Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

Journal of Hepatology

Volumn 66, Issue 3, 2017, Pages 601-609

  Ramirez, Teresa ^a   Li, Yong Mei ^a   Yin, Shi ^a,b   Xu, Ming Jiang ^a   Feng, Dechun ^a   Zhou, Zhou ^a   Zang, Mengwei ^c   Mukhopadhyay, Partha ^a   Varga, Zoltan V ^a   Pacher, Pal ^a   Gao, Bin ^a   Wang, Hua ^a,b  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Ethanol; Fatty liver; Hepatic stellate cells (HSCs); Middle age; PDGFR ; Steatohepatitis

Indexed keywords

ALCOHOL; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SIRTUIN 1; SIRT1 PROTEIN, MOUSE;

ADULT; AGING; ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; FEMALE; HEPATIC STELLATE CELL; IN VITRO STUDY; LIVER FIBROSIS; MALE; MIDDLE AGED; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; YOUNG ADULT; ALCOHOL LIVER DISEASE; ANIMAL; BINGE DRINKING; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; LIVER REGENERATION; METABOLISM; PATHOLOGY;

AGING; ANIMALS; BINGE DRINKING; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; HEPATIC STELLATE CELLS; LIVER DISEASES, ALCOHOLIC; LIVER REGENERATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; SIRTUIN 1;

EID: 85008683523     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.11.004     Document Type: Article

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