Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

EBioMedicine

Volumn 16, Issue , 2017, Pages 172-183

  Tsunekawa, Taku ^a   Banno, Ryoichi ^a   Mizoguchi, Akira ^a   Sugiyama, Mariko ^a   Tominaga, Takashi ^a   Onoue, Takeshi ^a   Hagiwara, Daisuke ^a   Ito, Yoshihiro ^a   Iwama, Shintaro ^a,b   Goto, Motomitsu ^a   Suga, Hidetaka ^a   Sugimura, Yoshihisa ^a   Arima, Hiroshi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

High fat diet; Hypothalamic inflammation; Microglia; Obesity; Protein tyrosine phosphatase 1B; Signal transducer and activator of transcription 3

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; CHLORDANE; CLODRONIC ACID; INTERLEUKIN 10; JANUS KINASE 2; LEPTIN; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; JAK2 PROTEIN, MOUSE; PTPN1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS FAT; GENE INACTIVATION; HYPOPHYSITIS; HYPOTHALAMIC INFLAMMATION; IMMUNOHISTOCHEMISTRY; LIPID DIET; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; CONFOCAL MICROSCOPY; DEFICIENCY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENETICS; HYPOTHALAMUS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOTTING, WESTERN; DIET, HIGH-FAT; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; INFLAMMATION; INTERLEUKIN-10; JANUS KINASE 2; MALE; MICE, KNOCKOUT; MICROGLIA; MICROSCOPY, CONFOCAL; ORGAN CULTURE TECHNIQUES; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85009742434     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2017.01.007     Document Type: Article

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