The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways

PLoS ONE

Volumn 12, Issue 1, 2017, Pages

  Youns, Mhmoud ^a,b   Hegazy, Wael Abdel Halim ^c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Helwan   (Egypt)

^c Zagazig University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOCHROME P450 3A4; FISETIN; GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; CYTOCHROME P450 3A; FLAVONOID; PROSTAGLANDIN E2; TUMOR MARKER;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CCNB1 GENE; CCNB2 GENE; CDK5 GENE; CDKN1A GENE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ERK GENE; GADD45A GENE; GADD45B GENE; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC50; KIF20A GENE; LIVER CANCER CELL LINE; OXIDATIVE STRESS; PANCREATIC CANCER CELL LINE; SEMA3E GENE; SIGNAL TRANSDUCTION; TOP2A GENE; UPREGULATION; VALIDATION PROCESS; BIOSYNTHESIS; CELL CYCLE; COLORECTAL TUMOR; DNA DAMAGE; DNA MICROARRAY; DRUG EFFECTS; ENZYME ASSAY; GENETICS; LIVER TUMOR; METABOLISM; PANCREAS TUMOR; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; TUMOR CELL LINE;

APOPTOSIS; BIOMARKERS, TUMOR; CASPASE 3; CASPASE 7; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYTOCHROME P-450 CYP3A; DINOPROSTONE; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ASSAYS; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE TRANSFERASE; HUMANS; LIVER NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 85008392019     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0169335     Document Type: Article

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