Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice

Gastroenterology

Volumn 149, Issue 7, 2015, Pages 1860-1871.e8

  Zhao, Junjie ^a,b,c   Bulek, Katarzyna ^a,c   Gulen, Muhammet F ^a   Zepp, Jarod A ^a,b   Karagkounis, Georgio ^a   Martin, Bradley N ^a   Zhou, Hao ^a   Yu, Minjia ^a   Liu, Xiuli ^a   Huang, Emina ^a   Fox, Paul L ^a   Kalady, Matthew F ^a   Markowitz, Sanford D ^c   Li, Xiaoxia ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Colorectal Cancer; TLR IL 1R; Tumor Suppressor

Indexed keywords

AZOXYMETHANE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 6; RNA ISOFORM; SINGLE IMMUNOGLOBULIN AND TOLL INTERLEUKIN 1 RECEPTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; AUTACOID; MESSENGER RNA; TIR8 PROTEIN, HUMAN; TIR8 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; CANCER TISSUE; CELL FUNCTION; CELL MEMBRANE; CELL SURFACE; CELLULAR DISTRIBUTION; COLITIS; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTESTINAL TISSUE; INTESTINE EPITHELIUM; INVESTIGATIVE PROCEDURES; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; 129 MOUSE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COLON; COLON TUMOR; CYTOSOL; DNA MICROARRAY; DOMINANT GENE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; GLYCOSYLATION; HELA CELL LINE; INTESTINE MUCOSA; METABOLISM; MUTATION; PATHOLOGY; PHENOTYPE; PROCEDURES; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE;

ANIMALS; AZOXYMETHANE; CELL MEMBRANE; COLITIS; COLON; COLONIC NEOPLASMS; CYTOSOL; DEXTRAN SULFATE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, DOMINANT; GENETIC PREDISPOSITION TO DISEASE; GLYCOSYLATION; HELA CELLS; HUMANS; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; TRANSFECTION;

EID: 84952889382     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.08.051     Document Type: Article

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