Novel role for galectin-1 in T-cells under physiological and pathological conditions

Immunobiology

Volumn 220, Issue 4, 2015, Pages 483-489

  Deák, Magdolna ^a   Hornung, Ákos ^a,b   Novák, Julianna ^b   Demydenko, Dmytro ^b   Szabó, Eniko ^b   Czibula, Ágnes ^b   Fajka Boja, Roberta ^b   Kriston Pál, Éva ^b   Monostori, Éva ^b   Kovács, László ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Activated T cells; Apoptosis; Intracellular galectin 1; Systemic lupus erythematosus

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; EPRATUZUMAB; GALECTIN 1; METHOTREXATE; PREDNISOLONE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; IMMUNOREGULATION; JURKAT CELL LINE; KNOCKOUT MOUSE; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; CASE CONTROL STUDY; CELL LINE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INTRACELLULAR SPACE; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; APOPTOSIS; CASE-CONTROL STUDIES; CELL LINE; GALECTIN 1; GENE EXPRESSION; HUMANS; INTRACELLULAR SPACE; JURKAT CELLS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 84940164470     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2014.10.023     Document Type: Article

References (39)

1. Blaser C., Kaufmann M., Müller C., Zimmermann C., Wells V., et al. Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells. Eur. J. Immunol. 1998, 28:2311-2319. 10.1002/(SICI)1521-4141(199808)28:08<2311::AID-IMMU2311>3.0.CO;2-G.
2. Blaskó A., Fajka-Boja R., Ion G., Monostori É. How does it act when soluble? Critical evaluation of mechanism of galectin-1 induced T-cell apoptosis. Acta Biol. Hung. 2011, 62:106-111. 10.1556/ABiol.61.2011.1.11.
3. Brandt B., Büchse T., Abou-Eladab E.F., Tiedge M., Krause E., et al. Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem. Cell Biol. 2008, 129:599-609. 10.1007/s00418-008-0395-x.
4. Camby I., Le Mercier M., Lefranc F., Kiss R. Galectin-1: a small protein with major functions. Glycobiology 2006, 16:137R-157R. 10.1093/glycob/cwl025.
5. Crispín J.C., Liossis S.-N.C, Kis-Toth K., Lieberman L.A., Kyttaris V.C., et al. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol. Med. 2010, 16:47-57. 10.1016/j.molmed.2009.12.005.
6. De S., Barnes B.J. B cell transcription factors: potential new therapeutic targets for SLE. Clin. Immunol. 2014, 152:140-151. 10.1016/j.clim.2014.03.009.
7. De la Fuente H., Perez-Gala S., Bonay P., Cruz-Adalia A., Cibrian D., et al. Psoriasis in humans is associated with down-regulation of galectins in dendritic cells. J. Pathol. 2012, 228:193-203. 10.1002/path.3996.
8. Dolff S., Bijl M., Huitema M.G., Limburg P.C., Kallenberg C.G.M., et al. Disturbed Th1, Th2, Th17 and Treg balance in patients with systemic lupus erythematosus. Clin. Immunol. 2011, 141:197-204. 10.1016/j.clim.2011.08.005.
9. Fajka-Boja R., Szemes M., Ion G., Légrádi A., Caron M., et al. Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines. Immunol. Lett. 2002, 82:149-154. 10.1016/S0165-2478(02)00030-5.
10. Hahn H.P., Pang M., He J., Hernandez J.D., Yang R.-Y., et al. Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ. 2004, 11:1277-1286. 10.1038/sj.cdd.4401485.
11. Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997, 40:1725. 10.1002/1529-0131(199709)40:9<1725::AID-ART29>3.0.CO;2-Y.
12. Ion G., Fajka-Boja R., Tóth G.K., Caron M., Monostori E. Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death. Cell Death Differ. 2005, 12:1145-1147. 10.1038/sj.cdd.4401628.
13. Ion G., Fajka-Boja R., Kovács F., Szebeni G., Gombos I., et al. Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1. Cell. Signal. 2006, 18:1887-1896. 10.1016/j.cellsig.2006.02.007.
14. Iqbal A.J., Cooper D., Vugler A., Gittens B.R., Moore A., et al. Endogenous galectin-1 exerts tonic inhibition on experimental arthritis. J. Immunol. 2013, 191:171-177. 10.4049/jimmunol.1203291.
15. Jury E.C., Kabouridis P.S., Flores-Borja F., Mageed R.A., Isenberg D.A. Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J. Clin. Invest. 2004, 113:1176-1187. 10.1172/JCI200420345.
16. Kovács-Sólyom F., Blaskó A., Fajka-Boja R., Katona R.L., Végh L., et al. Mechanism of tumor cell-induced T-cell apoptosis mediated by galectin-1. Immunol. Lett. 2010, 127:108-118. 10.1016/j.imlet.2009.10.003.
17. Liu S., Lee S., Cava A.L., Motran C., Hahn B., et al. Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB×NZW) F1 mice from lupus-like disease. Lupus 2011, 20:473-484. 10.1177/0961203310388444.
18. Matarrese P., Tinari A., Mormone E., Bianco G.A., Toscano M.A., et al. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J. Biol. Chem. 2005, 280:6969-6985. 10.1074/jbc.M409752200.
19. Motran C.C., Molinder K.M., Liu S.D., Poirier F., Miceli M.C. Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function. Eur. J. Immunol. 2008, 38:3015-3027. 10.1002/eji.200838295.
20. Moulton V.R., Tsokos G.C. Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res. Ther. 2011, 13:207. 10.1186/ar3251.
21. Offner H., Celnik B., Bringman T.S., Casentini-Borocz D., Nedwin G.E., et al. Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1990, 28:177-184. 10.1016/0165-5728(90)90032-I.
22. Ouyang J., Plutschow A., von Strandmann E.P., Reiners K.S., Ponader S., et al. Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma. Blood 2013, 121:3431-3433. 10.1182/blood-2012-12-474569.
23. Park J.W., Voss P.G., Grabski S., Wang J.L., Patterson R.J. Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res. 2001, 29:3595-3602. 10.1093/nar/29.17.3595.
24. Paz A., Haklai R., Elad-Sfadia G., Ballan E., Kloog Y. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 2001, 20:7486-7493. 10.1038/sj.onc.1204950.
25. Perillo N.L., Pace K.E., Seilhamer J.J., Baum L.G. Apoptosis of T cells mediated by galectin-1. Nature 1995, 378:736-739. 10.1038/378736a0.
26. Rabinovich G.A., Daly G., Dreja H., Tailor H., Riera C.M., et al. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J. Exp. Med. 1999, 190:385-398. 10.1084/jem.190.3.385.
27. Rotblat B. Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res. 2004, 64:3112-3118. 10.1158/0008-5472.CAN-04-0026.
28. Santucci L., Fiorucci S., Cammilleri F., Servillo G., Federici B., et al. Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatol. Baltim. Md 2000, 31:399-406. 10.1002/hep.510310220.
29. Santucci L., Fiorucci S., Rubinstein N., Mencarelli A., Palazzetti B., et al. Galectin-1 suppresses experimental colitis in mice. Gastroenterology 2003, 124:1381-1394. 10.1016/S0016-5085(03)00267-1.
30. Stowell S.R., Karmakar S., Stowell C.J., Dias-Baruffi M., McEver R.P., et al. Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. Blood 2007, 109:219-227. 10.1182/blood-2006-03-007153.
31. Szebeni G.J., Kriston-Pál É., Blazsó P., Katona R.L., Novák J., et al. Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion. PLoS ONE 2012, 7:e41372. 10.1371/journal.pone.0041372.
32. Takeuchi T., Pang M., Amano K., Koide J., Abe T. Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE). Clin. Exp. Immunol. 1997, 109:20-26. 10.1046/j.1365-2249.1997.4371334.x.
33. Toscano M.A., Commodaro A.G., Ilarregui J.M., Bianco G.A., Liberman A., et al. Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. J. Immunol. Baltim. Md. 1950 2006, 176:6323-6332. 10.4049/jimmunol.176.10.6323.
34. Toscano M.A., Ilarregui J.M., Bianco G.A., Campagna L., Croci D.O., et al. Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity?. Cytokine Growth Factor Rev. 2007, 18:57-71. 10.1016/j.cytogfr.2007.01.006.
35. Toscano M.A., Bianco G.A., Ilarregui J.M., Croci D.O., Correale J., et al. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol. 2007, 8:825-834. 10.1038/ni1482.
36. Tsuchiyama Y., Wada J., Zhang H., Morita Y., Hiragushi K., et al. Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats. Kidney Int. 2000, 58:1941-1952. 10.1111/j.1523-1755.2000.00366.x.
37. Wang W., Park J.W., Wang J.L., Patterson R.J. Immunoprecipitation of spliceosomal RNAs by antisera to galectin-1 and galectin-3. Nucleic Acids Res. 2006, 34:5166-5174. 10.1093/nar/gkl673.
38. Yang R.Y., Hsu D.K., Liu F.T. Expression of galectin-3 modulates T-cell growth and apoptosis. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:6737-6742. 10.1073/pnas.93.13.6737.
39. Yang R.-Y., Rabinovich G.A., Liu F.-T. Galectins: structure, function and therapeutic potential. Expert Rev. Mol. Med. 2008, 10. 10.1017/S1462399408000719.