Characterization of stress response in human retinal epithelial cells

Journal of Cellular and Molecular Medicine

Volumn 17, Issue 1, 2013, Pages 103-115

  Giansanti, Vincenzo ^a   Villalpando Rodriguez, Gloria E ^b   Savoldelli, Michelle ^c   Gioia, Roberta ^d   Forlino, Antonella ^d   Mazzini, Giuliano ^a   Pennati, Marzia ^e   Zaffaroni, Nadia ^e   Scovassi, Anna Ivana ^a   Torriglia, Alicia ^b  

^a CNR   (Italy)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c HÔTEL DIEU   (France)

^d UNIVERSITY OF PAVIA   (Italy)

^e NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Apoptosis; ARPE 19 cells; Autophagy; Caspases; HMA; L DNase II; PARP 1

Indexed keywords

5 (N,N HEXAMETHYLENE)AMILORIDE; 5-(N,N-HEXAMETHYLENE)AMILORIDE; AMILORIDE; CASPASE; DNA TOPOISOMERASE INHIBITOR; DRUG DERIVATIVE; ETOPOSIDE; P62 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; RNA BINDING PROTEIN; SODIUM PROTON EXCHANGE PROTEIN;

ACTIVE TRANSPORT; ADULT; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL COUNT; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; OXIDATIVE STRESS; PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

ADULT; AMILORIDE; APOPTOSIS; AUTOPHAGY; BIOLOGICAL TRANSPORT, ACTIVE; CASPASES; CELL COUNT; CELL LINE; CELL SURVIVAL; EPITHELIAL CELLS; ETOPOSIDE; GENE EXPRESSION; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; TOPOISOMERASE INHIBITORS;

EID: 84873164307     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01652.x     Document Type: Article

References (25)

1. Khandhadia S, Cherry J, Lotery AJ. Age-related macular degeneration. Adv Exp Med Biol. 2012; 724: 15-36.
2. Binder S, Stanzel BV, Krebs I, et al. Transplantation of the RPE in AMD. Prog Retin Eye Res. 2007; 26: 516-54.
3. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005; 85: 845-81.
4. Adijanto J, Banzon T, Jalickee S, et al. CO2-induced ion and fluid transport in human retinal pigment epithelium. J Gen Physiol. 2009; 133: 603-22.
5. Nilsson C, Johansson U, Johansson AC, et al. Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells. Apoptosis. 2006; 11: 1149-59.
6. Cho YL, Lee KS, Lee SJ, et al. Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation. Biochem Biophys Res Commun. 2005; 326: 752-8.
7. + antiport inhibition activates the LEI/L-DNase II pathway. Cell Death Differ. 2003; 10: 548-57.
8. Dunn KC, Aotaki-Keen AE, Putkey FR, et al. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res. 1996; 62: 155-69.
9. Giansanti V, Camboni T, Piscitelli F, et al. Study of the effects of a new pyrazolecarboxamide: changes in mitochondria and induction of apoptosis. Int J Biochem Cell Biol. 2009; 41: 1890-8.
10. Wang Y, Dawson VL, Dawson TM. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol. 2009; 218: 193-202.
11. Torriglia A, Lepretre C, Padron-Barthe L, et al. Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis. Biochem Pharmacol. 2008; 76: 1490-502.
12. Lepretre C, Scovassi AI, Shah GM, et al. Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis. Int J Biochem Cell Biol. 2009; 41: 1046-54.
13. Lepretre C, Sidoli G, Scovassi AI, et al. Leukocyte elastase inhibitor: a new regulator of PARP-1. Ann N Y Acad Sci. 2009; 1171: 25-31.
14. + exchanger inhibitor HMA (5-(N, N-hexamethylene) amiloride) are modulated by intracellular pH. Eur J Histochem. 2012; 56: e3.
15. Barth S, Glick D, Macleod KF. Autophagy: assays and artifacts. J Pathol. 2010; 221: 117-24.
16. Kurz T, Karlsson M, Brunk UT, et al. ARPE-19 retinal pigment epithelial cells are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron. Autophagy. 2009; 5: 494-501.
17. Corcelle E, Nebout M, Bekri S, et al. Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Cancer Res. 2006; 66: 6861-70.
18. Giansanti V, Tillhon M, Mazzini G, et al. Killing of tumor cells: a drama in two acts. Biochem Pharmacol. 2011; 82: 1304-10.
19. Munoz-Gamez JA, Martin-Oliva D, Aguilar-Quesada R, et al. PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis. Biochem J. 2005; 386: 119-25.
20. Munoz-Gamez JA, Rodriguez-Vargas JM, Quiles-Perez R, et al. PARP-1 is involved in autophagy induced by DNA damage. Autophagy. 2009; 5: 61-74.
21. Brossas JY, Tanguy R, Brignole-Baudouin F, et al. L-DNase II associated with active process during ethanol induced cell death in ARPE-19. Mol Vis. 2004; 10: 65-73.
22. Giansanti V, Torriglia A, Scovassi AI. Conversation between apoptosis and autophagy: "Is it your turn or mine?" Apoptosis. 2011; 16: 321-33.
23. Bergmann M, Schutt F, Holz FG, et al. Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J. 2004; 18: 562-4.
24. Chen PM, Gombart ZJ, Chen JW. Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration. Cell Biosci. 2011; 1: 10.
25. Zhao Z, Chen Y, Wang J, et al. Age-related retinopathy in NRF2-deficient mice. PLoS ONE. 2011; 6: e19456.