메뉴 건너뛰기




Volumn 26, Issue 2, 2014, Pages 196-203

The role of MEK inhibitors in the treatment of metastatic melanoma

Author keywords

BRAF; MAPK pathway; MEK inhibitors; Metastatic melanoma; NRAS

Indexed keywords

GTP PHOSPHOHYDROLASES; HUMANS; MAP KINASE KINASE 1; MELANOMA; MEMBRANE PROTEINS; MUTATION; NEOPLASM METASTASIS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRIDONES; PYRIMIDINONES; TREATMENT OUTCOME;

EID: 84894041494     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000050     Document Type: Review
Times cited : (42)

References (56)
  • 1
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001; 410:37-40
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 2
    • 0034807142 scopus 로고    scopus 로고
    • Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity
    • Liebmann C. Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity. Cell Signal 2001; 13:777-785
    • (2001) Cell Signal , vol.13 , pp. 777-785
    • Liebmann, C.1
  • 3
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005; 353:2135-2147
    • (2005) N Engl J Med , vol.353 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 4
    • 33644774541 scopus 로고    scopus 로고
    • Examination of mutations in braf, nras, and pten in primary cutaneous melanoma
    • Goel VK, Lazar AJ, Warneke CL, et al. Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J Invest Dermatol 2006; 126:154-160
    • (2006) J Invest Dermatol , vol.126 , pp. 154-160
    • Goel, V.K.1    Lazar, A.J.2    Warneke, C.L.3
  • 5
    • 84861490287 scopus 로고    scopus 로고
    • Aberrant b-raf signaling in human cancer-10 years from bench to bedside
    • Röring M, Brummer T. Aberrant B-Raf signaling in human cancer-10 years from bench to bedside. Crit Rev Oncog 2012; 17:97-121
    • (2012) Crit Rev Oncog , vol.17 , pp. 97-121
    • Röring, M.1    Brummer, T.2
  • 6
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the braf gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417:949-954
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 7
    • 42949149240 scopus 로고    scopus 로고
    • Discovery of a selective inhibitor of oncogenic braf kinase with potent antimelanoma activity
    • Tsai J, Lee JT, Wang W, et al. Discovery of a selective inhibitor of oncogenic BRaf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA 2008; 105:3041-3046
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3041-3046
    • Tsai, J.1    Lee, J.T.2    Wang, W.3
  • 8
    • 31144453233 scopus 로고    scopus 로고
    • Braf mutation predicts sensitivity to mek inhibition
    • Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006; 439:358-362
    • (2006) Nature , vol.439 , pp. 358-362
    • Solit, D.B.1    Garraway, L.A.2    Pratilas, C.A.3
  • 9
    • 33846230965 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-kinase and mitogen-Activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPR as mouse model
    • Bedogni B, Welford SM, Kwan AC, et al. Inhibition of phosphatidylinositol-3-kinase and mitogen-Activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPR as mouse model. Mol Cancer Ther 2006; 5:3071-3077
    • (2006) Mol Cancer Ther , vol.5 , pp. 3071-3077
    • Bedogni, B.1    Welford, S.M.2    Kwan, A.C.3
  • 10
    • 21644440921 scopus 로고    scopus 로고
    • Recent progress in targeting the raf/mek/erk pathway with inhibitors in cancer drug discovery
    • Thompson N, Lyons J. Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 2005; 5:350-356
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 350-356
    • Thompson, N.1    Lyons, J.2
  • 11
    • 84876233799 scopus 로고    scopus 로고
    • Novel biomarkers for diagnosis, prognosis, targeted therapy and clinical trials
    • Hsueh C-T, Liu D, Wang H. Novel biomarkers for diagnosis, prognosis, targeted therapy and clinical trials. Biomarker Res 2013; 1:1
    • (2013) Biomarker Res , vol.1 , pp. 1
    • Hsueh, C.-T.1    Liu, D.2    Wang, H.3
  • 12
    • 14444279192 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of mitogen-Activated protein kinase kinase
    • Favata MF, Horiuchi KY, Manos EJ, et al. Identification of a novel inhibitor of mitogen-Activated protein kinase kinase. J Biol Chem 1998; 273:18623-18632
    • (1998) J Biol Chem , vol.273 , pp. 18623-18632
    • Favata, M.F.1    Horiuchi, K.Y.2    Manos, E.J.3
  • 13
    • 79956018943 scopus 로고    scopus 로고
    • Antitumor activities of jtp-74057 (gsk1120212), a novel mek1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo
    • Yamaguchi T, Kakefuda R, Tajima N, et al. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol 2011; 39:23-31
    • (2011) Int J Oncol , vol.39 , pp. 23-31
    • Yamaguchi, T.1    Kakefuda, R.2    Tajima, N.3
  • 14
    • 79952261716 scopus 로고    scopus 로고
    • Gsk1120212 (jtp-74057) is an inhibitor of mek activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition
    • Gilmartin AG, Bleam MR, Groy A, et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin Cancer Res 2011; 17:989-1000
    • (2011) Clin Cancer Res , vol.17 , pp. 989-1000
    • Gilmartin, A.G.1    Bleam, M.R.2    Groy, A.3
  • 15
    • 84864340896 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral mek inhibitor trametinib: A phase 1 dose-escalation trial
    • Infante JR, Fecher LA, Falchook GS, et al. Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 dose-escalation trial. Lancet Oncol 2012; 13:773-781
    • (2012) Lancet Oncol , vol.13 , pp. 773-781
    • Infante, J.R.1    Fecher, L.A.2    Falchook, G.S.3
  • 16
    • 84874777853 scopus 로고    scopus 로고
    • Phase ii study of the mek1/mek2 inhibitor trametinib in patients with metastatic braf-mutant cutaneous melanoma previously treated with or without a braf inhibitor
    • Kim KB, Kefford R, Pavlick AC, et al. Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol 2013; 31:482-489
    • (2013) J Clin Oncol , vol.31 , pp. 482-489
    • Kim, K.B.1    Kefford, R.2    Pavlick, A.C.3
  • 17
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with mek inhibition in braf-mutated melanoma
    • Flaherty KT, Robert C, Hersey P, et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012; 367:107-114
    • (2012) N Engl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 18
    • 84891648456 scopus 로고    scopus 로고
    • Phase ii trial (break-2) of the braf inhibitor dabrafenib (gsk2118436) in patients with metastatic melanoma
    • Ascierto PA, Minor D, Ribas A, et al. Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol 2013; 31:3205-3211
    • (2013) J Clin Oncol , vol.31 , pp. 3205-3211
    • Ascierto, P.A.1    Minor, D.2    Ribas, A.3
  • 19
    • 43749103335 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-Activated protein kinase kinase 1/2 inhibitor azd6244 (arry-142886) in patients with advanced cancers
    • Adjei AA, Cohen RB, Franklin W, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-Activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol 2008; 26:2139-2146
    • (2008) J Clin Oncol , vol.26 , pp. 2139-2146
    • Adjei, A.A.1    Cohen, R.B.2    Franklin, W.3
  • 20
    • 84855487013 scopus 로고    scopus 로고
    • A phase ii, open-label, randomized study to assess the efficacy and safety of the mek1/2 inhibitor azd6244 (arry-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens
    • Bennouna J, Lang I, Valladares-Ayerbes M, et al. A phase II, open-label, randomized study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens. Invest New Drugs 2011; 29:1021-1028
    • (2011) Invest New Drugs , vol.29 , pp. 1021-1028
    • Bennouna, J.1    Lang, I.2    Valladares-Ayerbes, M.3
  • 21
    • 84864346162 scopus 로고    scopus 로고
    • A phase ii open-label randomized study to assess the efficacy and safety of selumetinib (azd6244 [arry-142886] versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy
    • Bodoky G, Timcheva C, Spigel DR, et al. A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy. Invest New Drugs 2012; 30:1216-1223
    • (2012) Invest New Drugs , vol.30 , pp. 1216-1223
    • Bodoky, G.1    Timcheva, C.2    Spigel, D.R.3
  • 22
    • 77958198647 scopus 로고    scopus 로고
    • A phase ii, open-label, randomized study to assess the efficacy and safety of azd6244 (arry-142886) versus pemetrexed in patients with nonsmall cell lung cancer who have failed one or two prior chemotherapeutic regimens
    • Hainsworth JD, Cebotaru CL, Kanarev V, et al. A phase II, open-label, randomized study to assess the efficacy and safety of AZD6244 (ARRY-142886) versus pemetrexed in patients with nonsmall cell lung cancer who have failed one or two prior chemotherapeutic regimens. J Thorac Oncol 2010; 5:1630-1636
    • (2010) J Thorac Oncol , vol.5 , pp. 1630-1636
    • Hainsworth, J.D.1    Cebotaru, C.L.2    Kanarev, V.3
  • 23
    • 84859410770 scopus 로고    scopus 로고
    • Phase ii efficacy and pharmacogenomic study of selumetinib (azd6244; Arry-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements
    • Hayes DN, Lucas AS, Tanvetyanon T, et al. Phase II efficacy and pharmacogenomic study of selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements. Clin Cancer Res 2012; 18:2056-2065
    • (2012) Clin Cancer Res , vol.18 , pp. 2056-2065
    • Hayes, D.N.1    Lucas, A.S.2    Tanvetyanon, T.3
  • 24
    • 84856009717 scopus 로고    scopus 로고
    • Phase ii, open-label, randomized trial of the mek1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma
    • Kirkwood JM, Bastholt L, Robert C, et al. Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin Cancer Res 2012; 18:555-567
    • (2012) Clin Cancer Res , vol.18 , pp. 555-567
    • Kirkwood, J.M.1    Bastholt, L.2    Robert, C.3
  • 25
    • 79959214127 scopus 로고    scopus 로고
    • Phase II study of the mitogen activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma
    • O'Neil BH, Goff LW, Kauh JS, et al. Phase II study of the mitogen activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2011; 29:2350-2356
    • (2011) J Clin Oncol , vol.29 , pp. 2350-2356
    • O'Neil, B.H.1    Goff, L.W.2    Kauh, J.S.3
  • 26
    • 84877092892 scopus 로고    scopus 로고
    • Phase ii trial of mek inhibitor selumetinib (azd6244, arry-142886) in patients with brafv600e/kmutated melanoma
    • Catalanotti F, Solit DB, Pulitzer MP, et al. Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/Kmutated melanoma. Clin Cancer Res 2013; 19:2257-2264
    • (2013) Clin Cancer Res , vol.19 , pp. 2257-2264
    • Catalanotti, F.1    Solit, D.B.2    Pulitzer, M.P.3
  • 27
    • 84879717023 scopus 로고    scopus 로고
    • Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study
    • Robert C, Dummer R, Gutzmer R, et al. Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study. Lancet Oncol 2013; 14:733-740
    • (2013) Lancet Oncol , vol.14 , pp. 733-740
    • Robert, C.1    Dummer, R.2    Gutzmer, R.3
  • 28
    • 76049113589 scopus 로고    scopus 로고
    • Mitogen-Activated protein/ extracellular signal-regulated kinase kinase inhibition results in biphasic alteration of epidermal homeostasis with keratinocytic apoptosis and pigmentation disorders
    • Schad K, Baumann Conzett K, Zipser MC, et al. Mitogen-Activated protein/ extracellular signal-regulated kinase kinase inhibition results in biphasic alteration of epidermal homeostasis with keratinocytic apoptosis and pigmentation disorders. Clin Cancer Res 2010; 16:1058-1064
    • (2010) Clin Cancer Res , vol.16 , pp. 1058-1064
    • Schad, K.1    Baumann Conzett, K.2    Zipser, M.C.3
  • 29
    • 85047656288 scopus 로고    scopus 로고
    • Selumetinib shows promise in metastatic uveal melanoma
    • No Authors Listed].
    • No authors listed]. Selumetinib shows promise in metastatic uveal melanoma. Cancer Discov 2013; 3:OF8
    • (2013) Cancer Discov , vol.3
  • 31
    • 84883559976 scopus 로고    scopus 로고
    • A phase i dose-escalation study of mek inhibitor mek162 (arry-438162) in patients with advanced solid tumors
    • abstract B243
    • Bendell JC, Papadopoulos K, Jones SF, et al. A phase I dose-escalation study of MEK inhibitor MEK162 (ARRY-438162) in patients with advanced solid tumors. Mol Cancer Ther 2011; 10 (Suppl. 1); abstract B243
    • (2011) Mol Cancer Ther , vol.10 , Issue.SUPPL.1
    • Bendell, J.C.1    Papadopoulos, K.2    Jones, S.F.3
  • 32
    • 84875235432 scopus 로고    scopus 로고
    • Mek162 for patients with advanced melanoma harbouring nras or val600 braf mutations: A nonrandomised, open-label phase 2 study
    • Ascierto PA, Schadendorf D, Berking C, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A nonrandomised, open-label phase 2 study. Lancet Oncol 2013; 14:249-256
    • (2013) Lancet Oncol , vol.14 , pp. 249-256
    • Ascierto, P.A.1    Schadendorf, D.2    Berking, C.3
  • 33
    • 46849117955 scopus 로고    scopus 로고
    • Xl518, a potent selective orally bioavailable mek1 inhibitor, downregulates the ras/raf/mek/erk pathway in vivo, resulting in tumor growth inhibition and regression in preclinical models
    • San Francisco, California, USA
    • Johnston S. XL518, a potent selective orally bioavailable MEK1 inhibitor, downregulates the RAS/RAF/MEK/ERK pathway in vivo, resulting in tumor growth inhibition and regression in preclinical models. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics 2007; San Francisco, California, USA
    • (2007) AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics
    • Johnston, S.1
  • 34
    • 84871183627 scopus 로고    scopus 로고
    • A first-in-human phase ib study to evaluate the mek inhibitor gdc-0973, combined with the pan-pi3k inhibitor gdc-0941, in patients with advanced solid tumors
    • ASCO Meeting Abstracts Suppl.); abstract 2566
    • LoRusso P, Shapiro G, Pandya SS, et al. A first-in-human phase Ib study to evaluate the MEK inhibitor GDC-0973, combined with the pan-PI3K inhibitor GDC-0941, in patients with advanced solid tumors. J Clin Oncol, ASCO Meeting Abstracts 2012; 30 (15 Suppl.); abstract 2566
    • (2012) J Clin Oncol , vol.30 , Issue.15
    • Lorusso, P.1    Shapiro, G.2    Pandya, S.S.3
  • 35
    • 77951678924 scopus 로고    scopus 로고
    • Blockade of the mek/erk signalling cascade by as703026, a novel selective mek1/2 inhibitor, induces pleiotropic antimyeloma activity in vitro and in vivo
    • Kim K, Kong SY, Fulciniti M, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic antimyeloma activity in vitro and in vivo. Br J Haematol 2010; 149:537-549
    • (2010) Br J Haematol , vol.149 , pp. 537-549
    • Kim, K.1    Kong, S.Y.2    Fulciniti, M.3
  • 36
    • 78751480476 scopus 로고    scopus 로고
    • Mek1/2 inhibitors as703026 and azd6244 may be potential therapies for kras mutated colorectal cancer that is resistant to egfr monoclonal antibody therapy
    • Yoon J, Koo KH, Choi KY. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res 2011; 71:445-453
    • (2011) Cancer Res , vol.71 , pp. 445-453
    • Yoon, J.1    Koo, K.H.2    Choi, K.Y.3
  • 37
    • 85084273516 scopus 로고    scopus 로고
    • Selection of indications for pimasertib in phase II testing based on signals of activity and rational choice of target disease
    • Massimini G, Laffranchi B, Rejeb N, et al. Selection of indications for pimasertib in phase II testing based on signals of activity and rational choice of target disease. Ann Oncol 2013; 24 (Suppl. 1):i33-i35
    • (2013) Ann Oncol , vol.24 , Issue.SUPPL.1
    • Massimini, G.1    Laffranchi, B.2    Rejeb, N.3
  • 38
    • 84867019275 scopus 로고    scopus 로고
    • Sensitivity to the mek inhibitor e6201 in melanoma cells is associated with mutant braf and wild-Type pten status
    • Byron SA, Loch DC, Wellens CL, et al. Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wild-Type PTEN status. Mol Cancer 2012; 11:75
    • (2012) Mol Cancer , vol.11 , pp. 75
    • Byron, S.A.1    Loch, D.C.2    Wellens, C.L.3
  • 39
    • 78650343267 scopus 로고    scopus 로고
    • Phase i dose-escalation study of E6201, a MEK-1 inhibitor, in advanced solid tumors
    • Suppl.)); abstract
    • Borad MJ, Akerele CE, Ramanathan RK, et al. Phase I dose-escalation study of E6201, a MEK-1 inhibitor, in advanced solid tumors. J Clin Oncol 2010; 28 (15(Suppl.)); abstract 2505
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 2505
    • Borad, M.J.1    Akerele, C.E.2    Ramanathan, R.K.3
  • 40
    • 79951722555 scopus 로고    scopus 로고
    • Discovery of tak-733, a potent and selective mek allosteric site inhibitor for the treatment of cancer
    • Dong Q, Dougan DR, Gong X, et al. Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett 2011; 21:1315-1319
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 1315-1319
    • Dong, Q.1    Dougan, D.R.2    Gong, X.3
  • 41
    • 84859810061 scopus 로고    scopus 로고
    • Antitumor effects of the investigational selective mek inhibitor tak733 against cutaneous and uveal melanoma cell lines
    • Von Euw E, Atefi M, Attar N, et al. Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines. Mol Cancer 2012; 11:22
    • (2012) Mol Cancer , vol.11 , pp. 22
    • Von Euw, E.1    Atefi, M.2    Attar, N.3
  • 42
    • 79952360230 scopus 로고    scopus 로고
    • Design and synthesis of novel allosteric mek inhibitor ch4987655 as an orally available anticancer agent
    • Isshiki Y, Kohchi Y, Iikura H, et al. Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg Med Chem Lett 2011; 21:1795-1801
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 1795-1801
    • Isshiki, Y.1    Kohchi, Y.2    Iikura, H.3
  • 43
    • 84865702746 scopus 로고    scopus 로고
    • Phase i dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the mek inhibitor ro4987655 (ch4987655) in patients with advanced solid tumors
    • Leijen S, Middleton MR, Tresca P, et al. Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors. Clin Cancer Res 2012; 18:4794-4805
    • (2012) Clin Cancer Res , vol.18 , pp. 4794-4805
    • Leijen, S.1    Middleton, M.R.2    Tresca, P.3
  • 44
    • 84880064248 scopus 로고    scopus 로고
    • Enhanced inhibition of erk signaling by a novel allosteric mek inhibitor, ch5126766, that suppresses feedback reactivation of raf activity
    • Ishii N, Harada N, Joseph EW, et al. Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity. Cancer Res 2013; 73:4050-4060
    • (2013) Cancer Res , vol.73 , pp. 4050-4060
    • Ishii, N.1    Harada, N.2    Joseph, E.W.3
  • 45
    • 84865749357 scopus 로고    scopus 로고
    • First-in-human, phase i dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of ro5126766, a first-in-class dual mek/raf inhibitor in patients with solid tumors
    • Martinez-Garcia M, Banerji U, Albanell J, et al. First-in-human, phase I dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of RO5126766, a first-in-class dual MEK/RAF inhibitor in patients with solid tumors. Clin Cancer Res 2012; 18:4806-4819
    • (2012) Clin Cancer Res , vol.18 , pp. 4806-4819
    • Martinez-Garcia, M.1    Banerji, U.2    Albanell, J.3
  • 46
    • 77953276524 scopus 로고    scopus 로고
    • Recovery of phospho-erk activity allows melanoma cells to escape from braf inhibitor therapy
    • Paraiso KH, Fedorenko IV, Cantini LP, et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 2010; 102:1724-1730
    • (2010) Br J Cancer , vol.102 , pp. 1724-1730
    • Paraiso, K.H.1    Fedorenko, I.V.2    Cantini, L.P.3
  • 47
    • 84862908097 scopus 로고    scopus 로고
    • Ras mutations in cutaneous squamous-cell carcinomas in patients treated with braf inhibitors
    • Su F, Viros A, Milagre C, et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med 2012; 366:207-215
    • (2012) N Engl J Med , vol.366 , pp. 207-215
    • Su, F.1    Viros, A.2    Milagre, C.3
  • 48
    • 84868224906 scopus 로고    scopus 로고
    • Combined braf and mek inhibition in melanoma with braf v600 mutations
    • Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367:1694-1703
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 49
    • 84988646297 scopus 로고    scopus 로고
    • Vemurafenib (vem) and mek inhibitor, cobimetinib (gdc0973), in advanced braf v600-mutated melanoma (brim-7): Dose-escalation and expansion results of a phase ib study
    • abstract 3703
    • McArthur G, Gonzalez R, Pavlick A, et al. Vemurafenib (VEM) and MEK inhibitor, cobimetinib (GDC0973), in advanced BRAF V600-mutated melanoma (BRIM-7): Dose-escalation and expansion results of a phase Ib study. Eur J Cancer 2013; 49 (Suppl. 2); abstract 3703
    • (2013) Eur J Cancer , vol.49 , Issue.SUPPL.2
    • McArthur, G.1    Gonzalez, R.2    Pavlick, A.3
  • 50
    • 84882829380 scopus 로고    scopus 로고
    • Preliminary results from a phase ib/ii, open-label, dose-escalation study of the oral braf inhibitor lgx818 in combination with the oral mek1/2 inhibitor mek162 in braf v600-dependent advanced solid tumors
    • Suppl.): Abstract 9029
    • Kefford R, Miller WH, Shao-Weng Tan D, et al. Preliminary results from a phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in BRAF V600-dependent advanced solid tumors. J Clin Oncol 2013; 31 (Suppl.): Abstract 9029
    • (2013) J Clin Oncol , vol.31
    • Kefford, R.1    Miller, W.H.2    Shao-Weng Tan, D.3
  • 51
    • 0033630308 scopus 로고    scopus 로고
    • Serine/threonine phosphorylation in cytokine signal transduction
    • McCubrey JA, May WS, Duronio V, Mufson A. Serine/threonine phosphorylation in cytokine signal transduction. Leukemia 2000; 14:9-21
    • (2000) Leukemia , vol.14 , pp. 9-21
    • McCubrey, J.A.1    May, W.S.2    Duronio, V.3    Mufson, A.4
  • 52
    • 0037806885 scopus 로고    scopus 로고
    • Regulation of cell cycle progression and apoptosis by the ras/raf/mek/erk pathway
    • Chang F, Steelman LS, Shelton JG, et al. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway. Int J Oncol 2003; 22:469-480
    • (2003) Int J Oncol , vol.22 , pp. 469-480
    • Chang, F.1    Steelman, L.S.2    Shelton, J.G.3
  • 53
    • 84881077536 scopus 로고    scopus 로고
    • Mek inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner
    • Shindo T, Kim TK, Benjamin CL, et al. MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner. Blood 2013; 121:4617-4626
    • (2013) Blood , vol.121 , pp. 4617-4626
    • Shindo, T.1    Kim, T.K.2    Benjamin, C.L.3
  • 54
    • 84856693628 scopus 로고    scopus 로고
    • Interleukin 6 mediates production of interleukin 10 in metastatic melanoma
    • Terai M, Eto M, Young GD, et al. Interleukin 6 mediates production of interleukin 10 in metastatic melanoma. Cancer Immunol Immunother 2012; 61:145-155
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 145-155
    • Terai, M.1    Eto, M.2    Young, G.D.3
  • 56
    • 84877817680 scopus 로고    scopus 로고
    • Inhibition of both braf and mek in braf(v600e) mutant melanoma restores compromised dendritic cell (dc) function while having differential direct effects on dc properties
    • Ott PA, Henry T, Baranda SJ, et al. Inhibition of both BRAF and MEK in BRAF(V600E) mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties. Cancer Immunol Immunother 2013; 62:811-822
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 811-822
    • Ott, P.A.1    Henry, T.2    Baranda, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.