Hypermethylation of growth arrest DNA damage-inducible gene 45 β promoter in human hepatocellular carcinoma

American Journal of Pathology

Volumn 165, Issue 5, 2004, Pages 1689-1699

  Qiu, Weihua ^a   Zhou, Bingsen ^a   Zou, Hongzhi ^c   Liu, Xiyong ^a   Chu, Peiguo G ^a   Lopez, Richard ^b   Shih, Jennifer ^a   Chung, Christopher ^a   Yen, Yun ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b St Vincent's Hospital   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; COMPLEMENTARY DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PLASMID VECTOR; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL CULTURE; CELL LINE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA TRANSFECTION; DOWN REGULATION; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETICS; EXPRESSION VECTOR; GENE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; GROWTH ARREST DEOXYRIBONUCLEIC ACID DAMAGE INDUCIBLE GENE 45 BETA; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMETHOD COMPARISON; LIVER CELL; LIVER CELL CARCINOMA; METHYLATION; MOLECULAR CLONING; MOLECULAR DYNAMICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; STATISTICAL SIGNIFICANCE;

EID: 7244239107     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63425-6     Document Type: Article

References (30)

1. Parkin DM, Pisani P, Ferlay J: Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999, 80:827-841
2. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ: Cancer statistics, 2003. Ca Cancer J Clin 2003, 53:5-26
3. Takekawa M, Saito H: A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAP-KKK. Cell 1998, 95:521-530
4. Nakayama K, Hara T, Hibi M, Hirano T, Miyajima A: A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. J Biol Chem 1999, 274:24766-24772
5. Zhang W, Bae I, Krishnaraju K, Azam N, Fan W, Smith K, Hoffman B, Leibermann DA: CR6: a third member in the MyD118 and GADD45 gene family which functions in negative growth control. Oncogene 1999, 18:4899-4907
6. Qiu W, David D, Zhou B, Chu PG, Zhang B, Wu M, Xiao J, Han T, Zhu Z, Wang T, Liu X, Lopez R, Frankel P, Jong A, Yen Y: Down-regulation of growth arrest DNA damage-inducible gene 45 β expression is associated with human hepatocellular carcinoma. Am J Pathol 2003, 6:1961-1974
7. Yoo J, Ghiassi M, Jirmanova L, Balliet AG, Hoffman B, Fornace Jr AJ, Liebermann DA, Böttinger EP, Roberts AB: Transforming growth factor-β-induced apoptosis is mediated by Smad-dependent expression GADD45β through p53 activation. J Biol Chem 2003, 278:43001-43007
8. Takekawa M, Tatebayashi K, Itoh F, Adachi M, Imai K, Saito H: Smad-dependent GADD45β expression mediates delayed activation of p53 MAP kinase by TGF-β. EMBO J 2002, 21:6473-6482
9. Geng CX, Zeng ZC, Wang JY: Docetaxel inhibits SMMC-7721 human hepatocellular carcinoma cells growth and induces apoptosis. World J Gastroenterol 2003, 9:696-700
10. Xu HY, Yang YL, Gao YY, Wu QL, Gao GQ: Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro. World J Gastroenterol 2000, 6:681-687
11. Wang XW, Xie H: Presence of Fas and Bcl-2 proteins in BEL-7404 human hepatoma cells. World J Gastroenterol 1998, 4:540-543
12. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996, 93:9821-9826
13. Jin R, De Smaele E, Zazzeroni F, Nguyen DU, Papa S, Jones J, Cox C, Gelinas C, Franzoso G: Regulation of the gadd45beta promoter by NF-kappaB. DNA Cell Biol 2002, 21:491-503
14. Ferguson AT, Evron E, Umbricht CB, Pandita TK, Chan TA, Hermeking H, Marks JR, Lambers AR, Futreal PA, Stampfer MR, Sukumar S: High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc Natl Acad Sci USA 2000, 97:6049-6054
15. Widschwendter M, Berger J, Hermann M, Muller HM, Amberger A, Zeschnigk M, Widschwendter A, Abendstein B, Zeimet AG, Daxenbichler G, Marth C: Methylation and silencing of the retinoic acid receptor-β2 gene in breast cancer. J Natl Cancer Inst 2000, 92:826-832
16. Santini V, Kantarjian HM, Issa JP: Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 2001, 134:573-586
17. El-Serag HB, Mason AC: Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999, 340:745-750
18. Abdollahi A, Lord KA, Hoffman-Liebemann B, Liebermann DA: Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. Oncogene 1991, 6:165-167
19. Heinemeyer T, Chen X, Karas H, Kel AE, Kel OV, Liebich I, Meinhardt T, Reuter I, Schacherer F, Wingender E: Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res 1999, 27:318-322
20. Zhan Q, Lord KA, Alamo Jr I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace Jr AJ: The GADD and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol 1994, 14:2361-2371
21. Fornace Jr AJ, Jackman J, Hollander MC, Hoffman-Liebermann B, Leibermann DA: Genotoxic-stress-response genes and growth-arrest genes, GADD, MyD, and other genes induced by treatments eliciting growth arrest. Ann NY Acad Sci 1992, 663:139-153
22. Selvakumaran M, Lin HK, Sjin RT, Reed JC, Liebermann DA, Hoffman B: The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor β1-inductd apoptosis of myeloid leukemia cells. Mol Cell Biol 1994, 14:2352-2360
23. Lenardo MJ, Baltimore D: NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989, 58:227-229
24. Nevins JR: E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 1992, 258:424-429
25. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG: Aberrant patterns of DNA methylation, chromatin formation and gene expression In cancer. Hum Mol Genet 2001, 10:687-692
26. Wajed SA, Laird PW, DeMeester TR: DNA methylation: an alternative pathway to cancer. Ann Surg 2001, 234:10-20
27. Liebermann DA, Hoffman B: MyD in negative growth control. Oncogene 1998, 17:3319-3329
28. Zhan Q, Lord KA, Alamo Jr I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace Jr AJ: The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol 1994, 14:2361-2371
29. Toyota M, Ohe-Toyota M, Ahuja N, Issa JP: Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA 2000, 97:710-715
30. 2 gene in head and neck carcinogenesis. Clin Cancer Res 2004, 10:1733-1742