메뉴 건너뛰기




Volumn 10, Issue 10, 2016, Pages 1135-1144

Methotrexate in Crohn’s disease: a new face for an old drug?

Author keywords

anti TNF alfa agent; Crohn s disease; immunomodulator; Methotrexate; steroid free remission

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZATHIOPRINE; FOLIC ACID; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; PLACEBO; PREDNISOLONE; PREDNISONE; TUMOR NECROSIS FACTOR ANTIBODY;

EID: 84988474791     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1080/17474124.2016.1185363     Document Type: Review
Times cited : (6)

References (87)
  • 1
    • 0030462249 scopus 로고    scopus 로고
    • Molecular therapeutics: methotrexate and its mechanism of action
    • B.N.Cronstein Molecular therapeutics:methotrexate and its mechanism of action. Arthritis Rheum. 1996;39:1951–1960.
    • (1996) Arthritis Rheum , vol.39 , pp. 1951-1960
    • Cronstein, B.N.1
  • 2
    • 0021923633 scopus 로고
    • Efficacy of low dose methotrexate in rheumatoid arthritis
    • M.E.Weinblatt, J.S.Coblyn, D.A.Fox, et al. Efficacy of low dose methotrexate in rheumatoid arthritis. N Engl J Med. 1985;312(13):818–822.
    • (1985) N Engl J Med , vol.312 , Issue.13 , pp. 818-822
    • Weinblatt, M.E.1    Coblyn, J.S.2    Fox, D.A.3
  • 3
    • 84911477709 scopus 로고    scopus 로고
    • Methotrexate: an old new drug in autoimmune disease
    • P.Cipriani, P.Ruscitti, F.Carubbi, et al. Methotrexate:an old new drug in autoimmune disease. Expert Rev Clin Immunol. 2014;10(11):1519–1530.
    • (2014) Expert Rev Clin Immunol , vol.10 , Issue.11 , pp. 1519-1530
    • Cipriani, P.1    Ruscitti, P.2    Carubbi, F.3
  • 4
    • 0024517127 scopus 로고
    • Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease
    • R.A.Kozarek, D.J.Patterson, M.D.Gelfand, et al. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989;110(5):353–356.
    • (1989) Ann Intern Med , vol.110 , Issue.5 , pp. 353-356
    • Kozarek, R.A.1    Patterson, D.J.2    Gelfand, M.D.3
  • 5
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn’s disease. The North American Crohn’s Study Group Investigators
    • B.G.Feagan, J.Rochon, R.N.Fedorak, et al. Methotrexate for the treatment of Crohn’s disease. The North American Crohn’s Study Group Investigators. N Engl J Med. 1995;332(5):292–297.•• Pivotal RCT demonstrating the efficacy of methotrexate monotherapy for inducing remission in steroid-dependent Crohn’s disease.
    • (1995) N Engl J Med , vol.332 , Issue.5 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3
  • 6
    • 0034214336 scopus 로고    scopus 로고
    • A comparison of methotrexate with placebo for the maintenance of remission in Crohn’s disease. North American Crohn’s Study Group Investigators
    • B.G.Feagan, R.N.Fedorak, E.J.Irvine, et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn’s disease. North American Crohn’s Study Group Investigators. N Engl J Med. 2000;342(22):1627–1632.•• Pivotal RCT demonstrating the efficacy of methotrexate monotherapy for maintaing remission in Crohn’s disease.
    • (2000) N Engl J Med , vol.342 , Issue.22 , pp. 1627-1632
    • Feagan, B.G.1    Fedorak, R.N.2    Irvine, E.J.3
  • 7
    • 84881273549 scopus 로고    scopus 로고
    • Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease
    • N.Chande, D.J.Tsoulis, J.K.MacDonald. Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2013;4:CD000545.
    • (2013) Cochrane Database Syst Rev , vol.4 , pp. CD000545
    • Chande, N.1    Tsoulis, D.J.2    MacDonald, J.K.3
  • 8
    • 67650416300 scopus 로고    scopus 로고
    • Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn’s disease
    • E.Prefontaine, L.R.Sutherland, J.K.Macdonald, et al. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2009;1:CD000067.
    • (2009) Cochrane Database Syst Rev , vol.1 , pp. CD000067
    • Prefontaine, E.1    Sutherland, L.R.2    Macdonald, J.K.3
  • 9
    • 0033679444 scopus 로고    scopus 로고
    • 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease
    • J.Maté-Jiménez, C.Hermida, J.Cantero-Perona, et al. 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2000;12:1227–1233.
    • (2000) Eur J Gastroenterol Hepatol , vol.12 , pp. 1227-1233
    • Maté-Jiménez, J.1    Hermida, C.2    Cantero-Perona, J.3
  • 10
    • 1542603602 scopus 로고    scopus 로고
    • Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn’s disease: a randomised, investigator-blind study
    • S.Ardizzone, S.Bollani, G.Manzionna, et al. Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn’s disease:a randomised, investigator-blind study. Dig Liver Dis. 2003;35(9):619–627.
    • (2003) Dig Liver Dis , vol.35 , Issue.9 , pp. 619-627
    • Ardizzone, S.1    Bollani, S.2    Manzionna, G.3
  • 11
    • 0030784425 scopus 로고    scopus 로고
    • Methotrexate in chronic active Crohn’s disease: a double-blind, randomized, Israeli multicenter trial
    • R.Oren, M.Moshkowitz, S.Odes, et al. Methotrexate in chronic active Crohn’s disease:a double-blind, randomized, Israeli multicenter trial. Am J Gastroenterol. 1997;92(12):2203–2209.
    • (1997) Am J Gastroenterol , vol.92 , Issue.12 , pp. 2203-2209
    • Oren, R.1    Moshkowitz, M.2    Odes, S.3
  • 12
    • 0009447497 scopus 로고    scopus 로고
    • Methotrexate in Crohn’s disease: results of a randomized, double-blind, placebo-controlled trial
    • S.Arora, W.Katkov, J.Cooley, et al. Methotrexate in Crohn’s disease:results of a randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1999;46(27):1724–1729.
    • (1999) Hepatogastroenterology , vol.46 , Issue.27 , pp. 1724-1729
    • Arora, S.1    Katkov, W.2    Cooley, J.3
  • 13
    • 0033406747 scopus 로고    scopus 로고
    • A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn’s disease and ulcerative colitis
    • L.J.Egan, W.J.Sandborn, W.J.Tremaine, et al. A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn’s disease and ulcerative colitis. Aliment Pharmacol Ther. 1999;13(12):1597–1604.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.12 , pp. 1597-1604
    • Egan, L.J.1    Sandborn, W.J.2    Tremaine, W.J.3
  • 14
    • 67549101312 scopus 로고    scopus 로고
    • Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature
    • K.Visser, D.van der Heijde. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis:a systematic review of the literature. Ann Rheum Dis. 2009;68(7):1094–1099.
    • (2009) Ann Rheum Dis , vol.68 , Issue.7 , pp. 1094-1099
    • Visser, K.1    van der Heijde, D.2
  • 15
    • 0041843894 scopus 로고    scopus 로고
    • Bioavailability of oral vs. subcutaneous low-dose methotrexate in patients with Crohn’s disease
    • D.Kurnik, R.Loebstein, E.Fishbein, et al. Bioavailability of oral vs. subcutaneous low-dose methotrexate in patients with Crohn’s disease. Aliment Pharmacol Ther. 2003;18(1):57–63.
    • (2003) Aliment Pharmacol Ther , vol.18 , Issue.1 , pp. 57-63
    • Kurnik, D.1    Loebstein, R.2    Fishbein, E.3
  • 16
    • 84907210665 scopus 로고    scopus 로고
    • Methotrexate for induction of remission in refractory Crohn’s disease
    • J.W.McDonald, Y.Wang, D.J.Tsoulis, et al. Methotrexate for induction of remission in refractory Crohn’s disease. Cochrane Database Syst Rev. 2014;8:CD003459.
    • (2014) Cochrane Database Syst Rev , vol.8 , pp. CD003459
    • McDonald, J.W.1    Wang, Y.2    Tsoulis, D.J.3
  • 17
    • 84907200724 scopus 로고    scopus 로고
    • Methotrexate for maintenance of remission in Crohn’s disease
    • V.Patel, Y.Wang, J.K.MacDonald, et al. Methotrexate for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2014;8:CD006884.
    • (2014) Cochrane Database Syst Rev , vol.8 , pp. CD006884
    • Patel, V.1    Wang, Y.2    MacDonald, J.K.3
  • 18
    • 75149161836 scopus 로고    scopus 로고
    • European Crohn’s and Colitis Organisation (ECCO). The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: current management
    • A.Dignass, G.Van Assche, J.O.Lindsay, et al. European Crohn’s and Colitis Organisation (ECCO). The second European evidence-based consensus on the diagnosis and management of Crohn’s disease:current management. J Crohns and Colitis. 2010;4(1):28–62.• A comprehensive review addressing the efficacy and safety of methotrexate in the treatment of inflammatory bowel disease.
    • (2010) J Crohns and Colitis , vol.4 , Issue.1 , pp. 28-62
    • Dignass, A.1    Van Assche, G.2    Lindsay, J.O.3
  • 19
    • 0031596842 scopus 로고    scopus 로고
    • Methotrexate in patients with Crohn’s disease after 6-mercaptopurine
    • D.R.Mack, R.Young, S.S.Kaufman, et al. Methotrexate in patients with Crohn’s disease after 6-mercaptopurine. J Pediatr. 1998;132(5):830–835.
    • (1998) J Pediatr , vol.132 , Issue.5 , pp. 830-835
    • Mack, D.R.1    Young, R.2    Kaufman, S.S.3
  • 20
    • 33750519460 scopus 로고    scopus 로고
    • Efficacy of methotrexate in pediatric Crohn’s disease: a French multicenter study
    • S.Uhlen, R.Belbouab, K.Narebski, et al. Efficacy of methotrexate in pediatric Crohn’s disease:a French multicenter study. Inflamm Bowel Dis. 2006;12(11):1053–1057.
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.11 , pp. 1053-1057
    • Uhlen, S.1    Belbouab, R.2    Narebski, K.3
  • 21
    • 36549026839 scopus 로고    scopus 로고
    • Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn’s disease
    • D.Turner, A.B.Grossman, J.Rosh, et al. Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn’s disease. Am J Gastroenterol. 2007;102(12):2804–2812.
    • (2007) Am J Gastroenterol , vol.102 , Issue.12 , pp. 2804-2812
    • Turner, D.1    Grossman, A.B.2    Rosh, J.3
  • 23
    • 67650882729 scopus 로고    scopus 로고
    • Methotrexate treatment in pediatric Crohn’s disease patients intolerant or resistant to purine analogues
    • B.Weiss, A.Lerner, R.Shapiro, et al. Methotrexate treatment in pediatric Crohn’s disease patients intolerant or resistant to purine analogues. J Pediatr Gastroenterol Nutr. 2009;48(5):526–530.
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , Issue.5 , pp. 526-530
    • Weiss, B.1    Lerner, A.2    Shapiro, R.3
  • 24
    • 78650512361 scopus 로고    scopus 로고
    • A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn’s disease
    • B.Boyle, L.Mackner, C.Ross, et al. A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn’s disease. J Pediatr Gastroenterol Nutr. 2010;51(6):714–717.
    • (2010) J Pediatr Gastroenterol Nutr , vol.51 , Issue.6 , pp. 714-717
    • Boyle, B.1    Mackner, L.2    Ross, C.3
  • 25
    • 80053649708 scopus 로고    scopus 로고
    • Methotrexate in the treatment of inflammatory bowel disease: an 8-year retrospective study in a Canadian pediatric IBD center
    • S.Willot, A.Noble, C.Deslandres. Methotrexate in the treatment of inflammatory bowel disease:an 8-year retrospective study in a Canadian pediatric IBD center. Inflamm Bowel Dis. 2011;17(12):2521–2526.
    • (2011) Inflamm Bowel Dis , vol.17 , Issue.12 , pp. 2521-2526
    • Willot, S.1    Noble, A.2    Deslandres, C.3
  • 26
    • 84905463638 scopus 로고    scopus 로고
    • Pediatric inflammatory bowel disease collaborative research group. Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn’s disease
    • W.Sunseri, J.S.Hyams, T.Lerer, et al. Pediatric inflammatory bowel disease collaborative research group. Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn’s disease. Inflamm Bowel Dis. 2014;20(8):1341–1345.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.8 , pp. 1341-1345
    • Sunseri, W.1    Hyams, J.S.2    Lerer, T.3
  • 27
    • 84954243731 scopus 로고    scopus 로고
    • Efficacy of oral methotrexate in paediatric Crohn’s disease: a multicentre propensity score study
    • D.Turner, E.Doveh, A.Cohen, et al. Efficacy of oral methotrexate in paediatric Crohn’s disease:a multicentre propensity score study. Gut. 2015;64(12):1898–1904.•• Retrospective cohort study with large sample size addressing the efficacy of methotrexate in children with Crohn’s disease.
    • (2015) Gut , vol.64 , Issue.12 , pp. 1898-1904
    • Turner, D.1    Doveh, E.2    Cohen, A.3
  • 28
    • 84953345006 scopus 로고    scopus 로고
    • Methotrexate for maintaining remission in paediatric Crohn’s patients with prior failure or intolerance to thiopurines: a multicenter cohort study
    • S.M.Haisma, T.Lijftogt, A.Kindermann, et al. Methotrexate for maintaining remission in paediatric Crohn’s patients with prior failure or intolerance to thiopurines:a multicenter cohort study. J Crohns Colitis. 2015;9(4):305–311.
    • (2015) J Crohns Colitis , vol.9 , Issue.4 , pp. 305-311
    • Haisma, S.M.1    Lijftogt, T.2    Kindermann, A.3
  • 29
    • 84937156672 scopus 로고    scopus 로고
    • Methotrexate is an efficient therapeutic alternative in children with thiopurine-resistant Crohn’s disease
    • I.Hojsak, Z.Mišak, O.Jadrešin, et al. Methotrexate is an efficient therapeutic alternative in children with thiopurine-resistant Crohn’s disease. Scand J Gastroenterol. 2015;50(10):1208–1213.
    • (2015) Scand J Gastroenterol , vol.50 , Issue.10 , pp. 1208-1213
    • Hojsak, I.1    Mišak, Z.2    Jadrešin, O.3
  • 30
    • 0027454451 scopus 로고
    • Low-dose oral methotrexate in refractory inflammatory bowel disease
    • T.H.Baron, C.D.Truss, C.O.Elson. Low-dose oral methotrexate in refractory inflammatory bowel disease. Dig Dis Sci. 1993;38(10):1851–1856.
    • (1993) Dig Dis Sci , vol.38 , Issue.10 , pp. 1851-1856
    • Baron, T.H.1    Truss, C.D.2    Elson, C.O.3
  • 31
    • 0030004052 scopus 로고    scopus 로고
    • Methotrexate for the treatment of refractory Crohn’s disease
    • M.Lémann, C.Chamiot-Prieur, B.Mesnard, et al. Methotrexate for the treatment of refractory Crohn’s disease. Aliment Pharmacol Ther. 1996;10(3):309–314.
    • (1996) Aliment Pharmacol Ther , vol.10 , Issue.3 , pp. 309-314
    • Lémann, M.1    Chamiot-Prieur, C.2    Mesnard, B.3
  • 32
    • 0033070617 scopus 로고    scopus 로고
    • Methotrexate in refractory Crohn’s disease
    • L.Vandeputte, G.D’Haens, F.Baert, et al. Methotrexate in refractory Crohn’s disease. Inflamm Bowel Dis. 1999;5(1):11–15.
    • (1999) Inflamm Bowel Dis , vol.5 , Issue.1 , pp. 11-15
    • Vandeputte, L.1    D’Haens, G.2    Baert, F.3
  • 33
    • 0343081012 scopus 로고    scopus 로고
    • Methotrexate in Crohn’s disease: long-term efficacy and toxicity
    • M.Lémann, T.Zenjari, Y.Bouhnik, et al. Methotrexate in Crohn’s disease:long-term efficacy and toxicity. Am J Gastroenterol. 2000;95(7):1730–1734.
    • (2000) Am J Gastroenterol , vol.95 , Issue.7 , pp. 1730-1734
    • Lémann, M.1    Zenjari, T.2    Bouhnik, Y.3
  • 34
    • 0035176366 scopus 로고    scopus 로고
    • Efficacy of parenteral methotrexate in refractory Crohn’s disease
    • R.Y.Chong, S.B.Hanauer, R.D.Cohen. Efficacy of parenteral methotrexate in refractory Crohn’s disease. Aliment Pharmacol Ther. 2001;15(1):35–44.
    • (2001) Aliment Pharmacol Ther , vol.15 , Issue.1 , pp. 35-44
    • Chong, R.Y.1    Hanauer, S.B.2    Cohen, R.D.3
  • 35
    • 4444319475 scopus 로고    scopus 로고
    • Experience with the use of low-dose methotrexate for inflammatory bowel disease
    • S.Y.Soon, A.Ansari, M.Yaneza, et al. Experience with the use of low-dose methotrexate for inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2004;16(9):921–926.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , Issue.9 , pp. 921-926
    • Soon, S.Y.1    Ansari, A.2    Yaneza, M.3
  • 36
    • 23944525347 scopus 로고    scopus 로고
    • Methotrexate for Crohn’s disease: experience in a district general hospital
    • B.H.Hayee, A.W.Harris. Methotrexate for Crohn’s disease:experience in a district general hospital. Eur J Gastroenterol Hepatol. 2005;17(9):893–898.
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , Issue.9 , pp. 893-898
    • Hayee, B.H.1    Harris, A.W.2
  • 37
    • 43049108076 scopus 로고    scopus 로고
    • Methotrexate as single therapy in Crohn’s disease: is its long-term efficacy limited?
    • C.Charpignon, P.Beau. Methotrexate as single therapy in Crohn’s disease:is its long-term efficacy limited? Gastroenterol Clin Biol. 2008;32(2):153–157.
    • (2008) Gastroenterol Clin Biol , vol.32 , Issue.2 , pp. 153-157
    • Charpignon, C.1    Beau, P.2
  • 38
    • 46049088744 scopus 로고    scopus 로고
    • Use of methotrexate in refractory Crohn’s disease: the Edinburgh experience
    • S.Din, A.Dahele, J.Fennel, et al. Use of methotrexate in refractory Crohn’s disease:the Edinburgh experience. Inflamm Bowel Dis. 2008;14(6):756–762.
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.6 , pp. 756-762
    • Din, S.1    Dahele, A.2    Fennel, J.3
  • 39
    • 41349114688 scopus 로고    scopus 로고
    • Long-term methotrexate for Crohn’s disease: safety and efficacy in clinical practice
    • E.Domènech, M.Mañosa, M.Navarro, et al. Long-term methotrexate for Crohn’s disease:safety and efficacy in clinical practice. J Clin Gastroenterol. 2008;42(4):395–399.
    • (2008) J Clin Gastroenterol , vol.42 , Issue.4 , pp. 395-399
    • Domènech, E.1    Mañosa, M.2    Navarro, M.3
  • 40
    • 44949155702 scopus 로고    scopus 로고
    • A single center experience of methotrexate in the treatment of Crohn’s disease and ulcerative colitis: a case for subcutaneous administration
    • D.M.Nathan, J.H.Iser, P.R.J.Gibson. A single center experience of methotrexate in the treatment of Crohn’s disease and ulcerative colitis:a case for subcutaneous administration. Gastroenterol Hepatol. 2008;23(6):954–958.
    • (2008) Gastroenterol Hepatol , vol.23 , Issue.6 , pp. 954-958
    • Nathan, D.M.1    Iser, J.H.2    Gibson, P.R.J.3
  • 41
    • 68949209778 scopus 로고    scopus 로고
    • Efficacy of methotrexate in Crohn’s disease and ulcerative colitis patients unresponsive or intolerant to azathioprine
    • M.Wahed, J.R.Louis-Auguste, L.M.Baxter, et al. Efficacy of methotrexate in Crohn’s disease and ulcerative colitis patients unresponsive or intolerant to azathioprine. Aliment Pharmacol Ther. 2009;30(6):614–620.
    • (2009) Aliment Pharmacol Ther , vol.30 , Issue.6 , pp. 614-620
    • Wahed, M.1    Louis-Auguste, J.R.2    Baxter, L.M.3
  • 42
    • 77953700438 scopus 로고    scopus 로고
    • Methotrexate for maintenance of remission in chronic active Crohn’s disease: long-term single-center experience and meta-analysis of observational studies
    • J.Hausmann, K.Zabel, E.Herrmann, et al. Methotrexate for maintenance of remission in chronic active Crohn’s disease:long-term single-center experience and meta-analysis of observational studies. Inflamm Bowel Dis. 2010;16(7):1195–1202.
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.7 , pp. 1195-1202
    • Hausmann, J.1    Zabel, K.2    Herrmann, E.3
  • 43
    • 77950823180 scopus 로고    scopus 로고
    • Clinical experience of methotrexate in Crohn’s disease: response, safety and monitoring of treatment
    • R.Parker, A.Dixit, A.Fraser, et al. Clinical experience of methotrexate in Crohn’s disease:response, safety and monitoring of treatment. Postgrad Med J. 2010;86(1014):208–211.
    • (2010) Postgrad Med J , vol.86 , Issue.1014 , pp. 208-211
    • Parker, R.1    Dixit, A.2    Fraser, A.3
  • 44
    • 79960600311 scopus 로고    scopus 로고
    • The safety and tolerability of methotrexate for treating patients with Crohn’s disease
    • N.Chande, I.Abdelgadir, J.Gregor. The safety and tolerability of methotrexate for treating patients with Crohn’s disease. J Clin Gastroenterol. 2011;45(7):599–601.
    • (2011) J Clin Gastroenterol , vol.45 , Issue.7 , pp. 599-601
    • Chande, N.1    Abdelgadir, I.2    Gregor, J.3
  • 45
    • 83855161552 scopus 로고    scopus 로고
    • Efficacy and tolerability of methotrexate therapy for refractory Crohn’s disease: a large single-centre experience
    • N.C.Suares, P.J.Hamlin, D.P.Greer, et al. Efficacy and tolerability of methotrexate therapy for refractory Crohn’s disease:a large single-centre experience. Aliment Pharmacol Ther. 2012;35(2):284–291.
    • (2012) Aliment Pharmacol Ther , vol.35 , Issue.2 , pp. 284-291
    • Suares, N.C.1    Hamlin, P.J.2    Greer, D.P.3
  • 46
    • 84864869595 scopus 로고    scopus 로고
    • Madrid Group for Study of Inflammatory Bowel Diseases (ENICMAD). Methotrexate in inflammatory bowel disease: a multicenter retrospective study focused on long-term efficacy and safety. The Madrid experience
    • Y.González-Lama, C.Taxonera, A.López-Sanromán, et al. Madrid Group for Study of Inflammatory Bowel Diseases (ENICMAD). Methotrexate in inflammatory bowel disease:a multicenter retrospective study focused on long-term efficacy and safety. The Madrid experience. Eur J Gastroenterol Hepatol. 2012;24(9):1086–1091.
    • (2012) Eur J Gastroenterol Hepatol , vol.24 , Issue.9 , pp. 1086-1091
    • González-Lama, Y.1    Taxonera, C.2    López-Sanromán, A.3
  • 47
    • 84878143518 scopus 로고    scopus 로고
    • Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn’s disease
    • M.L.Seinen, C.Y.Ponsioen, N.K.de Boer, et al. Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2013;11(6):667–672.•• Retrospective cohort study with large sample size addressing the efficacy and safety of methotrexate in adult Crohn’s disease patients.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.6 , pp. 667-672
    • Seinen, M.L.1    Ponsioen, C.Y.2    de Boer, N.K.3
  • 48
    • 84855735860 scopus 로고    scopus 로고
    • The use of methotrexate for treatment of inflammatory bowel disease in clinical practice
    • S.Saibeni, S.Bollani, A.Losco, et al. The use of methotrexate for treatment of inflammatory bowel disease in clinical practice. Dig Liver Dis. 2012;44(2):123–127.
    • (2012) Dig Liver Dis , vol.44 , Issue.2 , pp. 123-127
    • Saibeni, S.1    Bollani, S.2    Losco, A.3
  • 49
    • 84875371455 scopus 로고    scopus 로고
    • Long-term outcome of patients with crohn’s disease who respond to azathioprine
    • M.Camus, P.Seksik, A.Bourrier, et al. Long-term outcome of patients with crohn’s disease who respond to azathioprine. Clin Gastroenterol Hepatol. 2013;11(4):389–394.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.4 , pp. 389-394
    • Camus, M.1    Seksik, P.2    Bourrier, A.3
  • 50
    • 0036278519 scopus 로고    scopus 로고
    • The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review
    • A.G.Fraser, T.R.Orchard, D.P.Jewell. The efficacy of azathioprine for the treatment of inflammatory bowel disease:a 30 year review. Gut. 2002;50(4):485–489.
    • (2002) Gut , vol.50 , Issue.4 , pp. 485-489
    • Fraser, A.G.1    Orchard, T.R.2    Jewell, D.P.3
  • 51
    • 45549107735 scopus 로고    scopus 로고
    • Comparative effectiveness of azathioprine in Crohn’s disease and ulcerative colitis: prospective, long-term, follow-up study of 394 patients
    • J.P.Gisbert, P.Nino, C.Cara, et al. Comparative effectiveness of azathioprine in Crohn’s disease and ulcerative colitis:prospective, long-term, follow-up study of 394 patients. Aliment Pharmacol Ther. 2008;28(2):228–238.
    • (2008) Aliment Pharmacol Ther , vol.28 , Issue.2 , pp. 228-238
    • Gisbert, J.P.1    Nino, P.2    Cara, C.3
  • 52
    • 84901490124 scopus 로고    scopus 로고
    • Crohn’s disease outcome in patients under azathioprine: a tertiary referral center experience
    • F.Magro, J.Santos-Antunes, F.Vilas-Boas, et al. Crohn’s disease outcome in patients under azathioprine:a tertiary referral center experience. J Crohns Colitis. 2014;8(7):617–625.
    • (2014) J Crohns Colitis , vol.8 , Issue.7 , pp. 617-625
    • Magro, F.1    Santos-Antunes, J.2    Vilas-Boas, F.3
  • 53
    • 84860837896 scopus 로고    scopus 로고
    • Thiopurine treatment in inflammatory bowel disease: response predictors, safety, and withdrawal in follow-up
    • G.Costantino, F.Furfaro, A.Belvedere, et al. Thiopurine treatment in inflammatory bowel disease:response predictors, safety, and withdrawal in follow-up. J Crohns Colitis. 2012;6(5):588–596.
    • (2012) J Crohns Colitis , vol.6 , Issue.5 , pp. 588-596
    • Costantino, G.1    Furfaro, F.2    Belvedere, A.3
  • 54
    • 7044268960 scopus 로고    scopus 로고
    • Increased incidence of azathioprine-induced pancreatitis in Crohn’s disease compared with other diseases
    • R.K.Weersma, F.T.Peters, L.E.Oostenbrug, et al. Increased incidence of azathioprine-induced pancreatitis in Crohn’s disease compared with other diseases. Aliment Pharmacol Ther. 2004;20(8):843–850.
    • (2004) Aliment Pharmacol Ther , vol.20 , Issue.8 , pp. 843-850
    • Weersma, R.K.1    Peters, F.T.2    Oostenbrug, L.E.3
  • 55
    • 2642580003 scopus 로고    scopus 로고
    • Side effects of azathioprine in patients with Crohn’s disease
    • D.J.de Jong, M.Goullet, T.H.Naber. Side effects of azathioprine in patients with Crohn’s disease. Eur J Gastroenterol Hepatol. 2004;16(2):207–212.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , Issue.2 , pp. 207-212
    • de Jong, D.J.1    Goullet, M.2    Naber, T.H.3
  • 56
    • 4544239107 scopus 로고    scopus 로고
    • Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease
    • R.B.Gearry, M.L.Barclay, M.J.Burt, et al. Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease. Pharmacoepidemiol Drug Saf. 2004;13(8):563–567.
    • (2004) Pharmacoepidemiol Drug Saf , vol.13 , Issue.8 , pp. 563-567
    • Gearry, R.B.1    Barclay, M.L.2    Burt, M.J.3
  • 57
    • 44649187924 scopus 로고    scopus 로고
    • Efficacy and safety of tumor necrosis factor antagonists in Crohn’s disease: meta-analysis of placebo-controlled trials
    • L.Peyrin-Biroulet, P.Deltenre, N.de Suray, et al. Efficacy and safety of tumor necrosis factor antagonists in Crohn’s disease:meta-analysis of placebo-controlled trials. Clin Gastroenterol Hepatol. 2008;6(6):644–653.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , Issue.6 , pp. 644-653
    • Peyrin-Biroulet, L.1    Deltenre, P.2    de Suray, N.3
  • 58
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn’s disease
    • F.Baert, M.Noman, S.Vermeire, et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn’s disease. N Engl J Med. 2003;348(7):601–608.
    • (2003) N Engl J Med , vol.348 , Issue.7 , pp. 601-608
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 59
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or combination therapy for Crohn’s disease
    • SONIC study group
    • J.F.Colombel, W.J.Sandborn, W.Reinisch, et al. SONIC study group. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010;362(15):1383–1395.
    • (2010) N Engl J Med , vol.362 , Issue.15 , pp. 1383-1395
    • Colombel, J.F.1    Sandborn, W.J.2    Reinisch, W.3
  • 60
    • 27744514865 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial
    • Y.P.Goekoop-Ruiterman, J.K.de Vries-Bouwstra, C.F.Allaart, et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study):a randomized, controlled trial. Arthritis Rheum. 2005;52(11):3381–3390.
    • (2005) Arthritis Rheum , vol.52 , Issue.11 , pp. 3381-3390
    • Goekoop-Ruiterman, Y.P.1    de Vries-Bouwstra, J.K.2    Allaart, C.F.3
  • 61
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy withadalimumab plus methotrexate versus methotrexatealone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • F.C.Breedveld, M.H.Weisman, A.F.Kavanaugh, et al. The PREMIER study:a multicenter, randomized, double-blind clinical trial of combination therapy withadalimumab plus methotrexate versus methotrexatealone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 2006;54(1):26–37.
    • (2006) Arthritis Rheum , vol.54 , Issue.1 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3
  • 62
    • 33644895018 scopus 로고    scopus 로고
    • Active-controlled study of patients receiving infliximab for the treatment of rheumatoid arthritis of early onset (ASPIRE) study group. Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial
    • J.S.Smolen, D.M.Van DerHeijde, E.W.St Clair, et al. Active-controlled study of patients receiving infliximab for the treatment of rheumatoid arthritis of early onset (ASPIRE) study group. Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab:results from the ASPIRE trial. Arthritis Rheum. 2006;54(3):702–710.
    • (2006) Arthritis Rheum , vol.54 , Issue.3 , pp. 702-710
    • Smolen, J.S.1    Van DerHeijde, D.M.2    St Clair, E.W.3
  • 63
    • 84894302120 scopus 로고    scopus 로고
    • Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn’s disease
    • B.G.Feagan, J.W.McDonald, R.Panaccione, et al. Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn’s disease. Gastroenterology. 2014;146(3):681–688.•• Randomised controlled trial comparing combination therapy methotrexate and infliximab vs infliximab monotherapy in patients with Crohn’s disease.
    • (2014) Gastroenterology , vol.146 , Issue.3 , pp. 681-688
    • Feagan, B.G.1    McDonald, J.W.2    Panaccione, R.3
  • 64
    • 34548130215 scopus 로고    scopus 로고
    • Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn’s disease
    • S.Vermeire, M.Noman, G.Van Assche, et al. Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn’s disease. Gut. 2007;56(9):1226–1231.• This study suggests that methotrexate is as effective as thiopurines in reducing the immunogenicity of infliximab in Crohn’s disease.
    • (2007) Gut , vol.56 , Issue.9 , pp. 1226-1231
    • Vermeire, S.1    Noman, M.2    Van Assche, G.3
  • 65
    • 84875371134 scopus 로고    scopus 로고
    • Antidrug antibodies in serum and restores clinical response of patients with inflammatory bowel disease
    • S.Ben–Horin, M.Waterman, U.Kopylov, et al. Antidrug antibodies in serum and restores clinical response of patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013;11(4):444–447.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.4 , pp. 444-447
    • Ben–Horin, S.1    Waterman, M.2    Kopylov, U.3
  • 66
    • 22644446331 scopus 로고    scopus 로고
    • Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine
    • A.Kandiel, A.G.Fraser, B.I.Korelitz, et al. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut. 2005;54(8):1121–1125.
    • (2005) Gut , vol.54 , Issue.8 , pp. 1121-1125
    • Kandiel, A.1    Fraser, A.G.2    Korelitz, B.I.3
  • 67
    • 70449100743 scopus 로고    scopus 로고
    • Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
    • CESAME Study Group
    • L.Beaugerie, N.Brousse, A.M.Bouvier, et al. CESAME Study Group. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease:a prospective observational cohort study. Lancet. 2009;374(9701):1617–1625.
    • (2009) Lancet , vol.374 , Issue.9701 , pp. 1617-1625
    • Beaugerie, L.1    Brousse, N.2    Bouvier, A.M.3
  • 68
    • 78650239266 scopus 로고    scopus 로고
    • A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease
    • D.S.Kotlyar, M.T.Osterman, R.H.Diamond, et al. A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9(1):36–41.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , Issue.1 , pp. 36-41
    • Kotlyar, D.S.1    Osterman, M.T.2    Diamond, R.H.3
  • 69
    • 84886789606 scopus 로고    scopus 로고
    • Lymphoma: the bête noire of the long-term use of thiopurines in adult and elderly patients with inflammatory bowel disease
    • L.Beaugerie. Lymphoma:the bête noire of the long-term use of thiopurines in adult and elderly patients with inflammatory bowel disease. Gastroenterology. 2013;145(5):927–930.
    • (2013) Gastroenterology , vol.145 , Issue.5 , pp. 927-930
    • Beaugerie, L.1
  • 70
    • 84963761365 scopus 로고    scopus 로고
    • European evidence-based consensus: inflammatory bowel disease and malignancies
    • V.Annese, L.Beaugerie, L.Egan, et al. European evidence-based consensus:inflammatory bowel disease and malignancies. J Crohns Colitis. 2015;9(11):945–965.
    • (2015) J Crohns Colitis , vol.9 , Issue.11 , pp. 945-965
    • Annese, V.1    Beaugerie, L.2    Egan, L.3
  • 71
    • 84872093359 scopus 로고    scopus 로고
    • Methotrexate: underused and ignored?
    • H.H.Herfarth, M.D.Long, K.L.Isaacs. Methotrexate:underused and ignored? Dig Dis. 2012;30(Suppl 3):112–118.
    • (2012) Dig Dis , vol.30 , pp. 112-118
    • Herfarth, H.H.1    Long, M.D.2    Isaacs, K.L.3
  • 72
    • 0033763401 scopus 로고    scopus 로고
    • Comparative tolerability of treatments for inflammatory bowel disease
    • R.B.Stein, S.B.Hanauer. Comparative tolerability of treatments for inflammatory bowel disease. Drug Saf. 2000;23(5):429–448.
    • (2000) Drug Saf , vol.23 , Issue.5 , pp. 429-448
    • Stein, R.B.1    Hanauer, S.B.2
  • 73
    • 0028939349 scopus 로고
    • The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis. Rheumatoid arthritis clinical trial archive group
    • No authors listed. The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis. Rheumatoid arthritis clinical trial archive group. J Rheumatol. 1995;22(2):218–223.
    • (1995) J Rheumatol , vol.22 , Issue.2 , pp. 218-223
  • 74
    • 31144446053 scopus 로고    scopus 로고
    • Monitoring liver function during methotrexate therapy for psoriasis: are routine biopsies really necessary?
    • J.A.Thomas, G.P.Aithal. Monitoring liver function during methotrexate therapy for psoriasis:are routine biopsies really necessary? Am J Clin Dermatol. 2005;6(6):357–363.
    • (2005) Am J Clin Dermatol , vol.6 , Issue.6 , pp. 357-363
    • Thomas, J.A.1    Aithal, G.P.2
  • 75
    • 0033755922 scopus 로고    scopus 로고
    • Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease
    • H.S.Te, T.D.Schiano, S.F.Kuan, et al. Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease. Am J Gastroenterol. 2000;95(11):3150–3156.
    • (2000) Am J Gastroenterol , vol.95 , Issue.11 , pp. 3150-3156
    • Te, H.S.1    Schiano, T.D.2    Kuan, S.F.3
  • 76
    • 78049477991 scopus 로고    scopus 로고
    • Assessment of liver fibrosis with transient elastography and fibrotest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study
    • D.Laharie, J.Seneschal, T.Schaeverbeke, et al. Assessment of liver fibrosis with transient elastography and fibrotest in patients treated with methotrexate for chronic inflammatory diseases:a case-control study. J Hepatol. 2010;53(6):1035–1040.
    • (2010) J Hepatol , vol.53 , Issue.6 , pp. 1035-1040
    • Laharie, D.1    Seneschal, J.2    Schaeverbeke, T.3
  • 77
    • 77954424629 scopus 로고    scopus 로고
    • Changes in liver biochemistry during methotrexate use for inflammatory bowel disease
    • M.R.Fournier, J.Klein, G.Y.Minuk, et al. Changes in liver biochemistry during methotrexate use for inflammatory bowel disease. Am J Gastroenterol. 2010;105(7):1620–1626.
    • (2010) Am J Gastroenterol , vol.105 , Issue.7 , pp. 1620-1626
    • Fournier, M.R.1    Klein, J.2    Minuk, G.Y.3
  • 78
    • 0022648221 scopus 로고
    • Drug-induced pulmonary disease: cytotoxic drugs. Part 1
    • J.A.CooperJr, D.A.White, R.A.Matthay. Drug-induced pulmonary disease:cytotoxic drugs. Part 1. Am Rev Respir Dis. 1986;133(2):321–340.
    • (1986) Am Rev Respir Dis , vol.133 , Issue.2 , pp. 321-340
    • Cooper, J.A.1    White, D.A.2    Matthay, R.A.3
  • 79
    • 17044442903 scopus 로고    scopus 로고
    • Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group
    • G.S.Alarcón, J.M.Kremer, M.Macaluso, et al. Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group. Ann Intern Med. 1997;127(5):356–364.
    • (1997) Ann Intern Med , vol.127 , Issue.5 , pp. 356-364
    • Alarcón, G.S.1    Kremer, J.M.2    Macaluso, M.3
  • 80
    • 77952102218 scopus 로고    scopus 로고
    • Methotrexate-induced pneumonitis in a patient with Crohn’s disease
    • G.Margagnoni, V.Papi, A.Aratari, et al. Methotrexate-induced pneumonitis in a patient with Crohn’s disease. J Crohns Colitis. 2010;4(2):211–214.
    • (2010) J Crohns Colitis , vol.4 , Issue.2 , pp. 211-214
    • Margagnoni, G.1    Papi, V.2    Aratari, A.3
  • 81
    • 67549107120 scopus 로고    scopus 로고
    • Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research
    • C.Salliot, D.van der Heijde. Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis:a systematic literature research. Ann Rheum Dis. 2009;68(7):1100–1104.
    • (2009) Ann Rheum Dis , vol.68 , Issue.7 , pp. 1100-1104
    • Salliot, C.1    van der Heijde, D.2
  • 82
    • 2642554059 scopus 로고    scopus 로고
    • Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients
    • F.Wolfe, K.Michaud. Lymphoma in rheumatoid arthritis:the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum. 2004;50(6):1740– 1751.•• A large prospective study in patients enrolled in the National Data Bank for Rheumatic Diseases addressing the risk of lymphoma in patients with rheumatoid arthritis.
    • (2004) Arthritis Rheum , vol.50 , Issue.6 , pp. 1740-1751
    • Wolfe, F.1    Michaud, K.2
  • 83
    • 0032775962 scopus 로고    scopus 로고
    • Developmental delay in fetal aminopterin/methotrexate syndrome
    • M.Del Campo, K.Kosaki, F.C.Bennett, et al. Developmental delay in fetal aminopterin/methotrexate syndrome. Teratology. 1999;60(1):10–12.
    • (1999) Teratology , vol.60 , Issue.1 , pp. 10-12
    • Del Campo, M.1    Kosaki, K.2    Bennett, F.C.3
  • 84
    • 84988492478 scopus 로고
    • Administration FDA. Regulations. 1980;44:37434–37467.
    • (1980)
  • 85
    • 84953887240 scopus 로고    scopus 로고
    • European Crohn’s and colitis organization. The second European evidence-based consensus on reproduction and pregnancy in inflammatory bowel disease
    • C.J.van der Woude, S.Ardizzone, M.B.Bengtson, et al. European Crohn’s and colitis organization. The second European evidence-based consensus on reproduction and pregnancy in inflammatory bowel disease. J Crohns Colitis. 2015;9(2):107–124.
    • (2015) J Crohns Colitis , vol.9 , Issue.2 , pp. 107-124
    • van der Woude, C.J.1    Ardizzone, S.2    Bengtson, M.B.3
  • 86
    • 33745757123 scopus 로고    scopus 로고
    • American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy
    • U.Mahadevan, S.Kane. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006;131(1):283–311.
    • (2006) Gastroenterology , vol.131 , Issue.1 , pp. 283-311
    • Mahadevan, U.1    Kane, S.2
  • 87
    • 70350181571 scopus 로고    scopus 로고
    • Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding)
    • J.A.Martínez Lopez, E.Loza, L.Carmona. Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding). Clin Exp Rheumatol. 2009;27(4):678–684.
    • (2009) Clin Exp Rheumatol , vol.27 , Issue.4 , pp. 678-684
    • Martínez Lopez, J.A.1    Loza, E.2    Carmona, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.