L.1    Firth, J.A.2    Goldstein, G.W.3
  • 5
    • 85014656015 scopus 로고    scopus 로고
    • Pericytes of the neurovascular unit: Key functions and signaling pathways
    • Sweeney, M. D., Ayyadurai, S., and Zlokovic, B. V. (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nat. Neurosci. 19, 771-783
    • (2016) Nat. Neurosci. , vol.19 , pp. 771-783
    • Sweeney, M.D.1    Ayyadurai, S.2    Zlokovic, B.V.3
  • 7
    • 84956522491 scopus 로고    scopus 로고
    • Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice
    • Hartmann, D. A., Underly, R. G., Grant, R. I., Watson, A. N., Lindner, V., and Shih, A. Y. (2015) Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice. Neurophotonics 2, 041402
    • (2015) Neurophotonics , vol.2 , pp. 041402
    • Hartmann, D.A.1    Underly, R.G.2    Grant, R.I.3    Watson, A.N.4    Lindner, V.5    Shih, A.Y.6
  • 8
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler, E. A., Bell, R. D., and Zlokovic, B. V. (2011) Central nervous system pericytes in health and disease. Nat. Neurosci. 14, 1398-1405
    • (2011) Nat. Neurosci. , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 9
  • 12
    • 84929839390 scopus 로고    scopus 로고
    • Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells
    • Nakagomi, T., Kubo, S., Nakano-Doi, A., Sakuma, R., Lu, S., Narita, A., Kawahara, M., Taguchi, A., and Matsuyama, T. (2015) Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells. Stem Cells 33, 1962-1974
    • (2015) Stem Cells , vol.33 , pp. 1962-1974
    • Nakagomi, T.1    Kubo, S.2    Nakano-Doi, A.3    Sakuma, R.4    Lu, S.5    Narita, A.6    Kawahara, M.7    Taguchi, A.8    Matsuyama, T.9
  • 14
    • 0347756803 scopus 로고    scopus 로고
    • Astrocyte and oligodendrocyte connexins of the glial syncytium in relation to astrocyte anatomical domains and spatial buffering
    • Nagy, J. I., and Rash, J. E. (2003) Astrocyte and oligodendrocyte connexins of the glial syncytium in relation to astrocyte anatomical domains and spatial buffering. Cell Commun. Adhes. 10, 401-406
    • (2003) Cell Commun. Adhes. , vol.10 , pp. 401-406
    • Nagy, J.I.1    Rash, J.E.2
  • 15
    • 84893477159 scopus 로고    scopus 로고
    • Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain
    • Sosunov, A. A., Wu, X., Tsankova, N. M., Guilfoyle, E., McKhann, G. M., 2nd, and Goldman, J. E. (2014) Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain. J. Neurosci. 34, 2285-2298
    • (2014) J. Neurosci. , vol.34 , pp. 2285-2298
    • Sosunov, A.A.1    Wu, X.2    Tsankova, N.M.3    Guilfoyle, E.4    McKhann, G.M.5    Goldman, J.E.6
  • 16
    • 84927646770 scopus 로고    scopus 로고
    • Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone
    • Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W., and Kim, K. J. (2016) Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone. Neuroscience 323, 96-109
    • (2016) Neuroscience , vol.323 , pp. 96-109
    • Filosa, J.A.1    Morrison, H.W.2    Iddings, J.A.3    Du, W.4    Kim, K.J.5
  • 18
    • 84886641249 scopus 로고    scopus 로고
    • Glial influence on the blood brain barrier
    • Alvarez, J. I., Katayama, T., and Prat, A. (2013) Glial influence on the blood brain barrier. Glia 61, 1939-1958
    • (2013) Glia , vol.61 , pp. 1939-1958
    • Alvarez, J.I.1    Katayama, T.2    Prat, A.3
  • 19
    • 79952588804 scopus 로고    scopus 로고
    • Bidirectional control of arteriole diameter by astrocytes
    • Gordon, G. R., Howarth, C., and MacVicar, B. A. (2011) Bidirectional control of arteriole diameter by astrocytes. Exp. Physiol. 96, 393-399
    • (2011) Exp. Physiol. , vol.96 , pp. 393-399
    • Gordon, G.R.1    Howarth, C.2    MacVicar, B.A.3
  • 21
    • 84873883408 scopus 로고    scopus 로고
    • Astroglial integrins in the development and regulation of neurovascular units
    • Tanigami, H., Okamoto, T., Yasue, Y., and Shimaoka, M. (2012) Astroglial integrins in the development and regulation of neurovascular units. Pain Res. Treat. 2012, 964652
    • (2012) Pain Res. Treat. , vol.2012 , pp. 964652
    • Tanigami, H.1    Okamoto, T.2    Yasue, Y.3    Shimaoka, M.4
  • 22
    • 0034651103 scopus 로고    scopus 로고
    • Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex
    • Niwa, K., Araki, E., Morham, S. G., Ross, M. E., and Iadecola, C. (2000) Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J. Neurosci. 20, 763-770
    • (2000) J. Neurosci. , vol.20 , pp. 763-770
    • Niwa, K.1    Araki, E.2    Morham, S.G.3    Ross, M.E.4    Iadecola, C.5
  • 24
    • 0023214752 scopus 로고
    • Cortical vasodilatation produced by vasoactive intestinal polypeptide (VIP) and by physiological stimuli in the cat
    • Yaksh, T. L., Wang, J. Y., and Go, V. L. (1987) Cortical vasodilatation produced by vasoactive intestinal polypeptide (VIP) and by physiological stimuli in the cat. J. Cereb. Blood Flow Metab. 7, 315-326
    • (1987) J. Cereb. Blood Flow Metab. , vol.7 , pp. 315-326
    • Yaksh, T.L.1    Wang, J.Y.2    Go, V.L.3
  • 25
    • 0015598578 scopus 로고
    • Cholinergic control of blood flow in the cerebral cortex of the rat
    • Scremin, O. U., Rovere, A. A., Raynald, A. C., and Giardini, A. (1973) Cholinergic control of blood flow in the cerebral cortex of the rat. Stroke 4, 233-239
    • (1973) Stroke , vol.4 , pp. 233-239
    • Scremin, O.U.1    Rovere, A.A.2    Raynald, A.C.3    Giardini, A.4
  • 26
    • 23944467512 scopus 로고    scopus 로고
    • Corticotropin-releasing factor: Effect on cerebral blood flow in physiologic and ischaemic conditions
    • De Michele, M., Touzani, O., Foster, A. C., Fieschi, C., Sette, G., and McCulloch, J. (2005) Corticotropin-releasing factor: effect on cerebral blood flow in physiologic and ischaemic conditions. Exp. Brain Res. 165, 375-382
    • (2005) Exp. Brain Res. , vol.165 , pp. 375-382
    • De Michele, M.1    Touzani, O.2    Foster, A.C.3    Fieschi, C.4    Sette, G.5    McCulloch, J.6
  • 28
    • 5644289368 scopus 로고    scopus 로고
    • Cortical GABA interneurons in neurovascular coupling: Relays for subcortical vasoactive pathways
    • Cauli, B., Tong, X. K., Rancillac, A., Serluca, N., Lambolez, B., Rossier, J., and Hamel, E. (2004) Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways. J. Neurosci. 24, 8940-8949
    • (2004) J. Neurosci. , vol.24 , pp. 8940-8949
    • Cauli, B.1    Tong, X.K.2    Rancillac, A.3    Serluca, N.4    Lambolez, B.5    Rossier, J.6    Hamel, E.7
  • 29
    • 84876896980 scopus 로고    scopus 로고
    • Neurovascular development and links to disease
    • Ruhrberg, C., and Bautch, V. L. (2013) Neurovascular development and links to disease. Cell. Mol. Life Sci. 70, 1675-1684
    • (2013) Cell. Mol. Life Sci. , vol.70 , pp. 1675-1684
    • Ruhrberg, C.1    Bautch, V.L.2
  • 30
    • 84873841906 scopus 로고    scopus 로고
    • Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling
    • Ma, S., Kwon, H. J., Johng, H., Zang, K., and Huang, Z. (2013) Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 11, e1001469
    • (2013) PLoS Biol. , vol.11 , pp. e1001469
    • Ma, S.1    Kwon, H.J.2    Johng, H.3    Zang, K.4    Huang, Z.5
  • 31
    • 84907999477 scopus 로고    scopus 로고
    • Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex
    • Lacoste, B., Comin, C. H., Ben-Zvi, A., Kaeser, P. S., Xu, X., Costa Lda, F., and Gu, C. (2014) Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron 83, 1117-1130
    • (2014) Neuron , vol.83 , pp. 1117-1130
    • Lacoste, B.1    Comin, C.H.2    Ben-Zvi, A.3    Kaeser, P.S.4    Xu, X.5    Costa Lda, F.6    Gu, C.7
  • 32
    • 84951570642 scopus 로고    scopus 로고
    • Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?
    • Joutel, A., Haddad, I., Ratelade, J., and Nelson, M. T. (2016) Perturbations of the cerebrovascular matrisome: a convergent mechanism in small vessel disease of the brain? J. Cereb. Blood Flow Metab. 36, 143-157
    • (2016) J. Cereb. Blood Flow Metab. , vol.36 , pp. 143-157
    • Joutel, A.1    Haddad, I.2    Ratelade, J.3    Nelson, M.T.4
  • 34
    • 0032737272 scopus 로고    scopus 로고
    • Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    • Alliot, F., Godin, I., and Pessac, B. (1999) Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res. Dev. Brain Res. 117, 145-152
    • (1999) Brain Res. Dev. Brain Res. , vol.117 , pp. 145-152
    • Alliot, F.1    Godin, I.2    Pessac, B.3
  • 36
    • 84902549638 scopus 로고    scopus 로고
    • Neuroinflammation and M2 microglia: The good, the bad, and the inflamed
    • Cherry, J. D., Olschowka, J. A., and O'Banion, M. K. (2014) Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J. Neuroinflammation 11, 98
    • (2014) J. Neuroinflammation , vol.11 , pp. 98
    • Cherry, J.D.1    Olschowka, J.A.2    O'Banion, M.K.3
  • 37
    • 84925374812 scopus 로고    scopus 로고
    • Mechanisms and potential therapeutic applications of microglial activation after brain injury
    • Kim, J. Y., Kim, N., and Yenari, M. A. (2015) Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS Neurosci. Ther. 21, 309-319
    • (2015) CNS Neurosci. Ther. , vol.21 , pp. 309-319
    • Kim, J.Y.1    Kim, N.2    Yenari, M.A.3
  • 39
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey, W. F., and Kimura, H. (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239, 290-292
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 42
    • 84964754235 scopus 로고    scopus 로고
    • Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-A new role for the tumor perivascular space as highway for trafficking microglia
    • Bayerl, S. H., Niesner, R., Cseresnyes, Z., Radbruch, H., Pohlan, J., Brandenburg, S., Czabanka, M. A., and Vajkoczy, P. (2016) Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia. Glia 64, 1210-1226
    • (2016) Glia , vol.64 , pp. 1210-1226
    • Bayerl, S.H.1    Niesner, R.2    Cseresnyes, Z.3    Radbruch, H.4    Pohlan, J.5    Brandenburg, S.6    Czabanka, M.A.7    Vajkoczy, P.8
  • 45
    • 57649118670 scopus 로고    scopus 로고
    • Brain metabolism dictates the polarity of astrocyte control over arterioles
    • Gordon, G. R., Choi, H. B., Rungta, R. L., Ellis-Davies, G. C., and MacVicar, B. A. (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456, 745-749
    • (2008) Nature , vol.456 , pp. 745-749
    • Gordon, G.R.1    Choi, H.B.2    Rungta, R.L.3    Ellis-Davies, G.C.4    MacVicar, B.A.5
  • 49
    • 35548969443 scopus 로고    scopus 로고
    • Glial regulation of the cerebral microvasculature
    • Iadecola, C., and Nedergaard, M. (2007) Glial regulation of the cerebral microvasculature. Nat. Neurosci. 10, 1369-1376
    • (2007) Nat. Neurosci. , vol.10 , pp. 1369-1376
    • Iadecola, C.1    Nedergaard, M.2
  • 50
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B. V. (2008) The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 51
    • 84655176404 scopus 로고    scopus 로고
    • Functions of Aβ, sAPPα and sAPPβ: Similarities and differences
    • Chasseigneaux, S., and Allinquant, B. (2012) Functions of Aβ, sAPPα and sAPPβ: similarities and differences. J. Neurochem. 120, Suppl. 1, 99-108
    • (2012) J. Neurochem. , vol.120 , pp. 99-108
    • Chasseigneaux, S.1    Allinquant, B.2
  • 57
    • 84862670985 scopus 로고    scopus 로고
    • Mechanisms of amyloid-β peptide clearance: Potential therapeutic targets for Alzheimer's disease
    • Yoon, S. S., and Jo, S. A. (2012) Mechanisms of amyloid-β peptide clearance: potential therapeutic targets for Alzheimer's disease. Biomol. Ther. (Seoul) 20, 245-255
    • (2012) Biomol. Ther. (Seoul) , vol.20 , pp. 245-255
    • Yoon, S.S.1    Jo, S.A.2
  • 58
    • 0033527637 scopus 로고    scopus 로고
    • Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid β-peptide by microglial cells
    • Chung, H., Brazil, M. I., Soe, T. T., and Maxfield, F. R. (1999) Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid β-peptide by microglial cells. J. Biol. Chem. 274, 32301-32308
    • (1999) J. Biol. Chem. , vol.274 , pp. 32301-32308
    • Chung, H.1    Brazil, M.I.2    Soe, T.T.3    Maxfield, F.R.4
  • 60
    • 80055112704 scopus 로고    scopus 로고
    • The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
    • Zhao, J., O'Connor, T., and Vassar, R. (2011) The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis. J. Neuroinflammation 8, 150
    • (2011) J. Neuroinflammation , vol.8 , pp. 150
    • Zhao, J.1    O'Connor, T.2    Vassar, R.3
  • 61
    • 84905868301 scopus 로고    scopus 로고
    • When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease
    • Avila-Muñoz, E., and Arias, C. (2014) When astrocytes become harmful: functional and inflammatory responses that contribute to Alzheimer's disease. Ageing Res. Rev. 18, 29-40
    • (2014) Ageing Res. Rev. , vol.18 , pp. 29-40
    • Avila-Muñoz, E.1    Arias, C.2
  • 62
    • 77952573750 scopus 로고    scopus 로고
    • Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    • Olabarria, M., Noristani, H. N., Verkhratsky, A., and Rodríguez, J. J. (2010) Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 58, 831-838
    • (2010) Glia , vol.58 , pp. 831-838
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodríguez, J.J.4
  • 63
    • 77956803700 scopus 로고    scopus 로고
    • The perivascular niche microenvironment in brain tumor progression
    • Charles, N., and Holland, E. C. (2010) The perivascular niche microenvironment in brain tumor progression. Cell Cycle 9, 3012-3021
    • (2010) Cell Cycle , vol.9 , pp. 3012-3021
    • Charles, N.1    Holland, E.C.2
  • 64
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan, D., Becher, O. J., Rosenblum, M. K., Pandolfi, P. P., Manova-Todorova, K., and Holland, E. C. (2008) PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 22, 436-448
    • (2008) Genes Dev. , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3    Pandolfi, P.P.4    Manova-Todorova, K.5    Holland, E.C.6
  • 65
    • 77956626222 scopus 로고    scopus 로고
    • Glioblastoma cells incorporate into tumor vasculature and contribute to vascular radioresistance
    • Shaifer, C. A., Huang, J., and Lin, P. C. (2010) Glioblastoma cells incorporate into tumor vasculature and contribute to vascular radioresistance. Int. J. Cancer 127, 2063-2075
    • (2010) Int. J. Cancer , vol.127 , pp. 2063-2075
    • Shaifer, C.A.1    Huang, J.2    Lin, P.C.3
  • 66
    • 84950136752 scopus 로고    scopus 로고
    • Cancer stem cell-vascular endothelial cell interactions in glioblastoma
    • Sharma, A., and Shiras, A. (2016) Cancer stem cell-vascular endothelial cell interactions in glioblastoma. Biochem. Biophys. Res. Commun. 473, 688-692
    • (2016) Biochem. Biophys. Res. Commun. , vol.473 , pp. 688-692
    • Sharma, A.1    Shiras, A.2
  • 68
    • 84906082718 scopus 로고    scopus 로고
    • Type 1 collagen as a potential niche component for CD133-positive glioblastoma cells
    • Motegi, H., Kamoshima, Y., Terasaka, S., Kobayashi, H., and Houkin, K. (2014) Type 1 collagen as a potential niche component for CD133-positive glioblastoma cells. Neuropathology 34, 378-385
    • (2014) Neuropathology , vol.34 , pp. 378-385
    • Motegi, H.1    Kamoshima, Y.2    Terasaka, S.3    Kobayashi, H.4    Houkin, K.5
  • 71
    • 84904512087 scopus 로고    scopus 로고
    • Glioblastoma: A pathogenic crosstalk between tumor cells and pericytes
    • Caspani, E. M., Crossley, P. H., Redondo-Garcia, C., and Martinez, S. (2014) Glioblastoma: a pathogenic crosstalk between tumor cells and pericytes. PLoS ONE 9, e101402
    • (2014) PLoS ONE , vol.9 , pp. e101402
    • Caspani, E.M.1    Crossley, P.H.2    Redondo-Garcia, C.3    Martinez, S.4
  • 72
    • 84963614964 scopus 로고    scopus 로고
    • Areappraisal of macrophage polarization in glioblastoma: Histopathological and immunohistochemical findings and review of the literature
    • Mignogna, C., Signorelli, F., Vismara, M. F., Zeppa, P., Camastra, C., Barni, T., Donato, G., and Di Vito, A. (2016)Areappraisal of macrophage polarization in glioblastoma: histopathological and immunohistochemical findings and review of the literature. Pathol Res Pract 212, 491-499
    • (2016) Pathol Res Pract , vol.212 , pp. 491-499
    • Mignogna, C.1    Signorelli, F.2    Vismara, M.F.3    Zeppa, P.4    Camastra, C.5    Barni, T.6    Donato, G.7    Di-Vito, A.8
  • 73
    • 84961290723 scopus 로고    scopus 로고
    • Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes
    • Chen, W., Wang, D., Du, X., He, Y., Chen, S., Shao, Q., Ma, C., Huang, B., Chen, A., Zhao, P., Qu, X., and Li, X. (2015) Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes. Med. Oncol. 32, 43
    • (2015) Med. Oncol. , vol.32 , pp. 43
    • Chen, W.1    Wang, D.2    Du, X.3    He, Y.4    Chen, S.5    Shao, Q.6    Ma, C.7    Huang, B.8    Chen, A.9    Zhao, P.10    Qu, X.11    Li, X.12
  • 75
    • 84903183157 scopus 로고    scopus 로고
    • Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells
    • Watkins, S., Robel, S., Kimbrough, I. F., Robert, S. M., Ellis-Davies, G., and Sontheimer, H. (2014) Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells. Nat. Commun. 5, 4196
    • (2014) Nat. Commun. , vol.5 , pp. 4196
    • Watkins, S.1    Robel, S.2    Kimbrough, I.F.3    Robert, S.M.4    Ellis-Davies, G.5    Sontheimer, H.6
  • 78
    • 84955459485 scopus 로고    scopus 로고
    • Glioblastoma vasculogenic mimicry: Signaling pathways progression and potential anti-angiogenesis targets
    • Mao, J. M., Liu, J., Guo, G., Mao, X. G., and Li, C. X. (2015) Glioblastoma vasculogenic mimicry: signaling pathways progression and potential anti-angiogenesis targets. Biomark. Res. 3, 8
    • (2015) Biomark. Res. , vol.3 , pp. 8
    • Mao, J.M.1    Liu, J.2    Guo, G.3    Mao, X.G.4    Li, C.X.5
  • 81
    • 84929320945 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis
    • Pishko, G. L., Muldoon, L. L., Pagel, M. A., Schwartz, D. L., and Neuwelt, E. A. (2015) Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis. Fluids Barriers CNS 12, 5
    • (2015) Fluids Barriers CNS , vol.12 , pp. 5
    • Pishko, G.L.1    Muldoon, L.L.2    Pagel, M.A.3    Schwartz, D.L.4    Neuwelt, E.A.5
  • 84
    • 84957844086 scopus 로고    scopus 로고
    • Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease
    • Simon, M. J., and Iliff, J. J. (2016) Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease. Biochim. Biophys. Acta 1862, 442-451
    • (2016) Biochim. Biophys. Acta , vol.1862 , pp. 442-451
    • Simon, M.J.1    Iliff, J.J.2
  • 86
    • 84948773327 scopus 로고    scopus 로고
    • CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review
    • Kothur, K., Wienholt, L., Brilot, F., and Dale, R. C. (2016) CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: a systematic review. Cytokine 77, 227-237
    • (2016) Cytokine , vol.77 , pp. 227-237
    • Kothur, K.1    Wienholt, L.2    Brilot, F.3    Dale, R.C.4
  • 87
    • 84949424687 scopus 로고    scopus 로고
    • Tumor-associated CSF microRNAs for the prediction and evaluation of CNS malignancies
    • Shalaby, T., and Grotzer, M. A. (2015) Tumor-associated CSF microRNAs for the prediction and evaluation of CNS malignancies. Int. J. Mol. Sci. 16, 29103-29119
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 29103-29119
    • Shalaby, T.1    Grotzer, M.A.2
  • 88
    • 84900023528 scopus 로고    scopus 로고
    • In vitro models of the blood-brain barrier for the study of drug delivery to the brain
    • Wilhelm, I., and Krizbai, I. A. (2014) In vitro models of the blood-brain barrier for the study of drug delivery to the brain. Mol. Pharm. 11, 1949-1963
    • (2014) Mol. Pharm. , vol.11 , pp. 1949-1963
    • Wilhelm, I.1    Krizbai, I.A.2
  • 89
    • 84928006491 scopus 로고    scopus 로고
    • Understanding the rules of the road: Proteomic approaches to interrogate the blood brain barrier
    • Torbett, B. E., Baird, A., and Eliceiri, B. P. (2015) Understanding the rules of the road: proteomic approaches to interrogate the blood brain barrier. Front. Neurosci. 9, 70
    • (2015) Front. Neurosci. , vol.9 , pp. 70
    • Torbett, B.E.1    Baird, A.2    Eliceiri, B.P.3
  • 90
    • 84920768217 scopus 로고    scopus 로고
    • Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier
    • Lajoie, J. M., and Shusta, E. V. (2015) Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. Annu. Rev. Pharmacol. Toxicol. 55, 613-631
    • (2015) Annu. Rev. Pharmacol. Toxicol. , vol.55 , pp. 613-631
    • Lajoie, J.M.1    Shusta, E.V.2
  • 91
    • 84960433266 scopus 로고    scopus 로고
    • Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma
    • Oberoi, R. K., Parrish, K. E., Sio, T. T., Mittapalli, R. K., Elmquist, W. F., and Sarkaria, J. N. (2016) Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma. Neuro Oncol. 18, 27-36
    • (2016) Neuro Oncol. , vol.18 , pp. 27-36
    • Oberoi, R.K.1    Parrish, K.E.2    Sio, T.T.3    Mittapalli, R.K.4    Elmquist, W.F.5    Sarkaria, J.N.6
  • 92
    • 84937121327 scopus 로고    scopus 로고
    • Blood-brain barrier endogenous transporters as therapeutic targets: A new model for small molecule CNS drug discovery
    • Pardridge, W. M. (2015) Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery. Expert Opin. Ther. Targets 19, 1059-1072
    • (2015) Expert Opin. Ther. Targets , vol.19 , pp. 1059-1072
    • Pardridge, W.M.1
  • 93
    • 79959444718 scopus 로고    scopus 로고
    • Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein
    • Zhou, Q. H., Boado, R. J., Hui, E. K., Lu, J. Z., and Pardridge, W. M. (2011) Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein. Drug Metab. Dispos. 39, 1149-1154
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1149-1154
    • Zhou, Q.H.1    Boado, R.J.2    Hui, E.K.3    Lu, J.Z.4    Pardridge, W.M.5
  • 97
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott, N. J., Rönnbäck, L., and Hansson, E. (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41-53
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 98
    • 63249115678 scopus 로고    scopus 로고
    • The bloodbrain barrier in brain homeostasis and neurological diseases
    • Weiss, N., Miller, F., Cazaubon, S., and Couraud, P. O. (2009) The bloodbrain barrier in brain homeostasis and neurological diseases. Biochim. Biophys. Acta 1788, 842-857
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 99
    • 84942410929 scopus 로고    scopus 로고
    • Implications of the discovery of brain lymphatic pathways
    • Iliff, J. J., Goldman, S. A., and Nedergaard, M. (2015) Implications of the discovery of brain lymphatic pathways. Lancet Neurol. 14, 977-979
    • (2015) Lancet Neurol. , vol.14 , pp. 977-979
    • Iliff, J.J.1    Goldman, S.A.2    Nedergaard, M.3
  • 100
    • 33645809129 scopus 로고    scopus 로고
    • Perivascular nerves and the regulation of cerebrovascular tone
    • Hamel, E. (2006) Perivascular nerves and the regulation of cerebrovascular tone. J. Appl. Physiol. 100, 1059-1064
    • (2006) J. Appl. Physiol. , vol.100 , pp. 1059-1064
    • Hamel, E.1
  • 101
    • 59049104731 scopus 로고    scopus 로고
    • Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy
    • Hawkes, C. A., and McLaurin, J. (2009) Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy. Proc. Natl. Acad. Sci. U.S.A. 106, 1261-1266
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 1261-1266
    • Hawkes, C.A.1    McLaurin, J.2


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