메뉴 건너뛰기




Volumn 1831, Issue 7, 2013, Pages 1217-1227

Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts

Author keywords

COX 2; EP receptor; Oxidative stress; PGE2; Senescence

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; BETA GALACTOSIDASE; CYCLOOXYGENASE 2; INTERLEUKIN 6; L 161982; LACTATE TRANSPORTER; LACTIC ACID; MOLECULAR MARKER; MONOCYTE CHEMOTACTIC PROTEIN 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N [(5 BROMO 2 METHOXYPHENYL)SULFONYL] 3 [2 (2 NAPHTHYLMETHYL)PHENYL]ACRYLAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SULPROSTONE; UNCLASSIFIED DRUG;

EID: 84877093322     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.04.005     Document Type: Article
Times cited : (37)

References (61)
  • 1
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • L. Hayflick The limited in vitro lifetime of human diploid cell strains Exp. Cell Res. 37 1965 614 636
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 2
    • 0030016821 scopus 로고    scopus 로고
    • Longevity, genes, and aging
    • M. Jazwinski Longevity, genes, and aging Science 273 1996 54 59
    • (1996) Science , vol.273 , pp. 54-59
    • Jazwinski, M.1
  • 3
    • 0030038104 scopus 로고    scopus 로고
    • Replicative senescence: Implications for in vivo aging and tumor suppression
    • J.R. Smith, and O.M. Pereira-Smith Replicative senescence: implications for in vivo aging and tumor suppression Science 273 1996 63 67
    • (1996) Science , vol.273 , pp. 63-67
    • Smith, J.R.1    Pereira-Smith, O.M.2
  • 5
    • 0015292640 scopus 로고
    • Parameters of aging in chicken embryo fibroblasts cultivated in vitro
    • L. Lima, and A. Macieira-Coelho Parameters of aging in chicken embryo fibroblasts cultivated in vitro Exp. Cell Res. 70 1972 279 284
    • (1972) Exp. Cell Res. , vol.70 , pp. 279-284
    • Lima, L.1    Macieira-Coelho, A.2
  • 8
    • 0025145238 scopus 로고
    • Replicative senescence: The human fibroblast comes of age
    • S. Goldstein Replicative senescence: the human fibroblast comes of age Science 249 1990 1129 1133
    • (1990) Science , vol.249 , pp. 1129-1133
    • Goldstein, S.1
  • 12
    • 0041306060 scopus 로고    scopus 로고
    • Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics
    • C.N. Serhan, and B. Levy Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics Proc. Natl. Acad. Sci. U.S.A. 100 2003 8609 8611
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 8609-8611
    • Serhan, C.N.1    Levy, B.2
  • 13
    • 0032549175 scopus 로고    scopus 로고
    • Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "pGT"
    • B.S. Chan, J.A. Satriano, M. Pucci, and V.L. Schuster Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "PGT" J. Biol. Chem. 273 1998 6689 6697
    • (1998) J. Biol. Chem. , vol.273 , pp. 6689-6697
    • Chan, B.S.1    Satriano, J.A.2    Pucci, M.3    Schuster, V.L.4
  • 16
    • 0036080578 scopus 로고    scopus 로고
    • Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT
    • B.S. Chan, S. Endo, N. Kanai, and V.L. Schuster Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT Am. J. Physiol. Renal Physiol. 282 2002 F1097 F1102
    • (2002) Am. J. Physiol. Renal Physiol. , vol.282
    • Chan, B.S.1    Endo, S.2    Kanai, N.3    Schuster, V.L.4
  • 17
    • 0032750211 scopus 로고    scopus 로고
    • Dietary modulation of prostanoid synthesis in the aging process: Role of cyclooxygenase-2
    • H.Y. Chung, H.J. Kim, K.H. Shim, and K.W. Kim Dietary modulation of prostanoid synthesis in the aging process: role of cyclooxygenase-2 Mech. Ageing Dev. 111 1999 97 106
    • (1999) Mech. Ageing Dev. , vol.111 , pp. 97-106
    • Chung, H.Y.1    Kim, H.J.2    Shim, K.H.3    Kim, K.W.4
  • 18
    • 0034102203 scopus 로고    scopus 로고
    • The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation
    • H.J. Kim, K.W. Kim, B.P. Yu, and H.Y. Chung The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation Free Radic. Biol. Med. 28 2000 683 692
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 683-692
    • Kim, H.J.1    Kim, K.W.2    Yu, B.P.3    Chung, H.Y.4
  • 19
    • 4544257961 scopus 로고    scopus 로고
    • Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate
    • A.F. Badawi, Y. Liu, M.B. Eldeen, W. Morrow, Z.R. Razak, M. Maradeo, and M.Z. Badr Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate Carcinogenesis 25 2004 1681 1688
    • (2004) Carcinogenesis , vol.25 , pp. 1681-1688
    • Badawi, A.F.1    Liu, Y.2    Eldeen, M.B.3    Morrow, W.4    Razak, Z.R.5    Maradeo, M.6    Badr, M.Z.7
  • 21
    • 0036569812 scopus 로고    scopus 로고
    • Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat
    • P. Casolini, A. Catalani, A.R. Zuena, and L. Angelucci Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat J. Neurosci. Res. 68 2002 337 343
    • (2002) J. Neurosci. Res. , vol.68 , pp. 337-343
    • Casolini, P.1    Catalani, A.2    Zuena, A.R.3    Angelucci, L.4
  • 22
    • 4344595492 scopus 로고    scopus 로고
    • Mechanism of age-associated up-regulation in macrophage PGE2 synthesis
    • D. Wu, and S.N. Meydani Mechanism of age-associated up-regulation in macrophage PGE2 synthesis Brain Behav. Immun. 18 2004 487 494
    • (2004) Brain Behav. Immun. , vol.18 , pp. 487-494
    • Wu, D.1    Meydani, S.N.2
  • 25
    • 0016836753 scopus 로고
    • Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland
    • L.J. Marnett, P. Wlodawer, and B. Samuelsson Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland J. Biol. Chem. 250 1975 8510 8517
    • (1975) J. Biol. Chem. , vol.250 , pp. 8510-8517
    • Marnett, L.J.1    Wlodawer, P.2    Samuelsson, B.3
  • 27
    • 0017091041 scopus 로고
    • Mechanism for irreversible self-deactivation of prostaglandin synthetase
    • R.W. Egan, J. Paxton, and F.A. Kuehl Jr. Mechanism for irreversible self-deactivation of prostaglandin synthetase J. Biol. Chem. 251 1976 7329 7335
    • (1976) J. Biol. Chem. , vol.251 , pp. 7329-7335
    • Egan, R.W.1    Paxton, J.2    Kuehl, Jr.F.A.3
  • 28
    • 0035853707 scopus 로고    scopus 로고
    • Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress
    • M. Kondo, T. Oya-Ito, T. Kumagai, T. Osawa, and K. Uchida Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress J. Biol. Chem. 276 2001 12076 12083
    • (2001) J. Biol. Chem. , vol.276 , pp. 12076-12083
    • Kondo, M.1    Oya-Ito, T.2    Kumagai, T.3    Osawa, T.4    Uchida, K.5
  • 29
    • 0027788884 scopus 로고
    • Prostaglandin E2 suppresses phytohemagglutinin-induced immune responses of normal human mononuclear cells by decreasing intracellular glutathione generation, but not due to increased DNA strand breaks or apoptosis
    • C.L. Yu, C.L. Liu, C.Y. Tsai, K.H. Sun, T.S. Liao, W.M. Lin, H.L. Chen, and H.S. Yu Prostaglandin E2 suppresses phytohemagglutinin-induced immune responses of normal human mononuclear cells by decreasing intracellular glutathione generation, but not due to increased DNA strand breaks or apoptosis Agents Actions 40 1993 191 199
    • (1993) Agents Actions , vol.40 , pp. 191-199
    • Yu, C.L.1    Liu, C.L.2    Tsai, C.Y.3    Sun, K.H.4    Liao, T.S.5    Lin, W.M.6    Chen, H.L.7    Yu, H.S.8
  • 31
    • 0242636439 scopus 로고    scopus 로고
    • Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway
    • M. Murakami, and I. Kudo Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway Prog. Lipid Res. 43 2004 3 35
    • (2004) Prog. Lipid Res. , vol.43 , pp. 3-35
    • Murakami, M.1    Kudo, I.2
  • 32
    • 0029879179 scopus 로고    scopus 로고
    • In vitro senescence enhances IL-6 production in human gingival fibroblasts induced by lipopolysaccharide from Campylobacter rectus
    • N. Ogura, U. Matsuda, F. Tanaka, Y. Shibata, H. Takiguchi, and Y. Abiko In vitro senescence enhances IL-6 production in human gingival fibroblasts induced by lipopolysaccharide from Campylobacter rectus Mech. Ageing Dev. 87 1996 47 59
    • (1996) Mech. Ageing Dev. , vol.87 , pp. 47-59
    • Ogura, N.1    Matsuda, U.2    Tanaka, F.3    Shibata, Y.4    Takiguchi, H.5    Abiko, Y.6
  • 33
    • 0034255633 scopus 로고    scopus 로고
    • Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model
    • W.D. Funk, C.K. Wang, D.N. Shelton, C.B. Harley, G.D. Pagon, and W.K. Hoeffler Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model Exp. Cell Res. 258 2000 270 278
    • (2000) Exp. Cell Res. , vol.258 , pp. 270-278
    • Funk, W.D.1    Wang, C.K.2    Shelton, D.N.3    Harley, C.B.4    Pagon, G.D.5    Hoeffler, W.K.6
  • 36
    • 84860608697 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by senescent fibroblasts
    • R.M. Laberge, P. Awad, J. Campisi, and P.Y. Desprez Epithelial- mesenchymal transition induced by senescent fibroblasts Cancer Microenviron 5 2012 39 44
    • (2012) Cancer Microenviron , vol.5 , pp. 39-44
    • Laberge, R.M.1    Awad, P.2    Campisi, J.3    Desprez, P.Y.4
  • 37
    • 84855361145 scopus 로고    scopus 로고
    • Regulation of immune responses by prostaglandin E2
    • P. Kalinski Regulation of immune responses by prostaglandin E2 J. Immunol. 188 2012 21 28
    • (2012) J. Immunol. , vol.188 , pp. 21-28
    • Kalinski, P.1
  • 38
    • 56949107189 scopus 로고    scopus 로고
    • Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner
    • S.R. Kim, J.H. Park, M.E. Lee, J.S. Park, S.C. Park, and J.A. Han Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner Mech. Ageing Dev. 129 2008 706 713
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 706-713
    • Kim, S.R.1    Park, J.H.2    Lee, M.E.3    Park, J.S.4    Park, S.C.5    Han, J.A.6
  • 39
    • 79958139009 scopus 로고    scopus 로고
    • Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts
    • H.H. Yang, C. Kim, B. Jung, K.S. Kim, and J.R. Kim Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts Biogerontology 12 2011 239 252
    • (2011) Biogerontology , vol.12 , pp. 239-252
    • Yang, H.H.1    Kim, C.2    Jung, B.3    Kim, K.S.4    Kim, J.R.5
  • 46
    • 4444262310 scopus 로고    scopus 로고
    • Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation
    • A.N. Hata, and R.M. Breyer Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation Pharmacol. Ther. 103 2004 147 166
    • (2004) Pharmacol. Ther. , vol.103 , pp. 147-166
    • Hata, A.N.1    Breyer, R.M.2
  • 47
    • 0034803940 scopus 로고    scopus 로고
    • Effect of COX-2 inhibitor NS-398 on expression of PGE2 receptor subtypes in M-1 mouse CCD cells
    • R. Nasrallah, O. Laneuville, S. Ferguson, and R.L. Hebert Effect of COX-2 inhibitor NS-398 on expression of PGE2 receptor subtypes in M-1 mouse CCD cells Am. J. Physiol. Renal Physiol. 281 2001 F123 F132
    • (2001) Am. J. Physiol. Renal Physiol. , vol.281
    • Nasrallah, R.1    Laneuville, O.2    Ferguson, S.3    Hebert, R.L.4
  • 48
    • 0036087493 scopus 로고    scopus 로고
    • Role of EP(1) and EP(4) PGE(2) subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation
    • T. Sanchez, and J.J. Moreno Role of EP(1) and EP(4) PGE(2) subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation Am. J. Physiol. Cell Physiol. 282 2002 C280 C288
    • (2002) Am. J. Physiol. Cell Physiol. , vol.282
    • Sanchez, T.1    Moreno, J.J.2
  • 49
    • 29344465614 scopus 로고    scopus 로고
    • GR 63799X, an EP3 receptor agonist, induced S phase arrest and 3T6 fibroblast growth inhibition
    • T. Sanchez, and J.J. Moreno GR 63799X, an EP3 receptor agonist, induced S phase arrest and 3T6 fibroblast growth inhibition Eur. J. Pharmacol. 529 2006 16 23
    • (2006) Eur. J. Pharmacol. , vol.529 , pp. 16-23
    • Sanchez, T.1    Moreno, J.J.2
  • 50
    • 28444491736 scopus 로고    scopus 로고
    • The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes
    • R.L. Konger, S. Brouxhon, S. Partillo, J. VanBuskirk, and A.P. Pentland The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes Exp. Dermatol. 14 2005 914 922
    • (2005) Exp. Dermatol. , vol.14 , pp. 914-922
    • Konger, R.L.1    Brouxhon, S.2    Partillo, S.3    Vanbuskirk, J.4    Pentland, A.P.5
  • 51
    • 45549086404 scopus 로고    scopus 로고
    • Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo
    • I.M. Macias-Perez, R. Zent, M. Carmosino, M.D. Breyer, R.M. Breyer, and A. Pozzi Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo J. Biol. Chem. 283 2008 12538 12545
    • (2008) J. Biol. Chem. , vol.283 , pp. 12538-12545
    • Macias-Perez, I.M.1    Zent, R.2    Carmosino, M.3    Breyer, M.D.4    Breyer, R.M.5    Pozzi, A.6
  • 52
    • 79953277872 scopus 로고    scopus 로고
    • Prostaglandin E2 increases cardiac fibroblast proliferation and increases cyclin D expression via EP1 receptor
    • P. Harding, and M.C. LaPointe Prostaglandin E2 increases cardiac fibroblast proliferation and increases cyclin D expression via EP1 receptor Prostaglandins Leukot. Essent. Fatty Acids 84 2011 147 152
    • (2011) Prostaglandins Leukot. Essent. Fatty Acids , vol.84 , pp. 147-152
    • Harding, P.1    Lapointe, M.C.2
  • 53
    • 0029910675 scopus 로고    scopus 로고
    • Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells
    • T. Watanabe, H. Satoh, M. Togoh, S. Taniguchi, Y. Hashimoto, and K. Kurokawa Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells J. Cell. Physiol. 169 1996 401 409
    • (1996) J. Cell. Physiol. , vol.169 , pp. 401-409
    • Watanabe, T.1    Satoh, H.2    Togoh, M.3    Taniguchi, S.4    Hashimoto, Y.5    Kurokawa, K.6
  • 54
    • 33847037980 scopus 로고    scopus 로고
    • Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via e prostanoid 2 receptor and cAMP signaling
    • S. Huang, S.H. Wettlaufer, C. Hogaboam, D.M. Aronoff, and M. Peters-Golden Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling Am. J. Physiol. Lung Cell. Mol. Physiol. 292 2007 L405 L413
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.292
    • Huang, S.1    Wettlaufer, S.H.2    Hogaboam, C.3    Aronoff, D.M.4    Peters-Golden, M.5
  • 55
    • 69249127916 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac
    • E. Weinberg, E. Zeldich, M.M. Weinreb, O. Moses, C. Nemcovsky, and M. Weinreb Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac J. Cell. Biochem. 108 2009 207 215
    • (2009) J. Cell. Biochem. , vol.108 , pp. 207-215
    • Weinberg, E.1    Zeldich, E.2    Weinreb, M.M.3    Moses, O.4    Nemcovsky, C.5    Weinreb, M.6
  • 56
    • 84887826662 scopus 로고    scopus 로고
    • Effect of prostaglandin E2 and EP receptor agonists on cell proliferation and basic fibroblast growth factor synthesis of rheumatoid synovial fibroblasts in vitro
    • R. Saura, S. Hirata, H. Ishikawa, and K. Mizuno Effect of prostaglandin E2 and EP receptor agonists on cell proliferation and basic fibroblast growth factor synthesis of rheumatoid synovial fibroblasts in vitro Bull Health Sci Kobe 16 2000 1 10
    • (2000) Bull Health Sci Kobe , vol.16 , pp. 1-10
    • Saura, R.1    Hirata, S.2    Ishikawa, H.3    Mizuno, K.4
  • 57
    • 40449095435 scopus 로고    scopus 로고
    • Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors
    • K.E. White, Q. Ding, B.B. Moore, M. Peters-Golden, L.B. Ware, M.A. Matthay, and M.A. Olman Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors J. Immunol. 180 2008 637 646
    • (2008) J. Immunol. , vol.180 , pp. 637-646
    • White, K.E.1    Ding, Q.2    Moore, B.B.3    Peters-Golden, M.4    Ware, L.B.5    Matthay, M.A.6    Olman, M.A.7
  • 58
    • 0025985547 scopus 로고
    • Augmentation of functional prostaglandin e levels on the respiratory epithelial surface by aerosol administration of prostaglandin e
    • Z. Borok, A. Gillissen, R. Buhl, R.F. Hoyt, R.C. Hubbard, T. Ozaki, S.I. Rennard, and R.G. Crystal Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E Am. Rev. Respir. Dis. 144 1991 1080 1084
    • (1991) Am. Rev. Respir. Dis. , vol.144 , pp. 1080-1084
    • Borok, Z.1    Gillissen, A.2    Buhl, R.3    Hoyt, R.F.4    Hubbard, R.C.5    Ozaki, T.6    Rennard, S.I.7    Crystal, R.G.8
  • 59
    • 0028954821 scopus 로고
    • Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages
    • J. Wilborn, D.L. DeWitt, and M. Peters-Golden Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages Am. J. Physiol. 268 1995 L294 L301
    • (1995) Am. J. Physiol. , vol.268
    • Wilborn, J.1    Dewitt, D.L.2    Peters-Golden, M.3
  • 60
    • 0034038206 scopus 로고    scopus 로고
    • Different expression of TNF-alpha receptors and prostaglandin E(2)Production in normal and fibrotic lung fibroblasts: Potential implications for the evolution of the inflammatory process
    • C. Vancheri, M.A. Sortino, V. Tomaselli, C. Mastruzzo, F. Condorelli, G. Bellistri, M.P. Pistorio, P.L. Canonico, and N. Crimi Different expression of TNF-alpha receptors and prostaglandin E(2)Production in normal and fibrotic lung fibroblasts: potential implications for the evolution of the inflammatory process Am. J. Respir. Cell Mol. Biol. 22 2000 628 634
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.22 , pp. 628-634
    • Vancheri, C.1    Sortino, M.A.2    Tomaselli, V.3    Mastruzzo, C.4    Condorelli, F.5    Bellistri, G.6    Pistorio, M.P.7    Canonico, P.L.8    Crimi, N.9
  • 61
    • 67349102250 scopus 로고    scopus 로고
    • P53 and ATF-2 partly mediate the overexpression of COX-2 in H(2)O (2)-induced premature senescence of human fibroblasts
    • S. Zdanov, O. Toussaint, and F. Debacq-Chainiaux p53 and ATF-2 partly mediate the overexpression of COX-2 in H(2)O (2)-induced premature senescence of human fibroblasts Biogerontology 10 2009 291 298
    • (2009) Biogerontology , vol.10 , pp. 291-298
    • Zdanov, S.1    Toussaint, O.2    Debacq-Chainiaux, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.