Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

Gastroenterology

Volumn 149, Issue 4, 2015, Pages 1030-1041.e6

  Xu, Ming Jiang ^a,b   Cai, Yan ^a,c   Wang, Hua ^a,d   Altamirano, José ^e   Chang, Binxia ^a   Bertola, Adeline ^a   Odena, Gemma ^f   Lu, Jim ^g   Tanaka, Naoki ^c   Matsusue, Kimihiko ^h   Matsubara, Tsutomu ^c   Mukhopadhyay, Partha ^a   Kimura, Shioko ^c   Pacher, Pal ^a   Gonzalez, Frank J ^c   Bataller, Ramon ^e,f,i   Gao, Bin ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ANHUI MEDICAL UNIVERSITY   (China)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f University of North Carolina   (United States)

^g GoPath Diagnostics LLC   (United States)

^h FUKUOKA UNIVERSITY   (Japan)

ⁱ UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Endoplasmic Reticulum; Inflammation; Lipid Metabolism; Translational Research

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CELL DEATH INDUCING DFF45 LIKE EFFECTOR C PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN H; FAT DROPLET; FAT SPECIFIC PROTEIN 27; MALONALDEHYDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; CIDEC PROTEIN, HUMAN; CREB3L3 PROTEIN, MOUSE; FAT-SPECIFIC PROTEIN 27, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BINGE DRINKING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRINKING BEHAVIOR; FEMALE; FSP27ALPHA GENE; FSP27BETA GENE; GENE; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER BIOPSY; LIVER CELL CULTURE; LIVER FIBROSIS; LIVER INJURY; LIVER MITOCHONDRION; MALE; MICROARRAY ANALYSIS; MORTALITY; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENE; UPREGULATION; WHITE ADIPOSE TISSUE; ADULT; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FATTY LIVER, ALCOHOLIC; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; KNOCKOUT MOUSE; LIVER; LIVER CELL; METABOLISM; MIDDLE AGED; PATHOLOGY; PROCEDURES; RNA INTERFERENCE; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TIME FACTOR;

ADULT; ANIMALS; BINGE DRINKING; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; FATTY LIVER, ALCOHOLIC; FEMALE; GENE EXPRESSION PROFILING; HEPATOCYTES; HUMANS; LIVER; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; MITOCHONDRIA, LIVER; PPAR GAMMA; PROTEINS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84942309525     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.06.009     Document Type: Article

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