Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Bettini, Sarah ^a   Boutet Robinet, Elisa ^a   Cartier, Christel ^a   Coméra, Christine ^a   Gaultier, Eric ^a   Dupuy, Jacques ^a   Naud, Nathalie ^a   Taché, Sylviane ^a   Grysan, Patrick ^b   Reguer, Solenn ^c   Thieriet, Nathalie ^d   Réfrégiers, Matthieu ^c   Thiaudière, Dominique ^c   Cravedi, Jean Pierre ^a   Carrière, Marie ^e,f   Audinot, Jean Nicolas ^b   Pierre, Fabrice H ^a   Guzylack Piriou, Laurence ^a   Houdeau, Eric ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY   (Luxembourg)

^c SYNCHROTRON SOLEIL   (France)

^d FRENCH AGENCY FOR FOOD   (France)

^e UNIV GRENOBLE ALPES   (France)

^f CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL; CARCINOGENESIS; CELL COUNT; CELL FRACTIONATION; CELL SEPARATION; CHEMISTRY; COLON; DENDRITIC CELL; DNA DAMAGE; EPITHELIUM CELL; FOOD; HOMEOSTASIS; IMMUNE SYSTEM; IMMUNOLOGY; INFLAMMATION; LIVER; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PERMEABILITY; PEYER PATCH; PRECANCER; T LYMPHOCYTE; TISSUE DISTRIBUTION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CARCINOGENESIS; CELL COUNT; CELL SEPARATION; COLON; CYTOKINES; DENDRITIC CELLS; DNA DAMAGE; EPITHELIAL CELLS; FOOD; HOMEOSTASIS; IMMUNE SYSTEM; INFLAMMATION; LIVER; MALE; PERMEABILITY; PEYER'S PATCHES; PRECANCEROUS CONDITIONS; RATS, WISTAR; SUBCELLULAR FRACTIONS; T-LYMPHOCYTES; TISSUE DISTRIBUTION; TITANIUM;

EID: 85010036625     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep40373     Document Type: Article

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