Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7

Clinical Epigenetics

Volumn 8, Issue 1, 2016, Pages

  Sajadian, Sahar Olsadat ^a   Tripura, Chaturvedula ^a,b   Samani, Fazel Sahraneshin ^c   Ruoss, Marc ^a   Dooley, Steven ^d   Baharvand, Hossein ^c   Nussler, Andreas K ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

5 Azacytidine; 5hmC; EMT MET; GADD45B; Snail; TETs; Vitamin C

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; ASCORBIC ACID; AZACITIDINE; CYCLINE; GADD45B PROTEIN; GALACTOSE DEHYDROGENASE; MESSENGER RNA; PROTEIN P21; RESAZURIN; TET PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; DRUG POTENTIATION; ENZYME RELEASE; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; HEPATOCELLULAR CARCINOMA CELL LINE; HLE CELL LINE; HUH7 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; CELL SURVIVAL; DNA METHYLATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; LIVER CELL CARCINOMA; LIVER TUMOR; TUMOR CELL LINE;

ASCORBIC ACID; AZACITIDINE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA METHYLATION; DRUG SYNERGISM; EPIGENESIS, GENETIC; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS;

EID: 85007203345     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-016-0213-6     Document Type: Article

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