Assessment of the Public Health significance of meticillin resistant Staphylococcus aureus (MRSA) in animals and foods

EFSA Journal

Volumn 7, Issue 3, 2009, Pages

[No Author Info available]

Author keywords

antimicrobial resistance; companion animals; farm animals; meticillin; MRSA; pets

Indexed keywords

EID: 85009771212     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2009.993     Document Type: Note

References (262)

1. Abbott, Y., Leonard, F.C. and Markey, B.K., 2006. The prevalence of methicillin-resistant Staphylococcus aureus infection and colonisation in companion animals in Ireland. 1st International Conference on MRSA in Animals, University of Liverpool, United Kingdom.
2. Albrich, W.C. and Harbarth, S., 2008. Health-care workers: source, vector, or victim of MRSA? Lancet Infect Dis 8 (5), 289–301.
3. Allen, K.D., Anson, J.J., Parsons, L.A. and Frost, N.G., 1997. Staff carriage of methicillin-resistant Staphylococcus aureus (EMRSA 15) and the home environment: a case report. J Hosp Infect 35 (4), 307–311.
4. Allen, U.D., 2006. Public health implications of MRSA in Canada. CMAJ 175 (2), 161.
5. Anderson, M.E., Lefebvre, S.L. and Weese, J.S., 2008. Evaluation of prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization in veterinary personnel attending an international equine veterinary conference. Vet Microbiol 129 (3–4), 410–417.
6. Anzai, T., Kamada, M., Kanemaru, T., Sugita, S., Shimizu, A. and Higuchi, T., 1996. Isolation of methicillin-resistant Staphylococcus aureus (MRSA) from mares with metritis and its zooepidemiology. Journal of Equine Science 7, 7–11.
7. Armand-Lefevre, L., Ruimy, R. and Andremont, A., 2005. Clonal comparison of Staphylococcus aureus isolates from healthy pig farmers, human controls, and pigs. Emerg Infect Dis 11 (5), 711–714.
8. Asoh, N., Masaki, H., Watanabe, H., Watanabe, K., Mitsusima, H., Matsumoto, K., Oishi, K. and Nagatake, T., 2005. Molecular characterization of the transmission between the colonization of methicillin-resistant Staphylococcus aureus to human and environmental contamination in geriatric long-term care wards. Intern Med 44 (1), 41–45.
9. Aubry-Damon, H., Grenet, K., Sall-Ndiaye, P., Che, D., Cordeiro, E., Bougnoux, M.E., Rigaud, E., Le Strat, Y., Lemanissier, V., Armand-Lefevre, L., Delzescaux, D., Desenclos, J.C., Lienard, M. and Andremont, A., 2004. Antimicrobial resistance in commensal flora of pig farmers. Emerg Infect Dis 10 (5), 873–879.
10. Baptiste, K.E., Williams, K., Willams, N.J., Wattret, A., Clegg, P.D., Dawson, S., Corkill, J.E., O'Neill, T. and Hart, C.A., 2005. Methicillin-resistant staphylococci in companion animals. Emerg Infect Dis 11 (12), 1942–1944.
11. Barr, B., Wilcox, M.H., Brady, A., Parnell, P., Darby, B. and Tompkins, D., 2007. Prevalence of methicillin-resistant Staphylococcus aureus colonization among older residents of care homes in the United Kingdom. Infect Control Hosp Epidemiol 28 (7), 853–859.
12. Beard-Pegler, M.A., Stubbs, E. and Vickery, A.M., 1988. Observations on the resistance to drying of staphylococcal strains. J Med Microbiol 26 (4), 251–255.
13. Becker, K., Harmsen, D., Mellmann, A., Meier, C., Schumann, P., Peters, G. and von Eiff, C., 2004. Development and evaluation of a quality-controlled ribosomal sequence database for 16S ribosomal DNA-based identification of Staphylococcus species. J Clin Microbiol 42, 4988–4995.
14. Ben-David, D., Mermel, L.A. and Parenteau, S., 2008. Methicillin-resistant Staphylococcus aureus transmission: the possible importance of unrecognized health care worker carriage. Am J Infect Control 36 (2), 93–97.
15. Bens, C.C., Voss, A. and Klaassen, C.H., 2006. Presence of a novel DNA methylation enzyme in methicillin-resistant Staphylococcus aureus isolates associated with pig farming leads to uninterpretable results in standard pulsed-field gel electrophoresis analysis. J Clin Microbiol 44 (5), 1875–1876.
16. Biberstein, E.L., Jang, S.S. and Hirsh, D.C., 1984. Species distribution of coagulase-positive staphylococci in animals. J Clin Microbiol 19 (5), 610–615.
17. Bocher, S., Gervelmeyer, A., Monnet, D.L., Molbak, K. and Skov, R.L., 2008. Methicillin-resistant Staphylococcus aureus: risk factors associated with community-onset infections in Denmark. Clin Microbiol Infect 14 (10), 942–948.
18. Bocher, S., Smyth, R., Kahlmeter, G., Kerremans, J., Vos, M.C. and Skov, R., 2008. Evaluation of four selective agars and two enrichment broths in screening for methicillin-resistant Staphylococcus aureus. J Clin Microbiol 46 (9), 3136–3138.
19. Boost, M.V., O'Donoghue, M.M. and Siu, K.H., 2007. Characterisation of methicillin-resistant Staphylococcus aureus isolates from dogs and their owners. Clin Microbiol Infect 13 (7), 731–733.
20. Borch, E., Nesbakken, T. and Christensen, H., 1996. Hazard identification in swine slaughter with respect to foodborne bacteria. Int J Food Microbiol 30 (1–2), 9–25.
21. Boucher, H.W. and Corey, G.R., 2008. Epidemiology of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 46 Suppl 5, S344–349.
22. Boyce, J.M. and Havill, N.L., 2008. Comparison of BD GeneOhm methicillin-resistant Staphylococcus aureus (MRSA) PCR versus the CHROMagar MRSA assay for screening patients for the presence of MRSA strains. J Clin Microbiol 46 (1), 350–351.
23. Brakstad, O.G., Aasbakk, K. and Mealand, J.A., 1992. Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol 30, 1654–1660.
24. Broens, E.M., Graat, E.A., van der Wolf, P.J., van der Broek, I.V., Tiemersma, E.W., Van de Giessen, A.W. and de Jong, M.C. 2008. Prevalence study and risk factor analysis of NT-MRSA in pigs in the Netherlands. American Society for Microbiology meeting on: Antimicrobial resistance in zoonotic bacteria and foodborne pathogens, Copenhagen, Denmark.
25. Buehlmann, M., Frei, R., Fenner, L., Dangel, M., Fluckinger, U. and Widmer, A., 2008. Highly effective regimen for decolonization of methicillin-resistant Staphylococcus aureus carriers. Infect Control Hosp Epidemiol 29, 510–516.
26. Busscher, J.F., van Duijkeren, E. and Sloet van Oldruitenborgh-Oosterbaan, M.M., 2006. The prevalence of methicillin-resistant staphylococci in healthy horses in the Netherlands. Vet Microbiol 113 (1–2), 131–136.
27. CDC, 2003. Methicillin-resistant Staphylococcus aureus infections among competitive sports participants-Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000–2003. MMWR Morb Mortal Wkly Rep 52 (33), 793–795.
28. Cefai, C., Ashurst, S. and Owens, C., 1994. Human carriage of methicillin-resistant Staphylococcus aureus linked with pet dog. Lancet 344 (8921), 539–540.
29. Cimolai, N., 2008. MRSA and the environment: implications for comprehensive control measures. Eur J Clin Microbiol Infect Dis 27 (7), 481–493.
30. Clements, A., Halton, K., Graves, N., Pettitt, A., Morton, A., Looke, D. and Whitby, M., 2008. Overcrowding and understaffing in modern health-care systems: key determinants in meticillin-resistant Staphylococcus aureus transmission. Lancet Infect Dis 8 (7), 427–434.
31. Clements, M.O. and Foster, S.J., 1999. Stress resistance in Staphylococcus aureus. Trends Microbiol 7 (11), 458–462.
32. CLSI, 2005. Performance Standards for Antimicrobial Susceptibility Testing. 15th Informational Supplement (M100-S15) Clinical Laboratory Standards Institute, Wayne, Pa.
33. Cockfield, J.D., Pathak, S., Edgeworth, J.D. and Lindsay, J.A., 2007. Rapid determination of hospital-acquired meticillin-resistant Staphylococcus aureus lineages. J Med Microbiol 56 (Pt 5), 614–619.
34. Cook, H.A., Furuya, E. Y., Larson, E., et al., 2007. Heterosexual transmission of community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis 44, 410–413.
35. Cookson, B., 2008. HARMONY-the International Union of Microbiology Societies' European Staphylococcal Typing Network. Euro Surveill 13 (19).
36. Cosgrove, S.E., 2006. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs. Clin Infect Dis 42 Suppl 2, S82–89.
37. Cox, H.U., Hoskins, J.D., Newman, S.S., Foil, C.S., Turnwald, G.H. and Roy, A.F., 1988. Temporal study of staphylococcal species on healthy dogs. Am J Vet Res 49 (6), 747–751.
38. Cuny, C., Kuemmerle, J., Stanek, C., Willey, B., Strommenger, B. and Witte, W., 2006. Emergence of MRSA infections in horses in a veterinary hospital: strain characterisation and comparison with MRSA from humans. Euro Surveill 11 (1), 44–47.
39. Cuny, C. and Witte, W., 2008. Ist die Verbreitung Methicillin-resistenter S. aureus (MRSA) bei Mastschweinen für den Menschen von Bedeutung? MMW - Forschschr. Med. Originalien Nr. II, in press.
40. Dancer, S.J., 2008a. The effect of antibiotics on methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 61 (2), 246–253.
41. Dancer, S.J., 2008b. Importance of the environment in meticillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning. Lancet Infect Dis 8 (2), 101–113.
42. de Boer, E., Zwartkruis-Nahuis, J.T., Wit, B., Huijsdens, X.W., de Neeling, A.J., Bosch, T., van Oosterom, R.A., Vila, A. and Heuvelink, A.E., 2008. Prevalence of methicillin-resistant Staphylococcus aureus in meat. Int J Food Microbiol. In Press.
43. de Boer, H.E., van Elzelingen-Dekker, C.M., van Rheenen-Verberg, C.M. and Spanjaard, L., 2006. Use of gaseous ozone for eradication of methicillin-resistant Staphylococcus aureus from the home environment of a colonized hospital employee. Infect Control Hosp Epidemiol 27 (10), 1120–1122.
44. de Neeling, A.J., van den Broek, M.J., Spalburg, E.C., van Santen-Verheuvel, M.G., Dam-Deisz, W.D., Boshuizen, H.C., van de Giessen, A.W., van Duijkeren, E. and Huijsdens, X.W., 2007. High prevalence of methicillin resistant Staphylococcus aureus in pigs. Vet Microbiol 122 (3–4), 366–372.
45. Declercq, P., Petré, D., Gordts, B. and Voss, A., 2008. Complicated community-Acquired soft tissue infection by MRSA from porcine origin. Infection 36(6):590–592.
46. th European Congress of Clinical Microbiology and Infectious Diseases (ECCMIC), Barcelona, Spain,
47. Desjardins, M., Guibord, C., Lalonde, B., Toye, B. and Ramotar, K., 2006. Evaluation of the IDI-MRSA assay for detection of methicillin-resistant Staphylococcus aureus from nasal and rectal specimens pooled in a selective broth. J Clin Microbiol 44 (4), 1219–1223.
48. Desmarchelier, P.M., Higgs, G.M., Mills, L., Sullivan, A.M. and Vanderlinde, P.B., 1999. Incidence of coagulase positive Staphylococcus on beef carcasses in three Australian abattoirs. Int J Food Microbiol 47 (3), 221–229.
49. Devriese, L.A., 1984. A simplified system for biotyping Staphylococcus aureus strains isolated from animal species. J Appl Bacteriol 56 (2), 215–220.
50. Devriese, L.A., Van Damme, L.R. and Fameree, L., 1972. Methicillin (cloxacillin)-resistant Staphylococcus aureus strains isolated from bovine mastitis cases. Zentralbl Veterinarmed B 19 (7), 598–605.
51. Diekema, D.J., Pfaller, M.A., Schmitz, F.J., Smayevsky, J., Bell, J., Jones, R.N. and Beach, M., 2001. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis 32 Suppl 2, S114–132.
52. Diep, B.A., Carleton, H.A., Chang, R.F., Sensabaugh, G.F. and Perdreau-Remington, F., 2006. Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus. J Infect Dis 193 (11), 1495–1503.
53. Diep, B.A., Chambers, H.F., Graber, C.J., Szumowski, J.D., Miller, L.G., Han, L.L., Chen, J.H., Lin, F., Lin, J., Phan, T.H., Carleton, H.A., McDougal, L.K., Tenover, F.C., Cohen, D.E., Mayer, K.H., Sensabaugh, G.F. and Perdreau-Remington, F., 2008. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med 148 (4), 249–257.
54. Dietrich, D.W., Auld, D.B. and Mermel, L.A., 2004. Community-acquired methicillin-resistant Staphylococcus aureus in southern New England children. Pediatrics 113 (4), 347–352.
55. Dodd, C.E., Chaffey, B.J. and Waites, W.M., 1988. Plasmid profiles as indicators of the source of contamination of Staphylococcus aureus endemic within poultry processing plants. Appl Environ Microbiol 54 (6), 1541–1549.
56. Drancourt, M. and Raoult, D., 2002. rpoB gene sequence based identification of Staphylococcus species. J Clin Microbiol 40, 1333–1338.
57. Edgeworth, J.D., Yadegarfar, G., Pathak, S., Batra, R., Cockfield, J.D., Wyncoll, D., Beale, R. and Lindsay, J.A., 2007. An outbreak in an intensive care unit of a strain of methicillin-resistant Staphylococcus aureus sequence type 239 associated with an increased rate of vascular access device-related bacteremia. Clin Infect Dis 44 (4), 493–501.
58. EFSA, 2007. Report of the task force on zoonoses data collection including a porposal for technical specifications for a baseline survey on the prevalence of methicillin resistant Staphylococcus aureus (MRSA) in breeding pigs. The EFSA Journal 129, 1–14.
59. Ekkelenkamp, M.B., Sekkat, M., Carpaij, N., Troelstra, A. and Bonten, M.J., 2006. Endocarditis due to meticillin-resistant Staphylococcus aureus originating from pigs. Ned Tijdschr Geneeskd 150 (44), 2442–2447.
60. Emonts, M., Uitterlinden, A.G., Nouwen, J.L., Kardys, I., Maat, M.P., Melles, D.C., Witteman, J., Jong, P.T., Verbrugh, H.A., Hofman, A., Hermans, P.W. and Belkum, A., 2008. Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils. J Infect Dis 197 (9), 1244–1253.
61. Enright, M.C., Day, N.P., Davies, C.E., Peacock, S.J. and Spratt, B.G., 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38 (3), 1008–1015.
62. Eveillard, M., Lancien, E., de Lassence, A., Branger, C., Barnaud, G., Benlolo, J.A. and Joly-Guillou, M.L., 2006. Impact of the reinforcement of a methicillin-resistant Staphylococcus aureus control programme: a 3-year evaluation by several indicators in a French university hospital. Eur J Epidemiol 21 (7), 551–558.
63. Faires, M. and Weese, S. 2008a. Prevalence of methicillin-resistant Staphylococcus aureus colonization in people and pets in the same household. Antimicrobial resistance in zoonotic bacteria and foodborne pathogens, Cpenhagen, Denmark, American Society for Microbiology
64. Faires, M. and Weese, S. 2008b. Risk factors associated with methicillin-resistant Staphylococcus aureus infection in dogs and cats. American Society for Microbiology meeting on: Antimicrobial resistance in zoonotic bacteria and foodborne pathogens, Copenhagen, Denmark.
65. Fanoy, E., Helmhout, L.C., van der Vaart, W.L., Weijdema, K., van Santen-Verheuvel, M.G., Thijsen, S.F., de Neeling, A.J., van Wamel, W.J., Manaskova, S.H. and Kingma-Thijssen, J.L., 2009. An outbreak of non-typeable MRSA within a residential care facility. Euro Surveill 14 (1).
66. Farley, J.E., Ross, T., Stamper, P., Baucom, S., Larson, E. and Carroll, K.C., 2008. Prevalence, risk factors, and molecular epidemiology of methicillin-resistant Staphylococcus aureus among newly arrested men in Baltimore, Maryland. Am J Infect Control 36 (9), 644–650.
67. Farrington, M., Brenwald, N., Haines, D. and Walpole, E., 1992. Resistance to desiccation and skin fatty acids in outbreak strains of methicillin-resistant Staphylococcus aureus. J Med Microbiol 36 (1), 56–60.
68. Farzana, K., Shah, S. and Jabeen, F., 2004. Antibiotic resistance pattern against various isolates of Staphylococcus aureus from row milk samples. Journal of Research (Science) 15, 145–151.
69. Feil, E.J., Li, B.C., Aanensen, D.M., Hanage, W.P. and Spratt, B.G., 2004. eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J Bacteriol 186 (5), 1518–1530.
70. Flannagan, S.E., Chow, J.W., Donabedian, S.M., Brown, W.J., Perri, M.B., Zervos, M.J., Ozawa, Y. and Clewell, D.B., 2003. Plasmid content of a vancomycin-resistant Enterococcus faecalis isolate from a patient also colonized by Staphylococcus aureus with a VanA phenotype. Antimicrob Agents Chemother 47 (12), 3954–3959.
71. Friedrich, A.W., Witte, W., de Lencastre, H., Hryniewicz, W., Scheres, J. and Westh, H., 2008. A European laboratory network for sequence-based typing of methicillin-resistant Staphylococcus aureus (MRSA) as a communication platform between human and veterinary medicine-an update on SeqNet.org. Euro Surveill 13 (19).
72. Gebhardt, D.O., 2003. MRSA in The Netherlands: preventive measure raises a moral issue. J Med Ethics 29 (4), 212.
73. Gehanno, J., Louvel, A., Nouvellon, M., Caillard, J.F. and Pestel-Caron, M., 2009. Aerial dispersal of meticillin-resistant Staphylococcus aureus in hospital rooms by infected or colonised patients. J Hosp Infect 71 (3), 256–262.
74. Gibbs, S.G., Green, C.F., Tarwater, P.M., Mota, L.C., Mena, K.D. and Scarpino, P.V., 2006. Isolation of antibiotic-resistant bacteria from the air plume downwind of a swine confined or concentrated animal feeding operation. Environmental Health Perspective 114, 1032–1037.
75. Goh, S.H., Santucci, Z., Kloos, W.E., Faltyn, M., George, C.G., Driedger, D. and Hemmingsen, S.M., 1997. Identification of Staphylococcus aureus and subspecies by the chaperonin 60 gene identification method and reverse checkerboard hybridization. J Clin Microbiol 35, 3116–3121.
76. Goni, P., Vergara, Y., Ruiz, J., Albizu, I., Vila, J. and Gomez-Lus, R., 2004. Antibiotic resistance and epidemiological typing of Staphylococcus aureus strains from ovine and rabbit mastitis. Int J Antimicrob Agents 23 (3), 268–272.
77. Gonzalez, B.E., Rueda, A.M., Shelburne, S.A., 3rd, Musher, D.M., Hamill, R.J. and Hulten, K.G., 2006. Community-associated strains of methicillin-resistant Staphylococccus aureus as the cause of healthcare-associated infection. Infect Control Hosp Epidemiol 27 (10), 1051–1056.
78. Gopal Rao, G., Michalczyk, P., Nayeem, N., Walker, G. and Wigmore, L., 2007. Prevalence and risk factors for meticillin-resistant Staphylococcus aureus in adult emergency admissions: a case for screening all patients? J Hosp Infect 66 (1), 15–21.
79. Gould, I.M., 2006. Costs of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) and its control. Int J Antimicrob Agents 28 (5), 379–384.
80. Gould, I.M., 2007. MRSA bacteraemia. Int J Antimicrob Agents 30 Suppl 1, S66–70.
81. Graveland, H., Wagenaar, J.A., Broekhuizen-Stins, M.J., Oosting-Schothorst, I., Schoormans, A., Van Duijkeren, E., Huijsdens, X.W., Mevius, D. and Heederick, D. 2008. Methicillin-resistant Staphylococcus aureus (MRSA) in veal calf farmers and veal calves in The Netherlands. American Society for Microbiology on: Antimicrobial Resistance in zoonotic bacteria and foodborne pathogens, Copenhagen, Denmark.
82. Grundmann, H., Aires-de-Sousa, M., Boyce, J. and Tiemersma, E., 2006. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet 368 (9538), 874–885.
83. Guardabassi, L., Stegger, M. and Skov, R., 2007. Retrospective detection of methicillin resistant and susceptible Staphylococcus aureus ST398 in Danish slaughter pigs. Vet Microbiol 122 (3–4), 384–386.
84. Hamann, J. 2005. Diagnosis of mastitis and indicators of milk quality. In: Mastitis in dairy production, current knowledge and future solutions. Ed. H. Hogevenn. The Netherlands. Wageningen Academic Publishers. 82–90.
85. Hanselman, B.A., Kruth, S.A., Rousseau, J., Low, D.E., Willey, B.M., McGeer, A. and Weese, J.S., 2006. Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel. Emerg Infect Dis 12 (12), 1933–1938.
86. Harbarth, S., Dharan, S., Liassine, N., Herrault, P., Auckenthaler, R., and Pittet, D., 1999. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 43, 1312–1316.
87. Harmsen, D., Claus, H., Witte, W., Rothganger, J., Turnwald, D. and Vogel, U., 2003. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 41 (12), 5442–5448.
88. Hartmann, F.A., Trostle, S.S. and Klohnen, A.A., 1997. Isolation of methicillin-resistant Staphylococcus aureus from a postoperative wound infection in a horse. J Am Vet Med Assoc 211 (5), 590–592.
89. Hartstein, A.I., Sebastian, T.J. and Strausbaugh, L.J. 2004. Methicillin-resistant Staphylococcus aureus. In: Hospital Epidemiology and Infection Control. Ed. C.G. Mayhall. Philadelphia, USA, Lippincott Willkiams & Wilkins. 471–494
90. Hartung, J., 2005. Zur Abschirmung von Beständen aus tierhygienischer Sicht. Dtsch. tierärztl. Wschr. 112, 313–316.
91. Hata, E., Katsuda, K., Kobayashi, H., Nishimori, K., Uchida, I., Higashide, M., Shikawa, E., Sasaki, T. and Eguchi, M., 2008. Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci 91 (2), 564–569.
92. Holden, M.T., Feil, E.J., Lindsay, J.A., Peacock, S.J., Day, N.P., Enright, M.C., Foster, T.J., Moore, C.E., Hurst, L., Atkin, R., Barron, A., Bason, N., Bentley, S.D., Chillingworth, C., Chillingworth, T., Churcher, C., Clark, L., Corton, C., Cronin, A., Doggett, J., Dowd, L., Feltwell, T., Hance, Z., Harris, B., Hauser, H., Holroyd, S., Jagels, K., James, K.D., Lennard, N., Line, A., Mayes, R., Moule, S., Mungall, K., Ormond, D., Quail, M.A., Rabbinowitsch, E., Rutherford, K., Sanders, M., Sharp, S., Simmonds, M., Stevens, K., Whitehead, S., Barrell, B.G., Spratt, B.G. and Parkhill, J., 2004. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A 101 (26), 9786–9791.
93. HPA, 2008. Surveillance of health care associated infections. Health Protection Agency, London.
94. Huijsdens, X.W., van Dijke, B.J., Spalburg, E., Santen-Verheuvel, M.G., Heck, M.E., Pluister, G.N., Voss, A., Wannet, W.J. and de Neeling, A.J., 2006. Community-acquired MRSA and pig-farming. Ann Clin Microbiol Antimicrob 5, 26.
95. ICMSF. 1996. Staphylococcus aureus. In: Microorganisms in Foods 5. Characteristics of Microbial pathogens. Ed. T.A. Roberts, A.C. Baird-Parker and R.B. Tompkin. London, UK, Blackie Academic and Professional. 299–333.
96. Ito, T., Katayama, Y., Asada, K., Mori, N., Tsutsumimoto, K., Tiensasitorn, C. and Hiramatsu, K., 2001. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 45 (5), 1323–1336.
97. Ito, T., Katayama, Y. and Hiramatsu, K., 1999. Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrob Agents Chemother 43 (6), 1449–1458.
98. Johnson, A.P., Aucken, H.M., Cavendish, S., Ganner, M., Wale, M.C., Warner, M., Livermore, D.M. and Cookson, B.D., 2001. Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). J Antimicrob Chemother 48 (1), 143–144.
99. Jones, T.F., Kellum, M.E., Porter, S.S., Bell, M. and Schaffner, W., 2002. An outbreak of community-acquired foodborne illness caused by methicillin-resistant Staphylococcus aureus. Emerg Infect Dis 8 (1), 82–84.
100. Juhasz-Kaszanyitzky, E., Janosi, S., Somogyi, P., Dan, A., van der Graaf-van Bloois, L., van Duijkeren, E. and Wagenaar, J.A., 2007. MRSA transmission between cows and humans. Emerg Infect Dis 13 (4), 630–632.
101. Kahlmeter, G., 2008. Breakpoints for intravenously used cephalosporins in Enterobacteriaceae: EUCAST and CLSI breakpoints. Clin Microbiol Infect 14 Suppl 1, 169–174.
102. Kapur, V., Sischo, W.M., Greer, R.S., Whittam, T.S. and Musser, J.M., 1995. Molecular population genetic analysis of Staphylococcus aureus recovered from cows. J Clin Microbiol 33 (2), 376–380.
103. Kaszanyitzky, E.J., Egyed, Z., Janosi, S., Keseru, J., Gal, Z., Szabo, I., Veres, Z. and Somogyi, P., 2004. Staphylococci isolated from animals and food with phenotypically reduced susceptibility to beta-lactamase-resistant beta-lactam antibiotics. Acta Vet Hung 52 (1), 7–17.
104. Kaszanyitzky, E.J., Janosi, S., Egyed, Z., Agost, G. and Semjen, G., 2003. Antibiotic resistance of staphylococci from humans, food and different animal species according to data of the Hungarian resistance monitoring system in 2001. Acta Vet Hung 51 (4), 451–464.
105. Katayama, Y., Takeuchi, F., Ito, T., Ma, X.X., Ui-Mizutani, Y., Kobayashi, I. and Hiramatsu, K., 2003. Identification in methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec of methicillin-resistant Staphylococcus aureus. J Bacteriol 185 (9), 2711–2722.
106. Kawada, M., Okuzumi, K., Hitomi, S. and Sugishita, C., 2003. Transmission of Staphylococcus aureus between healthy, lactating mothers and their infants by breastfeeding. J Hum Lact 19 (4), 411–417.
107. Kehrenberg, C., Cuny, C., Strommenger, B., Schwarz, S. and Witte, W., 2009. Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. Antimicrob Agents Chemother 53 (2), 779–781.
108. Kelly, H., Bull, A., Russo, P. and McBryde, E.S., 2008. Estimating sensitivity and specificity from positive predictive value, negative predictive value and prevalence: application to surveillance systems for hospital-acquired infections. J Hosp Infect 69 (2), 164–168.
109. Kerouanton, A., Hennekinne, J.A., Letertre, C., Petit, L., Chesneau, O., Brisabois, A. and De Buyser, M.L., 2007. Characterization of Staphylococcus aureus strains associated with food poisoning outbreaks in France. Int J Food Microbiol 115 (3), 369–375.
110. Khanna, T., Friendship, R., Dewey, C. and Weese, J.S., 2008. Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers. Vet.Microbiol. 128 (3–4), 298–303.
111. Kitai, S., Shimizu, A., Kawano, J., Sato, E., Nakano, C., Uji, T. and Kitagawa, H., 2005. Characterization of methicillin-resistant Staphylococcus aureus isolated from retail raw chicken meat in Japan. J Vet Med Sci 67 (1), 107–110.
112. Klevens, R.M., Morrison, M.A., Fridkin, S.K., Reingold, A., Petit, S., Gershman, K., Ray, S., Harrison, L.H., Lynfield, R., Dumyati, G., Townes, J.M., Craig, A.S., Fosheim, G., McDougal, L.K. and Tenover, F.C., 2006. Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors. Emerg Infect Dis 12 (12), 1991–1993.
113. Klotz, M., Zimmermann, S., Opper, S., Heeg, K. and Mutters, R., 2005. Possible risk for re-colonization with methicillin-resistant Staphylococcus aureus (MRSA) by faecal transmission. Int J Hyg Environ Health 208 (5), 401–405.
114. Kluytmans, J., van Belkum, A. and Verbrugh, H., 1997. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10 (3), 505–520.
115. Kluytmans, J., van Leeuwen, W., Goessens, W., Hollis, R., Messer, S., Herwaldt, L., Bruining, H., Heck, M., Rost, J., van Leeuwen, N. and et al., 1995. Food-initiated outbreak of methicillin-resistant Staphylococcus aureus analyzed by pheno- and genotyping. J Clin Microbiol 33 (5), 1121–1128.
116. Kondo, Y., Ito, T., Ma, X.X., Watanabe, S., Kreiswirth, B.N., Etienne, J. and Hiramatsu, K., 2007. Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother 51 (1), 264–274.
117. Kwon, N.H., Park, K.T., Jung, W.K., Youn, H.Y., Lee, Y., Kim, S.H., Bae, W., Lim, J.Y., Kim, J.Y., Kim, J.M., Hong, S.K. and Park, Y.H., 2006. Characteristics of methicillin resistant Staphylococcus aureus isolated from chicken meat and hospitalized dogs in Korea and their epidemiological relatedness. Vet Microbiol 117 (2–4), 304–312.
118. Kwon, N.H., Park, K.T., Moon, J.S., Jung, W.K., Kim, S.H., Kim, J.M., Hong, S.K., Koo, H.C., Joo, Y.S. and Park, Y.H., 2005. Staphylococcal cassette chromosome mec (SCCmec) characterization and molecular analysis for methicillin-resistant Staphylococcus aureus and novel SCCmec subtype IVg isolated from bovine milk in Korea. J Antimicrob Chemother 56 (4), 624–632.
119. Larsen, A.R., Stegger, M., Bocher, S., Sorum, M., Monnet, D.L. and Skov, R.L., 2009. Emergence and characterization of community-associated methicillin-resistant Staphyloccocus aureus infections in Denmark, 1999 to 2006. J Clin Microbiol 47 (1), 73–78.
120. Le Loir, Y., Baron, F. and Gautier, M., 2003. Staphylococcus aureus and food poisoning. Genet Mol Res 2 (1), 63–76.
121. Lee, J.H., 2003. Methicillin (Oxacillin)-resistant Staphylococcus aureus strains isolated from major food animals and their potential transmission to humans. Appl Environ Microbiol 69 (11), 6489–6494.
122. Lee, J.H., 2006. Occurrence of methicillin-resistant Staphylococcus aureus strains from cattle and chicken, and analyses of their mecA, mecR1 and mecI genes. Vet Microbiol 114 (1–2), 155–159.
123. Leenders, A.C., Janssen, M., Renders, H.H.M. and Pelk, M., 2007. Pig's MRSA on a poultry farm? Infectieziekten Bulletin 18 (2), 43–44.
124. Lewis, H.C., Molbak, K., Reese, C., Aarestrup, F.M., Selchau, M., Sorum, M. and Skov, R.L., 2008. Pigs as source of methicillin-resistant Staphylococcus aureus CC398 infections in humans, Denmark. Emerg Infect Dis 14 (9), 1383–1389.
125. Lilenbaum, W., Nunes, E.L. and Azeredo, M.A., 1998. Prevalence and antimicrobial susceptibility of staphylococci isolated from the skin surface of clinically normal cats. Lett Appl Microbiol 27 (4), 224–228.
126. Lindenmayer, J.M., Schoenfeld, S., O'Grady, R. and Carney, J.K., 1998. Methicillin-resistant Staphylococcus aureus in a high school wrestling team and the surrounding community. Arch Intern Med 158 (8), 895–899.
127. Lindsay, J.A. and Holden, M.T., 2004. Staphylococcus aureus: superbug, super genome? Trends Microbiol 12 (8), 378–385.
128. Lindsay, J.A., Moore, C.E., Day, N.P., Peacock, S.J., Witney, A.A., Stabler, R.A., Husain, S.E., Butcher, P.D. and Hinds, J., 2006. Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes. J Bacteriol 188 (2), 669–676.
129. Lloyd, D.H., Boag, A.K. and Loeffler, A., 2007. Dealing with MRSA in companion animals practice. European Journal of Companion Animal Practice 17, 85–93.
130. Loeffler, A., Baines, S.J., Toleman, M.S., Felmingham, D., Milsom, S.K., Edwards, E.A. and Lloyd, D.H., 2008. In vitro activity of fusidic acid and mupirocin against coagulase-positive staphylococci from pets. J Antimicrob Chemother 62 (6), 1301–1304.
131. Loeffler, A., Boag, A.K., Sung, J., Lindsay, J.A., Guardabassi, L., Dalsgaard, A., Smith, H., Stevens, K.B. and Lloyd, D.H., 2005. Prevalence of methicillin-resistant Staphylococcus aureus among staff and pets in a small animal referral hospital in the UK. J Antimicrob Chemother 56 (4), 692–697.
132. Loeffler, A., Soares, M.R., Lindsay, J.A., Rich, M., Roberts, L., Smith, H., Lloyd, D.H. and Pfeiffer, D.U. 2008. When do dogs and cats acquire Staphylococcus aureus infection? Two case-control studies. International Symposium on Staphylococci and Staphylococcal Infections, Cairns, Australia.
133. Lopez, M., Lozano, C., Perez, V., Martinez, S., del Campo, C., Ruiz-Larrea, F., Zarazaga, M. and Torres, C., 2008. Deteccion de Enterococcus faecium vanB2 y Staphylococcus aureus resistente a meticilina en alimentos de origen animal. Congreso Nacional de la Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain.
134. Lu, J., Sanchez, S., Hofacre, C., Maurer, J.J., Harmon, B.G. and Lee, M.D., 2003. Evaluation of broiler litter with reference to the microbial composition as assessed by using 16S rRNA and functional gene markers. Appl Environ Microbiol 69 (2), 901–908.
135. Malik, S., Peng, H. and Barton, M.D., 2006. Partial nucleotide sequencing of the mecA genes of Staphylococcus aureus isolates from cats and dogs. J Clin Microbiol 44 (2), 413–416.
136. Manian, F.A., 2003. Asymptomatic nasal carriage of mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts. Clin Infect Dis 36 (2), e26–28.
137. Martineau, F., Picard, F.J., Ke, D., Paradis, S., Roy, P.H., Ouellette, M. and Bergeron, M.G., 2001. Development of a PCR assay for identification of staphylococci at genus and species levels. J Clin Microbiol 39 (7), 2541–2547.
138. Martineau, F., Picard, F.J., Roy, P.H., Quellette, M. and Bergeron, M.G., 1998. Species-specific and ubiquitous-DNA-based assays for rapid identification of Staphylococcus aureus. J Clin Microbiol 39, 618–623.
139. Meemken, D., Cuny, C., Witte, W., Eichler, U., Staudt, R. and Blaha, T., 2008. Occurrence of MRSA in pigs and in humans involved in pig production-preliminary results of a study in the northwest of Germany. Dtsch.Tierarztl.Wochenschr. 115 (4), 132–139.
140. Mellmann, A., Weniger, T., Berssenbrugge, C., Rothganger, J., Sammeth, M., Stoye, J. and Harmsen, D., 2007. Based Upon Repeat Pattern (BURP): an algorithm to characterize the long-term evolution of Staphylococcus aureus populations based on spa polymorphisms. BMC Microbiol 7, 98.
141. Merrer, J., Santoli, F., Appere de Vecchi, C., Tran, B., De Jonghe, B. and Outin, H., 2000. “Colonization pressure” and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 21 (11), 718–723.
142. Mertz, D., Frei, R., Jaussi, B. and al., e., 2007. Throat swabs are necessary to reliably detect carriers of Staphylococcus aureus. Clin Infect Dis 45, 475–477.
143. Miller, R., Esmail, H., Peto, T., Walker, S., Crook, D. and Wyllie, D., 2008. Is MRSA admission bacteraemia community-acquired? A case control study. J Infect 56 (3), 163–170.
144. Monecke, S., Jatzwauk, L., Weber, S., Slickers, P. and Ehricht, R., 2008. DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern Saxony. Clin.Microbiol.Infect. 14 (6), 534–545.
145. Moodley, A., Nightingale, E.C., Stegger, M., Nielsen, S.S., Skov, R.L. and Guardabassi, L., 2008. High risk for nasal carriage of methicillin-resistant Staphylococcus aureus among Danish veterinary practitioners. Scand J Work Environ Health 34 (2), 151–157.
146. Moon, J.S., Lee, A.R., Kang, H.M., Lee, E.S., Joo, Y.S., Park, Y.H., Kim, M.N. and Koo, H.C., 2007. Antibiogram and coagulase diversity in staphylococcal enterotoxin-producing Staphylococcus aureus from bovine mastitis. J Dairy Sci 90 (4), 1716–1724.
147. Moreillon, P., 2008. New and emerging treatment of Staphylococcus aureus infections in the hospital setting. Clin Microbiol Infect 14 (Suppl 3), 32–41.
148. Müller, W. and Gröning, K., 1981. The tenacity of airborne bacteria, 2nd communication: Experimental investigations carried out for determining the kill constant ßbiol for cocci. Zbl. Bakt. Hyg. 173, 180–187.
149. Muller, W. and Wieser, P. 1987. Dust and microbial emissions from animal production. Animal production and environmental health. Ed. D. Strauch. Amsterdam, Elsevier Sci. Pub. 47–89
150. Mulqueen, J., Cafferty, F., Cormican, M., Keane, J.D. and Rossney, A., 2007. Nasal carriage of meticillin-resistant Staphylococcus aureus in GPs in the West of Ireland. Br J Gen Pract 57 (543), 811–813.
151. Murakami, K., Minamide, W., Wada, K., Nakamura, E., Teraoka, H., Watanabe, S., 1991. Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction. J Clin Microbiol 29, 2240–2244.
152. Nakatoni, Y. and Sugiyama, J., 1998. A rapid latex agglutination test for the detection of penicillin binding protein PBP2′. Microbiol Immunol 42, 759–743.
153. Nemati, M., Hermans, K., Lipinska, U., Denis, O., Deplano, A., Struelens, M., Devriese, L.A., Pasmans, F. and Haesebrouck, F., 2008. Antimicrobial resistance of old and recent Staphylococcus aureus isolates from poultry: first detection of livestock-associated methicillin-resistant strain ST398. Antimicrob Agents Chemother 52(10):3817–3819.
154. Nitzsche, S., Zweifel, C. and Stephan, R., 2007. Phenotypic and genotypic traits of Staphylococcus aureus strains isolated from pig carcasses. Vet Microbiol 120 (3–4), 292–299.
155. Normanno, G., Corrente, M., La Salandra, G., Dambrosio, A., Quaglia, N.C., Parisi, A., Greco, G., Bellacicco, A.L., Virgilio, S. and Celano, G.V., 2007. Methicillin-resistant Staphylococcus aureus (MRSA) in foods of animal origin product in Italy. Int J Food Microbiol 117 (2), 219–222.
156. Notermans, S., Tips, P., Rost, J.A. and van Leeuwen, W.J., 1982. Staphylococcus aureus in poultry slaughter lines. Tijdschr Diergeneeskd 107 (23), 889–895.
157. Nouwen, J., Boelens, H., van Belkum, A. and Verbrugh, H., 2004. Human factor in Staphylococcus aureus nasal carriage. Infect Immun 72 (11), 6685–6688.
158. Nubel, U., Roumagnac, P., Feldkamp, M., Song, J.H., Ko, K.S., Huang, Y.C., Coombs, G., Ip, M., Westh, H., Skov, R., Struelens, M.J., Goering, R.V., Strommenger, B., Weller, A., Witte, W. and Achtman, M., 2008. Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci USA 105 (37), 14130–14135.
159. O'Mahony, R., Abbott, Y., Leonard, F.C., Markey, B.K., Quinn, P.J., Pollock, P.J., Fanning, S. and Rossney, A.S., 2005. Methicillin-resistant Staphylococcus aureus (MRSA) isolated from animals and veterinary personnel in Ireland. Vet Microbiol 109 (3–4), 285–296.
160. Oliveira, D.C. and de Lencastre, H., 2002. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 46 (7), 2155–2161.
161. Ornskov, D., Kolmos, B., Bendix Horn, P., Nederby Nielsen, J., Brandslund, I. and Schouenborg, P., 2008. Screening for methicillin-resistant Staphylococcus aureus in clinical swabs using a high-throughput real-time PCR-based method. Clin Microbiol Infect 14 (1), 22–28.
162. Paule, S.M., Hacek, D.M., Kufner, B., Truchon, K., Thomson, R.B., Jr., Kaul, K.L., Robicsek, A. and Peterson, L.R., 2007. Performance of the BD GeneOhm methicillin-resistant Staphylococcus aureus test before and during high-volume clinical use. J Clin Microbiol 45 (9), 2993–2998.
163. Peacock, S.J., de Silva, I. and Lowy, F.D., 2001. What determines nasal carriage of Staphylococcus aureus? Trends Microbiol 9 (12), 605–610.
164. Persoons, D., Van Hoorebeke, S., Hermans, K., Butaye, P., De Kruif, A. and Haesebrouck, F., 2009. Methicillin-resistant Staphylococcus aureus in poultry. Emerg Infect Dis. In Press.
165. Pinho, M.G., Filipe, S.R., de Lencastre, H. and Tomasz, A., 2001. Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus. J Bacteriol 183 (22), 6525–6531.
166. Poyart, C., Quesne, G., Boumaila, C. and Trieu-Cout, P., 2001. Rapid and acurate species-level identification of coagulase-negative staphylococci by using the sodA gene as a target. J Clin Microbiol 39, 4296–4301.
167. Pu, S., Han, F. and Ge, B., 2009. Isolation and Characterization of Methicillin-Resistant Staphylococcus aureus from Louisiana Retail Meats. Appl Environ Microbiol 75(1):265–267.
168. Quddoumi, S., Bdour, S. and Mahasneh, A., 2006. Isolation and characterisation of methicillin-resistant Staphylococcus aureus from livestock and poultry meats. Annals of Microbiology 56, 155–161.
169. Quinn, G.A. and Cole, A.M., 2007. Suppression of innate immunity by a nasal carriage strain of Staphylococcus aureus increases its colonization on nasal epithelium. Immunology 122 (1), 80–89.
170. Rabello, R.F., Moreira, B.M., Lopes, R.M., Teixeira, L.M., Riley, L.W. and Castro, A.C., 2007. Multilocus sequence typing of Staphylococcus aureus isolates recovered from cows with mastitis in Brazilian dairy herds. J Med Microbiol 56, 1505–1511.
171. Ribbens, S., Dewulf, J., Koenen, F., Mintiens, K., De Sadeleer, L., de Kruif, A. and Maes, D., 2008. A survey on biosecurity and management practices in Belgian pig herds. Prev Vet Med 83 (3–4), 228–241.
172. Rich, M. and Roberts, L., 2006. MRSA in companion animals. Vet Rec 159 (16), 535–536.
173. Roberson, J.R. (1999). The epidemiology of Staphylococcus aureus on dairy farms. National Mastitis Council 38th Annual Meeting. USA.
174. Robicsek, A., Suseno, M., Beaumont, J.L., Thomson, R.B., Jr. and Peterson, L.R., 2008. Prediction of methicillin-resistant Staphylococcus aureus involvement in disease sites by concomitant nasal sampling. J Clin Microbiol 46 (2), 588–592.
175. Rountree, P.M., 1963. The Effect of Desiccation on the Viability of Staphylococcus aureus. J Hyg (Lond) 61, 265–272.
176. Rubinovich, B. and Pittet, D., 2001. Screening for methicillin-resistant Staphylococcus aureus in the endemic hospital: what have we learned? J Hosp Infect 47, 9–18.
177. Russell, A.D., 2002. Antibiotic and biocide resistance in bacteria: comments and conclusions. J Appl Microbiol 92 Suppl, 171S–173S.
178. Safdar, N. and Bradley, E.A., 2008. The risk of infection after nasal colonization with Staphylococcus aureus. Am J Med 121 (4), 310–315.
179. Sahm, D.F., Marsilio, M.K. and Piazza, G., 1999. Antimicrobial resistance in key bloodstream bacterial isolates: electronic surveillance with the Surveillance Network Database USA. Clin Infect Dis 29 (2), 259–263.
180. Saiman, L., O'Keefe, M., Graham, P.L., 3rd, Wu, F., Said-Salim, B., Kreiswirth, B., LaSala, A., Schlievert, P.M. and Della-Latta, P., 2003. Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women. Clin Infect Dis 37 (10), 1313–1319.
181. Salgado, C.P., Farr, B. and Calfee, D., 2003. Community acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin. Infect. Dis. 36, 131–139.
182. Sasaki, T., Kikuchi, K., Tanaka, Y., Takahashi, N., Kamata, S. and Hiramatsu, K., 2007. Reclassification of phenotypically identified Staphylococcus intermedius strains. J Clin Microbiol 45 (9), 2770–2778.
183. Scalcini, M.C. and Sanders, C.V., 1980. Endocarditis from human-to-human transmission of Staphylococcus aureus. Arch Intern Med 140 (1), 111–112.
184. Schappler-Scheele, B., Schurmann, W., Hartung, J., Missel, T., Benning, C., Schroder, H. and Weber, J., 1999. Untersuchung der gesundheitlichen Gefährdung von Arbeitnehmern der Abfallwirtschaft in Kompostierungsanlagen. Ed. Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, Dortmund. Bremerhaven, Wirtschaftsverlag NW Verlag für neue Wissenschaft GmbH.
185. Schlegelova, J., 2004. Beef carcass contamination in a slaughterhouse and prevalence of resistance to antimicrobial drugs in isolates of selected microbial species. Meat Science 66, 557–565.
186. Schmitz, F.J., MacKenzie, C.R., Hofmann, B., Verhoef, J., Finken-Eigen, M., Heinz, H.P. and Köhrer, K., 1997. Specific information concerning toxonomy, pathogenicity and methicillin resistance of staphylococci obtained by a multiplex PCR. J Med Microbiol 46, 773–778.
187. Schraft, H., Kleinlein, N. and Untermann, F., 1992. Contamination of pig hindquarters with Staphylococcus aureus. Int J Food Microbiol 15 (1–2), 191–194.
188. Schulz, J. (2007). Zur Charakterisierung der Ausbreitungsentfernung von Bioaerosolen aus Masthühnerställen. Universität Bielefeld.
189. Scott, E., Duty, S. and Callahan, M., 2008. A pilot study to isolate Staphylococcus aureus and methicillin-resistant S. aureus from environmental surfaces in the home. Am J Infect Control 36 (6), 458–460.
190. Scott, G.M., Thomson, R., Malone-Lee, J. and Ridgway, G.L., 1988. Cross-infection between animals and man: possible feline transmission of Staphylococcus aureus infection in humans? J Hosp Infect 12 (1), 29–34.
191. Seedorf, J. and Hartung, J., 1999. Untersuchungen zum Rückhaltevermögen eines Biofilters und eines Biowäschers für Bioaerosole an zwei Schweineställen. Berl. Münch. Tierärztl. Wschr. 112, 444–447.
192. Seedorf, J. and Hartung, J., 2002. Stäube und Mikroorganismen in der Tierhaltung. KTBL-Schrift 393, Landwirtschaftsverlag GmbH, Münster.
193. Seedorf, J., Hartung, J., Schroder, M., Linkert, K.H., Phillips, V.R., Holden, M.R., Sneath, R.W., Short, J.L., White, R.P., Pedersen, S., Takai, T., Johnsen, J.O., Metz, J.H.M., Koerkamp, P.W.G., Uenk, G.H. and Wathes, C.M., 1998. Concentrations and emissions of airborne endotoxins and microorganisms in livestock buildings in Northern Europe. Journal of Agricultural Engineering Research 70, 97–109.
194. Seedorf, J., Schulz, J. and Hartung, J., 2005. Outdoor measurements of airborne emission of staphylococci from a broiler barn and its predictability by dispersion models. WIT Transactions on Ecology and the Environment 85, 33–42.
195. Seguin, J.C., Walker, R.D., Caron, J.P., Kloos, W.E., George, C.G., Hollis, R.J., Jones, R.N. and Pfaller, M.A., 1999. Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: potential human-to-animal transmission. J Clin Microbiol 37 (5), 1459–1463.
196. Sergio, D.M., Koh, T.H., Hsu, L.Y., Ogden, B.E., Goh, A.L. and Chow, P.K., 2007. Investigation of meticillin-resistant Staphylococcus aureus in pigs used for research. J Med Microbiol 56 (8), 1107–1109.
197. Shimamura, Y., Kidokoro, S. and Murata, M., 2006. Survey and properties of Staphylococcus aureus from Japanese-style desserts. Bioscience Biotechnology and Biochemistry 70, 1571–1577.
198. Shiomori, T., Miyamoto, H. and Makishima, K., 2001. Significance of airborne transmission of methicillin-resistant Staphylococcus aureus in an otolaryngology-head and neck surgery unit. Arch Otolaryngol Head Neck Surg 127 (6), 644–648.
199. Sievert, D.M., Rudrik, J.T., Patel, J.B., McDonald, L.C., Wilkins, M.J. and Hageman, J.C., 2008. Vancomycin-resistant Staphylococcus aureus in the United States, 2002–2006. Clin Infect Dis 46 (5), 668–674.
200. Sing, A., Tuschak, C. and Hormansdorfer, S., 2008. Methicillin-resistant Staphylococcus aureus in a family and its pet cat. N Engl J Med 358 (11), 1200–1201.
201. Smith, M.M., Vasseur, P.B. and Saunders, H.M., 1989. Bacterial growth associated with metallic implants in dogs. J Am Vet Med Assoc 195 (6), 765–767.
202. Smith, T.C., Male, M.J., Harper, A.L., Moritz-Koroloev, E., Kroeger, J.S., Diekema, D.J. and Herwaldt, L. 2008. Isolation of methicillin-resistant Staphylococcus aureus (MRSA) from swine in the Midwestern United States. International Conference on Emerging Infectious Diseases, Atlanta, USA.
203. Soares, M.J., Tokumaru-Miyazaki, N.H., Noleto, A.L. and Figueiredo, A.M., 1997. Enterotoxin production by Staphylococcus aureus clones and detection of Brazilian epidemic MRSA clone (III::B:A) among isolates from food handlers. J Med Microbiol 46 (3), 214–221.
204. Stratidis, J., Bia, F.J. and Edberg, S.C., 2007. Use of real-time polymerase chain reaction for identification of methicillin-resistant Staphylococcus aureus directly from positive blood culture bottles. Diagn Microbiol Infect Dis 58, 199–202.
205. Strommenger, B., Kehrenberg, C., Kettlitz, C., Cuny, C., Verspohl, J., Witte, W. and Schwarz, S., 2006. Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and their relationship to human isolates. J Antimicrob Chemother 57 (3), 461–465.
206. Strommenger, B., Kettlitz, C., Werner, G. and Witte, W., 2003. Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus. J Clin Microbiol 41 (9), 4089–4094.
207. Strommenger, B., Schmidt, C., Werner, G., Roessle-Lorch, B., Bachmann, T.T. and Witte, W., 2007. DNA microarray for the detection of therapeutically relevant antibiotic resistance determinants in clinical isolates of Staphylococcus aureus. Molecular and cellular probes 21 (3), 161–170.
208. Sung, J.M. and Lindsay, J.A., 2007. Staphylococcus aureus strains that are hypersusceptible to resistance gene transfer from enterococci. Antimicrob Agents Chemother 51 (6), 2189–2191.
209. Sung, J.M., Lloyd, D.H. and Lindsay, J.A., 2008. Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray. Microbiology 154 (Pt 7), 1949–1959.
210. Tacconelli, E., De Angelis, G., Cataldo, M.A., Pozzi, E. and Cauda, R., 2008. Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis. J.Antimicrob.Chemother. 61 (1), 26–38.
211. Thomas, S., Karas, J.A., Emery, M. and Clark, G., 2007. Meticillin-resistant Staphylococcus aureus carriage among district nurse patients and medical admissions in a UK district. J Hosp Infect 66 (4), 369–373.
212. Tiemersma, E.W., Bronzwaer, S.L., Lyytikainen, O., Degener, J.E., Schrijnemakers, P., Bruinsma, N., Monen, J., Witte, W. and Grundman, H., 2004. Methicillin-resistant Staphylococcus aureus in Europe, 1999–2002. Emerg Infect Dis 10 (9), 1627–1634.
213. Tomlin, J., Pead, M.J., Lloyd, D.H., Howell, S., Hartmann, F., Jackson, H.A. and Muir, P., 1999. Methicillin-resistant Staphylococcus aureus infections in 11 dogs. Vet Rec 144 (3), 60–64.
214. Tristan, A., Bes, M., Meugnier, H., Lina, G., Bozdogan, B., Courvalin, P., Reverdy, M.E., Enright, M.C., Vandenesch, F. and Etienne, J., 2007. Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006. Emerg Infect Dis 13 (4), 594–600.
215. Tristan, A., Ferry, T., Durand, G., Dauwalder, O., Bes, M., Lina, G., Vandenesch, F. and Etienne, J., 2007. Virulence determinants in community and hospital meticillin-resistant Staphylococcus aureus. J Hosp Infect 65 Suppl 2, 105–109.
216. Valderas, M.W., Gatson, J.W., Wreyford, N. and Hart, M.E., 2002. The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci. J Bacteriol 184, 2465–2472.
217. Van den Broek, I.V., van Cleef, B.A., Haenen, A., Broens, E.M., van der Wolf, P.J., van den Broek, M.J., Huijsdens, X.W., Kluytmans, J.A., van de Giessen, A.W., and Tiemersma, E.W., 2008. Methicillin-resistant Staphylococcus aureus in people living and working in pig farms. Epidemiol Infect 24: 1–9.
218. Van den Eede, A., Martens, A., Lipinska, U., Struelens, M., Deplano, A., Denis, O., Haesebrouck, F., Gasthuys, F. and Hermans, K., 2009. High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples. Vet Microbiol 133 (1–2), 138–144.
219. van Duijkeren, E., Box, A.T., Heck, M.E., Wannet, W.J. and Fluit, A.C., 2004. Methicillin-resistant staphylococci isolated from animals. Vet Microbiol 103 (1–2), 91–97.
220. van Duijkeren, E., Ikawaty, R., Broekhuizen-Stins, M.J., Jansen, M.D., Spalburg, E.C., de Neeling, A.J., Allaart, J.G., van Nes, A., Wagenaar, J.A. and Fluit, A.C., 2008. Transmission of methicillin-resistant Staphylococcus aureus strains between different kinds of pig farms. Vet.Microbiol. 126 (4), 383–389.
221. van Griethuysen, A., Bes, M., Etienne, J., Zbinden, R. and Kluytmans, J., 2001. International multicenter evaluation of latex agglutination tests for identification of Staphylococcus aureus. J Clin Microbiol 39 (1), 86–89.
222. van Loo, I., Huisdens, Tiemersma, E., de Neeling, A., van de Sande-Bruinsma, N., Bearijlan, D., Voss, A. and Kluytmans, J., 2007. Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerg Infect Dis 13, 1834–1839.
223. van Loo, I., van Dijk, S., Verbakel-Schelle, I. and Buiting, A., 2007. Evaluation of a chromogenic agar (MRSA-Select) for the detection of methicillin-resistant Staphylococcus aureus with clinical samples in the Netherlands. J Med Microbiol 56, 491–494.
224. van Loo, I.H., Diederen, B.M., Savelkoul, P.H., Woudenberg, J.H., Roosendaal, R., van Belkum, A., Lemmens-den Toom, N., Verhulst, C., van Keulen, P.H. and Kluytmans, J.A., 2007. Methicillin-resistant Staphylococcus aureus in meat products, the Netherlands. Emerg Infect Dis 13 (11), 1753–1755.
225. van Rijen, M.M., Van Keulen, P.H. and Kluytmans, J.A., 2008. Increase in a Dutch hospital of methicillin-resistant Staphylococcus aureus related to animal farming. Clin Infect Dis 46 (2), 261–263.
226. Vanderlinde, P.B., Fegan, N., Mills, L. and Desmarchelier, P.M., 1999. Use of pulse field gel electrophoresis for the epidemiological characterisation of coagulase positive Staphylococcus isolated from meat workers and beef carcasses. Int J Food Microbiol 48 (2), 81–85.
227. Vannuffel, P., Heusterspreute, M., Bouyer, M., Vandercam, B., Philippe, M. and Gala, J.L., 1999. Molecular characterization of femA from Staphylococcus hominis and Staphylococcus saprophyticus, and femA-gased discrimination of staphylococcal species. Res Microbiol 150(2): 129–141.
228. Vengust, M., Anderson, M.E., Rousseau, J. and Weese, J.S., 2006. Methicillin-resistant staphylococcal colonization in clinically normal dogs and horses in the community. Lett Appl Microbiol 43 (6), 602–606.
229. Vicca, J., Cerpentier, T. and Butaye, P. 2008. Prevalence at herd-level of MRSA in milk-samples of dairy herds. International Conference on mastitis control, from science to practice, The Hague, The Netherlands,
230. von Eiff, C., Becker, K., Machka, K., Stammer, H. and Peters, G., 2001. Nasal carriage as a source of Staphylococcus aureus bacteremia: Study Group. N Engl J Med 344, 11–16.
231. Voss, A., Loeffen, F., Bakker, J., Klaassen, C. and Wulf, M., 2005. Methicillin-resistant Staphylococcus aureus in pig farming. Emerg Infect Dis 11 (12), 1965–1966.
232. VWA, 2007. Prevalence of MRSA in meat: factsheet. www.vwa.nl/cdlpub/servlet/CDLServlet?p_file_id=25742.
233. Waldron, D.E. and Lindsay, J.A., 2006. Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages. J Bacteriol 188 (15), 5578–5585.
234. Walther, B., Wieler, L.H., Friedrich, A.W., Hanssen, A.M., Kohn, B., Brunnberg, L. and Lubke-Becker, A., 2008. Methicillin-resistant Staphylococcus aureus (MRSA) isolated from small and exotic animals at a university hospital during routine microbiological examinations. Vet Microbiol 127 (1–2), 171–178.
235. Wannet, W.J.B., Huijsdens, X.W., Heck, M.E.O.C., Pluister, N., Van Santen-Verheuvel, M.G. and Spalburg, E., 2007. MRSA in Nederlandse ziekenhuizen: surveillanceresultaten 2005–2006 en recente ontwikkelingen. Infectieziekten Bulletin 18, 347–351.
236. Warren, D.K., Liao, R.S., Merz, L.R., Eveland, M. and Dunne, W.M., Jr., 2004. Detection of methicillin-resistant Staphylococcus aureus directly from nasal swab specimens by a real-time PCR assay. J Clin Microbiol 42 (12), 5578–5581.
237. Wassenberg, M.W.M., Hopmans, T.E.M., Troelstra, A., Kluytmans, J.A.J.W. and Bonten, M.J.M., 2008. Meticillineresistente Staphyococcus aureus afkomstig uit de veestapel in Nederlandse ziekenhuizen: risicopatienten aleen controleren bij eventuele ziekenhuisopname. Ned. Tijdschr. Geneeskd. 152, 2681–2688.
238. Webb, S.J. 1965. Bound water in biological integrity. Springfield, USA, Charles C. Thomas Publishers.
239. Weese, J.S., 2007. Environmental surveillance for MRSA. Methods in Molecular Biology 391, 201–208.
240. Weese, J.S., Archambault, M., Willey, B.M., Hearn, P., Kreiswirth, B.N., Said-Salim, B., McGeer, A., Likhoshvay, Y., Prescott, J.F. and Low, D.E., 2005. Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000–2002. Emerg Infect Dis 11 (3), 430–435.
241. Weese, J.S., Caldwell, F., Willey, B.M., Kreiswirth, B.N., McGeer, A., Rousseau, J. and Low, D.E., 2006. An outbreak of methicillin-resistant Staphylococcus aureus skin infections resulting from horse to human transmission in a veterinary hospital. Vet Microbiol 114 (1–2), 160–164.
242. Weese, J.S., DaCosta, T., Button, L., Goth, K., Ethier, M. and Boehnke, K., 2004. Isolation of methicillin-resistant Staphylococcus aureus from the environment in a veterinary teaching hospital. J Vet Intern Med 18 (4), 468–470.
243. Weese, J.S. and Lefebvre, S.L., 2007. Risk factors for methicillin-resistant Staphylococcus aureus colonization in horses admitted to a veterinary teaching hospital. Can Vet J 48 (9), 921–926.
244. Weese, J.S. and Rousseau, J., 2005. Attempted eradication of methicillin-resistant Staphylococcus aureus colonisation in horses on two farms. Equine Vet J 37 (6), 510–514.
245. Weese, J.S., Rousseau, J., Traub-Dargatz, J.L., Willey, B.M., McGeer, A.J. and Low, D.E., 2005. Community-associated methicillin-resistant Staphylococcus aureus in horses and humans who work with horses. J Am Vet Med Assoc 226 (4), 580–583.
246. Weese, J.S., Rousseau, J., Willey, B.M., Archambault, M., McGeer, A. and Low, D.E., 2006. Methicillin-resistant Staphylococcus aureus in horses at a veterinary teaching hospital: frequency, characterization, and association with clinical disease. J Vet Intern Med 20 (1), 182–186.
247. Wertheim, H.F., Vos, M.C., Boelens, H.A., Voss, A., Vandenbroucke-Grauls, C.M., Meester, M.H., Kluytmans, J.A., van Keulen, P.H. and Verbrugh, H.A., 2004. Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use. J Hosp Infect 56 (4), 321–325.
248. West, S.K., Platenga, M. and Strausbaugh, L., 2007. Use of decolonization to prevent staphylococcal infections in various health care settings: results of an emerging infections network survey. Infect Control Hosp Epidemiol 28, 1111–1113.
249. Whyte, P., McGill, K., Monahan, C. and Collins, J.D., 2004. The effect of sampling time on the levels of micro-organisms in a commercial slaughter plant. Food Microbiology 21, 59–65.
250. Wiese-Posselt, M., Heuck, D., Draeger, A., Mielke, M., Witte, W., Ammon, A. and Hamouda, O., 2007. Successful termination of a furunculosis outbreak due to lukS-lukF-positive, methicillin-susceptible Staphylococcus aureus in a German village by stringent decolonization, 2002–2005. Clin Infect Dis 44 (11), e88–95.
251. Witte, W., 2000. Selective pressure by antibiotic use in livestock. Int J Antimicrob Agents 16 Suppl 1, S19–24.
252. Witte, W., Pasemann, B. and Cuny, C., 2007. Detection of low-level oxacillin resistance in mecA-positive Staphylococcus aureus. Clin Microbiol Infect 13 (4), 408–412.
253. Witte, W., Strommenger, B., Stanek, C. and Cuny, C., 2007. Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. Emerg Infect Dis 13 (2), 255–258.
254. Wulf, M., Markestein, A., Van der Linden, F., Vos, A., Klassen, C. and Verduin, C.M., 2008. First outbreak of methicillin-resistant Staphylococcus aureus ST398 in a Dutch hospital, June 2007. Euro Surveill 13 (9).
255. Wulf, M. and Voss, A., 2008. MRSA in livestock animals-an epidemic waiting to happen? Clin Microbiol Infect 14 (6), 519–521.
256. Wulf, M.W., Sorum, M., van Nes, A., Skov, R., Melchers, W.J., Klaassen, C.H. and Voss, A., 2008. Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study. Clin Microbiol Infect 14 (1), 29–34.
257. Wulf, M.W., Tiemersma, E., Kluytmans, J., Bogaers, D., Leenders, A.C., Jansen, M.W., Berkhout, J., Ruijters, E., Haverkate, D., Isken, M. and Voss, A., 2008. MRSA carriage in healthcare personnel in contact with farm animals. J Hosp Infect 70 (2), 186–190.
258. Yamaoka, T., 2007. The bactericidal effects of anti-MRSA agents with rifampicin and sulfamethoxazole-trimethoprim against intracellular phagocytized MRSA. J Infect Chemother 13, 141–146.
259. Yeh, K.S., Chen, S.P. and Lin, J.H., 2005. One-year (2003) nationwide pork carcass microbiological baseline data survey in Taiwan. J Food Prot 68 (3), 458–461.
260. Yu, F., Chen, Z., Liu, C., Zhang, X., Lin, X., Chi, S., Zhou, T., Chen, Z. and Chen, X., 2008. Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China. Clin Microbiol Infect 14, 3181–3184.
261. Yugueros, J., Temprano, A., Berzal, B., Sanchez, M., Hernanz, C., Luengo, J.M. and Naharro, G., 2000. Glyceraldehyde-3-phosphate dehydrogenase-encoding gene as a useful taxonomic tool for Staphylococcus spp. J Clin Microbiol 38 (12), 4351–4355.
262. Zhu, L.X., Zhang, Z.W., Wang, C., Yang, H.W., Jiang, D., Zhang, Q., Mitchelson, K. and Cheng, J., 2007. Use of a DNA microarray for simultaneous detection of antibiotic resistance genes among staphylococcal clinical isolates. J Clin Microbiol 45, 3514–3521.