메뉴 건너뛰기




Volumn 45, Issue , 2017, Pages 8-15

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis

Author keywords

[No Author keywords available]

Indexed keywords

GALECTIN; GLYCAN;

EID: 85009152051     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2016.12.003     Document Type: Review
Times cited : (126)

References (80)
  • 1
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • 1 Topalian, S.L., Drake, C.G., Pardoll, D.M., Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27 (2015), 450–461.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 2
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • 2 Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 3
    • 84966832820 scopus 로고    scopus 로고
    • Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
    • 3 Anderson, A.C., Joller, N., Kuchroo, V.K., Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity 44 (2016), 989–1004.
    • (2016) Immunity , vol.44 , pp. 989-1004
    • Anderson, A.C.1    Joller, N.2    Kuchroo, V.K.3
  • 4
    • 84969900633 scopus 로고    scopus 로고
    • Galectins and immune responses-just how do they do those things they do?
    • 4 Thiemann, S., Baum, L.G., Galectins and immune responses-just how do they do those things they do?. Annu Rev Immunol 34 (2016), 243–264.
    • (2016) Annu Rev Immunol , vol.34 , pp. 243-264
    • Thiemann, S.1    Baum, L.G.2
  • 5
    • 84975256659 scopus 로고    scopus 로고
    • Shaping the immune landscape in cancer by galectin-driven regulatory pathways
    • 5 Rabinovich, G.A., Conejo-Garcia, J.R., Shaping the immune landscape in cancer by galectin-driven regulatory pathways. J Mol Biol 428 (2016), 3266–3281.
    • (2016) J Mol Biol , vol.428 , pp. 3266-3281
    • Rabinovich, G.A.1    Conejo-Garcia, J.R.2
  • 6
    • 84858766894 scopus 로고    scopus 로고
    • Regulatory circuits mediated by lectin–glycan interactions in autoimmunity and cancer
    • 6 Rabinovich, G.A., Croci, D.O., Regulatory circuits mediated by lectin–glycan interactions in autoimmunity and cancer. Immunity 36 (2012), 322–335.
    • (2012) Immunity , vol.36 , pp. 322-335
    • Rabinovich, G.A.1    Croci, D.O.2
  • 7
    • 84942921705 scopus 로고    scopus 로고
    • Galectin-binding O-glycosylations as regulators of malignancy
    • 7 Dimitroff, C.J., Galectin-binding O-glycosylations as regulators of malignancy. Cancer Res 75 (2015), 3195–3202.
    • (2015) Cancer Res , vol.75 , pp. 3195-3202
    • Dimitroff, C.J.1
  • 8
    • 33947724303 scopus 로고    scopus 로고
    • Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation
    • 8 Lau, K.S., Partridge, E.A., Grigorian, A., Silvescu, C.I., Reinhold, V.N., Demetriou, M., Dennis, J.W., Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129 (2007), 123–134.
    • (2007) Cell , vol.129 , pp. 123-134
    • Lau, K.S.1    Partridge, E.A.2    Grigorian, A.3    Silvescu, C.I.4    Reinhold, V.N.5    Demetriou, M.6    Dennis, J.W.7
  • 9
    • 84962221817 scopus 로고    scopus 로고
    • Galectin-3 shapes antitumor immune responses by suppressing CD8+ T cells via LAG-3 and inhibiting expansion of plasmacytoid dendritic cells
    • This study reports the role of galectin-3 as a potent suppressor of CD8+ antitumor T cell responses via direct interaction with the checkpoint molecule LAG-3.
    • 9•• Kouo, T., Huang, L., Pucsek, A.B., Cao, M., Solt, S., Armstrong, T., Jaffee, E., Galectin-3 shapes antitumor immune responses by suppressing CD8+ T cells via LAG-3 and inhibiting expansion of plasmacytoid dendritic cells. Cancer Immunol Res 3 (2015), 412–423 This study reports the role of galectin-3 as a potent suppressor of CD8+ antitumor T cell responses via direct interaction with the checkpoint molecule LAG-3.
    • (2015) Cancer Immunol Res , vol.3 , pp. 412-423
    • Kouo, T.1    Huang, L.2    Pucsek, A.B.3    Cao, M.4    Solt, S.5    Armstrong, T.6    Jaffee, E.7
  • 10
    • 30744445427 scopus 로고    scopus 로고
    • Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death
    • 10 Stillman, B.N., Hsu, D.K., Pang, M., Brewer, C.F., Johnson, P., Liu, F.T., Baum, L.G., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol 176 (2006), 778–789.
    • (2006) J Immunol , vol.176 , pp. 778-789
    • Stillman, B.N.1    Hsu, D.K.2    Pang, M.3    Brewer, C.F.4    Johnson, P.5    Liu, F.T.6    Baum, L.G.7
  • 15
    • 84907311696 scopus 로고    scopus 로고
    • Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells
    • The authors demonstrate the relevance of galectin-9 in the differentiation and stability of inducible regulatory T cells through mechanisms involving formation of CD44-TGF-βRI complexes.
    • 15•• Wu, C., Thalhamer, T., Franca, R.F., Xiao, S., Wang, C., Hotta, C., Zhu, C., Hirashima, M., Anderson, A.C., Kuchroo, V.K., Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41 (2014), 270–282 The authors demonstrate the relevance of galectin-9 in the differentiation and stability of inducible regulatory T cells through mechanisms involving formation of CD44-TGF-βRI complexes.
    • (2014) Immunity , vol.41 , pp. 270-282
    • Wu, C.1    Thalhamer, T.2    Franca, R.F.3    Xiao, S.4    Wang, C.5    Hotta, C.6    Zhu, C.7    Hirashima, M.8    Anderson, A.C.9    Kuchroo, V.K.10
  • 16
    • 69049116053 scopus 로고    scopus 로고
    • Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    • 16 Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., Geffner, J.R., Rabinovich, G.A., Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 10 (2009), 981–991.
    • (2009) Nat Immunol , vol.10 , pp. 981-991
    • Ilarregui, J.M.1    Croci, D.O.2    Bianco, G.A.3    Toscano, M.A.4    Salatino, M.5    Vermeulen, M.E.6    Geffner, J.R.7    Rabinovich, G.A.8
  • 19
    • 33847376532 scopus 로고    scopus 로고
    • Galectin-1: a key effector of regulation mediated by CD4 + CD25+ T cells
    • 19 Garin, M.I., Chu, C.C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: a key effector of regulation mediated by CD4 + CD25+ T cells. Blood 109 (2007), 2058–2065.
    • (2007) Blood , vol.109 , pp. 2058-2065
    • Garin, M.I.1    Chu, C.C.2    Golshayan, D.3    Cernuda-Morollon, E.4    Wait, R.5    Lechler, R.I.6
  • 20
    • 12144285871 scopus 로고    scopus 로고
    • Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege
    • 20 Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Fainboim, L., Podhajcer, O.L., Rabinovich, G.A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege. Cancer Cell 5 (2004), 241–251.
    • (2004) Cancer Cell , vol.5 , pp. 241-251
    • Rubinstein, N.1    Alvarez, M.2    Zwirner, N.W.3    Toscano, M.A.4    Ilarregui, J.M.5    Bravo, A.6    Mordoh, J.7    Fainboim, L.8    Podhajcer, O.L.9    Rabinovich, G.A.10
  • 22
    • 84858977200 scopus 로고    scopus 로고
    • Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor
    • 22 Kuo, P.L., Huang, M.S., Cheng, D.E., Hung, J.Y., Yang, C.J., Chou, S.H., Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. J Biol Chem 287 (2012), 9753–9764.
    • (2012) J Biol Chem , vol.287 , pp. 9753-9764
    • Kuo, P.L.1    Huang, M.S.2    Cheng, D.E.3    Hung, J.Y.4    Yang, C.J.5    Chou, S.H.6
  • 23
    • 84968846665 scopus 로고    scopus 로고
    • Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis
    • 23 Hsu, Y.L., Hung, J.Y., Chiang, S.Y., Jian, S.F., Wu, C.Y., Lin, Y.S., Tsai, Y.M., Chou, S.H., Tsai, M.J., Kuo, P.L., Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis. Oncotarget 7 (2016), 27584–27598.
    • (2016) Oncotarget , vol.7 , pp. 27584-27598
    • Hsu, Y.L.1    Hung, J.Y.2    Chiang, S.Y.3    Jian, S.F.4    Wu, C.Y.5    Lin, Y.S.6    Tsai, Y.M.7    Chou, S.H.8    Tsai, M.J.9    Kuo, P.L.10
  • 24
    • 84894136530 scopus 로고    scopus 로고
    • Glycosylation-dependent lectin–receptor interactions preserve angiogenesis in anti-VEGF refractory tumors
    • This study defines a glycosylation-based mechanism mediated by galectin–receptor interactions that links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in settings of VEGF blockade.
    • 24• Croci, D.O., Cerliani, J.P., Dalotto-Moreno, T., Mendez-Huergo, S.P., Mascanfroni, I.D., Dergan-Dylon, S., Toscano, M.A., Caramelo, J.J., Garcia-Vallejo, J.J., Ouyang, J., et al. Glycosylation-dependent lectin–receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell 156 (2014), 744–758 This study defines a glycosylation-based mechanism mediated by galectin–receptor interactions that links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in settings of VEGF blockade.
    • (2014) Cell , vol.156 , pp. 744-758
    • Croci, D.O.1    Cerliani, J.P.2    Dalotto-Moreno, T.3    Mendez-Huergo, S.P.4    Mascanfroni, I.D.5    Dergan-Dylon, S.6    Toscano, M.A.7    Caramelo, J.J.8    Garcia-Vallejo, J.J.9    Ouyang, J.10
  • 26
    • 84863214425 scopus 로고    scopus 로고
    • Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
    • 26 Soldati, R., Berger, E., Zenclussen, A.C., Jorch, G., Lode, H.N., Salatino, M., Rabinovich, G.A., Fest, S., Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments. Int J Cancer 131 (2012), 1131–1141.
    • (2012) Int J Cancer , vol.131 , pp. 1131-1141
    • Soldati, R.1    Berger, E.2    Zenclussen, A.C.3    Jorch, G.4    Lode, H.N.5    Salatino, M.6    Rabinovich, G.A.7    Fest, S.8
  • 27
    • 84973169046 scopus 로고    scopus 로고
    • Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells
    • 27 Baker, G.J., Chockley, P., Zamler, D., Castro, M.G., Lowenstein, P.R., Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells. Oncoimmunology, 5, 2016, e1163461.
    • (2016) Oncoimmunology , vol.5 , pp. e1163461
    • Baker, G.J.1    Chockley, P.2    Zamler, D.3    Castro, M.G.4    Lowenstein, P.R.5
  • 28
    • 84922202505 scopus 로고    scopus 로고
    • Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation
    • This study identifies a regulatory circuit mediated by IL-6 and galectin-1 that links commensal microbiota, TLR5-driven systemic inflammation, immunosuppression and distal tumor growth.
    • 28• Rutkowski, M.R., Stephen, T.L., Svoronos, N., Allegrezza, M.J., Tesone, A.J., Perales-Puchalt, A., Brencicova, E., Escovar-Fadul, X., Nguyen, J.M., Cadungog, M.G., et al. Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell 27 (2015), 27–40 This study identifies a regulatory circuit mediated by IL-6 and galectin-1 that links commensal microbiota, TLR5-driven systemic inflammation, immunosuppression and distal tumor growth.
    • (2015) Cancer Cell , vol.27 , pp. 27-40
    • Rutkowski, M.R.1    Stephen, T.L.2    Svoronos, N.3    Allegrezza, M.J.4    Tesone, A.J.5    Perales-Puchalt, A.6    Brencicova, E.7    Escovar-Fadul, X.8    Nguyen, J.M.9    Cadungog, M.G.10
  • 29
    • 84859849194 scopus 로고    scopus 로고
    • Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma
    • 29 Cedeno-Laurent, F., Watanabe, R., Teague, J.E., Kupper, T.S., Clark, R.A., Dimitroff, C.J., Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood 119 (2012), 3534–3538.
    • (2012) Blood , vol.119 , pp. 3534-3538
    • Cedeno-Laurent, F.1    Watanabe, R.2    Teague, J.E.3    Kupper, T.S.4    Clark, R.A.5    Dimitroff, C.J.6
  • 30
    • 84903955050 scopus 로고    scopus 로고
    • Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation
    • This study explores the relevance of galectin-1 in tumor–stromal interactions within the complex microenvironment of pancreatic ductal adenocarcinoma.
    • 30•• Martinez-Bosch, N., Fernandez-Barrena, M.G., Moreno, M., Ortiz-Zapater, E., Munne-Collado, J., Iglesias, M., Andre, S., Gabius, H.J., Hwang, R.F., Poirier, F., et al. Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation. Cancer Res 74 (2014), 3512–3524 This study explores the relevance of galectin-1 in tumor–stromal interactions within the complex microenvironment of pancreatic ductal adenocarcinoma.
    • (2014) Cancer Res , vol.74 , pp. 3512-3524
    • Martinez-Bosch, N.1    Fernandez-Barrena, M.G.2    Moreno, M.3    Ortiz-Zapater, E.4    Munne-Collado, J.5    Iglesias, M.6    Andre, S.7    Gabius, H.J.8    Hwang, R.F.9    Poirier, F.10
  • 32
    • 84979626000 scopus 로고    scopus 로고
    • A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion
    • The authors demonstrate a galectin-3-driven immune evasive mechanism leading to defects in cytokine secretion, lack of completion of secretory synapses and impaired adhesion of tumor-infiltrating lymphocytes to their targets.
    • 32•• Petit, A.E., Demotte, N., Scheid, B., Wildmann, C., Bigirimana, R., Gordon-Alonso, M., Carrasco, J., Valitutti, S., Godelaine, D., van der Bruggen, P., A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion. Nat Commun, 7, 2016, 12242 The authors demonstrate a galectin-3-driven immune evasive mechanism leading to defects in cytokine secretion, lack of completion of secretory synapses and impaired adhesion of tumor-infiltrating lymphocytes to their targets.
    • (2016) Nat Commun , vol.7 , pp. 12242
    • Petit, A.E.1    Demotte, N.2    Scheid, B.3    Wildmann, C.4    Bigirimana, R.5    Gordon-Alonso, M.6    Carrasco, J.7    Valitutti, S.8    Godelaine, D.9    van der Bruggen, P.10
  • 35
    • 80051930613 scopus 로고    scopus 로고
    • Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells
    • 35 Markowska, A.I., Jefferies, K.C., Panjwani, N., Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells. J Biol Chem 286 (2011), 29913–29921.
    • (2011) J Biol Chem , vol.286 , pp. 29913-29921
    • Markowska, A.I.1    Jefferies, K.C.2    Panjwani, N.3
  • 38
    • 66949166399 scopus 로고    scopus 로고
    • Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size
    • 38 Liu, S.D., Tomassian, T., Bruhn, K.W., Miller, J.F., Poirier, F., Miceli, M.C., Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size. J Immunol 182 (2009), 5283–5295.
    • (2009) J Immunol , vol.182 , pp. 5283-5295
    • Liu, S.D.1    Tomassian, T.2    Bruhn, K.W.3    Miller, J.F.4    Poirier, F.5    Miceli, M.C.6
  • 39
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
    • 39 Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 409 (2001), 733–739.
    • (2001) Nature , vol.409 , pp. 733-739
    • Demetriou, M.1    Granovsky, M.2    Quaggin, S.3    Dennis, J.W.4
  • 40
    • 36849040950 scopus 로고    scopus 로고
    • Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling
    • 40 Chen, I.J., Chen, H.L., Demetriou, M., Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling. J Biol Chem 282 (2007), 35361–35372.
    • (2007) J Biol Chem , vol.282 , pp. 35361-35372
    • Chen, I.J.1    Chen, H.L.2    Demetriou, M.3
  • 44
    • 14844334137 scopus 로고    scopus 로고
    • Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission
    • 44 Matarrese, P., Tinari, A., Mormone, E., Bianco, G.A., Toscano, M.A., Ascione, B., Rabinovich, G.A., Malorni, W., Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem 280 (2005), 6969–6985.
    • (2005) J Biol Chem , vol.280 , pp. 6969-6985
    • Matarrese, P.1    Tinari, A.2    Mormone, E.3    Bianco, G.A.4    Toscano, M.A.5    Ascione, B.6    Rabinovich, G.A.7    Malorni, W.8
  • 48
    • 80052673578 scopus 로고    scopus 로고
    • Galectin-9 regulates T helper cell function independently of Tim-3
    • 48 Su, E.W., Bi, S., Kane, L.P., Galectin-9 regulates T helper cell function independently of Tim-3. Glycobiology 21 (2011), 1258–1265.
    • (2011) Glycobiology , vol.21 , pp. 1258-1265
    • Su, E.W.1    Bi, S.2    Kane, L.P.3
  • 50
    • 0029900083 scopus 로고    scopus 로고
    • Expression of galectin-3 modulates T-cell growth and apoptosis
    • 50 Yang, R.Y., Hsu, D.K., Liu, F.T., Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci U S A 93 (1996), 6737–6742.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6737-6742
    • Yang, R.Y.1    Hsu, D.K.2    Liu, F.T.3
  • 51
    • 34447330895 scopus 로고    scopus 로고
    • Human CD4 + CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function
    • 51 Kubach, J., Lutter, P., Bopp, T., Stoll, S., Becker, C., Huter, E., Richter, C., Weingarten, P., Warger, T., Knop, J., et al. Human CD4 + CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood 110 (2007), 1550–1558.
    • (2007) Blood , vol.110 , pp. 1550-1558
    • Kubach, J.1    Lutter, P.2    Bopp, T.3    Stoll, S.4    Becker, C.5    Huter, E.6    Richter, C.7    Weingarten, P.8    Warger, T.9    Knop, J.10
  • 54
    • 84858790272 scopus 로고    scopus 로고
    • Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression
    • 54 Cedeno-Laurent, F., Opperman, M., Barthel, S.R., Kuchroo, V.K., Dimitroff, C.J., Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 188 (2012), 3127–3137.
    • (2012) J Immunol , vol.188 , pp. 3127-3137
    • Cedeno-Laurent, F.1    Opperman, M.2    Barthel, S.R.3    Kuchroo, V.K.4    Dimitroff, C.J.5
  • 55
    • 84983127737 scopus 로고    scopus 로고
    • Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFbeta signaling
    • 55 Sampson, J.F., Suryawanshi, A., Chen, W.S., Rabinovich, G.A., Panjwani, N., Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFbeta signaling. Immunol Cell Biol 94 (2016), 213–219.
    • (2016) Immunol Cell Biol , vol.94 , pp. 213-219
    • Sampson, J.F.1    Suryawanshi, A.2    Chen, W.S.3    Rabinovich, G.A.4    Panjwani, N.5
  • 57
    • 84880015001 scopus 로고    scopus 로고
    • Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection
    • 57 Fermino, M.L., Dias, F.C., Lopes, C.D., Souza, M.A., Cruz, A.K., Liu, F.T., Chammas, R., Roque-Barreira, M.C., Rabinovich, G.A., Bernardes, E.S., Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection. Eur J Immunol 43 (2013), 1806–1817.
    • (2013) Eur J Immunol , vol.43 , pp. 1806-1817
    • Fermino, M.L.1    Dias, F.C.2    Lopes, C.D.3    Souza, M.A.4    Cruz, A.K.5    Liu, F.T.6    Chammas, R.7    Roque-Barreira, M.C.8    Rabinovich, G.A.9    Bernardes, E.S.10
  • 59
    • 84941585321 scopus 로고    scopus 로고
    • Galectin-1 regulates tissue exit of specific dendritic cell populations
    • The authors report a glycosylation-based mechanism by which galectin-1 selectively inhibits tissue emigration of immunogenic, but not tolerogenic, dendritic cells.
    • 59•• Thiemann, S., Man, J.H., Chang, M.H., Lee, B., Baum, L.G., Galectin-1 regulates tissue exit of specific dendritic cell populations. J Biol Chem 290 (2015), 22662–22677 The authors report a glycosylation-based mechanism by which galectin-1 selectively inhibits tissue emigration of immunogenic, but not tolerogenic, dendritic cells.
    • (2015) J Biol Chem , vol.290 , pp. 22662-22677
    • Thiemann, S.1    Man, J.H.2    Chang, M.H.3    Lee, B.4    Baum, L.G.5
  • 60
    • 33845958124 scopus 로고    scopus 로고
    • A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway
    • 60 Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., Toscano, M.A., Bianco, G.A., Isturiz, M.A., Rabinovich, G.A., A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway. J Immunol 178 (2007), 436–445.
    • (2007) J Immunol , vol.178 , pp. 436-445
    • Barrionuevo, P.1    Beigier-Bompadre, M.2    Ilarregui, J.M.3    Toscano, M.A.4    Bianco, G.A.5    Isturiz, M.A.6    Rabinovich, G.A.7
  • 61
    • 84889101128 scopus 로고    scopus 로고
    • Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype
    • 61 Rostoker, R., Yaseen, H., Schif-Zuck, S., Lichtenstein, R.G., Rabinovich, G.A., Ariel, A., Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype. Prostaglandins Other Lipid Mediat 107 (2013), 85–94.
    • (2013) Prostaglandins Other Lipid Mediat , vol.107 , pp. 85-94
    • Rostoker, R.1    Yaseen, H.2    Schif-Zuck, S.3    Lichtenstein, R.G.4    Rabinovich, G.A.5    Ariel, A.6
  • 65
    • 84912128135 scopus 로고    scopus 로고
    • Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack
    • 65 Wang, W., Guo, H., Geng, J., Zheng, X., Wei, H., Sun, R., Tian, Z., Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack. J Biol Chem 289 (2014), 33311–33319.
    • (2014) J Biol Chem , vol.289 , pp. 33311-33319
    • Wang, W.1    Guo, H.2    Geng, J.3    Zheng, X.4    Wei, H.5    Sun, R.6    Tian, Z.7
  • 67
    • 80053159303 scopus 로고    scopus 로고
    • The parallel lives of angiogenesis and immunosuppression: cancer and other tales
    • 67 Motz, G.T., Coukos, G., The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat Rev Immunol 11 (2011), 702–711.
    • (2011) Nat Rev Immunol , vol.11 , pp. 702-711
    • Motz, G.T.1    Coukos, G.2
  • 68
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • 68 Corzo, C.A., Condamine, T., Lu, L., Cotter, M.J., Youn, J.I., Cheng, P., Cho, H.I., Celis, E., Quiceno, D.G., Padhya, T., et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 207 (2010), 2439–2453.
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.I.5    Cheng, P.6    Cho, H.I.7    Celis, E.8    Quiceno, D.G.9    Padhya, T.10
  • 70
    • 77956233662 scopus 로고    scopus 로고
    • Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response
    • 70 Markowska, A.I., Liu, F.T., Panjwani, N., Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med 207 (2010), 1981–1993.
    • (2010) J Exp Med , vol.207 , pp. 1981-1993
    • Markowska, A.I.1    Liu, F.T.2    Panjwani, N.3
  • 73
    • 84964319308 scopus 로고    scopus 로고
    • Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
    • The authors report a galectin-8-driven pathway that controls lymphangiogenesis and links VEGF-C, podoplanin and α1β1 and α5β1 integrins.
    • 73•• Chen, W.S., Cao, Z., Sugaya, S., Lopez, M.J., Sendra, V.G., Laver, N., Leffler, H., Nilsson, U.J., Fu, J., Song, J., et al. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun, 7, 2016, 11302 The authors report a galectin-8-driven pathway that controls lymphangiogenesis and links VEGF-C, podoplanin and α1β1 and α5β1 integrins.
    • (2016) Nat Commun , vol.7 , pp. 11302
    • Chen, W.S.1    Cao, Z.2    Sugaya, S.3    Lopez, M.J.4    Sendra, V.G.5    Laver, N.6    Leffler, H.7    Nilsson, U.J.8    Fu, J.9    Song, J.10
  • 75
    • 85014766041 scopus 로고    scopus 로고
    • Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms
    • This study highlights the role of galectin-1 as a mechanism of resistance to anti-CD20 (rituximab) immunotherapy via regulation of antibody-mediated lymphoma phagocytosis.
    • 75•• Lykken, J.M., Horikawa, M., Minard-Colin, V., Kamata, M., Miyagaki, T., Poe, J.C., Tedder, T.F., Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. Blood 127 (2016), 1886–1895 This study highlights the role of galectin-1 as a mechanism of resistance to anti-CD20 (rituximab) immunotherapy via regulation of antibody-mediated lymphoma phagocytosis.
    • (2016) Blood , vol.127 , pp. 1886-1895
    • Lykken, J.M.1    Horikawa, M.2    Minard-Colin, V.3    Kamata, M.4    Miyagaki, T.5    Poe, J.C.6    Tedder, T.F.7
  • 76
    • 84967020039 scopus 로고    scopus 로고
    • Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells
    • 76 Luo, W., Song, L., Chen, X.L., Zeng, X.F., Wu, J.Z., Zhu, C.R., Huang, T., Tan, X.P., Lin, X.M., Yang, Q., et al. Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells. Oncotarget 7 (2016), 26709–26723.
    • (2016) Oncotarget , vol.7 , pp. 26709-26723
    • Luo, W.1    Song, L.2    Chen, X.L.3    Zeng, X.F.4    Wu, J.Z.5    Zhu, C.R.6    Huang, T.7    Tan, X.P.8    Lin, X.M.9    Yang, Q.10
  • 79
    • 84939229708 scopus 로고    scopus 로고
    • Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling
    • 79 Harazono, Y., Kho, D.H., Balan, V., Nakajima, K., Hogan, V., Raz, A., Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling. Oncotarget 6 (2015), 19592–19604.
    • (2015) Oncotarget , vol.6 , pp. 19592-19604
    • Harazono, Y.1    Kho, D.H.2    Balan, V.3    Nakajima, K.4    Hogan, V.5    Raz, A.6
  • 80
    • 84973573760 scopus 로고    scopus 로고
    • Turning-off signaling by siglecs selectins, and galectins: chemical inhibition of glycan-dependent interactions in cancer
    • 80 Cagnoni, A.J., Perez Saez, J.M., Rabinovich, G.A., Marino, K.V., Turning-off signaling by siglecs selectins, and galectins: chemical inhibition of glycan-dependent interactions in cancer. Front Oncol, 6, 2016, 109.
    • (2016) Front Oncol , vol.6 , pp. 109
    • Cagnoni, A.J.1    Perez Saez, J.M.2    Rabinovich, G.A.3    Marino, K.V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.