An outbreak in an intensive care unit of a strain of methicillin-resistant Staphylococcus aureus sequence type 239 associated with an increased rate of vascular access device-related bacteremia

Clinical Infectious Diseases

Volumn 44, Issue 4, 2007, Pages 493-502

  Edgeworth, Jonathan D ^a,d   Yadegarfar, Ghasem ^c   Pathak, Smriti ^a   Batra, Rahul ^a   Cockfield, Joshua D ^b   Wyncoll, Duncan ^a   Beale, Richard ^a   Lindsay, Jodi A ^b  

^a GUY S HOSPITAL   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METICILLIN;

ADULT; AGED; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; CONTROLLED STUDY; DEVICE INFECTION; EPIDEMIC; FEMALE; GENETIC ANALYSIS; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROARRAY ANALYSIS; MULTILOCUS SEQUENCE TYPING; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; UNITED KINGDOM; VASCULAR ACCESS DEVICE;

AGE DISTRIBUTION; AGED; BACTEREMIA; CATHETERS, INDWELLING; COHORT STUDIES; CONFIDENCE INTERVALS; CROSS INFECTION; DISEASE OUTBREAKS; FEMALE; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; MALE; METHICILLIN RESISTANCE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROBABILITY; PROPORTIONAL HAZARDS MODELS; SEX DISTRIBUTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 33846935744     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/511034     Document Type: Article

References (35)

1. Fluit AC, Verhoef J, Schmitz FJ. Frequency of isolation and antimicrobial resistance of gram-negative and gram-positive bacteria from patients in intensive care units of 25 European university hospitals participating in the European arm of the SENTRY Antimicrobial Surveillance Program 1997-1998. Eur J Clin Microbiol Infect Dis 2001; 20:617-25.
2. Panlilio AL, Culver DH, Gaynes RP, et al. Methicillin-resistant Staphylococcus aureus in US hospitals, 1975-1991. Infect Control Hosp Epidemiol 1992; 13:582-6.
3. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. Multilocus sequence typing for characterization of methicillin-resistant and methicillin- susceptible clones of Staphylococcus aureus. J Clin Microbiol 2000; 38:1008-15.
4. Enright MC, Robinson DA, Randle G, Feil EJ, Grundmann H, Spratt BG. The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci U S A 2002; 99:7687-92.
5. Johnson AP, Aucken HM, Cavendish S, et al. Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteremia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). J Antimicrob Chemother 2001; 48:143-4.
6. Moore PCL, Lindsay JA. Molecular characterisation of the dominant UK methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and EMRSA-16. J Med Microbiol 2002; 51:516-21.
7. Johnson AP, Pearson A, Duckworth G. Surveillance and epidemiology of MRSA bacteremia in the UK. J Antimicrob Chemother 2005; 56: 455-62.
8. Haddadin AS, Fappiano SA, Lipsett PA. Methicillin-resistant Staphylococcus aureus (MRSA) in the intensive care unit. Postgrad Med J 2002; 78:385-92.
9. Hardy KJ, Hawkey PM, Gao F, Oppenheim BA. Methicillin-resistant Staphylococcus aureus in the critically ill. Br J Anaesth 2004; 92:121-30.
10. Law MR, Gill ON. Hospital acquired infection with methicillin-resistant and methicillin-sensitive staphylococci. Epidemiol Infect 1988; 101:623-9.
11. Pujol M, Pena C, Pallares R, et al. Risk factors for nosocomial bacteremia due to methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 1994; 13:96-102.
12. Myers JP, Linnemann CC. Bacteremia due to methicillin-resistant Staphylococcus aureus. J Infect Dis 1982; 145:532-6.
13. Gurran C, Holliday MG, Perry JD, Ford M, Morgan S, Orr KE. A novel selective medium for the detection of methicillin-resistant Staphylococcus aureus result reporting in under 24 h. J Hosp Infect 2002; 52:148-51.
14. Maki DG, Weise CE, Sarafin HW, et al. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med 1977; 296:1305-9.
15. Witney AA, Marsden GL, Holden MTG, et al. Design, validation and application of a seven-strain S. aureus PCR product microarray for comparative genomics. Appl Environ Microbiol 2005; 71:7504-14.
16. Holden MT, Feil EJ, Lindsay JA, et al. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of vir-ulence and drug resistance. Proc Natl Acad Sci U S A 2004; 101: 9786-91.
17. Lindsay JA, Moore CE, Day NP, et al. Microarrays reveal each of the ten dominant lineages of Staphylococcus aureus have unique combinations of surface-associated and regulatory genes. J Bacteriol 2006; 188:669-76.
18. Hails J, Kwaku F, Wilson AP, Bellingan G, Singer M. Large variation in MRSA policies, procedures and prevalence in English intensive care units: a questionnaire analysis. Intensive Care Med 2003; 29:481-3.
19. Eveillard M, Martin Y, Hidri N, Boussougant Y, Joly-Guillou ML. Carriage of methicillin-resistant Staphylococcus aureus among hospital employees: prevalence, duration, and transmission to households. Infect Control Hosp Epidemiol 2004; 25:114-20.
20. Kollef MH, Rello J, Cammarata SK, Croos-Dabrera RV, Wunderink RG. Clinical cure and survival in gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin. Intensive Care Med 2004; 30:388-94.
21. Dufour P, Gillet Y, Bes M, et al. Community-acquired methicillin- resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis 2002; 35:819-24.
22. Huang SS, Platt R. Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization. Clin Infect Dis 2003; 36:281-5.
23. Coello R, Jimenez J, Garcia M, et al. Prospective study of infection, colonisation and carriage of methicillin-resistant Staphylococcus in an outbreak affecting 990 patients. Eur J Clin Microbiol Infect Dis 1994;13:74-81.
24. Aires de Sousa M, Crisostomo MI, Santos Sanches I, et al. Frequent recovery of a single clonal type of multidrug resistant Staphylococcus aureus from patients in two hospitals in Taiwan and China. J Clin Microbiol 2003; 41:159-63.
25. Teixeira LA, Resende CA, Ormonde LR, et al. Geographic spread of epidemic multiresistant Staphylococcus aureus clones in Brazil. J Clin Microbiol 1995; 33:2400-4.
26. Dominguez MA, de Lencastre H, Linares J, Tomasz A. Spread and maintenance of a dominant methicillin-resistant Staphylococcus aureus (MRSA) clone during an outbreak of MRSA disease in a Spanish hospital. J Clin Microbiol 1994; 32:2081-7.
27. Amorim ML, de Sousa MA, Santos Sanches I, et al. Clonal and antibiotic resistance profile of methicillin-resistant Staphylococcus aureus (MRSA) from a Portuguese hospital over time. Microb Drug Resist 2002; 8:301-9.
28. Robinson DA, Enright MC. Evolution of Staphylococcus aureus by large chromosomal replacements. J Bacteriol 2004; 186:1060-4.
29. Marples RR, Richardson JF, de Saxe MJ. Bacteriological characters of strains of Staphylococcus aureus submitted to a reference laboratory related to methicillin resistance. J Hyg (Lond) 1986; 96:217-23.
30. Lindsay JA, Holden MTG. Staphylococcus aureus: superbug, supergenome? Trends Microbiol 2004; 12:378-85.
31. Robinson DA, Kears AM, Holmes A, et al. Re-emergence of early pandemic Staphylococcus aureus as a community-acquired methicillin-resistant clone. Lancet 2005; 365:1256-8.
32. Tambic A, Power EGM, Talsania H, Anthony RM, French GL. Analysis of an outbreak of non-phage typable methicillin-resistant Staphylococcus aureus by using a randomly amplified polymorphic DNA assay. J Clin Microbiol 1997; 35:3092-7.
33. Peacock JE, Marsik FJ, Wenzel RP. Methicillin-resistant Staphylococcus aureus: introduction and spread within a hospital. Ann Intern Med 1980; 93:526-32.
34. Thompson DS. Methicillin-resistant Staphylococcus aureus in a general intensive care unit. J R Soc Med 2004; 97:521-6.
35. Amaral MM, Coelho LR, Flores RP, et al. The predominant variant of the Brazilian epidemic clonal complex of methicillin-resistant Staphylococcus aureus has an enhanced ability to produce biofilm and to adhere to and invade airway epithelial cells. J Infect Dis 2005; 192:801-10.