Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Suzuki, Ayako ^a   Matsushima, Koutatsu ^b   Makinoshima, Hideki ^b   Sugano, Sumio ^a   Kohno, Takashi ^b,c   Tsuchihara, Katsuya ^b   Suzuki, Yutaka ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL CANCER CENTER   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MYC PROTEIN; PROTEIN P53; PROTEIN RET; RNA; VANDETANIB; CCDC6 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; EGFR PROTEIN, HUMAN; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; RET PROTEIN, HUMAN; TRANSCRIPTOME;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG TARGETING; EGFR GENE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC VARIABILITY; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; ONCOGENE K RAS; ONCOGENE MYC; RET GENE; RNA SEQUENCE; SINGLE CELL ANALYSIS; TP53 GENE; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; ADENOCARCINOMA; DRUG DELIVERY SYSTEM; ESSENTIAL GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; MOLECULARLY TARGETED THERAPY; PROCEDURES; SEQUENCE ANALYSIS; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ESSENTIAL; HUMANS; LUNG NEOPLASMS; MOLECULAR TARGETED THERAPY; PIPERIDINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RET; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTOME;

EID: 84939202318     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0636-y     Document Type: Article

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