Serine Is an Essential Metabolite for Effector T Cell Expansion

Cell Metabolism

Volumn 25, Issue 2, 2017, Pages 345-357

  Ma, Eric H ^a,b   Bantug, Glenn ^c   Griss, Takla ^a,b   Condotta, Stephanie ^b   Johnson, Radia M ^a   Samborska, Bozena ^a,b   Mainolfi, Nello ^d   Suri, Vipin ^d   Guak, Hannah ^a,b   Balmer, Maria L ^c   Verway, Mark J ^a,b   Raissi, Thomas C ^a,b   Tsui, Harmony ^a,b   Boukhaled, Giselle ^a,b   Henriques da Costa, Sofia ^e   Frezza, Christian ^e   Krawczyk, Connie M ^a,b   Friedman, Adam ^d   Manfredi, Mark ^d   Richer, Martin J ^b   Hess, Christoph ^c   Jones, Russell G ^a,b   more..

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF BASEL   (Switzerland)

^d Raze Therapeutics   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

glycolysis; immunometabolism; immunotherapy; metabolic reprogramming; metabolism; Phgdh; serine; serine biosynthesis; Shmt; T cell

Indexed keywords

CARBON; FORMIC ACID; GLUCOSE; GLYCINE; SERINE; PURINE NUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CARBON METABOLISM; CELL EXPANSION; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LISTERIOSIS; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE METABOLISM; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CYTOLOGY; DIET; ENERGY METABOLISM; EXTRACELLULAR SPACE; IMMUNOLOGY; LISTERIA MONOCYTOGENES; METABOLISM; METABOLOME; T LYMPHOCYTE;

ANIMALS; CARBON; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DIET; ENERGY METABOLISM; EXTRACELLULAR SPACE; GLYCINE; LISTERIA MONOCYTOGENES; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MICE, INBRED C57BL; PURINE NUCLEOTIDES; SERINE; T-LYMPHOCYTES;

EID: 85009812381     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.12.011     Document Type: Article

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