Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways

Circulation Research

Volumn 89, Issue 11, 2001, Pages 1073-1080

  Davis, Michael E ^a   Cai, Hua ^a   Drummond, Grant R ^a   Harrison, David G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

c Src; Endothelial nitric oxide synthase; ERK1 2; mRNA stability; Raf

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRIC OXIDE SYNTHASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; UO 126;

ANIMAL CELL; ARTICLE; CATTLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA STABILITY; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

EID: 0035941411     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh2301.100806     Document Type: Article

References (38)

1. The endothelial cell nitric oxide synthase: Is it really constitutively expressed?
2. Pulsatile flow and atherosclerosis in the human carotid bifurcation: Positive correlation between plaque location and low oscillating shear stress
3. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression
4. Laminar shear stress: Mechanisms by which endothelial cells transduce an atheroprotective force
5. Fluid shear stress-mediated signal transduction: How do endothelial cells transduce mechanical force into biological responses?
6. Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase
7. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
8. Posttranscriptional regulation of endothelial nitric oxide synthase during cell growth
9. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide
10. The dynamic response of vascular endothelial cells to fluid shear stress
11. Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
12. Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation
13. A simplified system for generating recombinant adenoviruses
14. Mechanisms regulating Raf-1 activity in signal transduction pathways
15. Complexes of Ras. GTP with Raf-1 and mitogen-activated protein kinase kinase
16. Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells
17. Involvement of protein kinase C and Src family tyrosine kinase in Ga1phaq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
18. Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the phosphatidylinositol 3-kinase signaling pathway
19. Sp1 phosphorylation by Erk 2 stimulates DNA binding
20. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
21. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene
22. Endothelial gene regulation by laminar shear stress
23. Shear stress increases endothelial platelet-derived growth factor mRNA levels
24. Pulsatile and steady flow induces c-fos expression in human endothelial cells
25. Mechanotransduction in endothelial cells: Temporal signaling events in response to shear stress
26. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc
27. Interactions of oxidants with vascular signaling systems
28. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells: Essential role for a herbimycin-sensitive kinase
29. PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells
30. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
31. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
32. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases: Identification and characterization of a signaling pathway to the nucleus
33. Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium
34. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
35. Post-transcriptional regulation of the endothelial nitric oxide synthase by the RNA binding protein monsder II: Role of the cytoskeleton
36. Identification of Src, Fyn, and Lyn SH3-binding proteins: Implications for a function of SH3 domains
37. An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis
38. A target for Src in mitosis