Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

Journal of Neuroinflammation

Volumn 11, Issue , 2014, Pages

  Wellhauser, Leigh ^a   Belsham, Denise D ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Docosahexaenoic acid; Hypothalamus; Inflammation; Neuronal cell line; Signal transduction; Tumor necrosis factor

Indexed keywords

AGOUTI RELATED PROTEIN; BINDING PROTEIN; DOCOSAHEXAENOIC ACID; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA RECEPTOR; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEURON SPECIFIC ENOLASE; NEUROPEPTIDE Y; OMEGA 3 FATTY ACID; PROOPIOMELANOCORTIN; PROTEIN KINASE B; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1 BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 2; UNCLASSIFIED DRUG; 6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; ANTIINFLAMMATORY AGENT; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; G PROTEIN COUPLED RECEPTOR; GW9508; I KAPPA B; METHYLAMINE; O3FAR1 PROTEIN, RAT; PROPIONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; CYTOKINE RESPONSE; EMBRYO; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HYPOTHALAMUS NUCLEUS; INFLAMMATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HYPOTHALAMUS; IMMUNOPRECIPITATION; METABOLISM; NERVE CELL; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSFORMED CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TRANSFORMED; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 3-RING; HYPOTHALAMUS; I-KAPPA B PROTEINS; IMMUNOPRECIPITATION; METHYLAMINES; NEURONS; PROPIONATES; PYRIDINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84897408840     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-11-60     Document Type: Article

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