메뉴 건너뛰기




Volumn 28, Issue , 2016, Pages 171-182

Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling

Author keywords

Fisetin; Mitogen activated protein kinases; Nuclear factor kappa B; Primary peritoneal macrophages; Pro inflammatory cytokines; Ulcerative colitis

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; DEXTRAN SULFATE; FISETIN; GLUTATHIONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; NITRITE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; FLAVONOID;

EID: 84957800619     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.10.004     Document Type: Article
Times cited : (96)

References (43)
  • 1
    • 84929071728 scopus 로고    scopus 로고
    • Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice
    • Zhang Y., Brenner M., Yang W.L., Wang P. Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice. Lab Invest 2015, 95:480-490.
    • (2015) Lab Invest , vol.95 , pp. 480-490
    • Zhang, Y.1    Brenner, M.2    Yang, W.L.3    Wang, P.4
  • 2
    • 84924662545 scopus 로고    scopus 로고
    • An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-kB signaling pathway
    • Ren T., Tian T., Feng X., Ye S., Wang H., Wu W., et al. An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-kB signaling pathway. Sci Rep 2015, 5:9047. 10.1038/srep09047.
    • (2015) Sci Rep , vol.5 , pp. 9047
    • Ren, T.1    Tian, T.2    Feng, X.3    Ye, S.4    Wang, H.5    Wu, W.6
  • 4
    • 84878258216 scopus 로고    scopus 로고
    • Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice
    • Azuma T., Shigeshiro M., Kodama M., Tanabe S., Suzuki T. Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice. J Nutr 2013, 143:827-834.
    • (2013) J Nutr , vol.143 , pp. 827-834
    • Azuma, T.1    Shigeshiro, M.2    Kodama, M.3    Tanabe, S.4    Suzuki, T.5
  • 5
    • 84892609546 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitor C75 ameliorates experimental colitis
    • Matsuo S., Yang W.L., Aziz M., Kameoka Wang P. Fatty acid synthase inhibitor C75 ameliorates experimental colitis. Mol Med 2014, 20:1-9.
    • (2014) Mol Med , vol.20 , pp. 1-9
    • Matsuo, S.1    Yang, W.L.2    Aziz, M.3    Kameoka Wang, P.4
  • 6
    • 84907480659 scopus 로고    scopus 로고
    • Anti-inflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study
    • Aldini R., Micucci M., Cevenini M., Fato R., Bergamini C., Nanni C., et al. Anti-inflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study. PLoS One 2014, 9(9):e108112.
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e108112
    • Aldini, R.1    Micucci, M.2    Cevenini, M.3    Fato, R.4    Bergamini, C.5    Nanni, C.6
  • 7
    • 84922805496 scopus 로고    scopus 로고
    • Dietary squalene supplementation improves DSS-induced acute colitis by down regulating p38 MAPK and NF-kB signaling pathways
    • Sanchez-Fidalgo S., Villegas I., Rosillo M.A., Soto M.A., Lastra C.A.D.L. Dietary squalene supplementation improves DSS-induced acute colitis by down regulating p38 MAPK and NF-kB signaling pathways. Mol Nutr Food Res 2015, 59:284-292.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 284-292
    • Sanchez-Fidalgo, S.1    Villegas, I.2    Rosillo, M.A.3    Soto, M.A.4    Lastra, C.A.D.L.5
  • 8
    • 84863803189 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase and nuclear factor kappa B pathways mediates Fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells
    • Kim S.C., Kang S.H., Jeong S.J., Kim S.H., Ko H.S. Inhibition of c-Jun N-terminal kinase and nuclear factor kappa B pathways mediates Fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells. Immunopharmacol Immunotoxicol 2012, 34:645-650.
    • (2012) Immunopharmacol Immunotoxicol , vol.34 , pp. 645-650
    • Kim, S.C.1    Kang, S.H.2    Jeong, S.J.3    Kim, S.H.4    Ko, H.S.5
  • 9
    • 84908554137 scopus 로고    scopus 로고
    • Anti-inflammatory activity of fisetin in human gingival fibroblasts treated with lipopolysaccharide
    • Gutiérrez-Venegas G., Contreras-Sánchez A., Ventura-Arroyo J.A. Anti-inflammatory activity of fisetin in human gingival fibroblasts treated with lipopolysaccharide. J Asian Nat Prod Res 2014, 16:1009-1017.
    • (2014) J Asian Nat Prod Res , vol.16 , pp. 1009-1017
    • Gutiérrez-Venegas, G.1    Contreras-Sánchez, A.2    Ventura-Arroyo, J.A.3
  • 10
    • 84921456864 scopus 로고    scopus 로고
    • Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NF-kB signaling pathways in SKH-hairless mice
    • Pal H.C., Athar M., Elmets C.A., Afaq F. Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NF-kB signaling pathways in SKH-hairless mice. Photochem Photobiol 2015, 91:225-234.
    • (2015) Photochem Photobiol , vol.91 , pp. 225-234
    • Pal, H.C.1    Athar, M.2    Elmets, C.A.3    Afaq, F.4
  • 11
    • 79959596092 scopus 로고    scopus 로고
    • Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes
    • Maher P., Dargusch R., Ehren J.L., Okada S., Sharma K., Schubert D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One 2011, 6:e21226.
    • (2011) PLoS One , vol.6 , pp. e21226
    • Maher, P.1    Dargusch, R.2    Ehren, J.L.3    Okada, S.4    Sharma, K.5    Schubert, D.6
  • 12
    • 84879835492 scopus 로고    scopus 로고
    • The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts
    • Leotoing L., Wauquier F., Guicheux J., Miot-Noirault E., Wittrant Y., Coxam V. The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. PLoS One 2013, 8:e68388.
    • (2013) PLoS One , vol.8 , pp. e68388
    • Leotoing, L.1    Wauquier, F.2    Guicheux, J.3    Miot-Noirault, E.4    Wittrant, Y.5    Coxam, V.6
  • 13
    • 84886798070 scopus 로고    scopus 로고
    • Fisetin protects against hepatosteatosis in mice by inhibiting miR-378
    • Jeon T.I., Park J.W., Ahn J., Jung C.H., Ha Y.U. Fisetin protects against hepatosteatosis in mice by inhibiting miR-378. Mol Nutr Food Res 2013, 57:1931-1937.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 1931-1937
    • Jeon, T.I.1    Park, J.W.2    Ahn, J.3    Jung, C.H.4    Ha, Y.U.5
  • 14
    • 78049236184 scopus 로고    scopus 로고
    • Fisetin inhibits lipopolysaccharide-induced macrophage activation and dendritic cell maturation
    • Liu S.H., Lin C.H., Hung S.K., Chou J.H., Chi C.W., Fu S.L., et al. Fisetin inhibits lipopolysaccharide-induced macrophage activation and dendritic cell maturation. J Agric Food Chem 2010, 58:10831-10839.
    • (2010) J Agric Food Chem , vol.58 , pp. 10831-10839
    • Liu, S.H.1    Lin, C.H.2    Hung, S.K.3    Chou, J.H.4    Chi, C.W.5    Fu, S.L.6
  • 16
    • 60549095283 scopus 로고    scopus 로고
    • Flavonol-rich RVHxR from Rhus verniciflua stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models
    • Lee J.D., Huh J.E., Jeon G., Yang H.R., Woo H.S., Choi D.Y., et al. Flavonol-rich RVHxR from Rhus verniciflua stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models. Int Immunopharmacol 2009, 9:268-276.
    • (2009) Int Immunopharmacol , vol.9 , pp. 268-276
    • Lee, J.D.1    Huh, J.E.2    Jeon, G.3    Yang, H.R.4    Woo, H.S.5    Choi, D.Y.6
  • 17
    • 84857786880 scopus 로고    scopus 로고
    • Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB
    • Goh F.Y., Upton N., Guan S., Cheng C., Shanmugam M.K., Sethi G., et al. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. Eur J Pharmacol 2012, 679:109-116.
    • (2012) Eur J Pharmacol , vol.679 , pp. 109-116
    • Goh, F.Y.1    Upton, N.2    Guan, S.3    Cheng, C.4    Shanmugam, M.K.5    Sethi, G.6
  • 18
    • 84907455018 scopus 로고    scopus 로고
    • Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation
    • Dou W., Zhang J., Ren G., Ding L., Sun A., Deng C., et al. Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation. Int Immunopharmacol 2014, 23:170-178.
    • (2014) Int Immunopharmacol , vol.23 , pp. 170-178
    • Dou, W.1    Zhang, J.2    Ren, G.3    Ding, L.4    Sun, A.5    Deng, C.6
  • 19
    • 84880127162 scopus 로고    scopus 로고
    • Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats
    • Prasath G.S., Subramanian S.P. Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats. Food Chem Toxicol 2013, 59:249-255.
    • (2013) Food Chem Toxicol , vol.59 , pp. 249-255
    • Prasath, G.S.1    Subramanian, S.P.2
  • 20
    • 84886802690 scopus 로고    scopus 로고
    • Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway
    • Schwanke R.C., Marcon R., Meotti F.C., Bento A.F., Dutra R.C., Pizzollatti M.G., et al. Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway. Mol Nutr Food Res 2013, 57:1938-1949.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 1938-1949
    • Schwanke, R.C.1    Marcon, R.2    Meotti, F.C.3    Bento, A.F.4    Dutra, R.C.5    Pizzollatti, M.G.6
  • 22
    • 3042934967 scopus 로고
    • Tissue sulfhydryl group
    • Ellman G.L. Tissue sulfhydryl group. Arch Biochem Biophys 1959, 82:70-77.
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 23
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 24
    • 84906961778 scopus 로고    scopus 로고
    • Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-kB activation and antioxidant defence
    • Sahu B.D., Kalvala A.K., Koneru M., Mahesh Kumar J., Kuncha M., Rachamalla S.S., et al. Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-kB activation and antioxidant defence. PLoS One 2014, 9(9):e105070.
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e105070
    • Sahu, B.D.1    Kalvala, A.K.2    Koneru, M.3    Mahesh Kumar, J.4    Kuncha, M.5    Rachamalla, S.S.6
  • 25
    • 84926104156 scopus 로고    scopus 로고
    • Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis
    • Utrilla M.P., Peinado M.J., Ruiz R., Nogales A.R., Algieri F., Cabezas M.E.R., et al. Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis. Mol Nutr Food Res 2015, 59:807-819.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 807-819
    • Utrilla, M.P.1    Peinado, M.J.2    Ruiz, R.3    Nogales, A.R.4    Algieri, F.5    Cabezas, M.E.R.6
  • 26
    • 84909966025 scopus 로고    scopus 로고
    • Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages
    • Shin J.S., Cho E.J., Choi H.E., Seo J.H., An H.J., Park H.J., et al. Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages. J Ethnopharmacol 2014, 158:291-300.
    • (2014) J Ethnopharmacol , vol.158 , pp. 291-300
    • Shin, J.S.1    Cho, E.J.2    Choi, H.E.3    Seo, J.H.4    An, H.J.5    Park, H.J.6
  • 27
    • 84928657901 scopus 로고    scopus 로고
    • Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function
    • Xiong Y., Chen D., Yu C., Lv B., Peng J., Wang J., et al. Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function. Mol Nutr Food Res 2015, 59:829-842.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 829-842
    • Xiong, Y.1    Chen, D.2    Yu, C.3    Lv, B.4    Peng, J.5    Wang, J.6
  • 28
    • 84927689109 scopus 로고    scopus 로고
    • Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium-induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation
    • Kim K.M., Kim Y.S., Lim J.Y., Min S.J., Shin J.H., Ko H.C., et al. Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium-induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation. Nutr Res 2014, 34:894-905.
    • (2014) Nutr Res , vol.34 , pp. 894-905
    • Kim, K.M.1    Kim, Y.S.2    Lim, J.Y.3    Min, S.J.4    Shin, J.H.5    Ko, H.C.6
  • 29
    • 80051795214 scopus 로고    scopus 로고
    • PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis
    • Huang H.L., Xu J., Zhang X.H., Qiu B.Y., Peng L., Zhang M., et al. PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis. Inflamm Res 2011, 60:727-734.
    • (2011) Inflamm Res , vol.60 , pp. 727-734
    • Huang, H.L.1    Xu, J.2    Zhang, X.H.3    Qiu, B.Y.4    Peng, L.5    Zhang, M.6
  • 30
    • 84906829810 scopus 로고    scopus 로고
    • Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer
    • Viennois E., Xiao B., Ayyadurai S., Wang L., Wang P.G., Zhang Q., et al. Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer. Lab Invest 2014, 94:950-965.
    • (2014) Lab Invest , vol.94 , pp. 950-965
    • Viennois, E.1    Xiao, B.2    Ayyadurai, S.3    Wang, L.4    Wang, P.G.5    Zhang, Q.6
  • 31
    • 84922351579 scopus 로고    scopus 로고
    • γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor
    • Zhang H., Kovacs-Nolan J., Kodera T., Eto Y., Mine Y. γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor. Biochem Biophys Acta 2015, 1852:792-804.
    • (2015) Biochem Biophys Acta , vol.1852 , pp. 792-804
    • Zhang, H.1    Kovacs-Nolan, J.2    Kodera, T.3    Eto, Y.4    Mine, Y.5
  • 32
    • 84923082043 scopus 로고    scopus 로고
    • Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B
    • Cheng J., Zhang L., Dai W., Mao Y., Li S., Wang J., et al. Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B. Biochem Biophys Res Commun 2015, 458:140-147.
    • (2015) Biochem Biophys Res Commun , vol.458 , pp. 140-147
    • Cheng, J.1    Zhang, L.2    Dai, W.3    Mao, Y.4    Li, S.5    Wang, J.6
  • 33
    • 84928291943 scopus 로고    scopus 로고
    • Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice
    • Sanchez-Fidalgo S., Villegas I., Aparicio-Soto M., Cardeno A., Rosillo M.A., Gonzalez-Benzumea A., et al. Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice. J Nutr Biochem 2015, 26:513-520.
    • (2015) J Nutr Biochem , vol.26 , pp. 513-520
    • Sanchez-Fidalgo, S.1    Villegas, I.2    Aparicio-Soto, M.3    Cardeno, A.4    Rosillo, M.A.5    Gonzalez-Benzumea, A.6
  • 34
    • 84881472034 scopus 로고    scopus 로고
    • Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-kB signaling
    • Dou W., Zhang J., Sun A., Zhang E., Ding L., Mukherjee S., et al. Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-kB signaling. Br J Nutr 2013, 110:599-608.
    • (2013) Br J Nutr , vol.110 , pp. 599-608
    • Dou, W.1    Zhang, J.2    Sun, A.3    Zhang, E.4    Ding, L.5    Mukherjee, S.6
  • 35
    • 80051789298 scopus 로고    scopus 로고
    • Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease
    • Rosillo M.A., Sanchez-Hidalgo M., Cardeno A., de la Lastra C.A. Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease. Biochem Pharmacol 2011, 82:737-745.
    • (2011) Biochem Pharmacol , vol.82 , pp. 737-745
    • Rosillo, M.A.1    Sanchez-Hidalgo, M.2    Cardeno, A.3    de la Lastra, C.A.4
  • 36
    • 70350586944 scopus 로고    scopus 로고
    • Mitogen activated protein kinases: a role in inflammatory bowel disease?
    • Broom O.J., Widjaya B., Troelsen J., Olsen J., Nielsen O.H. Mitogen activated protein kinases: a role in inflammatory bowel disease?. Clin Exp Immunol 2009, 158:272-280.
    • (2009) Clin Exp Immunol , vol.158 , pp. 272-280
    • Broom, O.J.1    Widjaya, B.2    Troelsen, J.3    Olsen, J.4    Nielsen, O.H.5
  • 37
    • 4444360215 scopus 로고    scopus 로고
    • Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation
    • Sagara Y., Vanhnasy J., Maher P. Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation. J Neurochem 2004, 90:1144-1155.
    • (2004) J Neurochem , vol.90 , pp. 1144-1155
    • Sagara, Y.1    Vanhnasy, J.2    Maher, P.3
  • 38
    • 33750832268 scopus 로고    scopus 로고
    • Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
    • Maher P., Akaishi T., Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A 2006, 103:16568-16573.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16568-16573
    • Maher, P.1    Akaishi, T.2    Abe, K.3
  • 40
    • 73949145197 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice
    • Peng X.D., Wu X.H., Chen L.J., Wang Z.L., Hu X.H., Song L.F., et al. Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J Pharm Exp Ther 2009, 332:46-56.
    • (2009) J Pharm Exp Ther , vol.332 , pp. 46-56
    • Peng, X.D.1    Wu, X.H.2    Chen, L.J.3    Wang, Z.L.4    Hu, X.H.5    Song, L.F.6
  • 41
    • 0034724734 scopus 로고    scopus 로고
    • Effects of trimetazidine on oxidant/antioxidant status in trinitrobenzene sulfonic acid-induced chronic colitis
    • Girgin F., Karaoglu O., Erkus M., Tuzun S., Ozutemiz O., Dincer C., et al. Effects of trimetazidine on oxidant/antioxidant status in trinitrobenzene sulfonic acid-induced chronic colitis. J Toxicol Environ Health 2000, 59:641-652.
    • (2000) J Toxicol Environ Health , vol.59 , pp. 641-652
    • Girgin, F.1    Karaoglu, O.2    Erkus, M.3    Tuzun, S.4    Ozutemiz, O.5    Dincer, C.6
  • 42
    • 84923334381 scopus 로고    scopus 로고
    • Dietary cocoa protects against colitis associated cancer by activating the Nrf2/Keap1 pathway
    • Pandurangan A.K., Saadatdoust Z., Esa N.M., Hamzah H., Ismail A. Dietary cocoa protects against colitis associated cancer by activating the Nrf2/Keap1 pathway. Biofactors 2015, 41:1-14.
    • (2015) Biofactors , vol.41 , pp. 1-14
    • Pandurangan, A.K.1    Saadatdoust, Z.2    Esa, N.M.3    Hamzah, H.4    Ismail, A.5
  • 43
    • 0036352689 scopus 로고    scopus 로고
    • Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice
    • Korenaga D., Takesue F., Kido K., Yasuda M., Inutsuka S., Honda M., et al. Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice. J Surg Res 2002, 102:144-149.
    • (2002) J Surg Res , vol.102 , pp. 144-149
    • Korenaga, D.1    Takesue, F.2    Kido, K.3    Yasuda, M.4    Inutsuka, S.5    Honda, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.