The redox-sensitive induction of the local angiotensin system promotes both premature and replicative endothelial senescence: Preventive effect of a standardized crataegus extract

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 71, Issue 12, 2016, Pages 1581-1590

  Khemais Benkhiat, Sonia ^a   Idris Khodja, Noureddine ^a   Ribeiro, Thais Porto ^a   Silva, Grazielle Caroline ^a   Abbas, Malak ^a   Kheloufi, Marouane ^a   Lee, Jung Ok ^a   Toti, Florence ^a   Auger, Cyril ^a   Schini Kerth, Valérie B ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Crataegus extract; Endothelial senescence; ENOS; Local angiotensin system; Oxidative stress; P53 p21 pathway

Indexed keywords

ACE PROTEIN, HUMAN; ANGIOTENSIN DERIVATIVE; ANTIOXIDANT; CRATAEGUS EXTRACT; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE;

ANIMAL; CELL AGING; CORONARY BLOOD VESSEL; CRATAEGUS; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYSIOLOGY; PIG; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANGIOTENSINS; ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CELL AGING; CORONARY VESSELS; CRATAEGUS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDYL-DIPEPTIDASE A; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; SWINE;

EID: 85009877243     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glv213     Document Type: Article

References (51)

1. Herrera MD, Mingorance C, Rodríguez-Rodríguez R, Alvarez de Sotomayor M. Endothelial dysfunction and aging: an update. Ageing Res Rev. 2010;9:142-152. doi:10.1016/j.arr.2009.07.002
2. Algotsson A, Nordberg A, Winblad B. Influence of age and gender on skin vessel reactivity to endothelium-dependent and endothelium-independent vasodilators tested with iontophoresis and a laser Doppler perfusion imager. J Gerontol A Biol Sci Med Sci. 1995;50:M121-M127. doi:10.1093/gerona/50A.2.M121
3. Jane-Wit D, Chun HJ. Mechanisms of dysfunction in senescent pulmonary endothelium. J Gerontol A Biol Sci Med Sci. 2012;67:236-241. doi:10.1093/gerona/glr248
4. Foreman KE, Tang J. Molecular mechanisms of replicative senescence in endothelial cells. Exp Gerontol. 2003;38:1251-1257. doi:10.1016/j. exger.2003.09.005
5. Minamino T, Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res. 2007;100:15-26. doi:10.1161/01. RES.0000256837.40544.4a
6. Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985). 2009;106:326-332. doi:10.1152/ japplphysiol.91353.2008
7. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation. 2002;105:1541-1544. doi:10.1161/01.CIR.0000013836.85741.17
8. Han X, Ling S, Gan W, Sun L, Duan J, Xu JW. 2,3,5,4'-tetrahydroxystilbene-2-O-?-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis. 2012;225:76-82. doi:10.1016/j.atherosclerosis.2012.08.011
9. Chen J, Brodsky SV, Goligorsky DM, et al. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res. 2002;90:1290-1298. doi:10.1161/01.RES.0000022161.42655.98
10. Botden IP, Oeseburg H, Durik M, et al. Red wine extract protects against oxidative-stress-induced endothelial senescence. Clin Sci (Lond). 2012;123:499-507. doi:10.1042/CS20110679
11. Kumar A, Kim CS, Hoffman TA, et al. p53 impairs endothelial function by transcriptionally repressing Kruppel-Like Factor 2. Arterioscler Thromb Vasc Biol. 2011;31:133-141. doi:10.1161/ATVBAHA.110.215061
12. Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB. Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress. Biochem Biophys Res Commun. 2012;419:381-387. doi:10.1016/j.bbrc.2012.02.031
13. Idris Khodja N, Chataigneau T, Auger C, Schini-Kerth VB. Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system. PLoS One. 2012;7:e32039. doi:10.1371/journal.pone.0032039
14. Bhayadia R, Schmidt BM, Melk A, Homme M. Senescence-induced oxidative stress causes endothelial dysfunction. J Gerontol A Biol Sci Med Sci. 2015.
15. Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38:274-279. doi:10.1161/01.HYP.38.2.274
16. Rodriguez-Manas L, El-Assar M, Vallejo S, et al. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell. 2009;8:226-238. doi:10.1111/j.1474-9726.2009.00466.x
17. Dal-Ros S, Zoll J, Lang AL, et al. Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. Biochem Biophys Res Commun. 2011;404:743-749. doi:10.1016/j. bbrc.2010.12.060
18. Idris-Khodja N, Auger C, Koch E, Schini-Kerth VB. Crataegus special extract WS(®)1442 prevents aging-related endothelial dysfunction. Phytomedicine. 2012;19:699-706. doi:10.1016/j.phymed.2012.04.005
19. Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB. Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J. 2005;19:455-457. doi:10.1096/fj.04-2146fje
20. Alhosin M, Anselm E, Rashid S, et al. Redox-sensitive up-regulation of eNOS by purple grape juice in endothelial cells: Role of PI3-Kinase/ Akt, p38 MAPK, JNK, FoxO1 and FoxO3a. PLoS One. 2013;8:e57883. doi:10.1371/journal.pone.0057883
21. Goto K, Fujii K, Kansui Y, Iida M. Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: response to chronic treatment with renin-angiotensin system inhibitors. Clin Exp Pharmacol Physiol. 2004;31:650-655. doi:10.1111/j.1440-1681.2004.04054.x
22. Kansui Y, Fujii K, Goto K, Abe I, Iida M. Angiotensin II receptor antagonist improves age-related endothelial dysfunction. J Hypertens. 2002;20:439-446.
23. Wang M, Zhang J, Jiang LQ, et al. Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension. 2007;50:219-227. doi:10.1161/HYPERTENSIONAHA.107.089409
24. Auger C, Kim JH, Chabert P, et al. The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties. Biochem Biophys Res Commun. 2010;393:162-167. doi:10.1016/j.bbrc.2010.01.112
25. Hayashi T, Matsui-Hirai H, Miyazaki-Akita A, et al. Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes. Proc Natl Acad Sci U S A. 2006;103:17018-17023. doi:10.1073/pnas.0607873103
26. Erusalimsky JD, Skene C. Mechanisms of endothelial senescence. Exp Physiol. 2009;94:299-304. doi:10.1113/expphysiol.2008.043133
27. Ohara Y, Peterson TE, Sayegh HS, Subramanian RR, Wilcox JN, Harrison DG. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation. 1995;92:898-903. doi:10.1161/01.CIR.92.4.898
28. Li D, Saldeen T, Romeo F, Mehta JL. Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB. Circulation. 2000;102:1970-1976. doi:10.1161/01.CIR.102.16.1970
29. Mu X, He K, Sun H, et al. Hydrogen peroxide induces overexpression of angiotensin-converting enzyme in human umbilical vein endothelial cells. Free Radic Res. 2013;47:116-122. doi:10.3109/10715762.2012. 749987
30. Anselm E, Socorro VF, Dal-Ros S, Schott C, Bronner C, Schini-Kerth VB. Crataegus special extract WS 1442 causes endothelium-dependent relaxation via a redox-sensitive Src-and Akt-dependent activation of endothelial NO synthase but not via activation of estrogen receptors. J Cardiovasc Pharmacol. 2009;53:253-260. doi:10.1097/FJC.0b013e31819ccfc9
31. Freedman DA, Folkman J. CDK2 translational down-regulation during endothelial senescence. Exp Cell Res. 2005;307:118-130. doi:10.1016/j. yexcr.2005.03.025
32. Romagosa C, Simonetti S, Lopez-Vicente L, et al. p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and highgrade tumors. Oncogene. 2011;30:2087-2097. doi:10.1038/onc.2010.614
33. Lee MY, Wang Y, Vanhoutte PM. Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB. J Vasc Res. 2010;47:287-298. doi:10.1159/000265563
34. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Circ Res. 2001;89:793-798. doi:10.1161/hh2101.098443
35. Vasa M, Breitschopf K, Zeiher AM, Dimmeler S. Nitric oxide activates telomerase and delays endothelial cell senescence. Circ Res. 2000;87:540-542. doi:10.1161/01.RES.87.7.540
36. Schilder YD, Heiss EH, Schachner D, et al. NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells. Free Radic Biol Med. 2009;46:1598-1606. doi:10.1016/j. freeradbiomed.2009.03.013
37. Paneni F, Osto E, Costantino S, et al. Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates agerelated endothelial dysfunction. Circulation. 2013;127:1229-1240. doi:10.1161/CIRCULATIONAHA.112.000826
38. Lener B, Koziel R, Pircher H, et al. The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. Biochem J. 2009;423:363-374. doi:10.1042/BJ20090666
39. Martien S, Pluquet O, Vercamer C, et al. Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts. Biochim Biophys Acta. 2013;1831:1217-1227. doi:10.1042/BJ20090666
40. Hu Z, Zhang F, Yang Z, et al. Low-dose aspirin promotes endothelial progenitor cell migration and adhesion and prevents senescence. Cell Biol Int. 2008;32:761-768. doi:10.1016/j.cellbi.2008.03.004
41. Atkins GB, Jain MK. Role of Krüppel-like transcription factors in endothelial biology. Circ Res. 2007;100:1686-1695. doi:10.1161/01. RES.0000267856.00713.0a
42. Kim CS, Jung SB, Naqvi A, et al. p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc. Circ Res. 2008;103:1441-1450. doi:10.1161/CIRCRESAHA.108.181644
43. Davis ME, Cai H, Drummond GR, Harrison DG. Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Circ Res. 2001;89:1073-1080. doi:10.1161/ hh2301.100806
44. Doughan AK, Harrison DG, Dikalov SI. Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res. 2008;102:488-496. doi:10.1161/CIRCRESAHA.107.162800
45. Harrison DG, Cai H, Landmesser U, Griendling KK. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J Renin Angiotensin Aldosterone Syst. 2003;4:51-61. doi:10.3317/ jraas.2003.014
46. Shan H, Guo D, Li X, Zhao X, Li W, Bai X. From autophagy to senescence and apoptosis in Angiotensin II-treated vascular endothelial cells. APMIS. 2014;122:985-992. doi:10.1111/apm.12242
47. Kao CL, Chen LK, Chang YL, et al. Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation. J Atheroscler Thromb. 2010;17:970-979. doi:10.5551/jat.4333
48. Xia L, Wang XX, Hu XS, et al. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Aktdependent mechanisms. Br J Pharmacol. 2008;155:387-394. doi:10.1038/ bjp.2008.272
49. Vasile E, Tomita Y, Brown LF, Kocher O, Dvorak HF. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 2001;15:458-466. doi:10.1096/fj.00-0051com
50. Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev. 2011;91:327-387. doi:10.1152/physrev.00047.2009
51. Warboys CM, de Luca A, Amini N, et al. Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arterioscler Thromb Vasc Biol. 2014;34:985-995. doi:10.1161/ATVBAHA.114.303415