-
1
-
-
84864258996
-
A landscape of driver mutations in melanoma
-
Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, et al. A landscape of driver mutations in melanoma. Cell. 2012; 150:251-63.
-
(2012)
Cell
, vol.150
, pp. 251-263
-
-
Hodis, E.1
Watson, I.R.2
Kryukov, G.V.3
Arold, S.T.4
Imielinski, M.5
Theurillat, J.P.6
Nickerson, E.7
Auclair, D.8
Li, L.9
Place, C.10
Dicara, D.11
Ramos, A.H.12
Lawrence, M.S.13
-
2
-
-
84935009372
-
Genomic Classification of Cutaneous Melanoma
-
Cancer Genome Atlas Network. Genomic Classification of Cutaneous Melanoma. Cell. 2015; 161:1681-96.
-
(2015)
Cell
, vol.161
, pp. 1681-1696
-
-
-
3
-
-
84892403060
-
Major therapeutic developments and current challenges in advanced melanoma
-
Sullivan RJ, Flaherty KT. Major therapeutic developments and current challenges in advanced melanoma. Br J Dermatol. 2014; 170:36-44.
-
(2014)
Br J Dermatol
, vol.170
, pp. 36-44
-
-
Sullivan, R.J.1
Flaherty, K.T.2
-
4
-
-
84894041494
-
The role of MEK inhibitors in the treatment of metastatic melanoma
-
Grimaldi AM, Simeone E, Ascierto PA. The role of MEK inhibitors in the treatment of metastatic melanoma. Curr Opin Oncol. 2014; 26:196-203.
-
(2014)
Curr Opin Oncol
, vol.26
, pp. 196-203
-
-
Grimaldi, A.M.1
Simeone, E.2
Ascierto, P.A.3
-
5
-
-
84923341318
-
Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma
-
Long GV, Fung C, Menzies AM, Pupo GM, Carlino MS, Hyman J, Shahheydari H, Tembe V, Thompson JF, Saw RP, Howle J, Hayward NK, Johansson P, et al. Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma. Nat Commun. 2014; 5:5694.
-
(2014)
Nat Commun
, vol.5
, pp. 5694
-
-
Long, G.V.1
Fung, C.2
Menzies, A.M.3
Pupo, G.M.4
Carlino, M.S.5
Hyman, J.6
Shahheydari, H.7
Tembe, V.8
Thompson, J.F.9
Saw, R.P.10
Howle, J.11
Hayward, N.K.12
Johansson, P.13
-
6
-
-
84891894051
-
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
-
Van Allen EM1, Wagle N, Sucker A, Treacy DJ, Johannessen CM, Goetz EM, Place CS, Taylor-Weiner A, Whittaker S, Kryukov GV, Hodis E, Rosenberg M, McKenna A, et al. The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov. 2014; 4:94-109.
-
(2014)
Cancer Discov
, vol.4
, pp. 94-109
-
-
Van Allen, E.M.1
Wagle, N.2
Sucker, A.3
Treacy, D.J.4
Johannessen, C.M.5
Goetz, E.M.6
Place, C.S.7
Taylor-Weiner, A.8
Whittaker, S.9
Kryukov, G.V.10
Hodis, E.11
Rosenberg, M.12
McKenna, A.13
-
7
-
-
84941350733
-
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance
-
Hugo W, Shi H1, Sun L, Piva M, Song C, Kong X, Moriceau G, Hong A, Dahlman KB, Johnson DB, Sosman JA, Ribas A, Lo RS. Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance. Cell. 2015; 162:1271-85.
-
(2015)
Cell
, vol.162
, pp. 1271-1285
-
-
Hugo, W.1
Shi, H.2
Sun, L.3
Piva, M.4
Song, C.5
Kong, X.6
Moriceau, G.7
Hong, A.8
Dahlman, K.B.9
Johnson, D.B.10
Sosman, J.A.11
Ribas, A.12
Lo, R.S.13
-
8
-
-
84904070924
-
A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors
-
Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, Fisher DE, Mesirov JP, Hahn WC, et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 2014; 4:816-27.
-
(2014)
Cancer Discov
, vol.4
, pp. 816-827
-
-
Konieczkowski, D.J.1
Johannessen, C.M.2
Abudayyeh, O.3
Kim, J.W.4
Cooper, Z.A.5
Piris, A.6
Frederick, D.T.7
Barzily-Rokni, M.8
Straussman, R.9
Haq, R.10
Fisher, D.E.11
Mesirov, J.P.12
Hahn, W.C.13
-
9
-
-
84874354257
-
The implications of clonal genome evolution for cancer medicine
-
Aparicio S, Caldas C. The implications of clonal genome evolution for cancer medicine. N Engl J Med. 2013; 368:842-851.
-
(2013)
N Engl J Med
, vol.368
, pp. 842-851
-
-
Aparicio, S.1
Caldas, C.2
-
10
-
-
79960662814
-
Expression cartography of human tissues using self organizing maps
-
Wirth H, Loeffler M, von Bergen M, Binder H. Expression cartography of human tissues using self organizing maps. BMC Bioinformatics. 2011; 12, 306.
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 306
-
-
Wirth, H.1
Loeffler, M.2
von Bergen, M.3
Binder, H.4
-
11
-
-
84943388769
-
oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on bioconductor
-
Löffler-Wirth H, Kalcher M, Binder H. oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on bioconductor. Bioinformatics. 2015; 31:3225-3227.
-
(2015)
Bioinformatics
, vol.31
, pp. 3225-3227
-
-
Löffler-Wirth, H.1
Kalcher, M.2
Binder, H.3
-
12
-
-
84901354658
-
Portraying the Expression Landscapes of B-Cell Lymphoma-Intuitive Detection of Outlier Samples and of Molecular Subtypes
-
Hopp L, Lembcke K, Binder H, Wirth H. Portraying the Expression Landscapes of B-Cell Lymphoma-Intuitive Detection of Outlier Samples and of Molecular Subtypes. Biology. 2013; 2:1411-1437.
-
(2013)
Biology
, vol.2
, pp. 1411-1437
-
-
Hopp, L.1
Lembcke, K.2
Binder, H.3
Wirth, H.4
-
13
-
-
84916217121
-
Portraying the expression landscapes of cancer subtypes: A glioblastoma multiforme and prostate cancer case study
-
Hopp L, Wirth H, Fasold M, Binder H. Portraying the expression landscapes of cancer subtypes: A glioblastoma multiforme and prostate cancer case study. Systems Biomedicine. 2013; 1:99-121.
-
(2013)
Systems Biomedicine
, vol.1
, pp. 99-121
-
-
Hopp, L.1
Wirth, H.2
Fasold, M.3
Binder, H.4
-
14
-
-
0035985177
-
Identification of genes periodically expressed in the human cell cycle and their expression in tumors
-
Whitfield ML1, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, Matese JC, Perou CM, Hurt MM, Brown PO, Botstein D. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell. 2002; 13:1977-2000.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1977-2000
-
-
Whitfield, M.L.1
Sherlock, G.2
Saldanha, A.J.3
Murray, J.I.4
Ball, C.A.5
Alexander, K.E.6
Matese, J.C.7
Perou, C.M.8
Hurt, M.M.9
Brown, P.O.10
Botstein, D.11
-
15
-
-
84963614956
-
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
-
Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016; 352:189-96.
-
(2016)
Science
, vol.352
, pp. 189-196
-
-
Tirosh, I.1
Izar, B.2
Prakadan, S.M.3
Wadsworth, M.H.4
Treacy, D.5
Trombetta, J.J.6
Rotem, A.7
Rodman, C.8
Lian, C.9
Murphy, G.10
Fallahi-Sichani, M.11
Dutton-Regester, K.12
Lin, J.R.13
-
16
-
-
77954234849
-
Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome
-
Jönsson G, Busch C, Knappskog S, Geisler J, Miletic H, Ringnér M, Lillehaug JR, Borg A, Lønning PE. Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res. 2010; 16:3356-67.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3356-3367
-
-
Jönsson, G.1
Busch, C.2
Knappskog, S.3
Geisler, J.4
Miletic, H.5
Ringnér, M.6
Lillehaug, J.R.7
Borg, A.8
Lønning, P.E.9
-
17
-
-
84864443974
-
Molecular profiling reveals low-and high-grade forms of primary melanoma
-
Harbst K, Staaf J, Lauss M, Karlsson A, Måsbäck A, Johansson I, Bendahl PO, Vallon-Christersson J, Törngren T, Ekedahl H, Geisler J, Höglund M, Ringnér M, et al. Molecular profiling reveals low-and high-grade forms of primary melanoma. Clin Cancer Res. 2012; 18:4026-36.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4026-4036
-
-
Harbst, K.1
Staaf, J.2
Lauss, M.3
Karlsson, A.4
Måsbäck, A.5
Johansson, I.6
Bendahl, P.O.7
Vallon-Christersson, J.8
Törngren, T.9
Ekedahl, H.10
Geisler, J.11
Höglund, M.12
Ringnér, M.13
-
18
-
-
33645739022
-
Gene expression profiling of primary cutaneous melanoma and clinical outcome
-
Winnepenninckx V, Lazar V, Michiels S, Dessen P, Stas M, Alonso SR, Avril MF, Ortiz Romero PL, Robert T, Balacescu O, Eggermont AM, Lenoir G, Sarasin A, et al. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst. 2006; 98:472-82.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 472-482
-
-
Winnepenninckx, V.1
Lazar, V.2
Michiels, S.3
Dessen, P.4
Stas, M.5
Alonso, S.R.6
Avril, M.F.7
Ortiz Romero, P.L.8
Robert, T.9
Balacescu, O.10
Eggermont, A.M.11
Lenoir, G.12
Sarasin, A.13
-
19
-
-
38549169936
-
High expression of DNA repair pathways is associated with metastasis in melanoma patients
-
Kauffmann A1, Rosselli F, Lazar V, Winnepenninckx V, Mansuet-Lupo A, Dessen P, van den Oord JJ, Spatz A, Sarasin A. High expression of DNA repair pathways is associated with metastasis in melanoma patients. Oncogene. 2008; 27:565-73.
-
(2008)
Oncogene
, vol.27
, pp. 565-573
-
-
Kauffmann, A.1
Rosselli, F.2
Lazar, V.3
Winnepenninckx, V.4
Mansuet-Lupo, A.5
Dessen, P.6
van den Oord, J.J.7
Spatz, A.8
Sarasin, A.9
-
20
-
-
84920538713
-
Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma
-
Gerami P, Cook RW, Wilkinson J, Russell MC, Dhillon N, Amaria RN, Gonzalez R, Lyle S, Johnson CE, Oelschlager KM, Jackson GL, Greisinger AJ, Maetzold D, et al. Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma. Clin Cancer Res. 2015; 21:175-83.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 175-183
-
-
Gerami, P.1
Cook, R.W.2
Wilkinson, J.3
Russell, M.C.4
Dhillon, N.5
Amaria, R.N.6
Gonzalez, R.7
Lyle, S.8
Johnson, C.E.9
Oelschlager, K.M.10
Jackson, G.L.11
Greisinger, A.J.12
Maetzold, D.13
-
21
-
-
84885961193
-
Transcriptome Profiling Identifies HMGA2 as a Biomarker of Melanoma Progression and Prognosis
-
Raskin L, Fullen DR, Giordano TJ, Thomas DG, Frohm ML, Cha KB, Ahn J, Mukherjee B, Johnson TM, Gruber SB. Transcriptome Profiling Identifies HMGA2 as a Biomarker of Melanoma Progression and Prognosis. J Invest Dermatol. 2013; 133:2585-92.
-
(2013)
J Invest Dermatol
, vol.133
, pp. 2585-2592
-
-
Raskin, L.1
Fullen, D.R.2
Giordano, T.J.3
Thomas, D.G.4
Frohm, M.L.5
Cha, K.B.6
Ahn, J.7
Mukherjee, B.8
Johnson, T.M.9
Gruber, S.B.10
-
22
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002; 298:1912-34.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
23
-
-
84891512646
-
Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking
-
Lee N, Barthel SR, Schatton T. Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking. Lab Invest. 2014; 94:13-30.
-
(2014)
Lab Invest
, vol.94
, pp. 13-30
-
-
Lee, N.1
Barthel, S.R.2
Schatton, T.3
-
24
-
-
84866671365
-
ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets
-
Luo Y, Dallaglio K, Chen Y, Robinson WA, Robinson SE, McCarter MD, Wang J, Gonzalez R, Thompson DC, Norris DA, Roop DR, Vasiliou V, Fujita M. ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells. 2012; 30:2100-13.
-
(2012)
Stem Cells
, vol.30
, pp. 2100-2113
-
-
Luo, Y.1
Dallaglio, K.2
Chen, Y.3
Robinson, W.A.4
Robinson, S.E.5
McCarter, M.D.6
Wang, J.7
Gonzalez, R.8
Thompson, D.C.9
Norris, D.A.10
Roop, D.R.11
Vasiliou, V.12
Fujita, M.13
-
25
-
-
84970988732
-
ABC Transporters, Aldehyde Dehydrogenase, and Adult Stem Cells
-
Phinney DG, editor. Berlin, Heildelberg, Germany: Springer Humana Press
-
Guppy N, Nicholson L, Alison M: ABC Transporters, Aldehyde Dehydrogenase, and Adult Stem Cells. In: Phinney DG, editor. Adult Stem Cells. Berlin, Heildelberg, Germany: Springer Humana Press. 2011:181-199.
-
(2011)
Adult Stem Cells
, pp. 181-199
-
-
Guppy, N.1
Nicholson, L.2
Alison, M.3
-
26
-
-
84893194759
-
KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation
-
Kidder BL, Hu G, Zhao K. KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation. Genome Biol. 2014; 15:R32.
-
(2014)
Genome Biol
, vol.15
, pp. R32
-
-
Kidder, B.L.1
Hu, G.2
Zhao, K.3
-
27
-
-
85001089216
-
Function Shapes Content: DNA-Methylation Marker Genes and their Impact for Molecular Mechanisms of Glioma
-
Hopp L, Willscher E, Wirth-Loeffler H, Binder H. Function Shapes Content: DNA-Methylation Marker Genes and their Impact for Molecular Mechanisms of Glioma. Journal Can Res Updates. 2015; 4:127-148.
-
(2015)
Journal Can Res Updates
, vol.4
, pp. 127-148
-
-
Hopp, L.1
Willscher, E.2
Wirth-Loeffler, H.3
Binder, H.4
-
28
-
-
84944902293
-
Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers
-
Hopp L, Nersisyan L, Löffler-Wirth H, Arakelyan A, Binder H. Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers. Genes (Basel). 2015; 6:1076-112.
-
(2015)
Genes (Basel)
, vol.6
, pp. 1076-1112
-
-
Hopp, L.1
Nersisyan, L.2
Löffler-Wirth, H.3
Arakelyan, A.4
Binder, H.5
-
29
-
-
77952502408
-
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
-
Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, Basu D, Gimotty P, Vogt T, Herlyn M, et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell. 2010; 141:583-94.
-
(2010)
Cell
, vol.141
, pp. 583-594
-
-
Roesch, A.1
Fukunaga-Kalabis, M.2
Schmidt, E.C.3
Zabierowski, S.E.4
Brafford, P.A.5
Vultur, A.6
Basu, D.7
Gimotty, P.8
Vogt, T.9
Herlyn, M.10
-
30
-
-
84884846749
-
The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis
-
Wouters J1, Stas M, Gremeaux L, Govaere O, Van den Broeck A, Maes H, Agostinis P, Roskams T, van den Oord JJ, Vankelecom H. The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis. PLoS One. 2013; 8:e76550.
-
(2013)
PLoS One
, vol.8
-
-
Wouters, J.1
Stas, M.2
Gremeaux, L.3
Govaere, O.4
Van den Broeck, A.5
Maes, H.6
Agostinis, P.7
Roskams, T.8
van den Oord, J.J.9
Vankelecom, H.10
-
31
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath I1, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 2008; 40:499-507.
-
(2008)
Nat Genet
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
Thomson, M.W.2
Carey, V.J.3
Ge, R.4
Bell, G.W.5
Regev, A.6
Weinberg, R.A.7
-
32
-
-
49649125042
-
Genome-scale DNA methylation maps of pluripotent and differentiated cells
-
Meissner A1, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 2008; 454:766-770.
-
(2008)
Nature
, vol.454
, pp. 766-770
-
-
Meissner, A.1
Mikkelsen, T.S.2
Gu, H.3
Wernig, M.4
Hanna, J.5
Sivachenko, A.6
Zhang, X.7
Bernstein, B.E.8
Nusbaum, C.9
Jaffe, D.B.10
Gnirke, A.11
Jaenisch, R.12
Lander, E.S.13
-
33
-
-
79958724665
-
RNA sequencing reveals two major classes of gene expression levels in metazoan cells
-
Hebenstreit D, Fang M, Gu M, Charoensawan V, van Oudenaarden A, Teichmann SA. RNA sequencing reveals two major classes of gene expression levels in metazoan cells. Mol Syst Biol. 2011; 7.
-
(2011)
Mol Syst Biol
, pp. 7
-
-
Hebenstreit, D.1
Fang, M.2
Gu, M.3
Charoensawan, V.4
van Oudenaarden, A.5
Teichmann, S.A.6
-
34
-
-
84923362619
-
Integrative analysis of 111 reference human epigenomes
-
Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, et al. Integrative analysis of 111 reference human epigenomes. Nature. 2015; 518:317-30.
-
(2015)
Nature
, vol.518
, pp. 317-330
-
-
Kundaje, A.1
Meuleman, W.2
Ernst, J.3
Bilenky, M.4
Yen, A.5
Heravi-Moussavi, A.6
Kheradpour, P.7
Zhang, Z.8
Wang, J.9
Ziller, M.J.10
Amin, V.11
Whitaker, J.W.12
-
36
-
-
84875537133
-
Epigenetic reprogramming in cancer
-
Suvà ML, Riggi N, Bernstein BE. Epigenetic reprogramming in cancer. Science. 2013; 339:1567-70
-
(2013)
Science
, vol.339
, pp. 1567-1570
-
-
Suvà, M.L.1
Riggi, N.2
Bernstein, B.E.3
-
37
-
-
84964240053
-
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
-
McGranahan N, Swanton C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell. 2015; 27:15-26.
-
(2015)
Cancer Cell
, vol.27
, pp. 15-26
-
-
McGranahan, N.1
Swanton, C.2
-
38
-
-
84902668801
-
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
-
Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014; 344:1396-401.
-
(2014)
Science
, vol.344
, pp. 1396-1401
-
-
Patel, A.P.1
Tirosh, I.2
Trombetta, J.J.3
Shalek, A.K.4
Gillespie, S.M.5
Wakimoto, H.6
Cahill, D.P.7
Nahed, B.V.8
Curry, W.T.9
Martuza, R.L.10
Louis, D.N.11
Rozenblatt-Rosen, O.12
Suvà, M.L.13
-
39
-
-
84920876120
-
Genetic and functional diversity of propagating cells in glioblastoma
-
Piccirillo SG, Colman S, Potter NE, van Delft FW, Lillis S, Carnicer MJ, Kearney L, Watts C, Greaves M. Genetic and functional diversity of propagating cells in glioblastoma. Stem Cell Reports. 2015; 4:7-15.
-
(2015)
Stem Cell Reports
, vol.4
, pp. 7-15
-
-
Piccirillo, S.G.1
Colman, S.2
Potter, N.E.3
van Delft, F.W.4
Lillis, S.5
Carnicer, M.J.6
Kearney, L.7
Watts, C.8
Greaves, M.9
-
40
-
-
84943143136
-
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
-
Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015; 526:131-5.
-
(2015)
Nature
, vol.526
, pp. 131-135
-
-
Lawson, D.A.1
Bhakta, N.R.2
Kessenbrock, K.3
Prummel, K.D.4
Yu, Y.5
Takai, K.6
Zhou, A.7
Eyob, H.8
Balakrishnan, S.9
Wang, C.Y.10
Yaswen, P.11
Goga, A.12
Werb, Z.13
-
41
-
-
84905447834
-
EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing
-
Francis JM, Zhang CZ, Maire CL, Jung J, Manzo VE, Adalsteinsson VA, Homer H, Haidar S, Blumenstiel B, Pedamallu CS, Ligon AH, Love JC, Meyerson M, et al. EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing. Cancer Discov. 2014; 4:956-71.
-
(2014)
Cancer Discov
, vol.4
, pp. 956-971
-
-
Francis, J.M.1
Zhang, C.Z.2
Maire, C.L.3
Jung, J.4
Manzo, V.E.5
Adalsteinsson, V.A.6
Homer, H.7
Haidar, S.8
Blumenstiel, B.9
Pedamallu, C.S.10
Ligon, A.H.11
Love, J.C.12
Meyerson, M.13
-
42
-
-
84939202318
-
Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment
-
Suzuki A, Matsushima K, Makinoshima H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y. Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment. Genome Biol. 2015; 16:66.
-
(2015)
Genome Biol
, vol.16
, pp. 66
-
-
Suzuki, A.1
Matsushima, K.2
Makinoshima, H.3
Sugano, S.4
Kohno, T.5
Tsuchihara, K.6
Suzuki, Y.7
-
43
-
-
84941950930
-
Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment
-
VanArsdale T, BoshoffC, Arndt KT, Abraham RT. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015; 21:2905-10.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 2905-2910
-
-
VanArsdale, T.1
Boshoff, C.2
Arndt, K.T.3
Abraham, R.T.4
-
45
-
-
84937512066
-
Palbociclib: first global approval
-
Dhillon S. Palbociclib: first global approval. Drugs. 2015; 75:543-51.
-
(2015)
Drugs
, vol.75
, pp. 543-551
-
-
Dhillon, S.1
-
46
-
-
84931562619
-
Single-cell gene expression signatures reveal melanoma cell heterogeneity
-
Ennen M, Keime C, Kobi D, Mengus G, Lipsker D, Thibault-Carpentier C, Davidson I. Single-cell gene expression signatures reveal melanoma cell heterogeneity. Oncogene. 2015; 34:3251-63.
-
(2015)
Oncogene
, vol.34
, pp. 3251-3263
-
-
Ennen, M.1
Keime, C.2
Kobi, D.3
Mengus, G.4
Lipsker, D.5
Thibault-Carpentier, C.6
Davidson, I.7
-
47
-
-
84923248130
-
A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms
-
Cojoc M, Mäbert K, Muders MH, Dubrovska A. A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Semin Cancer Biol. 2015; 31:16-27.
-
(2015)
Semin Cancer Biol
, vol.31
, pp. 16-27
-
-
Cojoc, M.1
Mäbert, K.2
Muders, M.H.3
Dubrovska, A.4
-
48
-
-
78349252704
-
Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance
-
Moore N, Lyle S. Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J Oncol. 2011; 2011.
-
(2011)
J Oncol
, pp. 2011
-
-
Moore, N.1
Lyle, S.2
-
49
-
-
37349120730
-
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis
-
Ugurel S, Thirumaran RK, Bloethner S, Gast A, Sucker A, Mueller-Berghaus J, Rittgen W, Hemminki K, Becker JC, Kumar R, Schadendorf D. B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. PLoS One. 2007; 2:e236.
-
(2007)
PLoS One
, vol.2
-
-
Ugurel, S.1
Thirumaran, R.K.2
Bloethner, S.3
Gast, A.4
Sucker, A.5
Mueller-Berghaus, J.6
Rittgen, W.7
Hemminki, K.8
Becker, J.C.9
Kumar, R.10
Schadendorf, D.11
-
50
-
-
84952674076
-
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
-
Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, Lewitus E, Sykes A, Hevers W, Lancaster M, Knoblich JA, Lachmann R, Pääbo S, et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci U S A. 2015; 112:15672-7.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 15672-15677
-
-
Camp, J.G.1
Badsha, F.2
Florio, M.3
Kanton, S.4
Gerber, T.5
Wilsch-Bräuninger, M.6
Lewitus, E.7
Sykes, A.8
Hevers, W.9
Lancaster, M.10
Knoblich, J.A.11
Lachmann, R.12
Pääbo, S.13
-
51
-
-
84886402148
-
freeIbis: An efficient basecaller with calibrated quality scores for Illumina sequencers
-
Renaud G, Kircher M, Stenzel U, Kelso J. freeIbis: An efficient basecaller with calibrated quality scores for Illumina sequencers. Bioinformatics. 2013; 29:1208-9.
-
(2013)
Bioinformatics
, vol.29
, pp. 1208-1209
-
-
Renaud, G.1
Kircher, M.2
Stenzel, U.3
Kelso, J.4
-
52
-
-
84929008489
-
deML: Robust demultiplexing of Illumina sequences using a likelihood-based approach
-
Renaud G, Stenzel U, Maricic T, Wiebe V, Kelso J. deML: Robust demultiplexing of Illumina sequences using a likelihood-based approach. Bioinformatics. 2015; 31:770-772.
-
(2015)
Bioinformatics
, vol.31
, pp. 770-772
-
-
Renaud, G.1
Stenzel, U.2
Maricic, T.3
Wiebe, V.4
Kelso, J.5
-
53
-
-
84859210032
-
Fast gapped-read alignment with Bowtie 2
-
Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012; 9:357-59.
-
(2012)
Nat Methods
, vol.9
, pp. 357-359
-
-
Langmead, B.1
Salzberg, S.L.2
-
54
-
-
65449136284
-
TopHat: discovering splice junctions with RNA-Seq
-
Trapnell C, Pachter L, Salzberg S L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009; 25:1105-1111.
-
(2009)
Bioinformatics
, vol.25
, pp. 1105-1111
-
-
Trapnell, C.1
Pachter, L.2
Salzberg, S.L.3
-
55
-
-
77952123055
-
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
-
Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ, Pachter L. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010; 28:511-515.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 511-515
-
-
Trapnell, C.1
Williams, B.A.2
Pertea, G.3
Mortazavi, A.4
Kwan, G.5
van Baren, M.J.6
Salzberg, S.L.7
Wold, B.J.8
Pachter, L.9
-
56
-
-
84867095369
-
Mining SOM expression portraits: Feature selection and integrating concepts of molecular function
-
Wirth H, von Bergen M, Binder H. Mining SOM expression portraits: Feature selection and integrating concepts of molecular function. BioData Mining. 2012; 5:18.
-
(2012)
BioData Mining
, vol.5
, pp. 18
-
-
Wirth, H.1
von Bergen, M.2
Binder, H.3
-
57
-
-
70449392630
-
Robust extraction of functional signals from gene set analysis using a generalized threshold free scoring function
-
Toronen P, Ojala P, Marttinen P, Holm L. Robust extraction of functional signals from gene set analysis using a generalized threshold free scoring function. BMC Bioinformatics. 2009; 10: 307.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 307
-
-
Toronen, P.1
Ojala, P.2
Marttinen, P.3
Holm, L.4
-
58
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005; 102:15545-50.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
59
-
-
84929151009
-
Spatial reconstruction of single-cell gene expression data
-
Satija R, Farrell JA, Gennert D, Schier A, Regev A. Spatial reconstruction of single-cell gene expression data. Nat Biotechnology. 2015; 33 495-502.
-
(2015)
Nat Biotechnology
, vol.33
, pp. 495-502
-
-
Satija, R.1
Farrell, J.A.2
Gennert, D.3
Schier, A.4
Regev, A.5
-
60
-
-
57249084011
-
Visualizing Data using t-SNE
-
Van der Maaten L, Hinton J. Visualizing Data using t-SNE. JMLR. 2008; 9 2579-2605.
-
(2008)
JMLR
, vol.9
, pp. 2579-2605
-
-
Van der Maaten, L.1
Hinton, J.2
-
61
-
-
84931564704
-
Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1
-
Schmidt M, Gutknecht D, Simon JC, Schulz JN, Eckes B, Anderegg U, Saalbach A. Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1. Invest Dermatol. 2015; 135:1893-902.
-
(2015)
Invest Dermatol
, vol.135
, pp. 1893-1902
-
-
Schmidt, M.1
Gutknecht, D.2
Simon, J.C.3
Schulz, J.N.4
Eckes, B.5
Anderegg, U.6
Saalbach, A.7
-
62
-
-
39849096853
-
The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing
-
Nuytten M, Beke L, Van Eynde A, Ceulemans H, Beullens M, Van Hummelen P, Fuks F, Bollen M. The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing. Oncogene. 2008; 27:1449-60.
-
(2008)
Oncogene
, vol.27
, pp. 1449-1460
-
-
Nuytten, M.1
Beke, L.2
Van Eynde, A.3
Ceulemans, H.4
Beullens, M.5
Van Hummelen, P.6
Fuks, F.7
Bollen, M.8
-
63
-
-
57149089307
-
Lymphoma/Leukemia Molecular Profiling Project. Stromal gene signatures in large-B-cell lymphomas
-
Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, Fu K, et al. Lymphoma/Leukemia Molecular Profiling Project. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med. 2008; 359:2313-23.
-
(2008)
N Engl J Med
, vol.359
, pp. 2313-2323
-
-
Lenz, G.1
Wright, G.2
Dave, S.S.3
Xiao, W.4
Powell, J.5
Zhao, H.6
Xu, W.7
Tan, B.8
Goldschmidt, N.9
Iqbal, J.10
Vose, J.11
Bast, M.12
Fu, K.13
-
64
-
-
34248169728
-
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
-
Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol. 2007; 27:3769-79.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3769-3779
-
-
Pasini, D.1
Bracken, A.P.2
Hansen, J.B.3
Capillo, M.4
Helin, K.5
-
65
-
-
41449118521
-
Module map of stem cell genes guides creation of epithelial cancer stem cells
-
Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell. 2008; 2:333-44.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 333-344
-
-
Wong, D.J.1
Liu, H.2
Ridky, T.W.3
Cassarino, D.4
Segal, E.5
Chang, H.Y.6
-
66
-
-
77955895963
-
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
-
Lim E1, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 2010; 12:R21.
-
(2010)
Breast Cancer Res
, vol.12
, pp. R21
-
-
Lim, E.1
Wu, D.2
Pal, B.3
Bouras, T.4
Asselin-Labat, M.L.5
Vaillant, F.6
Yagita, H.7
Lindeman, G.J.8
Smyth, G.K.9
Visvader, J.E.10
-
67
-
-
84859823928
-
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices
-
M111.014647
-
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol Cell Proteomics. 2012; 11:M111.014647.
-
(2012)
Mol Cell Proteomics
, vol.11
-
-
Naba, A.1
Clauser, K.R.2
Hoersch, S.3
Liu, H.4
Carr, S.A.5
Hynes, R.O.6
-
68
-
-
24344465793
-
The BRG1-and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene
-
Wang L, Baiocchi RA, Pal S, Mosialos G, Caligiuri M, Sif S. The BRG1-and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene. Mol Cell Biol. 2005; 25:7953-65.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7953-7965
-
-
Wang, L.1
Baiocchi, R.A.2
Pal, S.3
Mosialos, G.4
Caligiuri, M.5
Sif, S.6
-
69
-
-
14844323978
-
Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB//CS allele or the noncancer-prone XPB//TTD allele
-
da Costa R M. A., Riou L, Paquola A, Menck CFM, Sarasin A. Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB//CS allele or the noncancer-prone XPB//TTD allele. Oncogene. 2004; 24:1359-1374.
-
(2004)
Oncogene
, vol.24
, pp. 1359-1374
-
-
da Costa, R.M.A.1
Riou, L.2
Paquola, A.3
Menck, C.F.M.4
Sarasin, A.5
-
70
-
-
33846594324
-
The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice
-
Liang Y, Jansen M, Aronow B, Geiger H, Van Zant G. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet. 2007; 39:178-188.
-
(2007)
Nat Genet
, vol.39
, pp. 178-188
-
-
Liang, Y.1
Jansen, M.2
Aronow, B.3
Geiger, H.4
Van Zant, G.5
-
71
-
-
56149086395
-
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
-
Wu Y, Siadaty MS, Berens ME, Hampton GM, Theodorescu D. Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene. 2008; 27:6679-6689.
-
(2008)
Oncogene
, vol.27
, pp. 6679-6689
-
-
Wu, Y.1
Siadaty, M.S.2
Berens, M.E.3
Hampton, G.M.4
Theodorescu, D.5
|