메뉴 건너뛰기




Volumn 51, Issue , 2017, Pages 14-19

The crosstalk between Wnt/β-catenin signaling pathway with DNA damage response and oxidative stress: Implications in cancer therapy

Author keywords

Cancer; DNA damage; DNA repair; Oxidative stress; Wnt

Indexed keywords

BETA CATENIN; WNT PROTEIN;

EID: 85009769627     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2017.01.003     Document Type: Review
Times cited : (99)

References (55)
  • 1
    • 84969988062 scopus 로고    scopus 로고
    • DNA damage response: cell thriving despite DNA damage
    • [1] Strzyz, P., DNA damage response: cell thriving despite DNA damage. Nat. Rev. Mol. Cell Biol., 17(7), 2016, 396.
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , Issue.7 , pp. 396
    • Strzyz, P.1
  • 2
    • 84965074483 scopus 로고    scopus 로고
    • DNA damage response: controlling ubiquitylation at DNA lesions
    • [2] Strzyz, P., DNA damage response: controlling ubiquitylation at DNA lesions. Nat. Rev. Mol. Cell Biol., 17(6), 2016, 329.
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , Issue.6 , pp. 329
    • Strzyz, P.1
  • 4
    • 84921373620 scopus 로고    scopus 로고
    • The DNA damage response: implications for tumor responses to radiation and chemotherapy
    • [4] Goldstein, M., Kastan, M.B., The DNA damage response: implications for tumor responses to radiation and chemotherapy. Annu. Rev. Med. 66 (2015), 129–143.
    • (2015) Annu. Rev. Med. , vol.66 , pp. 129-143
    • Goldstein, M.1    Kastan, M.B.2
  • 5
    • 84993940390 scopus 로고    scopus 로고
    • DNA damage response regulation by MicroRNAs as a therapeutic target in cancer
    • [5] Majidinia, M., Yousefi, B., DNA damage response regulation by MicroRNAs as a therapeutic target in cancer. DNA Repair 47 (2016), 1–11.
    • (2016) DNA Repair , vol.47 , pp. 1-11
    • Majidinia, M.1    Yousefi, B.2
  • 6
    • 84901052694 scopus 로고    scopus 로고
    • ROS function in redox signaling and oxidative stress
    • [6] Schieber, M., Chandel, N.S., ROS function in redox signaling and oxidative stress. Curr. Biol. 24:10 (2014), R453–R462.
    • (2014) Curr. Biol. , vol.24 , Issue.10 , pp. R453-R462
    • Schieber, M.1    Chandel, N.S.2
  • 7
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    • [7] Shiloh, Y., Ziv, Y., The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14:4 (2013), 197–210.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , Issue.4 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 8
    • 0003537508 scopus 로고    scopus 로고
    • Oxidative Damage & Repair: Chemical, Biological and Medical Aspects
    • Elsevier
    • [8] Davies, K.J., Oxidative Damage & Repair: Chemical, Biological and Medical Aspects. 2013, Elsevier.
    • (2013)
    • Davies, K.J.1
  • 9
    • 84871994057 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production
    • [9] Zhang, D-y, Pan, Y., Zhang, C., Yan, B-x, Yu, S-s, Wu, D-l, et al. Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production. Mol. Cell. Biochem. 374:1–2 (2013), 13–20.
    • (2013) Mol. Cell. Biochem. , vol.374 , Issue.1-2 , pp. 13-20
    • Zhang, D.-Y.1    Pan, Y.2    Zhang, C.3    Yan, B.-X.4    Yu, S.-S.5    Wu, D.-L.6
  • 10
    • 34547107319 scopus 로고    scopus 로고
    • WNT signaling pathway and stem cell signaling network
    • [10] Katoh, M., Katoh, M., WNT signaling pathway and stem cell signaling network. Clin. Cancer Res. 13:14 (2007), 4042–4045.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.14 , pp. 4042-4045
    • Katoh, M.1    Katoh, M.2
  • 12
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors
    • [12] Gordon, M.D., Nusse, R., Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. 281:32 (2006), 22429–22433.
    • (2006) J. Biol. Chem. , vol.281 , Issue.32 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 13
    • 27744535862 scopus 로고    scopus 로고
    • The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
    • [13] Wallingford, J.B., Habas, R., The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132:20 (2005), 4421–4436.
    • (2005) Development , vol.132 , Issue.20 , pp. 4421-4436
    • Wallingford, J.B.1    Habas, R.2
  • 14
    • 85007518387 scopus 로고    scopus 로고
    • Breast tumor stroma: a driving force in the development of resistance to therapies
    • Jan 2. [Epub ahead of print]
    • [14] Majidinia, M., Yousefi, B., Breast tumor stroma: a driving force in the development of resistance to therapies. Chem. Biol. Drug Des., 2017, 10.1111/cbdd.12893 Jan 2. [Epub ahead of print].
    • (2017) Chem. Biol. Drug Des.
    • Majidinia, M.1    Yousefi, B.2
  • 15
    • 45849117967 scopus 로고    scopus 로고
    • Wnt signal transduction pathways
    • [15] Komiya, Y., Habas, R., Wnt signal transduction pathways. Organogenesis 4:2 (2008), 68–75.
    • (2008) Organogenesis , vol.4 , Issue.2 , pp. 68-75
    • Komiya, Y.1    Habas, R.2
  • 16
    • 84894353718 scopus 로고    scopus 로고
    • DNA damage response: three levels of DNA repair regulation
    • [16] Sirbu, B.M., Cortez, D., DNA damage response: three levels of DNA repair regulation. Cold Spring Harbor Perspect. Biol., 5(8), 2013, a012724.
    • (2013) Cold Spring Harbor Perspect. Biol. , vol.5 , Issue.8 , pp. a012724
    • Sirbu, B.M.1    Cortez, D.2
  • 17
    • 77953287126 scopus 로고    scopus 로고
    • MRN and the race to the break
    • [17] Rupnik, A., Lowndes, N.F., Grenon, M., MRN and the race to the break. Chromosoma 119:2 (2010), 115–135.
    • (2010) Chromosoma , vol.119 , Issue.2 , pp. 115-135
    • Rupnik, A.1    Lowndes, N.F.2    Grenon, M.3
  • 18
    • 84905283334 scopus 로고    scopus 로고
    • Akt and p53R2, partners that dictate the progression and invasiveness of cancer
    • [18] Yousefi, B., Samadi, N., Ahmadi, Y., Akt and p53R2, partners that dictate the progression and invasiveness of cancer. DNA Repair 22 (2016), 24–29.
    • (2016) DNA Repair , vol.22 , pp. 24-29
    • Yousefi, B.1    Samadi, N.2    Ahmadi, Y.3
  • 19
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • [19] Bakkenist, C.J., Kastan, M.B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:6922 (2003), 499–506.
    • (2003) Nature , vol.421 , Issue.6922 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 20
    • 79951502221 scopus 로고    scopus 로고
    • Differential dynamics of ATR-mediated checkpoint regulators
    • [20] Warmerdam, D.O., Kanaar, R., Smits, V.A., Differential dynamics of ATR-mediated checkpoint regulators. J. Nucleic Acids, 2010, 2010.
    • (2010) J. Nucleic Acids , vol.2010
    • Warmerdam, D.O.1    Kanaar, R.2    Smits, V.A.3
  • 21
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • [21] Jackson, S.P., Bartek, J., The DNA-damage response in human biology and disease. Nature 461:7267 (2009), 1071–1078.
    • (2009) Nature , vol.461 , Issue.7267 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 22
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • [22] Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., Bonner, W.M., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:10 (1998), 5858–5868.
    • (1998) J. Biol. Chem. , vol.273 , Issue.10 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 23
    • 84855908936 scopus 로고    scopus 로고
    • Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
    • [23] Sørensen, C.S., Syljuåsen, R.G., Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res. 40:2 (2012), 477–486.
    • (2012) Nucleic Acids Res. , vol.40 , Issue.2 , pp. 477-486
    • Sørensen, C.S.1    Syljuåsen, R.G.2
  • 24
    • 84896696388 scopus 로고    scopus 로고
    • The roles of p53R2 in cancer progression based on the new function of mutant p53 and cytoplasmic p21
    • [24] Yousefi, B., Rahmati, M., Ahmadi, Y., The roles of p53R2 in cancer progression based on the new function of mutant p53 and cytoplasmic p21. Life Sci. 99:1 (2016), 14–17.
    • (2016) Life Sci. , vol.99 , Issue.1 , pp. 14-17
    • Yousefi, B.1    Rahmati, M.2    Ahmadi, Y.3
  • 25
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • [25] Shieh, S.-Y., Ikeda, M., Taya, Y., Prives, C., DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:3 (1997), 325–334.
    • (1997) Cell , vol.91 , Issue.3 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 26
    • 84964853264 scopus 로고    scopus 로고
    • Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
    • [26] Karimian, A., Ahmadi, Y., Yousefi, B., Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. DNA Repair 42 (2016), 63–71.
    • (2016) DNA Repair , vol.42 , pp. 63-71
    • Karimian, A.1    Ahmadi, Y.2    Yousefi, B.3
  • 27
    • 0035947080 scopus 로고    scopus 로고
    • Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses
    • [27] Matsuzawa, S-i., Reed, J.C., Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol. Cell 7:5 (2001), 915–926.
    • (2001) Mol. Cell , vol.7 , Issue.5 , pp. 915-926
    • Matsuzawa, S.-I.1    Reed, J.C.2
  • 29
    • 79959340540 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling induces the aging of mesenchymal stem cells though the DNA damage response and the p53/p21 pathway
    • [29] Zhang, D-y, Wangj, H-j, H-j, Wang, Wnt/β-catenin signaling induces the aging of mesenchymal stem cells though the DNA damage response and the p53/p21 pathway. PLoS One, 6(6), 2011, e21397.
    • (2011) PLoS One , vol.6 , Issue.6 , pp. e21397
    • Zhang, D.-Y.1    Wangj, H.-J.2    H-j, W.3
  • 30
    • 0037062403 scopus 로고    scopus 로고
    • Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage
    • [30] Watcharasit, P., Bijur, G.N., Zmijewski, J.W., Song, L., Zmijewska, A., Chen, X., et al. Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage. Proc. Natl. Acad. Sci. 99:12 (2002), 7951–7955.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , Issue.12 , pp. 7951-7955
    • Watcharasit, P.1    Bijur, G.N.2    Zmijewski, J.W.3    Song, L.4    Zmijewska, A.5    Chen, X.6
  • 31
    • 0242497228 scopus 로고    scopus 로고
    • Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
    • [31] Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Dorrello, N.V., et al. Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage. Nature 426:6962 (2003), 87–91.
    • (2003) Nature , vol.426 , Issue.6962 , pp. 87-91
    • Busino, L.1    Donzelli, M.2    Chiesa, M.3    Guardavaccaro, D.4    Ganoth, D.5    Dorrello, N.V.6
  • 32
    • 20444503830 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/β-catenin complex
    • [32] Idogawa, M., Yamada, T., Honda, K., Sato, S., Imai, K., Hirohashi, S., Poly (ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/β-catenin complex. Gastroenterology 128:7 (2005), 1919–1936.
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1919-1936
    • Idogawa, M.1    Yamada, T.2    Honda, K.3    Sato, S.4    Imai, K.5    Hirohashi, S.6
  • 33
    • 33847011050 scopus 로고    scopus 로고
    • Ku70 and poly (ADP-Ribose) polymerase-1 competitively regulate β-Catenin and T-Cell factor-4–Mediated gene transactivation: possible linkage of DNA damage recognition and wnt signaling
    • [33] Idogawa, M., Masutani, M., Shitashige, M., Honda, K., Tokino, T., Shinomura, Y., et al. Ku70 and poly (ADP-Ribose) polymerase-1 competitively regulate β-Catenin and T-Cell factor-4–Mediated gene transactivation: possible linkage of DNA damage recognition and wnt signaling. Cancer Res. 67:3 (2007), 911–918.
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 911-918
    • Idogawa, M.1    Masutani, M.2    Shitashige, M.3    Honda, K.4    Tokino, T.5    Shinomura, Y.6
  • 34
    • 57749190558 scopus 로고    scopus 로고
    • Current understanding of klotho
    • [34] Wang, Y., Sun, Z., Current understanding of klotho. Ageing Res. Rev. 8:1 (2009), 43–51.
    • (2009) Ageing Res. Rev. , vol.8 , Issue.1 , pp. 43-51
    • Wang, Y.1    Sun, Z.2
  • 35
    • 34547908461 scopus 로고    scopus 로고
    • Augmented Wnt signaling in a mammalian model of accelerated aging
    • [35] Liu, H., Fergusson, M.M., Castilho, R.M., Liu, J., Cao, L., Chen, J., et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317:5839 (2007), 803–806.
    • (2007) Science , vol.317 , Issue.5839 , pp. 803-806
    • Liu, H.1    Fergusson, M.M.2    Castilho, R.M.3    Liu, J.4    Cao, L.5    Chen, J.6
  • 36
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    • [36] Kops, G.J., Dansen, T.B., Polderman, P.E., Saarloos, I., Wirtz, K.W., Coffer, P.J., et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:6904 (2002), 316–321.
    • (2002) Nature , vol.419 , Issue.6904 , pp. 316-321
    • Kops, G.J.1    Dansen, T.B.2    Polderman, P.E.3    Saarloos, I.4    Wirtz, K.W.5    Coffer, P.J.6
  • 37
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • [37] Medema, R.H., Kops, G.J., Bos, J.L., Burgering, B.M., AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:6779 (2000), 782–787.
    • (2000) Nature , vol.404 , Issue.6779 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 38
    • 19144365650 scopus 로고    scopus 로고
    • Oxidative stress and cancer: a β-catenin convergence
    • [38] Bowerman, B., Oxidative stress and cancer: a β-catenin convergence. Science 308:5725 (2005), 1119–1120.
    • (2005) Science , vol.308 , Issue.5725 , pp. 1119-1120
    • Bowerman, B.1
  • 39
    • 58649095889 scopus 로고    scopus 로고
    • Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts
    • [39] Chen, J.R., Lazarenko, O.P., Haley, R.L., Blackburn, M.L., Badger, T.M., Ronis, M.J., Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts. J. Bone Miner. Res. 24:2 (2009), 221–230.
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.2 , pp. 221-230
    • Chen, J.R.1    Lazarenko, O.P.2    Haley, R.L.3    Blackburn, M.L.4    Badger, T.M.5    Ronis, M.J.6
  • 40
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • [40] Prockop, D.J., Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:5309 (1997), 71–74.
    • (1997) Science , vol.276 , Issue.5309 , pp. 71-74
    • Prockop, D.J.1
  • 41
    • 77953483918 scopus 로고    scopus 로고
    • A role for ethanol‐induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β‐catenin signaling
    • [41] Chen, J.R., Lazarenko, O.P., Shankar, K., Blackburn, M.L., Badger, T.M., Ronis, M.J., A role for ethanol‐induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β‐catenin signaling. J. Bone Miner. Res. 25:5 (2010), 1117–1127.
    • (2010) J. Bone Miner. Res. , vol.25 , Issue.5 , pp. 1117-1127
    • Chen, J.R.1    Lazarenko, O.P.2    Shankar, K.3    Blackburn, M.L.4    Badger, T.M.5    Ronis, M.J.6
  • 42
    • 28044436484 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress
    • [42] Gao, J., Liu, X., Rigas, B., Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 102:47 (2005), 17207–17212.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.47 , pp. 17207-17212
    • Gao, J.1    Liu, X.2    Rigas, B.3
  • 43
    • 84939443473 scopus 로고    scopus 로고
    • Kolaviron protects against benzo [a] pyrene-induced functional alterations along the brain-pituitary-gonadal axis in male rats
    • [43] Adedara, I.A., Owoeye, O., Aiyegbusi, M.A., Dagunduro, J.O., Daramola, Y.M., Farombi, E.O., Kolaviron protects against benzo [a] pyrene-induced functional alterations along the brain-pituitary-gonadal axis in male rats. Environ. Toxicol. Pharmacol. 40:2 (2015), 459–470.
    • (2015) Environ. Toxicol. Pharmacol. , vol.40 , Issue.2 , pp. 459-470
    • Adedara, I.A.1    Owoeye, O.2    Aiyegbusi, M.A.3    Dagunduro, J.O.4    Daramola, Y.M.5    Farombi, E.O.6
  • 44
    • 84978137361 scopus 로고    scopus 로고
    • Benzo (a) pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice
    • [44] Ajayi, B.O., Adedara, I.A., Farombi, E.O., Benzo (a) pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice. Food Chem. Toxicol. 95 (2016), 42–51.
    • (2016) Food Chem. Toxicol. , vol.95 , pp. 42-51
    • Ajayi, B.O.1    Adedara, I.A.2    Farombi, E.O.3
  • 45
    • 72749102524 scopus 로고    scopus 로고
    • Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis
    • [45] Walsh, N.C., Reinwald, S., Manning, C.A., Condon, K.W., Iwata, K., Burr, D.B., et al. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J. Bone Miner. Res. 24:9 (2009), 1572–1585.
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.9 , pp. 1572-1585
    • Walsh, N.C.1    Reinwald, S.2    Manning, C.A.3    Condon, K.W.4    Iwata, K.5    Burr, D.B.6
  • 46
    • 84455161897 scopus 로고    scopus 로고
    • Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts
    • [46] Almeida, M., Han, L., Ambrogini, E., Weinstein, R.S., Manolagas, S.C., Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J. Biol. Chem. 286:52 (2011), 44326–44335.
    • (2011) J. Biol. Chem. , vol.286 , Issue.52 , pp. 44326-44335
    • Almeida, M.1    Han, L.2    Ambrogini, E.3    Weinstein, R.S.4    Manolagas, S.C.5
  • 47
    • 84995932441 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated Receptors and their ligands in cancer drug resistance: opportunity or challenge
    • [47] Yousefi, B., Zarghami, N., Samadi, N., Majidinia, M., Peroxisome proliferator-activated Receptors and their ligands in cancer drug resistance: opportunity or challenge. Anticancer Agents Med. Chem. 16:12 (2016), 1541–1548.
    • (2016) Anticancer Agents Med. Chem. , vol.16 , Issue.12 , pp. 1541-1548
    • Yousefi, B.1    Zarghami, N.2    Samadi, N.3    Majidinia, M.4
  • 48
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: there is more to growth than just surviving
    • [48] Plas, D.R., Thompson, C.B., Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24:50 (2005), 7435–7442.
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 49
    • 78149448121 scopus 로고    scopus 로고
    • Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer
    • [49] Covey, T.M., Edes, K., Coombs, G.S., Virshup, D.M., Fitzpatrick, F.A., Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One, 5(10), 2010, e13545.
    • (2010) PLoS One , vol.5 , Issue.10 , pp. e13545
    • Covey, T.M.1    Edes, K.2    Coombs, G.S.3    Virshup, D.M.4    Fitzpatrick, F.A.5
  • 52
    • 84898471903 scopus 로고    scopus 로고
    • Targeting DNA damage response in cancer therapy
    • [52] Hosoya, N., Miyagawa, K., Targeting DNA damage response in cancer therapy. Cancer Sci. 105:4 (2014), 370–388.
    • (2014) Cancer Sci. , vol.105 , Issue.4 , pp. 370-388
    • Hosoya, N.1    Miyagawa, K.2
  • 53
    • 84856019858 scopus 로고    scopus 로고
    • The DNA damage response and cancer therapy
    • [53] Lord, C.J., Ashworth, A., The DNA damage response and cancer therapy. Nature 481:7381 (2012), 287–294.
    • (2012) Nature , vol.481 , Issue.7381 , pp. 287-294
    • Lord, C.J.1    Ashworth, A.2
  • 54
    • 84924087352 scopus 로고    scopus 로고
    • Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
    • [54] Tao, S., Tang, D., Morita, Y., Sperka, T., Omrani, O., Lechel, A., et al. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage. EMBO J. 34:5 (2015), 624–640.
    • (2015) EMBO J. , vol.34 , Issue.5 , pp. 624-640
    • Tao, S.1    Tang, D.2    Morita, Y.3    Sperka, T.4    Omrani, O.5    Lechel, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.