메뉴 건너뛰기




Volumn 147, Issue 1, 2017, Pages 3-10

Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

Author keywords

Biological activity; Bovine milk; Exosomes; Extracellular vesicles; Human milk; Infants; MicroRNA; Noncoding RNA

Indexed keywords

DNA; LIPID; MESSENGER RNA; MICRORNA; PROTEIN; UNTRANSLATED RNA;

EID: 85009260446     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.116.238949     Document Type: Article
Times cited : (199)

References (104)
  • 1
    • 84867073222 scopus 로고    scopus 로고
    • Breastfeeding and the use of human milk: an analysis of the American Academy of Pediatrics 2012 Breastfeeding Policy Statement
    • Eidelman AI. Breastfeeding and the use of human milk: an analysis of the American Academy of Pediatrics 2012 Breastfeeding Policy Statement. Breastfeed Med 2012;7:323-4.
    • (2012) Breastfeed Med , vol.7 , pp. 323-324
    • Eidelman, A.I.1
  • 2
    • 85009265423 scopus 로고    scopus 로고
    • Breastfeeding among U.S. children born 2002-2012. 2015 [database on the Internet; cited 2016 Jul 4]
    • CDC. CDC national immunization surveys. Breastfeeding among U.S. children born 2002-2012. 2015 [database on the Internet; cited 2016 Jul 4]. Available from: http://www.cdc.gov/breastfeeding/data/nis_data/index.htm.
    • CDC national immunization surveys
  • 4
    • 85009290488 scopus 로고    scopus 로고
    • Research Triangle Park (NC); [cited 2013 Nov 7]. Available from:
    • US Department of Health and Human Services, National Institute of Environmental Health and Safety. Soy infant formula. Research Triangle Park (NC); 2013 [cited 2013 Nov 7]. Available from: http://www.niehs.nih.gov/health/topics/agents/sya-soy-formula/.
    • (2013) Soy infant formula
  • 5
    • 84892393350 scopus 로고    scopus 로고
    • Regulating fatty acids in infant formula: critical assessment of U.S. policies and practices
    • Kent G. Regulating fatty acids in infant formula: critical assessment of U.S. policies and practices. Int Breastfeed J 2014;9:2.
    • (2014) Int Breastfeed J , vol.9 , pp. 2
    • Kent, G.1
  • 6
    • 84929715983 scopus 로고    scopus 로고
    • Oligosaccharides in infant formula: more evidence to validate the role of prebiotics
    • Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Br J Nutr 2015;113:1339-44.
    • (2015) Br J Nutr , vol.113 , pp. 1339-1344
    • Vandenplas, Y.1    Zakharova, I.2    Dmitrieva, Y.3
  • 7
    • 84865339380 scopus 로고    scopus 로고
    • Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions
    • Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J Dairy Sci 2012;95:4831-41.
    • (2012) J Dairy Sci , vol.95 , pp. 4831-4841
    • Izumi, H.1    Kosaka, N.2    Shimizu, T.3    Sekine, K.4    Ochiya, T.5    Takase, M.6
  • 11
    • 84886738545 scopus 로고    scopus 로고
    • Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies
    • Record M, Carayon K, Poirot M, Silvente-Poirot S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim Biophys Acta 2014;1841: 108-20.
    • (2014) Biochim Biophys Acta , vol.1841 , pp. 108-120
    • Record, M.1    Carayon, K.2    Poirot, M.3    Silvente-Poirot, S.4
  • 12
    • 84945429803 scopus 로고    scopus 로고
    • Rapid and comprehensive 'shotgun' lipidome profiling of colorectal cancer cell derived exosomes
    • Lydic TA, Townsend S, Adda CG, Collins C, Mathivanan S, Reid GE. Rapid and comprehensive 'shotgun' lipidome profiling of colorectal cancer cell derived exosomes. Methods 2015;87:83-95.
    • (2015) Methods , vol.87 , pp. 83-95
    • Lydic, T.A.1    Townsend, S.2    Adda, C.G.3    Collins, C.4    Mathivanan, S.5    Reid, G.E.6
  • 13
    • 79953081976 scopus 로고    scopus 로고
    • Interaction and uptake of exosomes by ovarian cancer cells
    • Escrevente C, Keller S, Altevogt P, Costa J. Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer 2011;11:108.
    • (2011) BMC Cancer , vol.11 , pp. 108
    • Escrevente, C.1    Keller, S.2    Altevogt, P.3    Costa, J.4
  • 14
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 2013;200:373-83.
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 15
    • 84943806021 scopus 로고    scopus 로고
    • The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma caco-2 cells and rat small intestinal IEC-6 cells
    • Wolf T, Baier SR, Zempleni J. The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma caco-2 cells and rat small intestinal IEC-6 cells. J Nutr 2015;145:2201-6.
    • (2015) J Nutr , vol.145 , pp. 2201-2206
    • Wolf, T.1    Baier, S.R.2    Zempleni, J.3
  • 17
    • 84954465966 scopus 로고    scopus 로고
    • investigation of content, stoichiometry and transfer of miRNA from human neural stem cell line derived exosomes
    • Stevanato L, Thanabalasundaram L, Vysokov N, Sinden JD. investigation of content, stoichiometry and transfer of miRNA from human neural stem cell line derived exosomes. PLoS One 2016;11:e0146353.
    • (2016) PLoS One , vol.11
    • Stevanato, L.1    Thanabalasundaram, L.2    Vysokov, N.3    Sinden, J.D.4
  • 18
    • 84962733931 scopus 로고    scopus 로고
    • Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake
    • Abels ER, Breakefield XO. Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake. Cell Mol Neurobiol 2016;36:301.
    • (2016) Cell Mol Neurobiol , vol.36 , pp. 301
    • Abels, E.R.1    Breakefield, X.O.2
  • 21
    • 84857309195 scopus 로고    scopus 로고
    • The ESCRT machinery
    • Schmidt O, Teis D. The ESCRT machinery. Curr Biol 2012;22:R116-20.
    • (2012) Curr Biol , vol.22 , pp. R116-R120
    • Schmidt, O.1    Teis, D.2
  • 22
    • 79960743373 scopus 로고    scopus 로고
    • MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between
    • Babst M. MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between. Curr Opin Cell Biol 2011;23:452-7.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 452-457
    • Babst, M.1
  • 23
    • 77954957013 scopus 로고    scopus 로고
    • Membrane budding and scission by the ESCRT machinery: it's all in the neck
    • Hurley JH, Hanson PI. Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol 2010;11:556-66.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 556-566
    • Hurley, J.H.1    Hanson, P.I.2
  • 24
    • 80054079071 scopus 로고    scopus 로고
    • Assembly and disassembly of the ESCRT-III membrane scission complex
    • Adell MA, Teis D. Assembly and disassembly of the ESCRT-III membrane scission complex. FEBS Lett 2011;585:3191-6.
    • (2011) FEBS Lett , vol.585 , pp. 3191-3196
    • Adell, M.A.1    Teis, D.2
  • 26
    • 84863199863 scopus 로고    scopus 로고
    • Get on the exosome bus with ALIX
    • Hurley JH, Odorizzi G. Get on the exosome bus with ALIX. Nat Cell Biol 2012;14:654-5.
    • (2012) Nat Cell Biol , vol.14 , pp. 654-655
    • Hurley, J.H.1    Odorizzi, G.2
  • 27
    • 81055157988 scopus 로고    scopus 로고
    • Exosome secretion: molecular mechanisms and roles in immune responses
    • Bobrie A, Colombo M, Raposo G, Thery C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 2011; 12:1659-68.
    • (2011) Traffic , vol.12 , pp. 1659-1668
    • Bobrie, A.1    Colombo, M.2    Raposo, G.3    Thery, C.4
  • 28
    • 85009261540 scopus 로고    scopus 로고
    • Identification of glycoproteins on the surface of cow's milk exosomes that mediate the uptake of exosomes into human colon carcinoma Caco-2 cells
    • ASN Scientific Sessions and Annual Meeting at Experimental Biology 2016, 2016 Apr 2-6; San Diego, CA
    • Sukreet S, Zhang H, Adamec J, Cui J, Zempleni J. Identification of glycoproteins on the surface of cow's milk exosomes that mediate the uptake of exosomes into human colon carcinoma Caco-2 cells. ASN Scientific Sessions and Annual Meeting at Experimental Biology 2016; 2016 Apr 2-6; San Diego, CA. FASEB J 2016;30(Suppl 1):125.1.
    • (2016) FASEB J , vol.30 , pp. 1251
    • Sukreet, S.1    Zhang, H.2    Adamec, J.3    Cui, J.4    Zempleni, J.5
  • 29
    • 84860218631 scopus 로고    scopus 로고
    • Intercellular communication: diverse structures for exchange of genetic information
    • Mittelbrunn M, Sanchez-Madrid F. Intercellular communication: diverse structures for exchange of genetic information. Nat Rev Mol Cell Biol 2012;13:328-35.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 328-335
    • Mittelbrunn, M.1    Sanchez-Madrid, F.2
  • 31
  • 32
    • 84942133834 scopus 로고    scopus 로고
    • Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome
    • Vilella F, Moreno-Moya JM, Balaguer N, Grasso A, Herrero M, Martinez S, Marcilla A, Simon C. Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome. Development 2015;142:3210-21.
    • (2015) Development , vol.142 , pp. 3210-3221
    • Vilella, F.1    Moreno-Moya, J.M.2    Balaguer, N.3    Grasso, A.4    Herrero, M.5    Martinez, S.6    Marcilla, A.7    Simon, C.8
  • 33
    • 84855502918 scopus 로고    scopus 로고
    • Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
    • Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 2012;22:107-26.
    • (2012) Cell Res , vol.22 , pp. 107-126
    • Zhang, L.1    Hou, D.2    Chen, X.3    Li, D.4    Zhu, L.5    Zhang, Y.6    Li, J.7    Bian, Z.8    Liang, X.9    Cai, X.10
  • 34
    • 84907255137 scopus 로고    scopus 로고
    • MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow's milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers
    • Baier SR, Nguyen C, Xie F, Wood JR, Zempleni J. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow's milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr 2014;144:1495-500.
    • (2014) J Nutr , vol.144 , pp. 1495-1500
    • Baier, S.R.1    Nguyen, C.2    Xie, F.3    Wood, J.R.4    Zempleni, J.5
  • 36
    • 85009237964 scopus 로고    scopus 로고
    • Bioavailability and biodistribution of fluorophore-labeled exosomes from cow's milk after intravenous and oral administration in C57Bl/6J mice
    • ASN Scientific Sessions and Annual Meeting at Experimental Biology 2016, 2016 Apr 2-6; San Diego, CA
    • Manca S, Giraud D, Zempleni J. Bioavailability and biodistribution of fluorophore-labeled exosomes from cow's milk after intravenous and oral administration in C57Bl/6J mice. ASN Scientific Sessions and Annual Meeting at Experimental Biology 2016; 2016 Apr 2-6; San Diego, CA. FASEB J 2016;30(Suppl 1):690.8.
    • (2016) FASEB J , vol.30 , pp. 6908
    • Manca, S.1    Giraud, D.2    Zempleni, J.3
  • 37
    • 84984706582 scopus 로고    scopus 로고
    • Identification of dietetically absorbed rapeseed (Brassica campestris, L.) bee pollen microRNAs in serum of mice
    • Chen X, Dai GH, Ren ZM, Tong YL, Yang F, Zhu YQ. Identification of dietetically absorbed rapeseed (Brassica campestris, L.) bee pollen microRNAs in serum of mice. Biomed Res Int 2016; 2016:5413849.
    • (2016) Biomed Res Int , vol.2016
    • Chen, X.1    Dai, G.H.2    Ren, Z.M.3    Tong, Y.L.4    Yang, F.5    Zhu, Y.Q.6
  • 42
    • 84880770383 scopus 로고    scopus 로고
    • Diversifying microRNA sequence and function
    • Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol 2013;14:475-88.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 475-488
    • Ameres, S.L.1    Zamore, P.D.2
  • 43
    • 34250677322 scopus 로고    scopus 로고
    • Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs
    • Lund E, Dahlberg JE. Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs. Cold Spring Harb Symp Quant Biol 2006;71:59-66.
    • (2006) Cold Spring Harb Symp Quant Biol , vol.71 , pp. 59-66
    • Lund, E.1    Dahlberg, J.E.2
  • 45
    • 84908572838 scopus 로고    scopus 로고
    • Gene regulation: structural basis for microRNA targeting
    • Schirle NT, Sheu-Gruttadauria J, MacRae IJ. Gene regulation: structural basis for microRNA targeting. Science 2014;346:608-13.
    • (2014) Science , vol.346 , pp. 608-613
    • Schirle, N.T.1    Sheu-Gruttadauria, J.2    MacRae, I.J.3
  • 46
    • 33846283385 scopus 로고    scopus 로고
    • The evolution of gene regulation by transcription factors and microRNAs
    • Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet 2007;8:93-103.
    • (2007) Nat Rev Genet , vol.8 , pp. 93-103
    • Chen, K.1    Rajewsky, N.2
  • 48
    • 84859632747 scopus 로고    scopus 로고
    • miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay
    • Djuranovic S, Nahvi A, Green R. miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science 2012;336:237-40.
    • (2012) Science , vol.336 , pp. 237-240
    • Djuranovic, S.1    Nahvi, A.2    Green, R.3
  • 49
  • 52
    • 84910010568 scopus 로고    scopus 로고
    • Extracellular vesicles in heart disease: excitement for the future?
    • Danielson KM, Das S. Extracellular vesicles in heart disease: excitement for the future? Exosomes Microvesicles 2014;2:1.
    • (2014) Exosomes Microvesicles , vol.2 , pp. 1
    • Danielson, K.M.1    Das, S.2
  • 53
    • 77957567010 scopus 로고    scopus 로고
    • Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products
    • Chen X, Gao C, Li H, Huang L, Sun Q, Dong Y, Tian C, Gao S, Dong H, Guan D, et al. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res 2010;20:1128-37.
    • (2010) Cell Res , vol.20 , pp. 1128-1137
    • Chen, X.1    Gao, C.2    Li, H.3    Huang, L.4    Sun, Q.5    Dong, Y.6    Tian, C.7    Gao, S.8    Dong, H.9    Guan, D.10
  • 55
    • 84943279958 scopus 로고    scopus 로고
    • Grazing affects exosomal circulating microRNAs in cattle
    • Muroya S, Ogasawara H, Hojito M. Grazing affects exosomal circulating microRNAs in cattle. PLoS One 2015;10:e0136475.
    • (2015) PLoS One , vol.10
    • Muroya, S.1    Ogasawara, H.2    Hojito, M.3
  • 58
    • 77957037314 scopus 로고    scopus 로고
    • microRNA as a new immune-regulatory agent in breast milk
    • Kosaka N, Izumi H, Sekine K, Ochiya T. microRNA as a new immune-regulatory agent in breast milk. Silence 2010;1:7.
    • (2010) Silence , vol.1 , pp. 7
    • Kosaka, N.1    Izumi, H.2    Sekine, K.3    Ochiya, T.4
  • 59
    • 84880852727 scopus 로고    scopus 로고
    • Ineffective delivery of diet-derived microRNAs to recipient animal organisms
    • Snow JW, Hale AE, Isaacs SK, Baggish AL, Chan SY. Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biol 2013;10:1107-16.
    • (2013) RNA Biol , vol.10 , pp. 1107-1116
    • Snow, J.W.1    Hale, A.E.2    Isaacs, S.K.3    Baggish, A.L.4    Chan, S.Y.5
  • 61
    • 84903218251 scopus 로고    scopus 로고
    • In silico identification of plant miRNAs in mammalian breast milk exosomes-a small step forward?
    • Lukasik A, Zielenkiewicz P. In silico identification of plant miRNAs in mammalian breast milk exosomes-a small step forward? PLoS One 2014;9:e99963.
    • (2014) PLoS One , vol.9
    • Lukasik, A.1    Zielenkiewicz, P.2
  • 65
    • 84926526961 scopus 로고    scopus 로고
    • Detection of dietary plant-based small RNAs in animals
    • Yang J, Farmer LM, Agyekum AA, Hirschi KD. Detection of dietary plant-based small RNAs in animals. Cell Res 2015;25:517-20.
    • (2015) Cell Res , vol.25 , pp. 517-520
    • Yang, J.1    Farmer, L.M.2    Agyekum, A.A.3    Hirschi, K.D.4
  • 66
    • 84879686252 scopus 로고    scopus 로고
    • Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis
    • Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, Xiang X, Deng ZB, Wang B, Zhang L, et al. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Mol Ther 2013;21:1345-57.
    • (2013) Mol Ther , vol.21 , pp. 1345-1357
    • Ju, S.1    Mu, J.2    Dokland, T.3    Zhuang, X.4    Wang, Q.5    Jiang, H.6    Xiang, X.7    Deng, Z.B.8    Wang, B.9    Zhang, L.10
  • 67
    • 84903545653 scopus 로고    scopus 로고
    • Interspecies communication between plant and mouse gut host cells through edible plant derived exosomelike nanoparticles
    • Mu J, Zhuang X, Wang Q, Jiang H, Deng ZB, Wang B, Zhang L, Kakar S, Jun Y, Miller D, et al. Interspecies communication between plant and mouse gut host cells through edible plant derived exosomelike nanoparticles. Mol Nutr Food Res 2014;58:1561-73.
    • (2014) Mol Nutr Food Res , vol.58 , pp. 1561-1573
    • Mu, J.1    Zhuang, X.2    Wang, Q.3    Jiang, H.4    Deng, Z.B.5    Wang, B.6    Zhang, L.7    Kakar, S.8    Jun, Y.9    Miller, D.10
  • 72
    • 84875603119 scopus 로고    scopus 로고
    • A comparative evaluation of the regulation of GM crops or products containing dsRNA and suggested improvements to risk assessments
    • Heinemann JA, Agapito-Tenfen SZ, Carman JA. A comparative evaluation of the regulation of GM crops or products containing dsRNA and suggested improvements to risk assessments. Environ Int 2013;55:43-55.
    • (2013) Environ Int , vol.55 , pp. 43-55
    • Heinemann, J.A.1    Agapito-Tenfen, S.Z.2    Carman, J.A.3
  • 74
    • 84881248839 scopus 로고    scopus 로고
    • The gut microbiota of insects-diversity in structure and function
    • Engel P, Moran NA. The gut microbiota of insects-diversity in structure and function. FEMS Microbiol Rev 2013;37:699-735.
    • (2013) FEMS Microbiol Rev , vol.37 , pp. 699-735
    • Engel, P.1    Moran, N.A.2
  • 76
    • 84951130620 scopus 로고    scopus 로고
    • Computational characterization of exogenous microRNAs that can be transferred into human circulation
    • Shu J, Chiang K, Zempleni J, Cui J. Computational characterization of exogenous microRNAs that can be transferred into human circulation. PLoS One 2015;10:e0140587.
    • (2015) PLoS One , vol.10
    • Shu, J.1    Chiang, K.2    Zempleni, J.3    Cui, J.4
  • 78
    • 84928256274 scopus 로고    scopus 로고
    • No effect of an elevated miR-30b level in mouse milk on its level in pup tissues
    • Laubier J, Castille J, Le Guillou S, Le Provost F. No effect of an elevated miR-30b level in mouse milk on its level in pup tissues. RNA Biol 2015;12:26-9.
    • (2015) RNA Biol , vol.12 , pp. 26-29
    • Laubier, J.1    Castille, J.2    Le Guillou, S.3    Le Provost, F.4
  • 79
    • 84942342323 scopus 로고    scopus 로고
    • Uptake and function studies of maternal milk-derived microRNAs
    • Title AC, Denzler R, Stoffel M. Uptake and function studies of maternal milk-derived microRNAs. J Biol Chem 2015;290:23680-91.
    • (2015) J Biol Chem , vol.290 , pp. 23680-23691
    • Title, A.C.1    Denzler, R.2    Stoffel, M.3
  • 80
    • 85026332227 scopus 로고    scopus 로고
    • Cell-free packaging of microRNAs into exosomes reveals Y-box protein I as a critical sorting factor
    • Dec 12 San Diego, CA [conference abstract]. American Society for Cell Biology 2015 ASCB Meeting abstracts. Mol Biol Cell 2015;26
    • Shurtleff M. Cell-free packaging of microRNAs into exosomes reveals Y-box protein I as a critical sorting factor. Annual meeting of the American Society for Cell Biology; 2015 Dec 12; San Diego, CA [conference abstract]. American Society for Cell Biology 2015 ASCB Meeting abstracts. Mol Biol Cell 2015;26:B1110.
    • (2015) Annual meeting of the American Society for Cell Biology , pp. B1110
    • Shurtleff, M.1
  • 82
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005;17:1-14.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 83
    • 84930317739 scopus 로고    scopus 로고
    • Viral single stranded RNA induces a trophoblast pro-inflammatory and antiviral response in a TLR8-dependent and-independent manner
    • Potter JA, Garg M, Girard S, Abrahams VM. Viral single stranded RNA induces a trophoblast pro-inflammatory and antiviral response in a TLR8-dependent and-independent manner. Biol Reprod 2015; 92:17.
    • (2015) Biol Reprod , vol.92 , pp. 17
    • Potter, J.A.1    Garg, M.2    Girard, S.3    Abrahams, V.M.4
  • 84
    • 84878563100 scopus 로고    scopus 로고
    • Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA
    • Tatematsu M, Nishikawa F, Seya T, Matsumoto M. Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA. Nat Commun 2013;4:1833.
    • (2013) Nat Commun , vol.4 , pp. 1833
    • Tatematsu, M.1    Nishikawa, F.2    Seya, T.3    Matsumoto, M.4
  • 89
    • 70350778445 scopus 로고    scopus 로고
    • Single-molecule analysis of protein-free U2-U6 snRNAs
    • Guo Z, Karunatilaka KS, Rueda D. Single-molecule analysis of protein-free U2-U6 snRNAs. Nat Struct Mol Biol 2009;16:1154-9.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 1154-1159
    • Guo, Z.1    Karunatilaka, K.S.2    Rueda, D.3
  • 90
    • 0030785688 scopus 로고    scopus 로고
    • Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem
    • Maden BE, Hughes JM. Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem. Chromosoma 1997;105:391-400.
    • (1997) Chromosoma , vol.105 , pp. 391-400
    • Maden, B.E.1    Hughes, J.M.2
  • 91
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9:654-9.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 93
    • 85009242136 scopus 로고    scopus 로고
    • [cited 2016 Jan 5]. Available from:
    • National Institute of Allergy and Infectious Diseases. Immune tolerance. 2014 [cited 2016 Jan 5]. Available from: https://www.niaid.nih. gov/topics/immunesystem/Pages/immuneTolerance.aspx.
    • (2014) Immune tolerance
  • 94
    • 84971605939 scopus 로고    scopus 로고
    • [cited 2016 Jan 5]. Available from:
    • National Institute of Allergy and Infectious Diseases. Food allergy. 2015 [cited 2016 Jan 5]. Available from: https://www.niaid.nih.gov/topics/foodallergy/Pages/default.aspx.
    • (2015) Food allergy
  • 95
    • 84878661930 scopus 로고    scopus 로고
    • Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3'-untranslated regions
    • Batagov AO, Kurochkin IV. Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3'-untranslated regions. Biol Direct 2013;8:12.
    • (2013) Biol Direct , vol.8 , pp. 12
    • Batagov, A.O.1    Kurochkin, I.V.2
  • 97
    • 84856781208 scopus 로고    scopus 로고
    • Identification of mouse serum miRNA endogenous references by global gene expression profiles
    • Mi QS, Weiland M, Qi RQ, Gao XH, Poisson LM, Zhou L. Identification of mouse serum miRNA endogenous references by global gene expression profiles. PLoS One 2012;7:e31278.
    • (2012) PLoS One , vol.7
    • Mi, Q.S.1    Weiland, M.2    Qi, R.Q.3    Gao, X.H.4    Poisson, L.M.5    Zhou, L.6
  • 98
    • 57849091628 scopus 로고    scopus 로고
    • Ascorbic acid degradation kinetics of sonicated juice during storage and comparison with thermally pasteurised juice
    • Tiwari BK, O'Donnell CP, Muthukumarappan K, Cullen PJ. Ascorbic acid degradation kinetics of sonicated juice during storage and comparison with thermally pasteurised juice. Food Sci Technol (Campinas) 2009;42:700-4.
    • (2009) Food Sci Technol (Campinas) , vol.42 , pp. 700-704
    • Tiwari, B.K.1    O'Donnell, C.P.2    Muthukumarappan, K.3    Cullen, P.J.4
  • 99
    • 84874819067 scopus 로고    scopus 로고
    • Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum
    • Sun Q, Chen X, Yu J, Zen K, Zhang CY, Li L. Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum. Protein Cell 2013;4:197-210.
    • (2013) Protein Cell , vol.4 , pp. 197-210
    • Sun, Q.1    Chen, X.2    Yu, J.3    Zen, K.4    Zhang, C.Y.5    Li, L.6
  • 100
    • 84908121669 scopus 로고    scopus 로고
    • Challenges posed by extracellular vesicles from eukaryotic microbes
    • Wolf JM, Casadevall A. Challenges posed by extracellular vesicles from eukaryotic microbes. Curr Opin Microbiol 2014;22:73-8.
    • (2014) Curr Opin Microbiol , vol.22 , pp. 73-78
    • Wolf, J.M.1    Casadevall, A.2
  • 102
    • 84879417292 scopus 로고    scopus 로고
    • Body fat and bone mineral content of infants fed breast milk, cow's milk formula, or soy formula during the first year of life
    • Andres A, Casey PH, Cleves MA, Badger TM. Body fat and bone mineral content of infants fed breast milk, cow's milk formula, or soy formula during the first year of life. J Pediatr 2013;163:49-54.
    • (2013) J Pediatr , vol.163 , pp. 49-54
    • Andres, A.1    Casey, P.H.2    Cleves, M.A.3    Badger, T.M.4
  • 103
    • 84957812818 scopus 로고    scopus 로고
    • Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk
    • Alsaweed M, Lai CT, Hartmann PE, Geddes DT, Kakulas F. Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk. Sci Rep 2016;6:20680.
    • (2016) Sci Rep , vol.6 , pp. 20680
    • Alsaweed, M.1    Lai, C.T.2    Hartmann, P.E.3    Geddes, D.T.4    Kakulas, F.5
  • 104
    • 84978473013 scopus 로고    scopus 로고
    • Uptake of dietary milk miRNAs by adult humans: a validation study
    • Auerbach A, Vyas G, Li A, Halushka M, Witwer K. Uptake of dietary milk miRNAs by adult humans: a validation study. F1000Res 2016; 5:721.
    • (2016) F1000Res , vol.5
    • Auerbach, A.1    Vyas, G.2    Li, A.3    Halushka, M.4    Witwer, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.