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1
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1 Topalian, S.L., Drake, C.G., Pardoll, D.M., Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27 (2015), 450–461.
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Topalian, S.L.1
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Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
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2 Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
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Sharma, P.1
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3
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Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
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3 Anderson, A.C., Joller, N., Kuchroo, V.K., Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity 44 (2016), 989–1004.
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Anderson, A.C.1
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4
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Galectins and immune responses-just how do they do those things they do?
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4 Thiemann, S., Baum, L.G., Galectins and immune responses-just how do they do those things they do?. Annu Rev Immunol 34 (2016), 243–264.
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5 Rabinovich, G.A., Conejo-Garcia, J.R., Shaping the immune landscape in cancer by galectin-driven regulatory pathways. J Mol Biol 428 (2016), 3266–3281.
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Rabinovich, G.A.1
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Regulatory circuits mediated by lectin–glycan interactions in autoimmunity and cancer
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6 Rabinovich, G.A., Croci, D.O., Regulatory circuits mediated by lectin–glycan interactions in autoimmunity and cancer. Immunity 36 (2012), 322–335.
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Rabinovich, G.A.1
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Galectin-binding O-glycosylations as regulators of malignancy
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7 Dimitroff, C.J., Galectin-binding O-glycosylations as regulators of malignancy. Cancer Res 75 (2015), 3195–3202.
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Dimitroff, C.J.1
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8
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Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation
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8 Lau, K.S., Partridge, E.A., Grigorian, A., Silvescu, C.I., Reinhold, V.N., Demetriou, M., Dennis, J.W., Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129 (2007), 123–134.
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Lau, K.S.1
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Reinhold, V.N.5
Demetriou, M.6
Dennis, J.W.7
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9
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84962221817
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Galectin-3 shapes antitumor immune responses by suppressing CD8+ T cells via LAG-3 and inhibiting expansion of plasmacytoid dendritic cells
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This study reports the role of galectin-3 as a potent suppressor of CD8+ antitumor T cell responses via direct interaction with the checkpoint molecule LAG-3.
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9•• Kouo, T., Huang, L., Pucsek, A.B., Cao, M., Solt, S., Armstrong, T., Jaffee, E., Galectin-3 shapes antitumor immune responses by suppressing CD8+ T cells via LAG-3 and inhibiting expansion of plasmacytoid dendritic cells. Cancer Immunol Res 3 (2015), 412–423 This study reports the role of galectin-3 as a potent suppressor of CD8+ antitumor T cell responses via direct interaction with the checkpoint molecule LAG-3.
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Cancer Immunol Res
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Kouo, T.1
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Armstrong, T.6
Jaffee, E.7
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10
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30744445427
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Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death
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10 Stillman, B.N., Hsu, D.K., Pang, M., Brewer, C.F., Johnson, P., Liu, F.T., Baum, L.G., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol 176 (2006), 778–789.
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Stillman, B.N.1
Hsu, D.K.2
Pang, M.3
Brewer, C.F.4
Johnson, P.5
Liu, F.T.6
Baum, L.G.7
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11
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84865351085
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Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration
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11 Starossom, S.C., Mascanfroni, I.D., Imitola, J., Cao, L., Raddassi, K., Hernandez, S.F., Bassil, R., Croci, D.O., Cerliani, J.P., Delacour, D., et al. Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration. Immunity 37 (2012), 249–263.
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Immunity
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Starossom, S.C.1
Mascanfroni, I.D.2
Imitola, J.3
Cao, L.4
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Hernandez, S.F.6
Bassil, R.7
Croci, D.O.8
Cerliani, J.P.9
Delacour, D.10
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12
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84901813814
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The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1
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12 de la Fuente, H., Cruz-Adalia, A., Martinez Del Hoyo, G., Cibrian-Vera, D., Bonay, P., Perez-Hernandez, D., Vazquez, J., Navarro, P., Gutierrez-Gallego, R., Ramirez-Huesca, M., et al. The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. Mol Cell Biol 34 (2014), 2479–2487.
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de la Fuente, H.1
Cruz-Adalia, A.2
Martinez Del Hoyo, G.3
Cibrian-Vera, D.4
Bonay, P.5
Perez-Hernandez, D.6
Vazquez, J.7
Navarro, P.8
Gutierrez-Gallego, R.9
Ramirez-Huesca, M.10
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13
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84923863050
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Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions
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13 Bonzi, J., Bornet, O., Betzi, S., Kasper, B.T., Mahal, L.K., Mancini, S.J., Schiff, C., Sebban-Kreuzer, C., Guerlesquin, F., Elantak, L., Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions. Nat Commun, 6, 2015, 6194.
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Bonzi, J.1
Bornet, O.2
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Mancini, S.J.6
Schiff, C.7
Sebban-Kreuzer, C.8
Guerlesquin, F.9
Elantak, L.10
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14
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30044434075
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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
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14 Zhu, C., Anderson, A.C., Schubart, A., Xiong, H., Imitola, J., Khoury, S.J., Zheng, X.X., Strom, T.B., Kuchroo, V.K., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6 (2005), 1245–1252.
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Zhu, C.1
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Khoury, S.J.6
Zheng, X.X.7
Strom, T.B.8
Kuchroo, V.K.9
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15
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84907311696
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Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells
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The authors demonstrate the relevance of galectin-9 in the differentiation and stability of inducible regulatory T cells through mechanisms involving formation of CD44-TGF-βRI complexes.
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15•• Wu, C., Thalhamer, T., Franca, R.F., Xiao, S., Wang, C., Hotta, C., Zhu, C., Hirashima, M., Anderson, A.C., Kuchroo, V.K., Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41 (2014), 270–282 The authors demonstrate the relevance of galectin-9 in the differentiation and stability of inducible regulatory T cells through mechanisms involving formation of CD44-TGF-βRI complexes.
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Immunity
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Wu, C.1
Thalhamer, T.2
Franca, R.F.3
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Hotta, C.6
Zhu, C.7
Hirashima, M.8
Anderson, A.C.9
Kuchroo, V.K.10
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16
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69049116053
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Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
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16 Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., Geffner, J.R., Rabinovich, G.A., Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 10 (2009), 981–991.
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Ilarregui, J.M.1
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Bianco, G.A.3
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Salatino, M.5
Vermeulen, M.E.6
Geffner, J.R.7
Rabinovich, G.A.8
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17
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84942436387
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Trypanosoma cruzi infection imparts a regulatory program in dendritic cells and T cells via galectin-1-dependent mechanisms
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17 Poncini, C.V., Ilarregui, J.M., Batalla, E.I., Engels, S., Cerliani, J.P., Cucher, M.A., van Kooyk, Y., Gonzalez-Cappa, S.M., Rabinovich, G.A., Trypanosoma cruzi infection imparts a regulatory program in dendritic cells and T cells via galectin-1-dependent mechanisms. J Immunol 195 (2015), 3311–3324.
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Poncini, C.V.1
Ilarregui, J.M.2
Batalla, E.I.3
Engels, S.4
Cerliani, J.P.5
Cucher, M.A.6
van Kooyk, Y.7
Gonzalez-Cappa, S.M.8
Rabinovich, G.A.9
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18
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84959123285
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Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells
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18 Tesone, A.J., Rutkowski, M.R., Brencicova, E., Svoronos, N., Perales-Puchalt, A., Stephen, T.L., Allegrezza, M.J., Payne, K.K., Nguyen, J.M., Wickramasinghe, J., et al. Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells. Cell Rep 14 (2016), 1774–1786.
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Cell Rep
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Tesone, A.J.1
Rutkowski, M.R.2
Brencicova, E.3
Svoronos, N.4
Perales-Puchalt, A.5
Stephen, T.L.6
Allegrezza, M.J.7
Payne, K.K.8
Nguyen, J.M.9
Wickramasinghe, J.10
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19
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33847376532
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Galectin-1: a key effector of regulation mediated by CD4 + CD25+ T cells
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19 Garin, M.I., Chu, C.C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: a key effector of regulation mediated by CD4 + CD25+ T cells. Blood 109 (2007), 2058–2065.
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Garin, M.I.1
Chu, C.C.2
Golshayan, D.3
Cernuda-Morollon, E.4
Wait, R.5
Lechler, R.I.6
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20
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12144285871
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Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege
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20 Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Fainboim, L., Podhajcer, O.L., Rabinovich, G.A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege. Cancer Cell 5 (2004), 241–251.
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Rubinstein, N.1
Alvarez, M.2
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Toscano, M.A.4
Ilarregui, J.M.5
Bravo, A.6
Mordoh, J.7
Fainboim, L.8
Podhajcer, O.L.9
Rabinovich, G.A.10
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21
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34548740090
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The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma
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21 Juszczynski, P., Ouyang, J., Monti, S., Rodig, S.J., Takeyama, K., Abramson, J., Chen, W., Kutok, J.L., Rabinovich, G.A., Shipp, M.A., The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A 104 (2007), 13134–13139.
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Juszczynski, P.1
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Monti, S.3
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Takeyama, K.5
Abramson, J.6
Chen, W.7
Kutok, J.L.8
Rabinovich, G.A.9
Shipp, M.A.10
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22
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84858977200
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Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor
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22 Kuo, P.L., Huang, M.S., Cheng, D.E., Hung, J.Y., Yang, C.J., Chou, S.H., Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. J Biol Chem 287 (2012), 9753–9764.
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Kuo, P.L.1
Huang, M.S.2
Cheng, D.E.3
Hung, J.Y.4
Yang, C.J.5
Chou, S.H.6
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23
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84968846665
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Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis
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23 Hsu, Y.L., Hung, J.Y., Chiang, S.Y., Jian, S.F., Wu, C.Y., Lin, Y.S., Tsai, Y.M., Chou, S.H., Tsai, M.J., Kuo, P.L., Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis. Oncotarget 7 (2016), 27584–27598.
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Oncotarget
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Hsu, Y.L.1
Hung, J.Y.2
Chiang, S.Y.3
Jian, S.F.4
Wu, C.Y.5
Lin, Y.S.6
Tsai, Y.M.7
Chou, S.H.8
Tsai, M.J.9
Kuo, P.L.10
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24
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84894136530
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Glycosylation-dependent lectin–receptor interactions preserve angiogenesis in anti-VEGF refractory tumors
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This study defines a glycosylation-based mechanism mediated by galectin–receptor interactions that links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in settings of VEGF blockade.
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24• Croci, D.O., Cerliani, J.P., Dalotto-Moreno, T., Mendez-Huergo, S.P., Mascanfroni, I.D., Dergan-Dylon, S., Toscano, M.A., Caramelo, J.J., Garcia-Vallejo, J.J., Ouyang, J., et al. Glycosylation-dependent lectin–receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell 156 (2014), 744–758 This study defines a glycosylation-based mechanism mediated by galectin–receptor interactions that links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in settings of VEGF blockade.
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Cell
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Croci, D.O.1
Cerliani, J.P.2
Dalotto-Moreno, T.3
Mendez-Huergo, S.P.4
Mascanfroni, I.D.5
Dergan-Dylon, S.6
Toscano, M.A.7
Caramelo, J.J.8
Garcia-Vallejo, J.J.9
Ouyang, J.10
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25
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84873449312
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Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease
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25 Dalotto-Moreno, T., Croci, D.O., Cerliani, J.P., Martinez-Allo, V.C., Dergan-Dylon, S., Mendez-Huergo, S.P., Stupirski, J.C., Mazal, D., Osinaga, E., Toscano, M.A., et al. Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease. Cancer Res 73 (2013), 1107–1117.
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Cancer Res
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Dalotto-Moreno, T.1
Croci, D.O.2
Cerliani, J.P.3
Martinez-Allo, V.C.4
Dergan-Dylon, S.5
Mendez-Huergo, S.P.6
Stupirski, J.C.7
Mazal, D.8
Osinaga, E.9
Toscano, M.A.10
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26
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84863214425
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Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
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26 Soldati, R., Berger, E., Zenclussen, A.C., Jorch, G., Lode, H.N., Salatino, M., Rabinovich, G.A., Fest, S., Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments. Int J Cancer 131 (2012), 1131–1141.
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Int J Cancer
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Soldati, R.1
Berger, E.2
Zenclussen, A.C.3
Jorch, G.4
Lode, H.N.5
Salatino, M.6
Rabinovich, G.A.7
Fest, S.8
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27
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84973169046
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Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells
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27 Baker, G.J., Chockley, P., Zamler, D., Castro, M.G., Lowenstein, P.R., Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells. Oncoimmunology, 5, 2016, e1163461.
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Oncoimmunology
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Baker, G.J.1
Chockley, P.2
Zamler, D.3
Castro, M.G.4
Lowenstein, P.R.5
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28
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84922202505
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Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation
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This study identifies a regulatory circuit mediated by IL-6 and galectin-1 that links commensal microbiota, TLR5-driven systemic inflammation, immunosuppression and distal tumor growth.
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28• Rutkowski, M.R., Stephen, T.L., Svoronos, N., Allegrezza, M.J., Tesone, A.J., Perales-Puchalt, A., Brencicova, E., Escovar-Fadul, X., Nguyen, J.M., Cadungog, M.G., et al. Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell 27 (2015), 27–40 This study identifies a regulatory circuit mediated by IL-6 and galectin-1 that links commensal microbiota, TLR5-driven systemic inflammation, immunosuppression and distal tumor growth.
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(2015)
Cancer Cell
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, pp. 27-40
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Rutkowski, M.R.1
Stephen, T.L.2
Svoronos, N.3
Allegrezza, M.J.4
Tesone, A.J.5
Perales-Puchalt, A.6
Brencicova, E.7
Escovar-Fadul, X.8
Nguyen, J.M.9
Cadungog, M.G.10
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29
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84859849194
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Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma
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29 Cedeno-Laurent, F., Watanabe, R., Teague, J.E., Kupper, T.S., Clark, R.A., Dimitroff, C.J., Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood 119 (2012), 3534–3538.
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Blood
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Cedeno-Laurent, F.1
Watanabe, R.2
Teague, J.E.3
Kupper, T.S.4
Clark, R.A.5
Dimitroff, C.J.6
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30
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84903955050
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Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation
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This study explores the relevance of galectin-1 in tumor–stromal interactions within the complex microenvironment of pancreatic ductal adenocarcinoma.
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30•• Martinez-Bosch, N., Fernandez-Barrena, M.G., Moreno, M., Ortiz-Zapater, E., Munne-Collado, J., Iglesias, M., Andre, S., Gabius, H.J., Hwang, R.F., Poirier, F., et al. Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation. Cancer Res 74 (2014), 3512–3524 This study explores the relevance of galectin-1 in tumor–stromal interactions within the complex microenvironment of pancreatic ductal adenocarcinoma.
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(2014)
Cancer Res
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Martinez-Bosch, N.1
Fernandez-Barrena, M.G.2
Moreno, M.3
Ortiz-Zapater, E.4
Munne-Collado, J.5
Iglesias, M.6
Andre, S.7
Gabius, H.J.8
Hwang, R.F.9
Poirier, F.10
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31
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77957355951
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A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice
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31 Demotte, N., Wieers, G., Van Der Smissen, P., Moser, M., Schmidt, C., Thielemans, K., Squifflet, J.L., Weynand, B., Carrasco, J., Lurquin, C., et al. A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice. Cancer Res 70 (2010), 7476–7488.
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Cancer Res
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Demotte, N.1
Wieers, G.2
Van Der Smissen, P.3
Moser, M.4
Schmidt, C.5
Thielemans, K.6
Squifflet, J.L.7
Weynand, B.8
Carrasco, J.9
Lurquin, C.10
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32
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84979626000
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A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
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The authors demonstrate a galectin-3-driven immune evasive mechanism leading to defects in cytokine secretion, lack of completion of secretory synapses and impaired adhesion of tumor-infiltrating lymphocytes to their targets.
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32•• Petit, A.E., Demotte, N., Scheid, B., Wildmann, C., Bigirimana, R., Gordon-Alonso, M., Carrasco, J., Valitutti, S., Godelaine, D., van der Bruggen, P., A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion. Nat Commun, 7, 2016, 12242 The authors demonstrate a galectin-3-driven immune evasive mechanism leading to defects in cytokine secretion, lack of completion of secretory synapses and impaired adhesion of tumor-infiltrating lymphocytes to their targets.
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(2016)
Nat Commun
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