Oligosaccharides in infant formula: More evidence to validate the role of prebiotics

British Journal of Nutrition

Volumn 113, Issue 9, 2015, Pages 1339-1344

  Vandenplas, Yvan ^a   Zakharova, Irina ^b   Dmitrieva, Yulia ^b  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b Russian Medical Academy of Postgraduate Education   (Russian Federation)

Author keywords

Breast feeding; Galacto oligosaccharides; Infant feeding; Infant formula; Oligosaccharides; Prebiotics

Indexed keywords

FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; GLUCOSE; OLIGOSACCHARIDE; PREBIOTIC AGENT; FRUCTOSE; GALACTOSE; GLUCAN; POLYDEXTROSE;

ARTIFICIAL MILK; BREAST FEEDING; BREAST MILK; DEFECATION; FECES; GOLD STANDARD; HUMAN; IMMUNE SYSTEM; INFANT FEEDING; INTESTINE FLORA; METABOLISM; PH; REVIEW; BIFIDOBACTERIUM; CHEMISTRY; DERMATITIS, ATOPIC; DRUG EFFECTS; GASTROINTESTINAL TRACT; HYPERSENSITIVITY; IMMUNITY; INFANT; MICROBIOLOGY; MICROFLORA; WEIGHT GAIN;

BIFIDOBACTERIUM; BREAST FEEDING; DEFECATION; DERMATITIS, ATOPIC; FECES; FRUCTOSE; GALACTOSE; GASTROINTESTINAL TRACT; GLUCANS; HUMANS; HYPERSENSITIVITY; IMMUNITY; INFANT; INFANT FORMULA; MICROBIOTA; MILK, HUMAN; OLIGOSACCHARIDES; PREBIOTICS; WEIGHT GAIN;

EID: 84929715983     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515000823     Document Type: Review

References (54)

1. Kunz C, Rudloff S, Baier W, et al. (2000) Oligosaccharides in human milk: structural, functional, and metabolic aspects. Annu Rev Nutr 20, 699-722.
2. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, et al. (2000) Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 30, 61-71.
3. Johnson CL & Versalovic J (2012) The human microbiome and its potential importance to pediatrics. Pediatrics 129, 950-960.
4. Gibson GR & Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125, 1401-1412.
5. Roberfroid M, Gibson GR, Hoyles L, et al. (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104, Suppl. 2, S1-S63.
6. Yaron S, Shachar D, Abramas L, et al. (2013) Effect of high β-palmitate content in infant formula on the intestinal microbiota of term infants. J Pediatr Gastroenterol Nutr 56, 376-381.
7. Stewart ML, Timm DA & Slavin JL (2008) Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system. Nutr Res 28, 329-334.
8. González R, Klaassens ES, Malinen E, et al. (2008) Differential transcriptional response of Bifidobacterium longum to human milk, formula milk, and galactooligosaccharide. Appl Environ Microbiol 74, 4686-4694.
9. Watson D, O'Connell Motherway M, Schoterman MH, et al. (2013) Selective carbohydrate utilization by lactobacilli and bifidobacteria. J Appl Microbiol 114, 1132-1146.
10. Veereman-Wauters G, Staelens S, Van de Broek H, et al. (2011) Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr 52, 763-771.
11. Knol J, Scholtens P, Kafka C, et al. (2005) Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants. J Pediatr Gastroenterol Nutr 40, 36-42.
12. Scholtens PA, Alliet P, Raes M, et al. (2008) Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and longchain fructo-oligosaccharides. J Nutr 138, 1141-1147.
13. Sierra C, Bernal MJ, Blasco J, et al. (2015) Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: a multicentre, randomised, double-blind and placebo-controlled trial. Eur J Nutr 54, 89-99.
14. Ben XM, Li J, Feng ZT, et al. (2008) Low level of galactooligosaccharide in infant formula stimulates growth of intestinal bifidobacteria and lactobacilli. World J Gastroenterol 14, 6564-6568.
15. Ben XM, Zhou XY, Zhao WH, et al. (2004) Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl) 117, 927-931.
16. Rinne MM, Gueimonde M, Kalliomäki M, et al. (2005) Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota. FEMS Immunol Med Microbiol 43, 59-65.
17. Fedorak RN & Madsen KI (2004) Probiotics and prebiotics in gastrointestinal disorders. Curr Opin Gastroenterol 20, 146-155.
18. Costalos C, Kapiki A, Apostolou M, et al. (2008) The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants. Early Hum Dev 84, 45-49.
19. Scalabrin DM, Mitmesser SH, Welling GW, et al. (2012) New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr 54, 343-352.
20. Kapiki A, Costalos C, Oikonomidou C, et al. (2007) The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Hum Dev 83, 335-339.
21. Nakamura N, Gaskins HR, Collier CT, et al. (2009) Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol 75, 1121-1128.
22. Walton GE, van den Heuvel EG, Kosters MH, et al. (2012) A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age. Br J Nutr 107, 1466-1475.
23. Ladirat SE, Schuren FH, Schoterman MH, et al. (2014) Impact of galacto-oligosaccharides on the gut microbiota composition and metabolic activity upon antibiotic treatment during in vitro fermentation. FEMS Microbiol Ecol 87, 41-51.
24. Bakker-Zierikzee AM, Alles MS, Knol J, et al. (2005) Effects of infant formula containing a mixture of galacto- and fructooligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life. Br J Nutr 94, 783-790.
25. Rodriguez-Colinas B, Kolida S, Baran M, et al. (2013) Analysis of fermentation selectivity of purified galacto-oligosaccharides by in vitro human faecal fermentation. Appl Microbiol Biotechnol 97, 5743-5752.
26. Schmelzle H, Wirth S, Skopnik H, et al. (2003) Randomized double-blind study of the nutritional efficacy and bifidogenicity of a new infant formula containing partially hydrolyzed protein, a high beta-palmitic acid level, and nondigestible oligosaccharides. J Pediatr Gastroenterol Nutr 36, 343-351.
27. Williams T, Choe Y, Price P, et al. (2014) Tolerance of formulas containing prebiotics in healthy, term infants. J Pediatr Gastroenterol Nutr 59, 653-658.
28. Mugambi MN, Musekiwa A, Lombard M, et al. (2012) Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review. Nutr J 11, 81.
29. Rao S, Srinivasjois R & Patole S (2009) Prebiotic supplementation in full-term neonates: a systematic review of randomized controlled trials. Arch Pediatr Adolesc Med 163, 755-764.
30. Piemontese P, Giannì ML, Braegger CP, et al. (2011) Tolerance and safety evaluation in a large cohort of healthy infants fed an innovative prebiotic formula: a randomized controlled trial. PLoS ONE 6, e28010.
31. dos Santos EF, Tsuboi KH, Araújo MR, et al. (2011) Dietary galactooligosaccharides increase calcium absorption in normal and gastrectomized rats. Rev Col Bras Cir 38, 186-191.
32. Alliet P, Scholtens P, Raes M, et al. (2007) Effect of prebiotic galacto-oligosaccharide, long-chain fructo-oligosaccharide infant formula on serum cholesterol and triacylglycerol levels. Nutrition 23, 719-723.
33. Bruzzese E, Volpicelli M, Squeglia V, et al. (2009) A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: an observational study. Clin Nutr 28, 156-161.
34. Arslanoglu S, Moro GE, Schmitt J, et al. (2008) Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr 138, 1091-1095.
35. Arslanoglu S, Moro GE & Boehm G (2007) Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J Nutr 137, 2420-2424.
36. van Stuijvenberg M, Eisses AM, Grüber C, et al. (2011) Do prebiotics reduce the number of fever episodes in healthy children in their first year of life: a randomised controlled trial. Br J Nutr 106, 1740-1748.
37. Braegger C, Chmielewska A, Decsi T, et al. (2011) Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 52, 238-250.
38. Fukushima Y, Kawata Y, Hara H, et al. (1998) Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol 42, 39-44.
39. Yasui H, Mike A & Ohwaki M (1989) Immunogenicity of Bifidobacterium breve and change in antibody production in Peyer's patches after oral administration. J Dairy Sci 72, 30-35.
40. Seifert S & Watzl B (2007) Inulin and oligofructose: review of experimental data on immune modulation. J Nutr 137, Suppl. 11, 2563S-2567S.
41. Field CJ, Van Aerde JE, Robinson LE, et al. (2008) Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates. Br J Nutr 99, 91-99.
42. Raes M, Scholtens PA, Alliet P, et al. (2010) Exploration of basal immune parameters in healthy infants receiving an infant milk formula supplemented with prebiotics. Pediatr Allergy Immunol 21, e377-e385.
43. Gopalakrishnan A, Clinthorne JF, Rondini EA, et al. (2012) Supplementation with galacto-oligosaccharides increases the percentage of NK cells and reduces colitis severity in Smad3-deficient mice. J Nutr 142, 1336-1342.
44. van Hoffen E, Ruiter B, Faber J, et al. (2009) A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy. Allergy 64, 484-487.
45. Bakker-Zierikzee AM, Tol EA, Kroes H, et al. (2006) Faecal SIgA secretion in infants fed on pre- or probiotic infant formula. Pediatr Allergy Immunol 17, 134-140.
46. Schouten B, Van Esch BC, Kormelink TG, et al. (2011) Nondigestible oligosaccharides reduce immunoglobulin free light-chain concentrations in infants at risk for allergy. Pediatr Allergy Immunol 22, 537-542.
47. Tanabe S & Hochi S (2010) Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice. Int J Mol Med 25, 331-336.
48. Moro G, Arslanoglu S, Stahl B, et al. (2006) A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 91, 814-819.
49. Williams HC & Grindlay DJ (2010) What's new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 2. Disease prevention and treatment. Clin Exp Dermatol 35, 223-227.
50. Vos AP, van Esch B, M'Rabet L, et al. (2007) Dietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in mice. Int Immunopharmacol 6, 1277-1286.
51. Vos AP, Haarman M, Buco A, et al. (2006) A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model. Int Immunopharmacol 6, 1277-1286.
52. Gourbeyre P, Desbuards N, Grémy G, et al. (2013) Perinatal and postweaning exposure to galactooligosaccharides/inulin prebiotics induced biomarkers linked to tolerance mechanism in a mouse model of strong allergic sensitization. J Agric Food Chem 61, 6311-6320.
53. Osborn DA & Sinn JK (2013) Prebiotics in infants for prevention of allergy. The Cochrane Database of Systematic Reviews 2013, issue 3, CD006474.
54. Grüber C, van Stuijvenberg M, Mosca F, et al. (2010) Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol 126, 791-797.