Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 170-177

  Youns, Mahmoud ^a,b,c   Efferth, Thomas ^b   Hoheisel, Jörg D ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Helwan University   (Egypt)

Author keywords

Ingenuity; Microarray; NS 398; Pancreatic cancer

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CELL PROTEIN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLINE; DEATH RECEPTOR; MESSENGER RNA; MINICHROMOSOME MAINTENANCE PROTEIN 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROTEIN NAG 1; PROTEIN P53; PROTEIN RRM2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; NITROBENZENES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; SULFONAMIDES; UP-REGULATION;

EID: 78649727958     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.026     Document Type: Article

References (57)

1. T. Aikawa, J. Gunn, S.M. Spong, S.J. Klaus, and M. Korc Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer Mol. Cancer Ther. 5 2006 1108 1116
2. J. Andrews, D. Djakiew, S. Krygier, and P. Andrews Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells Cancer Chemother. Pharmacol. 50 2002 277 284
3. J.Y. Baek, W. Hur, J.S. Wang, S.H. Bae, and S.K. Yoon Selective COX-2 inhibitor, NS-398, suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest World J. Gastroenterol. 13 2007 1175 1181
4. G.D. Basu, L.B. Pathangey, T.L. Tinder, S.J. Gendler, and P. Mukherjee Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells Breast Cancer Res. 7 2005 R422 R435
5. A. Bauer, J. Kleeff, M. Bier, M. Wirtz, H. Kayed, I. Esposito, M. Korc, M. Hafner, J.D. Hoheisel, and H. Friess Identification of malignancy factors by analyzing cystic tumors of the pancreas Pancreatology 9 2008 34 44
6. V. Beier, A. Bauer, M. Baum, and J.D. Hoheisel Fluorescent sample labeling for DNA microarray analyses Meth. Mol. Biol. 283 2004 127 135
7. A. Brazma, P. Hingamp, J. Quackenbush, G. Sherlock, P. Spellman, C. Stoeckert, J. Aach, W. Ansorge, C.A. Ball, H.C. Causton, T. Gaasterland, P. Glenisson, F.C. Holstege, I.F. Kim, V. Markowitz, J.C. Matese, H. Parkinson, A. Robinson, U. Sarkans, S. Schulze-Kremer, J. Stewart, R. Taylor, J. Vilo, and M. Vingron Minimum information about a microarray experiment (MIAME)-toward standards for microarray data Nat. Genet. 29 2001 365 371
8. B. Chen, B. Su, and S. Chen A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms Biochem. Pharmacol. 77 2009 1787 1794
9. J. Cheng, H. Imanishi, Y. Amuro, and T. Hada NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines Int. J. Cancer 99 2002 755 761
10. D.J. de Groot, E.G. de Vries, H.J. Groen, and S. de Jong Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to clinic Crit. Rev. Oncol. Hematol. 61 2007 52 69
11. F.F. di Mola, H. Friess, E. Riesle, A. Koliopanos, P. Buchler, Z. Zhu, D.R. Brigstock, M. Korc, and M.W. Buchler Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis Ann. Surg. 235 2002 60 67
12. X.Z. Ding, W.G. Tong, and T.E. Adrian Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells Anticancer Res. 20 2000 2625 2631
13. N. Dornhofer, S. Spong, K. Bennewith, A. Salim, S. Klaus, N. Kambham, C. Wong, F. Kaper, P. Sutphin, R. Nacamuli, M. Hockel, Q. Le, M. Longaker, G. Yang, A. Koong, and A. Giaccia Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis Cancer Res. 66 2006 5816 5827
14. M.S. Duxbury, H. Ito, M.J. Zinner, S.W. Ashley, and E.E. Whang RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine Oncogene 23 2004 1539 1548 (Pubitemid 38406516)
15. T. Efferth, U. Fabry, P. Glatte, and R. Osieka Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in human leukemic cells J. Cancer Res. Clin. Oncol. 121 1995 648 656
16. T. Efferth, U. Fabry, and R. Osieka Apoptosis and resistance to daunorubicin in human leukemic cells Leukemia 11 1997 1180 1186
17. B.F. El-Rayes, M.M. Zalupski, A.F. Shields, A.M. Ferris, U. Vaishampayan, L.K. Heilbrun, R. Venkatramanamoorthy, V. Adsay, and P.A. Philip A phase II study of celecoxib, gemcitabine, and cisplatin in advanced pancreatic cancer Invest New Drugs 23 2005 583 590
18. I. Esposito, A. Bauer, J.D. Hoheisel, J. Kleeff, H. Friess, F. Bergmann, R.J. Rieker, H.F. Otto, G. Kloppel, and R. Penzel Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity? Virchows Arch. 444 2004 447 453
19. K. Fellenberg, C.H. Busold, O. Witt, A. Bauer, B. Beckmann, N.C. Hauser, M. Frohme, S. Winter, J. Dippon, and J.D. Hoheisel Systematic interpretation of microarray data using experiment annotations BMC Genomics 7 2006 319
20. K. Fellenberg, N.C. Hauser, B. Brors, A. Neutzner, J.D. Hoheisel, and M. Vingron Correspondence analysis applied to microarray data Proc. Natl Acad. Sci. USA 98 2001 10781 10786
21. S. Fulda, and K.M. Debatin Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy Oncogene 25 2006 4798 4811
22. N. Futaki, I. Arai, Y. Hamasaka, S. Takahashi, S. Higuchi, and S. Otomo Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation J. Pharm. Pharmacol. 45 1993 753 755
23. N. Futaki, S. Takahashi, M. Yokoyama, I. Arai, S. Higuchi, and S. Otomo NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro Prostaglandins 47 1994 55 59
24. O. Galamb, S. Spisak, F. Sipos, K. Toth, N. Solymosi, B. Wichmann, T. Krenacs, G. Valcz, Z. Tulassay, and B. Molnar Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor Br. J. Cancer 2010 2010 10.1038/sj.bjc.6605515
25. X.Q. Gao, J.X. Han, H.Y. Huang, B. Song, B. Zhu, and C.Z. Song Effect of NS398 on metastasis-associated gene expression in a human colon cancer cell line World J. Gastroenterol. 11 2005 4337 4343
26. Y.G. Goan, B. Zhou, E. Hu, S. Mi, and Y. Yen Overexpression of ribonucleotide reductase as a mechanism of resistance to 2, 2- difluorodeoxycytidine in the human KB cancer cell line Cancer Res. 59 1999 4204 4207
27. D. Guardavaccaro, G. Corrente, F. Covone, L. Micheli, I. D'Agnano, G. Starace, M. Caruso, and F. Tirone Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription Mol. Cell. Biol. 20 2000 1797 1815
28. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M.J. Thun Cancer statistics, 2009 CA Cancer J. Clin. 59 2009 225 249
29. M. Johansson, and J.L. Persson Cancer therapy: targeting cell cycle regulators Anticancer Agents Med. Chem. 8 2008 723 731
30. M. John-Aryankalayil, S.T. Palayoor, D. Cerna, M.T. Falduto, S.R. Magnuson, and C.N. Coleman NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells Mol. Cancer Ther. 8 2009 261 273
31. M.K. Jones, I.L. Szabo, H. Kawanaka, S.S. Husain, and A.S. Tarnawski von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis FASEB J. 16 2002 264 266
32. J.S. Kim, S.J. Baek, T. Sali, and T.E. Eling The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15 Mol. Cancer Ther. 4 2005 487 493
33. H. Koga Hepatocellular carcinoma: is there a potential for chemoprevention using cyclooxygenase-2 inhibitors? Cancer 98 2003 661 667
34. M.W. Konstan, P.J. Byard, C.L. Hoppel, and P.B. Davis Effect of high-dose ibuprofen in patients with cystic fibrosis N. Engl. J. Med. 332 1995 848 854
35. S. Kwon, X. Munroe, S.C. Crawley, H.Y. Lee, S. Spong, D. Bradham, J.R. Gum Jr., M.H. Sleisenger, and Y.S. Kim Expression of connective tissue growth factor in pancreatic cancer cell lines Int. J. Oncol. 31 2007 693 703
36. S.H. Lee, J.S. Kim, K. Yamaguchi, T.E. Eling, and S.J. Baek Indole-3-carbinol and 3, 3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner Biochem. Biophys. Res. Commun. 328 2005 63 69
37. J. Li, X. Chen, X. Dong, Z. Xu, H. Jiang, and X. Sun Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells J. Gastroenterol. Hepatol. 21 2006 1814 1820
38. J.F. Liu, G.J. Zhu, G.G. Jamieson, T.C. Wu, T.N. Zhu, B.E. Shan, and P.A. Drew NS-398 induces apoptosis in human esophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2 Cancer Invest 27 2009 17 23
39. X.H. Liu, S. Yao, A. Kirschenbaum, and A.C. Levine NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells Cancer Res. 58 1998 4245 4249
40. J.L. Masferrer, B.S. Zweifel, P.T. Manning, S.D. Hauser, K.M. Leahy, W.G. Smith, P.C. Isakson, and K. Seibert Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic Proc. Natl Acad. Sci. USA 91 1994 3228 3232
41. M.A. Molina, M. Sitja-Arnau, M.G. Lemoine, M.L. Frazier, and F.A. Sinicrope Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs Cancer Res. 59 1999 4356 4362
42. E. Mysler Lumiracoxib (Prexige): a new selective COX-2 inhibitor Int. J. Clin. Pract. 58 2004 606 611
43. H. Nakata, Y. Uemura, M. Kobayashi, R. Harada, and H. Taguchi Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells Cancer Sci. 94 2003 173 180
44. R.P. Pang, J.G. Zhou, Z.R. Zeng, X.Y. Li, W. Chen, M.H. Chen, and P.J. Hu Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway Cancer Lett. 251 2007 268 277
45. R. Perini, S. Fiorucci, and J.L. Wallace Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: a window of opportunity for cyclooxygenase-inhibiting nitric oxide donors Can. J. Gastroenterol. 18 2004 229 236
46. M.W. Saif Controversies in the adjuvant treatment of pancreatic adenocarcinoma JOP 8 2007 545 552
47. R.F. Souza, K. Shewmake, D.G. Beer, B. Cryer, and S.J. Spechler Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells Cancer Res. 60 2000 5767 5772
48. Y. Sun, X.M. Tang, E. Half, M.T. Kuo, and F.A. Sinicrope Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells Cancer Res. 62 2002 6323 6328
49. G. Volans, V. Hartley, S. McCrea, and J. Monaghan Non-opioid analgesic poisoning Clin. Med. 3 2003 119 123
50. J. Wang, G.Y. Zhang, and X.H. Li Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells Chin. J. Dig. Dis. 7 2006 219 224
51. X.F. Xu, C.G. Xie, X.P. Wang, J. Liu, Y.C. Yu, H.L. Hu, and C.Y. Guo Selective inhibition of cyclooxygenase-2 suppresses the growth of pancreatic cancer cells in vitro and in vivo Tohoku J. Exp. Med. 215 2008 149 157
52. Y. Yamanaka, K. Shiraki, T. Inoue, K. Miyashita, H. Fuke, Y. Yamaguchi, N. Yamamoto, K. Ito, K. Sugimoto, and T. Nakano COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis Int. J. Mol. Med. 18 2006 41 47
53. T.S. Yeh, C.W. Wu, K.W. Hsu, W.J. Liao, M.C. Yang, A.F. Li, A.M. Wang, M.L. Kuo, and C.W. Chi The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2 Cancer Res. 69 2009 5039 5048
54. M.T. Yip-Schneider, D.S. Barnard, S.D. Billings, L. Cheng, D.K. Heilman, A. Lin, S.J. Marshall, P.L. Crowell, M.S. Marshall, and C.J. Sweeney Cyclooxygenase-2 expression in human pancreatic adenocarcinomas Carcinogenesis 21 2000 139 146
55. M. Youns, T. Efferth, J. Reichling, K. Fellenberg, A. Bauer, and J.D. Hoheisel Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells Biochem. Pharmacol. 2009
56. Z.J. Zeng, L.Y. Yang, X. Ding, and W. Wang Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance World J. Gastroenterol. 10 2004 3414 3418
57. Z. Zhang, and R.N. DuBois Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor Oncogene 20 2001 4450 4456