iRegNet3D: Three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations

Genome Biology

Volumn 18, Issue 1, 2017, Pages

  Liang, Siqi ^a,b   Tippens, Nathaniel D ^a,b   Zhou, Yaoda ^a,b   Mort, Matthew ^c   Stenson, Peter D ^c   Cooper, David N ^c   Yu, Haiyuan ^a,b  

^a Department of Biological Statistics and Computational Biology ^*  (United States)

^b School of Integrative Plant Sciences   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Chromatin interaction network; Disease associated mutation; Inherited disease; IRegNet3D; Missense mutation; Non coding mutation; TF DNA interaction network; TF TF interaction network; Transcriptional regulation

Indexed keywords

TRANSCRIPTION FACTOR; CHROMATIN; DNA; DNA BINDING PROTEIN; UNTRANSLATED REGION;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DIMERIZATION; DISEASE ASSOCIATION; DNA BINDING; GENE REGULATORY NETWORK; GENOME ANALYSIS; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; BINDING SITE; CHEMISTRY; EPISTASIS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; NUCLEOTIDE MOTIF; OPEN READING FRAME; PROCEDURES; QUANTITATIVE STRUCTURE ACTIVITY RELATION; UNTRANSLATED REGION;

BINDING SITES; CHROMATIN; DNA; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; MODELS, MOLECULAR; MUTATION; NUCLEOTIDE MOTIFS; OPEN READING FRAMES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; UNTRANSLATED REGIONS;

EID: 85009997095     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-1138-2     Document Type: Article

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