Disturbed flow promotes endothelial senescence via a p53-dependent pathway

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 5, 2014, Pages 985-995

  Warboys, Christina M ^a   De Luca, Amalia ^a   Amini, Narges ^a   Luong, Le ^c   Duckles, Hayley ^c   Hsiao, Sarah ^c   White, Alex ^c   Biswas, Shukti ^c   Khamis, Ramzi ^a   Chong, Chuh K ^c   Cheung, Wai Mun ^a   Sherwin, Spencer J ^b   Bennett, Martin R ^d   Gil, Jesus ^b   Mason, Justin C ^a   Haskard, Dorian O ^a   Evans, Paul C ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

aging; endothelium; sirtuin 1

Indexed keywords

BETA GALACTOSIDASE; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN P21; PROTEIN P53; RESVERATROL; SIRTUIN 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROGENESIS; BLOOD FLOW; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SHEAR STRESS; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; WOUND CLOSURE;

AGING; ENDOTHELIUM; SIRTUIN 1;

ANIMALS; AORTIC DISEASES; ATHEROSCLEROSIS; BIOREACTORS; CELL AGING; CELL MOVEMENT; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LDL; REGIONAL BLOOD FLOW; RNA INTERFERENCE; SIRTUIN 1; STRESS, MECHANICAL; SWINE; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; WOUND HEALING;

EID: 84899648675     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303415     Document Type: Article

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