Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

Immunology and Cell Biology

Volumn 94, Issue 2, 2016, Pages 213-219

  Sampson, James F ^a   Suryawanshi, Amol ^b   Chen, Wei Sheng ^a   Rabinovich, Gabriel A ^c,d   Panjwani, Noorjahan ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Consejo Nacional de Investigaciones Científicas y Técnicas ^*  (Argentina)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GALECTIN 8; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 4; SMAD3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; GALECTIN; GALECTIN-8, MOUSE; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CTLA-4 ANTIGEN; GALECTINS; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84983127737     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2015.72     Document Type: Article

References (30)

1. Josefowicz SZ, Lu L-F, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012; 30: 531-564.
2. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007; 8: 191-197.
3. Tai X, Van Laethem F, Sharpe AH, Singer A. Induction of autoimmune disease in CTLA-4/mice depends on a specific CD28 motif that is required for in vivo costimulation. Proc Natl Acad Sci USA 2007; 104: 13756-13761.
4. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008; 28: 546-558.
5. Rizzo L V, Xu H, Chan CC, Wiggert B, Caspi RR. IL-10 has a protective role in experimental autoimmune uveoretinitis. Int Immunol 1998; 10: 807-814.
6. Toscano MA, Commodaro AG, Ilarregui JM, Bianco GA, Liberman A, Serra HM et al. Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2-and T regulatory-mediated anti-inflammatory responses. J Immunol 2006; 176: 6323-6332.
7. Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C et al. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 2014; 41: 270-282.
8. Rabinovich GA, Toscano MA. Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009; 9: 338-352.
9. Wu M-H, Ying N-W, Hong T-M, Chiang W-F, Lin Y-T, Chen Y-L. Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex. Angiogenesis 2014; 17: 839-849.
10. Seki M, Oomizu S, Sakata K-M, Sakata A, Arikawa T, Watanabe K et al. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 2008; 127: 78-88.
11. Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 2012; 188: 3127-3137.
12. Fermino ML, Dias FC, Lopes CD, Souza MA, Cruz ÂK, Liu F-T et al. Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection. Eur J Immunol 2013; 43: 1806-1817.
13. Ideo H, Seko A, Ishizuka I, Yamashita K. The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity. Glycobiology 2003; 13: 713-723.
14. Sampson JF, Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen W-S et al. Galectin-8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response. PLoS ONE 2015; 10: e0130772.
15. Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K. Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J Biol Chem 2011; 286: 11346-11355.
16. Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD et al. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 2007; 8: 825-834.
17. Dong GW, Kim J, Park JH, Choi JY, Cho SI, Lim SC. Galectin-8 expression in laryngeal squamous cell carcinoma. Clin Exp Otorhinolaryngol 2009; 2: 13-19.
18. Savin S, Cveji D, Jankovi M, Isi T, Paunovi I, Tati S. Evaluation of galectin-8 expression in thyroid tumors. Med Oncol 2009; 26: 314-318.
19. Delgado VMC, Nugnes LG, Colombo LL, Troncoso MF, Fernández MM, Malchiodi EL et al. Modulation of endothelial cell migration and angiogenesis: a novel function for the 'tandem-repeat' lectin galectin-8. FASEB J 2011; 25: 242-254.
20. Hirabayashi J, Hashidate T, Arata Y, Nishi N, Nakamura T, Hirashima M et al. Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochim Biophys Acta 2002; 1572: 232-254.
21. Stowell SR, Arthur CM, Mehta P, Slanina KA, Blixt O, Leffler H et al. Galectin-1,-2, and-3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem 2008; 283: 10109-10123.
22. Zhuo Y, Chammas R, Bellis SL. Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis. J Biol Chem 2008; 283: 22177-22185.
23. Garner OB, Baum LG. Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans 2008; 36: 1472-1477.
24. Lajoie P, Goetz JG, Dennis JW, Nabi IR. Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane. J Cell Biol 2009; 185: 381-385.
25. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005; 6: 1245-1252.
26. Lu L-H, Nakagawa R, Kashio Y, Ito A, Shoji H, Nishi N et al. Characterization of galectin-9-induced death of Jurkat T cells. J Biochem 2007; 141: 157-172.
27. Stillman BN, Hsu DK, Pang M, Brewer CF, Johnson P, Liu F-T et al. Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol 2006; 176: 778-789.
28. Hang L, Blum AM, Setiawan T, Joseph P, Stoyanoff KM, Weinstock JV. Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+T cells enhancing their capacity to prevent colitis. J Immunol 2015; 191: 1927-1934.
29. Diskin S, Chen W-S, Cao Z, Gyawali S, Gong H, Soza A et al. Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling. PLoS ONE 2012; 7: e44400.
30. Markowska AI, Jefferies KC, Panjwani N. Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells. J Biol Chem 2011; 286: 29913-29921.