Inhibition of BET bromodomains alleviates inflammation in human RPE cells

Biochemical Pharmacology

Volumn 110-111, Issue , 2016, Pages 71-79

  Hytti, M ^a   Tokarz, P ^b   Maatta E ^a   Piippo, N ^a   Korhonen, E ^a   Suuronen, T ^a   Honkakoski, P ^a   Kaarniranta, K ^a,c   Lahtela Kakkonen, M ^a   Kauppinen, A ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF LODZ   (Poland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Age related macular degeneration; Bromodomains; Inflammation; Retinal pigment epithelium; Sirtuin 1

Indexed keywords

2 METHOXY N (1,2,3,4 TETRAHYDRO 3 METHYL 2 OXO 6 QUINAZOLINYL)BENZENESULFONAMIDE; 4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; BROMODOMAIN INHIBITOR; BROMODOMAIN PROTEIN; ETOPOSIDE; IBET 151; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; PEPTIDES AND PROTEINS; PROTEIN P53; SELISISTAT; SIRTUIN 1; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE; ANTIINFLAMMATORY AGENT; AZABICYCLO DERIVATIVE; AZEPINE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CARBAZOLE DERIVATIVE; GYRASE INHIBITOR; IL6 PROTEIN, HUMAN; INTERLEUKIN 6; MOLIBRESIB; PF-06687252; PYRIDINE DERIVATIVE; SIRT1 PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DEACETYLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN PROTEIN INTERACTION; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN DOMAIN;

ANTI-INFLAMMATORY AGENTS; AZABICYCLO COMPOUNDS; AZEPINES; BENZODIAZEPINES; CARBAZOLES; CELL LINE; CELL SURVIVAL; EPITHELIAL CELLS; ETOPOSIDE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; MODELS, BIOLOGICAL; NF-KAPPA B; PROTEIN DOMAINS; PYRIDINES; RETINAL PIGMENT EPITHELIUM; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 1; TOPOISOMERASE II INHIBITORS; TRANSCRIPTION FACTORS; TRIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84964389711     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.04.009     Document Type: Article

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