Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation

Nature Immunology

Volumn 14, Issue 4, 2013, Pages 404-412

  Best, J Adam ^a   Blair, David A ^b   Knell, Jamie ^a   Yang, Edward ^a   Mayya, Viveka ^b   Doedens, Andrew ^a   Dustin, Michael L ^b   Goldrath, Ananda W ^a   Monach, Paul ^c   Shinton, Susan A ^d   Hardy, Richard R ^d   Jianu, Radu ^e   Koller, David ^e   Collins, Jim ^f   Gazit, Roi ^g   Garrison, Brian S ^g   Rossi, Derrick J ^g   Narayan, Kavitha ^h   Sylvia, Katelyn ^h   Kang, Joonsoo ^h   Fletcher, Anne ⁱ   Elpek, Kutlu ⁱ   Bellemare Pelletier, Angelique ⁱ   Malhotra, Deepali ⁱ   Turley, Shannon ⁱ   Jojic, Vladimir ^j   Koller, Daphne ^j   Shay, Tal ^k   Regev, Aviv ^k   Cohen, Nadia ^l   Brennan, Patrick ^l   Brenner, Michael ^l   Kreslavsky, Taras ^l   Bezman, Natalie A ⁱ   Sun, Joseph C ^m   Kim, Charlie C ^m   Lanier, Lewis L ^m   Miller, Jennifer ⁿ   Brown, Brian ⁿ   Merad, Miriam ⁿ   Gautier, Emmanuel L ^n,o   Jakubzick, Claudia ⁿ   Randolph, Gwendalyn J ^n,o   Kim, Francis ^p   Rao, Tata Nageswara ^p   Wagers, Amy ^p   Heng, Tracy ⁱ   Painter, Michio ⁱ   Ericson, Jeffrey ⁱ   Davis, Scott ⁱ   Ergun, Ayla ⁱ   Mingueneau, Michael ⁱ   Mathis, Diane ⁱ   Benoist, Christophe ⁱ   more..

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e Brown Univerity   (United States)

^f Boston University   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j Stanford University   (United States)

^k BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^l BRIGHAM AND WOMEN S HOSPITAL   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^o WASHINGTON UNIVERSITY   (United States)

^p JOSLIN DIABETES CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MIGRATION; CELL POPULATION; CELLULAR IMMUNITY; GAMMA DELTA T LYMPHOCYTE; GENE EXPRESSION; INFECTION; MALE; MEMORY T LYMPHOCYTE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRE T LYMPHOCYTE; PREDICTION; PRIORITY JOURNAL; VIRUS VIRULENCE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNOLOGIC MEMORY; INFECTION; MALE; MICE; RECEPTORS, ANTIGEN, T-CELL; TRANSCRIPTION, GENETIC;

EID: 84875448616     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2536     Document Type: Article

References (35)

1. Heng, T.S. & Painter, M.W. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9, 1091-1094 (2008).
2. Haining, W.N. et al. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J. Immunol. 181, 1859-1868 (2008).
3. Kaech, S.M., Hemby, S., Kersh, E. & Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837-851 (2002).
4. Sarkar, S. et al. Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J. Exp. Med. 205, 625-640 (2008).
5. Wirth, T.C. et al. Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8+ T cell differentiation. Immunity 33, 128-140 (2010).
6. Kaech, S.M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415-422 (2001).
7. Busch, D.H., Kerksiek, K.M. & Pamer, E.G. Differing roles of inflammation and antigen in T cell proliferation and memory generation. J. Immunol. 164, 4063-4070 (2000).
8. Badovinac, V.P., Haring, J.S. & Harty, J.T. Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8+ T cell response to infection. Immunity 26, 827-841 (2007).
9. Haluszczak, C. et al. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J. Exp. Med. 206, 435-448 (2009).
10. Yamada, T., Park, C.S., Mamonkin, M. & Lacorazza, H.D. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2. Nat. Immunol. 10, 618-626 (2009).
11. Beuneu, H. et al. Visualizing the functional diversification of CD8+ T cell responses in lymph nodes. Immunity 33, 412-423 (2010).
12. Grayson, J.M., Zajac, A.J., Altman, J.D. & Ahmed, R. Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J. Immunol. 164, 3950-3954 (2000).
13. Grundemann, C. et al. Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. J. Immunol. 176, 1311-1315 (2006).
14. Dietz, S.B., Whitaker-Menezes, D. & Lessin, S.R. The role of E7 integrin (CD103) and E-cadherin in epidermotropism in cutaneous T-cell lymphoma. J. Cutan. Pathol. 23,312-318 (1996).
15. Pearce, E.L. et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460, 103-107 (2009).
16. Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009).
17. van der Windt, G.J. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68-78 (2012).
18. Gautier, E.L. et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13,1118-1128 (2012).
19. Joshi, N.S. et al. Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor. Immunity 27,281-295 (2007).
20. Rutishauser, R.L. et al. Transcriptional repressor Blimp-1 promotes CD8+ T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity 31, 296-308 (2009).
21. Kaech, S.M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191-1198 (2003).
22. Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1, 426-432 (2000).
23. Huster, K.M. et al. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. USA 101, 5610-5615 (2004).
24. Yang, C.Y. et al. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat. Immunol. 12, 1221-1229 (2011).
25. Cannarile, M.A. et al. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nat. Immunol. 7, 1317-1325 (2006).
26. D'Cruz, L.M., Lind, K.C., Wu, B.B., Fujimoto, J.K. & Goldrath, A.W. Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response. Eur. J. Immunol. 8, 2031-2041 (2012).
27. Harty, J.T. & Badovinac, V.P. Shaping and reshaping CD8+ T-cell memory. Nat. Rev. Immunol. 8, 107-119 (2008).
28. Obar, J.J., Khanna, K.M. & Lefrancois, L. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity 28, 859-869 (2008).
29. Obar, J.J. et al. Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J. Immunol. 187, 4967-4978 (2011).
30. Marzo, A.L. et al. Initial T cell frequency dictates memory CD8+ T cell lineage commitment. Nat. Immunol. 6, 793-799 (2005).
31. Agarwal, P. et al. Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory. J. Immunol. 183, 1695-1704 (2009).
32. Sacerdote, P., Massi, P., Panerai, A.E. & Parolaro, D. In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors.J. Neuroimmunol. 109, 155-163 (2000).
33. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S.H. & Zerrahn, J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immunol. 16, 1535-1548 (2004).
34. Kallies, A. Distinct regulation of effector and memory T-cell differentiation. Immunol. Cell Biol. 86, 325-332 (2008).
35. Sundrud, M.S. & Rao, A. Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just RORt anymore. Immunity 28, 5-7 (2008).