-
1
-
-
84879693217
-
New anti-inflammatory targets for chronic obstructive pulmonary disease
-
Barnes PJ. New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov 2013;12:543-559.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 543-559
-
-
Barnes, P.J.1
-
2
-
-
84893722023
-
Bronchodilators: Current and future
-
Cazzola M, Matera MG. Bronchodilators: current and future. Clin Chest Med 2014;35:191-201.
-
(2014)
Clin Chest Med
, vol.35
, pp. 191-201
-
-
Cazzola, M.1
Matera, M.G.2
-
3
-
-
84962425777
-
The bronchodilator effects of extrafine glycopyrronium added to combination treatment with beclometasone dipropionate plus formoterol in COPD: A randomised crossover study (the TRIDENT Study)
-
Singh D, Schröder-Babo W, Cohuet G, Muraro A, Bonnet-Gonod F, Petruzzelli S, Hoffmann M, Siergiejko Z; TRIDENT Study Investigators. The bronchodilator effects of extrafine glycopyrronium added to combination treatment with beclometasone dipropionate plus formoterol in COPD: a randomised crossover study (the TRIDENT Study). Respir Med 2016;114:84-90.
-
(2016)
Respir Med
, vol.114
, pp. 84-90
-
-
Singh, D.1
Schröder-Babo, W.2
Cohuet, G.3
Muraro, A.4
Bonnet-Gonod, F.5
Petruzzelli, S.6
Hoffmann, M.7
Siergiejko, Z.8
-
4
-
-
84886523953
-
The MABA approach: A new option to improve bronchodilator therapy
-
Cazzola M, Lopez-Campos JL, Puente-Maestu L. The MABA approach: a new option to improve bronchodilator therapy. Eur Respir J 2013;42: 885-887.
-
(2013)
Eur Respir J
, vol.42
, pp. 885-887
-
-
Cazzola, M.1
Lopez-Campos, J.L.2
Puente-Maestu, L.3
-
5
-
-
84887896772
-
The expression and relaxant effect of bitter taste receptors in human bronchi
-
Grassin-Delyle S, Abrial C, Fayad-Kobeissi S, Brollo M, Faisy C, Alvarez JC, Naline E, Devillier P. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 2013;14: 134.
-
(2013)
Respir Res
, vol.14
, pp. 134
-
-
Grassin-Delyle, S.1
Abrial, C.2
Fayad-Kobeissi, S.3
Brollo, M.4
Faisy, C.5
Alvarez, J.C.6
Naline, E.7
Devillier, P.8
-
6
-
-
85016649721
-
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
-
Yarova PL, Stewart AL, Sathish V, Britt RD Jr, Thompson MA, Lowe APP, Freeman M, Aravamudan B, Kita H, Brennan SC, et al. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med 2015;7:284ra260.
-
(2015)
Sci Transl Med
, vol.7
, pp. 284ra260
-
-
Yarova, P.L.1
Stewart, A.L.2
Sathish, V.3
Britt, R.D.4
Thompson, M.A.5
Lowe, A.P.P.6
Freeman, M.7
Aravamudan, B.8
Kita, H.9
Brennan, S.C.10
-
7
-
-
84933673873
-
Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds
-
Sundahl N, Bridelance J, Libert C, De Bosscher K, Beck IM. Selective glucocorticoid receptor modulation: new directions with non-steroidal scaffolds. Pharmacol Ther 2015;152:28-41.
-
(2015)
Pharmacol Ther
, vol.152
, pp. 28-41
-
-
Sundahl, N.1
Bridelance, J.2
Libert, C.3
De Bosscher, K.4
Beck, I.M.5
-
8
-
-
84938739930
-
The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma
-
Leaker BR, O'Connor B, Singh D, Barnes PJ. The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma. J Allergy Clin Immunol 2015;136:501-2.e6.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 501e6-502e6
-
-
Leaker, B.R.1
O'Connor, B.2
Singh, D.3
Barnes, P.J.4
-
11
-
-
84949209195
-
Phosphodiesterase 4 inhibitors for the treatment of chronic obstructive pulmonary disease: A review of current and developing drugs
-
Mulhall AM, Droege CA, Ernst NE, Panos RJ, Zafar MA. Phosphodiesterase 4 inhibitors for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs. Expert Opin Investig Drugs 2015;24: 1597-1611.
-
(2015)
Expert Opin Investig Drugs
, vol.24
, pp. 1597-1611
-
-
Mulhall, A.M.1
Droege, C.A.2
Ernst, N.E.3
Panos, R.J.4
Zafar, M.A.5
-
12
-
-
84882569009
-
Safety and tolerability of the inhaled phosphodiesterase 4 inhibitor GSK256066 in moderate COPD
-
Watz H, Mistry SJ, Lazaar AL; IPC101939 Investigators. Safety and tolerability of the inhaled phosphodiesterase 4 inhibitor GSK256066 in moderate COPD. Pulm Pharmacol Ther 2013;26: 588-595.
-
(2013)
Pulm Pharmacol Ther
, vol.26
, pp. 588-595
-
-
Watz, H.1
Mistry, S.J.2
Lazaar, A.L.3
-
13
-
-
84978280542
-
A novel inhaled phosphodiesterase 4 inhibitor (CHF6001) reduces the allergen challenge response in asthmatic patients
-
Singh D, Leaker B, Boyce M, Nandeuil MA, Collarini S, Mariotti F, Santoro D, Barnes PJ. A novel inhaled phosphodiesterase 4 inhibitor (CHF6001) reduces the allergen challenge response in asthmatic patients. Pulm Pharmacol Ther 2016;40:1-6.
-
(2016)
Pulm Pharmacol Ther
, vol.40
, pp. 1-6
-
-
Singh, D.1
Leaker, B.2
Boyce, M.3
Nandeuil, M.A.4
Collarini, S.5
Mariotti, F.6
Santoro, D.7
Barnes, P.J.8
-
14
-
-
84887115924
-
Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: Findings from four clinical trials
-
Franciosi LG, Diamant Z, Banner KH, Zuiker R, Morelli N, Kamerling IM, de Kam ML, Burggraaf J, Cohen AF, Cazzola M, et al. Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. Lancet Respir Med 2013;1:714-727.
-
(2013)
Lancet Respir Med
, vol.1
, pp. 714-727
-
-
Franciosi, L.G.1
Diamant, Z.2
Banner, K.H.3
Zuiker, R.4
Morelli, N.5
Kamerling, I.M.6
De Kam, M.L.7
Burggraaf, J.8
Cohen, A.F.9
Cazzola, M.10
-
15
-
-
84979085064
-
Kinases as novel therapeutic targets in asthma and COPD
-
Barnes PJ. Kinases as novel therapeutic targets in asthma and COPD. Pharmacol Rev 2016;68:788-815.
-
(2016)
Pharmacol Rev
, vol.68
, pp. 788-815
-
-
Barnes, P.J.1
-
16
-
-
84923044041
-
Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease
-
Norman P. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs 2015;24: 383-392.
-
(2015)
Expert Opin Investig Drugs
, vol.24
, pp. 383-392
-
-
Norman, P.1
-
17
-
-
84864239168
-
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma
-
Mercado N, Hakim A, Kobayashi Y, Meah S, Usmani OS, Chung KF, Barnes PJ, Ito K. Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One 2012;7:e41582.
-
(2012)
PLoS One
, vol.7
, pp. e41582
-
-
Mercado, N.1
Hakim, A.2
Kobayashi, Y.3
Meah, S.4
Usmani, O.S.5
Chung, K.F.6
Barnes, P.J.7
Ito, K.8
-
18
-
-
84891373802
-
Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: A randomised, double-blind, placebo-controlled trial
-
Watz H, Barnacle H, Hartley BF, Chan R. Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2014;2:63-72.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 63-72
-
-
Watz, H.1
Barnacle, H.2
Hartley, B.F.3
Chan, R.4
-
19
-
-
84879955170
-
Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: A randomised clinical trial
-
MacNee W, Allan RJ, Jones I, De Salvo MC, Tan LF. Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial. Thorax 2013;68: 738-745.
-
(2013)
Thorax
, vol.68
, pp. 738-745
-
-
MacNee, W.1
Allan, R.J.2
Jones, I.3
De Salvo, M.C.4
Tan, L.F.5
-
20
-
-
84941315721
-
Oral and inhaled p38 MAPK inhibitors: Effects on inhaled LPS challenge in healthy subjects
-
Singh D, Siew L, Christensen J, Plumb J, Clarke GW, Greenaway S, Perros-Huguet C, Clarke N, Kilty I, Tan L. Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects. Eur J Clin Pharmacol 2015;71:1175-1184.
-
(2015)
Eur J Clin Pharmacol
, vol.71
, pp. 1175-1184
-
-
Singh, D.1
Siew, L.2
Christensen, J.3
Plumb, J.4
Clarke, G.W.5
Greenaway, S.6
Perros-Huguet, C.7
Clarke, N.8
Kilty, I.9
Tan, L.10
-
21
-
-
84953638651
-
Molecules in medicine mini-review: Isoforms of PI3K in biology and disease
-
Vanhaesebroeck B, Whitehead MA, Piñeiro R. Molecules in medicine mini-review: isoforms of PI3K in biology and disease. J Mol Med (Berl) 2016;94:5-11.
-
(2016)
J Mol Med (Berl)
, vol.94
, pp. 5-11
-
-
Vanhaesebroeck, B.1
Whitehead, M.A.2
Piñeiro, R.3
-
22
-
-
77958173826
-
Targeting phosphoinositide-3-kinase-d with theophylline reverses corticosteroid insensitivity in COPD
-
To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, Elliot M, Hogg JC, Adcock IM, Barnes PJ. Targeting phosphoinositide-3-kinase-d with theophylline reverses corticosteroid insensitivity in COPD. Am J Respir Crit Care Med 2010;182:897-904.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 897-904
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
Failla, M.4
Ito, M.5
Kusama, T.6
Elliot, M.7
Hogg, J.C.8
Adcock, I.M.9
Barnes, P.J.10
-
23
-
-
85012927476
-
Restoration of corticosteroid sensitivity in chronic obstructive pulmonary disease by inhibition of mammalian target of rapamycin
-
Mitani A, Ito K, Vuppusetty C, Barnes PJ, Mercado N. Restoration of corticosteroid sensitivity in chronic obstructive pulmonary disease by inhibition of mammalian target of rapamycin. Am J Respir Crit Care Med 2016;193:143-153.
-
(2016)
Am J Respir Crit Care Med
, vol.193
, pp. 143-153
-
-
Mitani, A.1
Ito, K.2
Vuppusetty, C.3
Barnes, P.J.4
Mercado, N.5
-
24
-
-
84957884373
-
Phosphoinositide 3-kinase-d regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress
-
Lee KS, Jeong JS, Kim SR, Cho SH, Kolliputi N, Ko YH, Lee KB, Park SC, Park HJ, Lee YC. Phosphoinositide 3-kinase-d regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax 2016;71:52-63.
-
(2016)
Thorax
, vol.71
, pp. 52-63
-
-
Lee, K.S.1
Jeong, J.S.2
Kim, S.R.3
Cho, S.H.4
Kolliputi, N.5
Ko, Y.H.6
Lee, K.B.7
Park, S.C.8
Park, H.J.9
Lee, Y.C.10
-
25
-
-
84896479862
-
Safety, tolerability and pharmacokinetics (PK) of single and repeat nebulised doses of a novel phosphoinositide 3-kinase d inhibitor (PI3Kd), GSK2269557, administered to healthy male subjects in a phase i study
-
Wilson R, Cahn AAD, McSherry L, Rambaran C, Sousa A, Wilbraham D. Safety, tolerability and pharmacokinetics (PK) of single and repeat nebulised doses of a novel phosphoinositide 3-kinase d inhibitor (PI3Kd), GSK2269557, administered to healthy male subjects in a phase I study. Eur Respir J 2013;42(Suppl 57): P729.
-
(2013)
Eur Respir J
, vol.42
, pp. P729
-
-
Wilson, R.1
Cahn, A.A.D.2
McSherry, L.3
Rambaran, C.4
Sousa, A.5
Wilbraham, D.6
-
26
-
-
84942279293
-
Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase d for the treatment of respiratory disease
-
Down K, Amour A, Baldwin IR, Cooper AW, Deakin AM, Felton LM, Guntrip SB, Hardy C, Harrison ZA, Jones KL, et al. Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase d for the treatment of respiratory disease. J Med Chem 2015;58:7381-7399.
-
(2015)
J Med Chem
, vol.58
, pp. 7381-7399
-
-
Down, K.1
Amour, A.2
Baldwin, I.R.3
Cooper, A.W.4
Deakin, A.M.5
Felton, L.M.6
Guntrip, S.B.7
Hardy, C.8
Harrison, Z.A.9
Jones, K.L.10
-
27
-
-
84939162409
-
Effect of JAK inhibitors on release of CXCL9, CXCL10 and CXCL11 from human airway epithelial cells
-
Fenwick PS, Macedo P, Kilty IC, Barnes PJ, Donnelly LE. Effect of JAK inhibitors on release of CXCL9, CXCL10 and CXCL11 from human airway epithelial cells. PLoS One 2015;10:e0128757.
-
(2015)
PLoS One
, vol.10
, pp. e0128757
-
-
Fenwick, P.S.1
Macedo, P.2
Kilty, I.C.3
Barnes, P.J.4
Donnelly, L.E.5
-
28
-
-
85009755599
-
New inhaled jak inhibitor las194046 inhibits allergen-induced airway inflammation in brown Norway rats
-
Ramis I, Calama E, Domènech A, Carreño C, Calaf E, Cordoba M, Alberti J, De Alba J, Bach J, Prats N, et al. New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats. Eur Respir J 2014;44(Suppl 58):22.
-
(2014)
Eur Respir J
, vol.44
, pp. 22
-
-
Ramis, I.1
Calama, E.2
Domènech, A.3
Carreño, C.4
Calaf, E.5
Cordoba, M.6
Alberti, J.7
De Alba, J.8
Bach, J.9
Prats, N.10
-
29
-
-
84905459655
-
Getting Syk: Spleen tyrosine kinase as a therapeutic target
-
Geahlen RL. Getting Syk: spleen tyrosine kinase as a therapeutic target. Trends Pharmacol Sci 2014;35:414-422.
-
(2014)
Trends Pharmacol Sci
, vol.35
, pp. 414-422
-
-
Geahlen, R.L.1
-
30
-
-
84935896446
-
A novel inhaled syk inhibitor blocks mast cell degranulation and early asthmatic response
-
Ramis I, Otal R, Carreño C, Domènech A, Eichhorn P, Orellana A, Maldonado M, De Alba J, Prats N, Fernández JC, et al. A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response. Pharmacol Res 2015;99:116-124.
-
(2015)
Pharmacol Res
, vol.99
, pp. 116-124
-
-
Ramis, I.1
Otal, R.2
Carreño, C.3
Domènech, A.4
Eichhorn, P.5
Orellana, A.6
Maldonado, M.7
De Alba, J.8
Prats, N.9
Fernández, J.C.10
-
31
-
-
84989904460
-
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: A single-centre, randomised, double-blind, parallel-group, placebo-controlled trial
-
Gonem S, Berair R, Singapuri A, Hartley R, Laurencin MF, Bacher G, Holzhauer B, Bourne M, Mistry V, Pavord ID, et al. Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. Lancet Respir Med 2016;4: 699-707.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 699-707
-
-
Gonem, S.1
Berair, R.2
Singapuri, A.3
Hartley, R.4
Laurencin, M.F.5
Bacher, G.6
Holzhauer, B.7
Bourne, M.8
Mistry, V.9
Pavord, I.D.10
-
32
-
-
84979210470
-
The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma
-
Erpenbeck VJ, Popov TA, Miller D, Weinstein SF, Spector S, Magnusson B, Osuntokun W, Goldsmith P, Weiss M, Beier J. The oral CRTh2 antagonist QAW039 (fevipiprant): a phase II study in uncontrolled allergic asthma. Pulm Pharmacol Ther 2016; 39:54-63.
-
(2016)
Pulm Pharmacol Ther
, vol.39
, pp. 54-63
-
-
Erpenbeck, V.J.1
Popov, T.A.2
Miller, D.3
Weinstein, S.F.4
Spector, S.5
Magnusson, B.6
Osuntokun, W.7
Goldsmith, P.8
Weiss, M.9
Beier, J.10
-
33
-
-
84941584712
-
Targeting the interleukin pathway in the treatment of asthma
-
Chung KF. Targeting the interleukin pathway in the treatment of asthma. Lancet 2015;386:1086-1096.
-
(2015)
Lancet
, vol.386
, pp. 1086-1096
-
-
Chung, K.F.1
-
34
-
-
84964573673
-
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting b2 agonist: A randomised double-blind placebocontrolled pivotal phase 2b dose-ranging trial
-
Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, Pirozzi G, Sutherland ER, Evans RR, Joish VN, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting b2 agonist: a randomised double-blind placebocontrolled pivotal phase 2b dose-ranging trial. Lancet 2016;388: 31-44.
-
(2016)
Lancet
, vol.388
, pp. 31-44
-
-
Wenzel, S.1
Castro, M.2
Corren, J.3
Maspero, J.4
Wang, L.5
Zhang, B.6
Pirozzi, G.7
Sutherland, E.R.8
Evans, R.R.9
Joish, V.N.10
-
35
-
-
84941028441
-
Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes
-
Barnes PJ. Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes. J Allergy Clin Immunol 2015;136:531-545.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 531-545
-
-
Barnes, P.J.1
-
36
-
-
84929774279
-
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
-
Krug N, Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM, Kappeler D, Korn S, Ignatenko S, Timmer W, Rogon C, et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 2015;372:1987-1995.
-
(2015)
N Engl J Med
, vol.372
, pp. 1987-1995
-
-
Krug, N.1
Hohlfeld, J.M.2
Kirsten, A.M.3
Kornmann, O.4
Beeh, K.M.5
Kappeler, D.6
Korn, S.7
Ignatenko, S.8
Timmer, W.9
Rogon, C.10
-
37
-
-
84890026323
-
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
-
Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, Lin SL. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 2013; 188:1294-1302.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, pp. 1294-1302
-
-
Busse, W.W.1
Holgate, S.2
Kerwin, E.3
Chon, Y.4
Feng, J.5
Lin, J.6
Lin, S.L.7
-
38
-
-
84862519263
-
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: A randomized, placebo-controlled clinical trial
-
Nair P, Gaga M, Zervas E, Alagha K, Hargreave FE, O'Byrne PM, Stryszak P, Gann L, Sadeh J, Chanez P; Study Investigators. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy 2012;42: 1097-1103.
-
(2012)
Clin Exp Allergy
, vol.42
, pp. 1097-1103
-
-
Nair, P.1
Gaga, M.2
Zervas, E.3
Alagha, K.4
Hargreave, F.E.5
O'Byrne, P.M.6
Stryszak, P.7
Gann, L.8
Sadeh, J.9
Chanez, P.10
-
39
-
-
84928985245
-
CXCR2 antagonist MK-7123: A phase 2 proof-of-concept trial for chronic obstructive pulmonary disease
-
Rennard SI, Dale DC, Donohue JF, Kanniess F, Magnussen H, Sutherland ER, Watz H, Lu S, Stryszak P, Rosenberg E, et al. CXCR2 antagonist MK-7123: a phase 2 proof-of-concept trial for chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2015; 191:1001-1011.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. 1001-1011
-
-
Rennard, S.I.1
Dale, D.C.2
Donohue, J.F.3
Kanniess, F.4
Magnussen, H.5
Sutherland, E.R.6
Watz, H.7
Lu, S.8
Stryszak, P.9
Rosenberg, E.10
-
40
-
-
77951165310
-
SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects
-
Holz O, Khalilieh S, Ludwig-Sengpiel A, Watz H, Stryszak P, Soni P, Tsai M, Sadeh J, Magnussen H. SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J 2010;35:564-570.
-
(2010)
Eur Respir J
, vol.35
, pp. 564-570
-
-
Holz, O.1
Khalilieh, S.2
Ludwig-Sengpiel, A.3
Watz, H.4
Stryszak, P.5
Soni, P.6
Tsai, M.7
Sadeh, J.8
Magnussen, H.9
-
41
-
-
84890290253
-
Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist
-
Leaker BR, Barnes PJ, O'Connor B. Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist. Respir Res 2013;14:137.
-
(2013)
Respir Res
, vol.14
, pp. 137
-
-
Leaker, B.R.1
Barnes, P.J.2
O'Connor, B.3
-
42
-
-
84963864319
-
Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease
-
Lee S, Suh GY, Ryter SW, Choi AM. Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease. Am J Respir Cell Mol Biol 2016;54:151-160.
-
(2016)
Am J Respir Cell Mol Biol
, vol.54
, pp. 151-160
-
-
Lee, S.1
Suh, G.Y.2
Ryter, S.W.3
Choi, A.M.4
-
43
-
-
84924415042
-
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
-
Coll RC, Robertson AA, Chae JJ, Higgins SC, Munoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 2015;21: 248-255.
-
(2015)
Nat Med
, vol.21
, pp. 248-255
-
-
Coll, R.C.1
Robertson, A.A.2
Chae, J.J.3
Higgins, S.C.4
Munoz-Planillo, R.5
Inserra, M.C.6
Vetter, I.7
Dungan, L.S.8
Monks, B.G.9
Stutz, A.10
-
44
-
-
34547815598
-
Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in Guinea pigs
-
Churg A, Wang R, Wang X, Onnervik PO, Thim K, Wright JL. Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax 2007;62:706-713.
-
(2007)
Thorax
, vol.62
, pp. 706-713
-
-
Churg, A.1
Wang, R.2
Wang, X.3
Onnervik, P.O.4
Thim, K.5
Wright, J.L.6
-
45
-
-
84880079298
-
Oxidative stress in COPD
-
Kirkham PA, Barnes PJ. Oxidative stress in COPD. Chest 2013;144: 266-273.
-
(2013)
Chest
, vol.144
, pp. 266-273
-
-
Kirkham, P.A.1
Barnes, P.J.2
-
46
-
-
77956764327
-
Small-molecule inhibitors of NADPH oxidase 4
-
Borbély G, Szabadkai I, Horváth Z, Markó P, Varga Z, Breza N, Baska F, Vántus T, Huszár M, Geiszt M, et al. Small-molecule inhibitors of NADPH oxidase 4. J Med Chem 2010;53: 6758-6762.
-
(2010)
J Med Chem
, vol.53
, pp. 6758-6762
-
-
Borbély, G.1
Szabadkai, I.2
Horváth, Z.3
Markó, P.4
Varga, Z.5
Breza, N.6
Baska, F.7
Vántus, T.8
Huszár, M.9
Geiszt, M.10
-
47
-
-
84892368437
-
Antioxidants as therapies: Can we improve on nature?
-
Murphy MP. Antioxidants as therapies: can we improve on nature? Free Radic Biol Med 2014;66:20-23.
-
(2014)
Free Radic Biol Med
, vol.66
, pp. 20-23
-
-
Murphy, M.P.1
-
49
-
-
84925670869
-
Advances in allergen immunotherapy: Aiming for complete tolerance to allergens
-
Akdis CA, Akdis M. Advances in allergen immunotherapy: aiming for complete tolerance to allergens. Sci Transl Med 2015;7: 280ps6.
-
(2015)
Sci Transl Med
, vol.7
, pp. 280ps6
-
-
Akdis, C.A.1
Akdis, M.2
-
51
-
-
84857722564
-
Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease
-
Usmani OS, Barnes PJ. Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease. Ann Med 2012; 44:146-156.
-
(2012)
Ann Med
, vol.44
, pp. 146-156
-
-
Usmani, O.S.1
Barnes, P.J.2
-
52
-
-
84987757834
-
Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ delivery technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD
-
Fabbri LM, Kerwin EM, Spangenthal S, Ferguson GT, Rodriguez-Roisin R, Pearle J, Sethi S, Orevillo C, Darken P, St Rose E, et al. Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ delivery technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD. Respir Res 2016;17:109.
-
(2016)
Respir Res
, vol.17
, pp. 109
-
-
Fabbri, L.M.1
Kerwin, E.M.2
Spangenthal, S.3
Ferguson, G.T.4
Rodriguez-Roisin, R.5
Pearle, J.6
Sethi, S.7
Orevillo, C.8
Darken, P.9
St Rose, E.10
-
53
-
-
84875225940
-
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
-
Barnes PJ. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2013; 131:636-645.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 636-645
-
-
Barnes, P.J.1
-
54
-
-
84901921079
-
Pro-resolving lipid mediators are leads for resolution physiology
-
Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014;510:92-101.
-
(2014)
Nature
, vol.510
, pp. 92-101
-
-
Serhan, C.N.1
-
55
-
-
85002649098
-
Therapeutic approach to adult fibrotic lung diseases
-
Adegunsoye A, Strek ME. Therapeutic approach to adult fibrotic lung diseases. Chest 2016;150:1371-1386.
-
(2016)
Chest
, vol.150
, pp. 1371-1386
-
-
Adegunsoye, A.1
Strek, M.E.2
-
56
-
-
84975489208
-
Preclinical studies of mesenchymal stem cell (MSC) administration in chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis
-
Liu X, Fang Q, Kim H. Preclinical studies of mesenchymal stem cell (MSC) administration in chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis. PLoS One 2016;11: e0157099.
-
(2016)
PLoS One
, vol.11
, pp. e0157099
-
-
Liu, X.1
Fang, Q.2
Kim, H.3
-
57
-
-
84924006883
-
Mechanisms of development of multimorbidity in the elderly
-
Barnes PJ. Mechanisms of development of multimorbidity in the elderly. Eur Respir J 2015;45:790-806.
-
(2015)
Eur Respir J
, vol.45
, pp. 790-806
-
-
Barnes, P.J.1
-
58
-
-
85013098594
-
Senescence in COPD and its comorbidities
-
[online ahead of print] 9 Dec
-
Barnes PJ. Senescence in COPD and its comorbidities. Annu Rev Physiol [online ahead of print] 9 Dec 2016; DOI: 10.1146/annurevphysiol-022516-034314.
-
(2016)
Annu Rev Physiol
-
-
Barnes, P.J.1
-
59
-
-
84928999108
-
Barriers to new drug development in respiratory disease
-
Barnes PJ, Bonini S, Seeger W, Belvisi MG, Ward B, Holmes A. Barriers to new drug development in respiratory disease. Eur Respir J 2015; 45:1197-1207.
-
(2015)
Eur Respir J
, vol.45
, pp. 1197-1207
-
-
Barnes, P.J.1
Bonini, S.2
Seeger, W.3
Belvisi, M.G.4
Ward, B.5
Holmes, A.6
-
60
-
-
84958985825
-
Blood eosinophils and inhaled corticosteroid/long-acting b2 agonist efficacy in COPD
-
Pavord ID, Lettis S, Locantore N, Pascoe S, Jones PW, Wedzicha JA, Barnes NC. Blood eosinophils and inhaled corticosteroid/long-acting b2 agonist efficacy in COPD. Thorax 2016;71:118-125.
-
(2016)
Thorax
, vol.71
, pp. 118-125
-
-
Pavord, I.D.1
Lettis, S.2
Locantore, N.3
Pascoe, S.4
Jones, P.W.5
Wedzicha, J.A.6
Barnes, N.C.7
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