Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder

Neuropsychopharmacology

Volumn 39, Issue 10, 2014, Pages 2423-2431

  Hodges, Laura M ^a   Fyer, Abby J ^b   Weissman, Myrna M ^b   Logue, Mark W ^c   Haghighi, Fatemeh ^d   Evgrafov, Oleg ^e   Rotondo, Allessandro ^f   Knowles, James A ^e   Hamilton, Steven P ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Psychiatry Columbia University College of Physicians and Surg New York State Psychiatric Institute ^*  (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF PISA   (Italy)

^g KAISER PERMANENTE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME 15Q; GABRA5 GENE; GABRB3 GENE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PANIC; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CAUCASIAN; CELL LINE; FAMILY; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; ITALY; LYMPHOCYTE; METABOLISM; MUTATION; UNITED STATES;

4 AMINOBUTYRIC ACID A RECEPTOR; GABRA5 PROTEIN, HUMAN; GABRB3 PROTEIN, HUMAN; MICROSATELLITE DNA;

ALLELES; CELL LINE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAMILY; GENE EXPRESSION; GENETIC ASSOCIATION STUDIES; GENETIC LINKAGE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; HUMANS; ITALY; LYMPHOCYTES; MICROSATELLITE REPEATS; MUTATION; PANIC DISORDER; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A; UNITED STATES;

EID: 84906317536     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2014.92     Document Type: Article

References (57)

1. Battaglia M, Bertella S, Bajo S, Binaghi F, Ogliari A, Bellodi L (1999). Assessment of parent-of-origin effect in families unlineally affected with panic disorder-Agoraphobia. J Psychiatr Res 33: 37-39
2. Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews PM, Cowen PJ (2004). Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor. Am J Psychiatry 161: 368-370
3. Bremner JD, Innis RB, White T, Fujita M, Silbersweig D, Goddard AW et al (2000). SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biol Psychiatry 47: 96-106
4. Cameron OG, Huang GC, Nichols T, Koeppe RA, Minoshima S, Rose D et al (2007). Reduced {gamma}-Aminobutyric acidAbenzodiazepine binding sites in insular cortex of individuals with panic disorder. Arch Gen Psychiatry 64: 793-800
5. Cottingham RW Jr., Idury RM, Schaffer AA (1993). Faster sequential genetic linkage computations. Am J Hum Genet 53: 252-263
6. Crowe RR, Goedken R, Wilson R, Samuelson S, Nelson J, Noyes JrR (2001). A genome-wide survey of panic disorder. Am J Med Genet (Neuropsychiatr Genet) 105: 105-109
7. Crowe RR, Wang Z, Noyes RJ, Albrecht BE, Darlison MG, Bailey ME et al (1997). Candidate gene study of eight GABAA receptor subunits in panic disorder. Am J Psychiatry 154: 1096-1100
8. Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JM, White R (1990). Centre d'etude du polymorphisme humain (CEPH): Collaborative genetic mapping of the human genome. Genomics 6: 575-577
9. Delahanty RJ, Kang JQ, Brune CW, Kistner EO, Courchesne E, Cox NJ et al (2011). Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism. Mol Psychiatry 16: 86-96
10. DeLorey TM, Handforth A, Anagnostaras SG, Homanics GE, Minassian BA, Asatourian A et al (1998). Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci 18: 8505-8514
11. DeLorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD (2008). Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: A potential model of autism spectrum disorder. Behav Brain Res 187: 207-220
12. Dudbridge F (2003). Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25: 115-121
13. Eaton WW, Kessler RC, Wittchen HU, Magee WJ (1994). Panic and panic disorder in the United States. Am J Psychiatry 151: 413-420
14. Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, Muller-Myhsok B et al (2012). Replication and meta-Analysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2: E156
15. Fyer AJ, Weissman MM (1999). Genetic linkage study of panic: Clinical methodology and description of pedigrees. Am J Med Genet 88: 173-181
16. Fyer AJ, Hamilton SP, Durner M, Haghighi F, Heiman GA, Costa R et al (2006). A third-pass genome scan in panic disorder: Evidence for multiple susceptibility loci. Biol Psychiatry 60: 388-401
17. Gelernter J, Bonvicini K, Page G, Woods SW, Goddard AW, Kruger S et al (2001). Linkage genome scan for loci predisposing to panic disorder or agoraphobia. Am J Med Genet 105: 548-557
18. Gimelbrant A, Hutchinson JN, Thompson BR, Chess A (2007). Widespread monoallelic expression on human autosomes. Science 318: 1136-1140
19. Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL et al (2004). Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am J Psychiatry 161: 2186-2193
20. Grant BF, Hasin DS, Stinson FS, Dawson DA, Goldstein RB, Smith S et al (2006). The epidemiology of DSM-IV panic disorder and agoraphobia in the United States: Results from the National Epidemiologic Survey on alcohol and related conditions. J Clin Psychiatry 67: 363-374
21. Greenberg DA, Abreu P, Hodge SE (1998). The power to detect linkage in complex disease by means of simple LOD-score analyses. Am J Hum Genet 63: 870-879
22. Gregersen N, Dahl HA, Buttenschon HN, Nyegaard M, Hedemand A, Als TD et al (2012). A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1as a candidate gene. Eur J Hum Genet 20: 84-90
23. Haghighi F, Fyer AJ, Weissman MM, Hodge SE (1999). Parent-oforigin effect in panic disorder. Am J Med Genet B Neuropsychiatr Genet 88: 131-135
24. Hamilton SP, Heiman GA, Haghighi F, Mick S, Klein DF, Hodge SE et al (1999). Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatr Genet 9: 1-6
25. Hettema JM, Neale MC, Kendler KS (2001). A review and metaanalysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158: 1568-1578
26. Hodge SE, Abreu PC, Greenberg DA (1997). Magnitude of type I error when single-locus linkage analysis is maximized over models: A simulation study. Am J Hum Genet 60: 217-227
27. Hogart A, Nagarajan RP, Patzel KA, Yasui DH, LaSalle JM (2007). 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet 16: 691-703
28. Holopainen IE, Metsahonkala EL, Kokkonen H, Parkkola RK, Manner TE, Nagren K et al (2001). Decreased binding of [11C]flumazenil in Angelman syndrome patients with GABA(A) receptor beta3 subunit deletions. Ann Neurol 49: 110-113
29. Horvath S, Xu X, Laird NM (2001). The family based association test method: Strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9: 301-306
30. Ihaka R, Gentleman R (1996). R: A language for data analysis and graphics. J Comput Graph Stat 5: 299-314
31. Kessler RC, Chiu WT, Jin R, Ruscio AM, Shear K, Walters EE (2006). The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch Gen Psychiatry 63: 415-424
32. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA et al (1998). Results of a genome-wide genetic screen for panic disorder. Am J Med Genet B Neuropsychiatr Genet 81: 139-147
33. Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S et al (2009). Parental origin of sequence variants associated with complex diseases. Nature 462: 868-874
34. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996). Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58: 1347-1363
35. Laird NM, Horvath S, Xu X (2000). Implementing a unified approach to family-based tests of association. Genet Epidemiol 19(Suppl 1): S36-S42
36. Long Z, Medlock C, Dzemidzic M, Shin YW, Goddard AW, Dydak U (2013). Decreased GABA levels in anterior cingulate cortex/ medial prefrontal cortex in panic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 44: 131-135
37. Marquez M, Segui J, Garcia L, Canet J, Ortiz M (2001). Is panic disorder with psychosensorial symptoms (depersonalizationderealization) a more severe clinical subtype? J Nerv Ment Dis 189: 332-335
38. Meguro M, Mitsuya K, Sui H, Shigenami K, Kugoh H, Nakao M et al (1997). Evidence for uniparental, paternal expression of the human GABAA receptor subunit genes, using microcell-mediated chromosome transfer. Hum Mol Genet 6: 2127-2133
39. Otowa T, Kawamura Y, Nishida N, Sugaya N, Koike A, Yoshida E et al (2012). Meta-Analysis of genome-wide association studies for panic disorder in the Japanese population. Transl Psychiatry 2: E186
40. Parent MB, Master S, Kashlub S, Baker GB (2002). Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gammaaminobutyric acid levels in the striatum. Biochem Pharmacol 63: 57-64
41. Pernhorst K, Raabe A, Niehusmann P, van Loo KM, Grote A, Hoffmann P et al (2011). Promoter variants determine gammaaminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi. J Neuropathol Exp Neurol 70: 1080-1088
42. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al (2007). PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575
43. Russo L, Mariotti P, Sangiorgi E, Giordano T, Ricci I, Lupi F et al (2005). A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes. Am J Hum Genet 76: 327-333
44. Sanacora G, Mason GF, Rothman DL, Krystal JH (2002). Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry 159: 663-665
45. Schaffer AA, Gupta SK, Shriram K, Cottingham RW Jr. (1994). Avoiding recomputation in linkage analysis. Hum Hered 44: 225-237
46. Shete S, Zhou X (2005). Parametric approach to genomic imprinting analysis with applications to Angelman's syndrome. Hum Hered 59: 26-33
47. Sinkkonen ST, Homanics GE, Korpi ER (2003). Mouse models of Angelman syndrome, a neurodevelopmental disorder, display different brain regional GABAA receptor alterations. Neurosci Lett 340: 205-208
48. Song J, Koller DL, Foroud T, Carr K, Zhao J, Rice J et al (2003). Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. Am J Med Genet B Neuropsychiatr Genet 117: 39-45
49. Spielman RS, McGinnis RE, Ewens WJ (1993). Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52: 506-516
50. Starcevic V, Kellner R, Uhlenhuth EH, Pathak D (1993). The phenomenology of panic attacks in panic disorder with and without agoraphobia. Compr Psychiatry 34: 36-41
51. Strakhova MI, Harvey SC, Cook CM, Cook JM, Skolnick P (2000). A single amino acid residue on the alpha 5 subunit (Ile215) is essential for ligand selectivity at alpha 5beta 3gamma 2gamma-Aminobutyric acidA receptors. Mol Pharmacol 58: 1434-1440
52. Strohle A, Romeo E, di Michele F, Pasini A, Hermann B, Gajewsky G et al (2003). Induced panic attacks shift {gamma}-Aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic Disorder: Preliminary results. Arch Gen Psychiatry 60: 161-168
53. Tanaka M, Bailey JN, Bai D, Ishikawa-Brush Y, Delgado-Escueta AV, Olsen RW (2012). Effects on promoter activity of common SNPs in 5' region of GABRB3 exon 1A. Epilepsia 53: 1450-1456
54. van Rijnsoever C, Tauber M, Choulli MK, Keist R, Rudolph U, Mohler H et al (2004). Requirement of {alpha}5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice. J Neurosci 24: 6785-6790
55. Vieland VJ, Goodman DW, Chapman T, Fyer AJ (1996). New segregation analysis of panic disorder. Am J Med Genet 67: 147-153
56. Weissman MM, Fyer AJ, Haghighi F, Heiman GA, Deng Z, Hen R et al (2000). Potential panic disorder syndrome: Clinical and genetic linkage evidence. Am J Med Genet (Neuropsychiatr Genet) 96: 24-35
57. Weissman MM, Gross R, Fyer A, Heiman GA, Gameroff MJ, Hodge SE et al (2004). Interstitial cystitis and panic disorder: A potential genetic syndrome. Arch Gen Psychiatry 61: 273-279