Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells

Journal of Nutritional Biochemistry

Volumn 42, Issue , 2017, Pages 37-42

  Hytti, Maria ^a   Szabó, Dora ^b   Piippo, Niina ^a   Korhonen, Eveliina ^a   Honkakoski, Paavo ^a   Kaarniranta, Kai ^a,c   Petrovski, Goran ^b,d   Kauppinen, Anu ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF SZEGED   (Hungary)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Age related macular degeneration; Dietary polyphenols; DNA damage; Fisetin; Inflammation; Luteolin

Indexed keywords

CASPASE 3; DIMETHYL SULFOXIDE; ETOPOSIDE; FISETIN; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; LUTEOLIN; PROTEIN P53; SIRTUIN 1; CYTOKINE; FLAVONOID; NONSTEROID ANTIINFLAMMATORY AGENT; SIRT1 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DIET SUPPLEMENTATION; DNA DAMAGE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; MTT ASSAY; OXIDATIVE STRESS; PHASE CONTRAST MICROSCOPE; PROTEIN ACETYLATION; RETINAL PIGMENT EPITHELIUM; ACETYLATION; CELL LINE; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; PATHOLOGY; RETINITIS;

ACETYLATION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DEATH; CELL LINE; CYTOKINES; DIETARY SUPPLEMENTS; DNA DAMAGE; ETOPOSIDE; FLAVONOIDS; HUMANS; LUTEOLIN; RETINAL PIGMENT EPITHELIUM; RETINITIS; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85009863275     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2016.12.014     Document Type: Article

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