Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Zhang, Zi Teng ^a   Du, Xiu Ming ^a   Ma, Xiu Juan ^a   Zong, Ying ^a   Chen, Ji Kuai ^a   Yu, Chen Lin ^a   Liu, Yan Gang ^a   Chen, Yong Chun ^a   Zhao, Li Jun ^b   Lu, Guo Cai ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chronic fatigue syndrome; IL 1 ; LPS; NLRP3 inflammasome; NLRP3 knockout mice

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LACTIC ACID; LIPOPOLYSACCHARIDE; MALONALDEHYDE; NLRP3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; C57BL 6 MOUSE; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIENCEPHALON; ENZYME ACTIVATION; EXPERIMENTAL BEHAVIORAL TEST; FATIGUE; FEMALE; GENE ACTIVATION; GENE EXPRESSION; KNOCKOUT MOUSE; LACTATE BLOOD LEVEL; LOCOMOTION; MOUSE; MOUSE MODEL; NONHUMAN; PATHOGENESIS; PROTEIN BLOOD LEVEL; ROTAROD TEST; SWIM STRESS TEST; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PSYCHOLOGY; SWIMMING;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; FATIGUE; FATIGUE SYNDROME, CHRONIC; FEMALE; INFLAMMASOMES; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 84962199721     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0539-1     Document Type: Article

References (44)

1. Cleare AJ, Reid S, Chalder T, Hotopf M, Wessely S. Chronic fatigue syndrome. BMJ Clin Evid. 2015;2015.
2. van't Leven M, Zielhuis GA, van der Meer JW, Verbeek AL, Bleijenberg G. Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Pub Health. 2010;20(3):251-7. doi: 10.1093/eurpub/ckp113.
3. Theoharides TC. Atopic conditions in search of pathogenesis and therapy. Clin Ther. 2013;35(5):544-7. doi: 10.1016/j.clinthera.2013.04.002.
4. Martinez-Martinez LA, Mora T, Vargas A, Fuentes-Iniestra M, Martinez-Lavin M. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies. J Clin Rheumatol. 2014;20(3):146-50. doi: 10.1097/rhu.0000000000000089.
5. Abbi B, Natelson BH. Is chronic fatigue syndrome the same illness as fibromyalgia: evaluating the 'single syndrome' hypothesis. QJM. 2013;106(1):3-9. doi: 10.1093/qjmed/hcs156.
6. Faro M, Saez-Francas N, Castro-Marrero J, Aliste L, Fernandez de Sevilla T, Alegre J. Gender differences in chronic fatigue syndrome. Reumatol Clin. 2015. doi: 10.1016/j.reuma.2015.05.007.
7. Ousman SS, Kubes P. Immune surveillance in the central nervous system. Nat Neurosci. 2012;15(8):1096-101. doi: 10.1038/nn.3161.
8. Romano GF, Tomassi S, Russell A, Mondelli V, Pariante CM. Fibromyalgia and chronic fatigue: the underlying biology and related theoretical issues. Adv Psychosom Med. 2015;34:61-77. doi: 10.1159/000369085.
9. Vasiadi M, Newman J, Theoharides TC. Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators-relevance to chronic fatigue syndrome. J Neuroinflammation. 2014;11:168. doi: 10.1186/s12974-014-0168-5.
10. Ifuku M, Hossain SM, Noda M, Katafuchi T. Induction of interleukin-1beta by activated microglia is a prerequisite for immunologically induced fatigue. Eur J Neurosci. 2014;40(8):3253-63. doi: 10.1111/ejn.12668.
11. Gur A, Oktayoglu P. Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment. Curr Pharm Des. 2008;14(13):1274-94.
12. Tomas C, Newton J, Watson S. A review of hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome. ISRN Neurosci. 2013;2013:784520. doi: 10.1155/2013/784520.
13. Aschbacher K, Adam EK, Crofford LJ, Kemeny ME, Demitrack MA, Ben-Zvi A. Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study. Brain Behav Immun. 2012;26(7):1047-56. doi: 10.1016/j.bbi.2012.06.002.
14. Cleare AJ, Miell J, Heap E, Sookdeo S, Young L, Malhi GS, et al. Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy. J Clin Endocrinol Metab. 2001;86(8):3545-54. doi: 10.1210/jcem.86.8.7735.
15. Diao L, Marshall AH, Dai X, Bogdanovic E, Abdullahi A, Amini-Nik S, et al. Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1alpha in liver. Shock. 2014;41(2):138-44. doi: 10.1097/shk.0000000000000075.
16. Kim HK, Chen W, Andreazza AC. The potential role of the NLRP3 inflammasome as a link between mitochondrial complex I dysfunction and inflammation in bipolar disorder. Neural Plast. 2015;2015:408136. doi: 10.1155/2015/408136.
17. Morris G, Maes M. Oxidative and nitrosative stress and immune-inflammatory pathways in patients with myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). Curr Neuropharmacol. 2014;12(2):168-85. doi: 10.2174/1570159x11666131120224653.
18. Rajeevan MS, Dimulescu I, Murray J, Falkenberg VR, Unger ER. Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome. Hum Immunol. 2015;76(8):553-60. doi: 10.1016/j.humimm.2015.06.014.
19. Cordero MD, Alcocer-Gomez E, Culic O, Carrion AM, de Miguel M, Diaz-Parrado E, et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014;20(8):1169-80. doi: 10.1089/ars.2013.5198.
20. Gupta A, Vij G, Chopra K. Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract. J Neuroimmunol. 2010;226(1-2):3-7. doi: 10.1016/j.jneuroim.2010.05.021.
21. Martin SA, Pence BD, Greene RM, Johnson SJ, Dantzer R, Kelley KW, et al. Effects of voluntary wheel running on LPS-induced sickness behavior in aged mice. Brain Behav Immun. 2013;29:113-23. doi: 10.1016/j.bbi.2012.12.014.
22. Huai W, Zhao R, Song H, Zhao J, Zhang L, Zhang L, et al. Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription. Nat Commun. 2014;5:4738. doi: 10.1038/ncomms5738.
23. Katafuchi T, Kondo T, Yasaka T, Kubo K, Take S, Yoshimura M. Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue. Neuroscience. 2003;120(3):837-45.
24. Fischer DB, William AH, Strauss AC, Unger ER, Jason L, Marshall Jr GD, et al. Chronic fatigue syndrome: the current status and future potentials of emerging biomarkers. Fatigue. 2014;2(2):93-109. doi: 10.1080/21641846.2014.906066.
25. Weiland TJ, Anthony-Harvey-Beavis D, Voudouris NJ, Kent S. Metabotropic glutamate receptors mediate lipopolysaccharide-induced fever and sickness behavior. Brain Behav Immun. 2006;20(3):233-45. doi: 10.1016/j.bbi.2005.08.007.
26. Weiland TJ, Voudouris NJ, Kent S. CCK(2) receptor nullification attenuates lipopolysaccharide-induced sickness behavior. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R112-23. doi: 10.1152/ajpregu.00156.2006.
27. Gupta A, Vij G, Sharma S, Tirkey N, Rishi P, Chopra K. Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model. Immunobiology. 2009;214(1):33-9. doi: 10.1016/j.imbio.2008.04.003.
28. Smith ME, Haney E, McDonagh M, Pappas M, Daeges M, Wasson N, et al. Treatment of myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med. 2015;162(12):841-50. doi: 10.7326/m15-0114.
29. Blundell S, Ray KK, Buckland M, White PD. Chronic fatigue syndrome and circulating cytokines: a systematic review. Brain Behav Immun. 2015. doi: 10.1016/j.bbi.2015.07.004.
30. Cairns SP. Lactic acid and exercise performance: culprit or friend? Sports Med. 2006;36(4):279-91.
31. Kim NH, Moon PD, Pak SC, Kim HM, Jeong HJ. Anti-fatigue effect of Zizania caudiflora (Turczaninow) Nakai. Am J Chin Med. 2012;40(1):111-20. doi: 10.1142/s0192415x12500097.
32. Sheng R, Xu X, Tang Q, Bian D, Li Y, Qian C, et al. Polysaccharide of radix pseudostellariae improves chronic fatigue syndrome induced by poly I:C in mice. Evid Based Complement Alternat Med. 2011;2011:840516. doi: 10.1093/ecam/nep208.
33. Vij G, Gupta A, Chopra K. Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant. Fundam Clin Pharmacol. 2009;23(3):331-7. doi: 10.1111/j.1472-8206.2009.00675.x.
34. Wada J, Makino H. Innate immunity in diabetes and diabetic nephropathy. Nat Rev Nephrol. 2016;12(1):13-26. doi: 10.1038/nrneph.2015.175.
35. Jo EK, Kim JK, Shin DM, Sasakawa C. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2015. doi: 10.1038/cmi.2015.95.
36. Alcocer-Gomez E, Ulecia-Moron C, Marin-Aguilar F, Rybkina T, Casas-Barquero N, Ruiz-Cabello J et al. Stress-induced depressive behaviors require a functional NLRP3 inflammasome. Mol Neurobiol. 2015. doi: 10.1007/s12035-015-9408-7.
37. Nomura J, So A, Tamura M, Busso N. Intracellular ATP decrease mediates NLRP3 inflammasome activation upon nigericin and crystal stimulation. J Immunol. 2015;195(12):5718-24. doi: 10.4049/jimmunol.1402512.
38. Kummerle-Deschner JB. Cryopyrin-associated periodic syndrome. Z Rheumatol. 2012;71(3):199-208. doi: 10.1007/s00393-011-0856-9.
39. Roerink ME, Knoop H, Bredie SJ, Heijnen M, Joosten LA, Netea MG, et al. Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial. Trials. 2015;16(1):439. doi: 10.1186/s13063-015-0971-z.
40. Bonsall DR, Kim H, Tocci C, Ndiaye A, Petronzio A, McKay-Corkum G, et al. Suppression of locomotor activity in female C57Bl/6J mice treated with interleukin-1beta: investigating a method for the study of fatigue in laboratory animals. PLoS One. 2015;10(10):e0140678. doi: 10.1371/journal.pone.0140678.
41. Lavieri R, Rubartelli A, Carta S. Redox stress unbalances the inflammatory cytokine network: role in autoinflammatory patients and healthy subjects. J Leukoc Biol. 2015. doi: 10.1189/jlb.3MR0415-159R.
42. Liu SB, Mi WL, Wang YQ. Research progress on the NLRP3 inflammasome and its role in the central nervous system. Neurosci Bull. 2013;29(6):779-87. doi: 10.1007/s12264-013-1328-9.
43. Hanstein R, Negoro H, Patel NK, Charollais A, Meda P, Spray DC, et al. Promises and pitfalls of a pannexin1 transgenic mouse line. Front Pharmacol. 2013;4:61. doi: 10.3389/fphar.2013.00061.
44. MacVicar BA, Thompson RJ. Non-junction functions of pannexin-1 channels. Trends Neurosci. 2010;33(2):93-102. doi: 10.1016/j.tins.2009.11.007.