Have we been ignoring the elephant in the room? Seven arguments for considering the cerebellum as part of addiction circuitry

Neuroscience and Biobehavioral Reviews

Volumn 60, Issue , 2016, Pages 1-11

  Miquel, Marta ^a   Vazquez Sanroman, Dolores ^b   Carbo Gas, María ^a   Gil Miravet, Isis ^a   Sanchis Segura, Carla ^a   Carulli, Daniela ^c   Manzo, Jorge ^d   Coria Avila, Genaro A ^d  

^a UNIVERSITAT JAUME I   (Spain)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSIDAD VERACRUZANA   (Mexico)

Author keywords

Addiction; Cerebellum; Learning; Neuroplasticity

Indexed keywords

CEREBELLUM; CONCEPTUAL FRAMEWORK; CONNECTOME; CORPUS STRIATUM; DRUG DEPENDENCE; EMOTION; ENDOPHENOTYPE; EXECUTIVE FUNCTION; FUNCTIONAL ANATOMY; HUMAN; INSTRUMENTAL MEMORY; LEARNING; LIMBIC SYSTEM; MEMORY; NERVE CELL PLASTICITY; NEUROANATOMY; NEUROIMAGING; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SYNAPTIC TRANSMISSION; ADDICTION; ANIMAL; NERVE TRACT; PATHOPHYSIOLOGY; PSYCHOLOGY;

ANIMALS; BEHAVIOR, ADDICTIVE; CEREBELLUM; HUMANS; NEURAL PATHWAYS; SUBSTANCE-RELATED DISORDERS;

EID: 84948799917     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2015.11.005     Document Type: Review

References (164)

1. Albus J.S. A theory of cerebellar function. Math. Biosci. 1971, 10:25-61.
2. Alfonso-Loeches S., Guerri C. Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Crit. Rev. Clin. Lab. Sci. 2011, 48:19-47.
3. Allen G., Müller R.A., Courchesne E. Cerebellar function in autism: functional magnetic resonance image activation during a simple motor task. Biol. Psychiatry 2004, 56:269-278.
4. Anderson C.M., Maas L.C., Frederick B.dB., Bendor J.T., Spencer T.J., Livni E., Lukas S.E., Fischman A.J., Madras B.K., Renshaw P.F., Kaufman M.J. Cerebellar vermis involvement in cocaine-related behaviors. Neuropsychopharmacology 2006, 31:1318-1326.
5. Andreasen N.C., Paradiso S., O'Leary D.S. "Cognitive dysmetria" as an integrative theory of schizophrenia: a dysfunction in cortical subcortical-cerebellar circuitry?. Schizophr. Bull. 1998, 24:203-218.
6. Azevedo F.A., Carvalho L.R., Grinberg L.T., Farfel J.M., Ferretti R.E., Leite R.E., Jacob-Filho W., Lent R., Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J. Comp. Neurol. 2009, 5:532-541.
7. Ball K.T., Slane M. Differential involvement of prelimbic and infralimbic medial prefrontal cortex in discrete cue-induced reinstatement of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) seeking in rats. Psychopharmacology (Berl.) 2012, 224:377-385.
8. Balsters J.H., Ramnani N. Cerebellar plasticity and the automation of first-order rules. J. Neurosci. 2011, 31:2305-2312.
9. Barrós-Loscertales A., Garavan H., Bustamante J.C., Ventura-Campos N., Llopis J.J., Belloch V., Parcet M.A., Avila C. Reduced striatal volume in cocaine-dependent patients. Neuroimage 2011, 56:1021-1026.
10. Bastian A.J. Learning to predict the future: the cerebellum adapts feedforward movement control. Curr. Opin. Neurobiol. 2006, 16:645-649.
11. Batchelor A.M., Garthwaite J. Novel synaptic potentials in cerebellar Purkinje cells: probable mediation by metabotropic glutamate receptors. Neuropharmacology 1993, 32:11-20.
12. Battistella G., Fornari E., Annoni J.M., Chtioui H., Dao K., Fabritius M., Favrat B., Mall J.F., Maeder P., Giroud C. Long-term effects of cannabis on brain structure. Neuropsychopharmacology 2014, 39:2041-2048.
13. Baumgartner T., Luzt K., Schidt C.F., Jäncke L. The emotional power of the music. How music enhances the feeling of affective pictures. Brain Res. 2006, 1075:151-164.
14. Bekheet S.H., Saker S.A., Abdel-Kader A.M., Younis A.E. Histopathological and biochemical changes of morphine sulphate administration on the cerebellum of albino rats. Tissue Cell 2010, 42:165-175.
15. Bhargava H.N., Kumar S. Sensitization to the locomotor stimulant effect of cocaine modifies the binding of [3H]MK-801 to brain regions and spinal cord of the mouse. Gen. Pharmacol. 1999, 3:359-363.
16. Bobée S., Mariette E., Tremblay-Leveau H., Caston J. Effects of early midline cerebellar lesion on cognitive and emotional functions in the rat. Behav. Brain Res. 2000, 112:107-117.
17. Bolla K.I., Eldreth D.A., Matochik J.A., Cadet J.L. Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage 2005, 26:480-492.
18. Bonson K.R., Grant S.J., Contoreggi C.S., Links J.M., Metcalfe J., Weyl H.L., Kurian V., Ernst M., London E.D. Neural systems and cue-induced cocaine craving. Neuropsychopharmacology 2002, 26:376-386.
19. Bora E., Yücel M., Fornito A., Pantelis C., Harrison B.J., Cocchi L., Pell G., Lubman D.I. White matter microstructure in opiate addiction. Addict. Biol. 2012, 17:141-148.
20. Bostan A.C., Dum R.P., Strick P.L. Cerebellar networks with the cerebral cortex and basal ganglia. Trends Cogn. Sci. 2013, 17:241-254.
21. Brunamonti E., Chiricozzi F.R., Clausi S., Olivito G., Giusti M.A., Molinari M., Ferraina S., Leggio M. Cerebellar damage impairs executive control and monitoring of movement generation. PLOS ONE 2014, 9:e85997.
22. Callu D., Puget S., Faure A., Guegan M., El Massioui N. Habit learning dissociation in rats with lesions to the vermis and the interpositus of the cerebellum. Neurobiol. Dis. 2007, 27:228-237.
23. Capriles N., Rodaros D., Sorge R.E., Stewart J. A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl.) 2003, 168:66-74.
24. Carbo-Gas M., Vazquez-Sanroman D., Aguirre-Manzo L., Coria-Avila G.A., Manzo J., Sanchis-Segura C., Miquel M. Involving the cerebellum in cocaine-induced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine. Addict. Biol. 2014, 19:61-76.
25. Carbo-Gas M., Vazquez-Sanroman D., Gil-Miravet I., De Las Heras-Chanes J., Coria-Avila G.A., Manzo J., Sanchis-Segura C., Miquel M. Cerebellar hallmarks of conditioned preference for cocaine. Physiol. Behav. 2014, 132:24-35.
26. Cardoso C., de O., Branco L.D., Cotrena C., Kristensen C.H., Schneider Bakos D.D., Fonseca R.P. The impact of frontal and cerebellar lesions on decision making: evidence from the Iowa Gambling Task. Front. Neurosci. 2014, 8:61.
27. Cerminara N.L., Lang E.J., Sillitoe R.V., Apps R. Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits. Nat. Rev. Neurosci. 2015, 2:79-93.
28. Chevaleyre V., Takahashi K.A., Castillo P.E. Endocannabinoid mediated synaptic plasticity in the CNS. Ann. Rev. Neurosci. 2006, 29:37-76.
29. Cohen-Cory S. The developing synapse: construction and modulation of synaptic structures and circuits. Science 2002, 298:770-776.
30. Conti E., Calderoni S., Marchi V., Muratori F., Cioni G., Guzzetta A. The first 1000 days of the autistic brain: a systematic review of diffusion imaging studies. Front. Hum. Neurosci. 2015, 9:159.
31. Corbit L.H., Nie H., Janak P.H. Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum. Biol. Psychiatry 2012, 72:389-395.
32. Couceyro P., Pollock K.M., Drews K., Douglass J. Cocaine differentially regulates activator protein-1 mRNA levels and DNA-binding complexes in the rat striatum and cerebellum. Mol. Pharmacol. 1994, 4:667-676.
33. Courchesne E., Allen G. Prediction and preparation, fundamental functions of the cerebellum. Learn. Mem. 1997, 4:1-35.
34. Cousijn J., Wiers R.W., Ridderinkhof K.R., Van den Brink W., Veltman D.J., Goudriaan A.E. Grey matter alterations associated with cannabis use: results of a VBM study in heavy cannabis users and healthy controls. Neuroimage 2012, 59:3845-3851.
35. D'Angelo E., Casali S. Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition. Front. Neural Circuits 2013, 6:116.
36. De Zeeuw C.I., Yeo C.H. Time and tide in cerebellar memory formation. Curr. Opin. Neurobiol. 2005, 15:667-674.
37. Deroche-Gamonet V., Piazza P.V. Psychobiology of cocaine addiction: contribution of a multi-symptomatic animal model of loss of control. Neuropharmacology 2014, 76:437-449.
38. Desmond J.E., Chen S.H., DeRosa E., Pryor M.R., Pfefferbaum A., Sullivan E.V. Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study. Neuroimage 2003, 19:1510-1520.
39. Diamond A. Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex. Child Dev. 2000, 71:44-56.
40. Doyon J., Benali H. Reorganization and plasticity in the adult brain during learning of motor skills. Curr. Opin. Neurobiol. 2005, 2:161-167.
41. Eccles J., Llinas R., Sasaki K. Golgi cell inhibition in the cerebellar cortex. Nature 1964, 204:1265-1266.
42. Edmonson C., Ziats M.N., Rennert O.M. Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum. Mol. Autism 2014, 5:3.
43. Edwards D.J., Rizk M. Conversion of 3,4-dihydroxyphenylalanine and deuterated 3,4-dihydroxyphenylalanine to alcoholic metabolites of catecholamines in rat brain. J. Neurochem. 1981, 36:1641-1647.
44. Enoch M.A., Rosser A.A., Zhou Z., Mash D.C., Yuan Q., Goldman D. Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. Genes Brain Behav. 2014, 13:758-768.
45. Ersche K.D., Jones P.S., Williams G.B., Turton A.J., Robbins T.W., Bullmore E.T. Abnormal brain structure implicated in stimulant drug addiction. Science 2012, 335:601-604.
46. Everitt B.J. Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories-indications for novel treatments of addiction. Eur. J. Neurosci. 2014, 40:2163-2182.
47. Everitt B.J., Robbins T.W. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 2005, 8:1481-1489.
48. Fatemi S.H., Aldinger K.A., Ashwood P., Bauman M.L., Blaha C.D., Blatt G.J., Chauhan A., Chauhan V., Dager S.R., Dickson P.E., Estes A.M., Goldowitz D., Heck D.H., Kemper T.L., King B.H., Martin L.A., Millen K.J., Mittleman G., Mosconi M.W., Persico A.M., Sweeney J.A., Webb S.J., Welsh J.P. Consensus paper: pathological role of the cerebellum in autism. Cerebellum 2012, 11:777-807.
49. Ferrucci M., Busceti C.L., Nori S.L., Lazzeri G., Bovolin P., Falleni A., Mastroiacovo F., Pompili E., Fumagalli L., Paparelli A., Fornai F. Methamphetamine induces ectopic expression of tyrosine hydroxylase and increases noradrenaline levels within the cerebellar cortex. Neuroscience 2007, 149:871-884.
50. Forster G.L., Blaha C.D. Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat. Eur. J. Neurosci. 2003, 17:751-762.
51. Fumagalli F., Di Pasquale L., Caffino L., Racagni G., Riva M.A. Repeated exposure to cocaine differently modulates BDNF mRNA and protein levels in rat striatum and prefrontal cortex. Eur. J. Neurosci. 2007, 26:2756-2763.
52. Gabay A.S., Radua J., Kempton M.J., Mehta M.A. The Ultimatum Game and the brain: a meta-analysis of neuroimaging studies. Neurosci. Biobehav. Rev. 2014, 47:549-558.
53. Galliano E., Gao Z., Schonewille M., Todorov B., Simons E., Pop A.S., D'Angelo E., van den Maagdenberg A.M., Hoebeek F.E., De Zeeuw C.I. Silencing the majority of cerebellar granule cells uncovers their essential role in motor learning and consolidation. Cell Rep. 2013, 3:1239-1251.
54. Garcia-Martinez R., Miquel M., Garcia L.I., Coria-Avila G.A., Perez C.A., Aranda-Abreu G.E., Toledo R., Hernandez M.E., Manzo J. Multiunit recording of the cerebellar cortex, inferior olive, and fastigial nucleus during copulation in naive and sexually experienced male rats. Cerebellum 2010, 9:96-102.
55. Gil-Miravet I., Carbo-Gas M., Torres-Garrido Z., Gonzalez-Hernandez F., Palma-Gomez A., Sanchis-Segura C., Miquel M. Effects of prelimbic and cerebellar lesions on the acquisition of preference memory towards cocaine-related cues. 5th International Mediterranean Neuroscience Society (MNS) Meeting 2015.
56. Gilbert P.F., Thach W.T. Purkinje cell activity during motor learning. Brain Res. 1977, 2:309-328.
57. Gipson C.D., Kupchik Y.M., Kalivas P.W. Rapid, transient synaptic plasticity in addiction. Neuropharmacology 2014, 76:276-286.
58. Glaser P.E., Surgener S.P., Grondin R., Gash C.R., Palmer M., Castellanos F.X., Gerhardt G.A. Cerebellar neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in the cerebellar vermis?. J. Neurosci. Methods 2006, 151:62-67.
59. Glickstein M., Sultan F., Voogd J. Functional localization in the cerebellum. Cortex 2011, 47:59-80.
60. Goldstein R.Z., Tomasi D., Alia-Klein N., Zhang L., Telang F., Volkow N.D. The effect of practice on a sustained attention task in cocaine abusers. Neuroimage 2007, 35:194-206.
61. Grant S., London E.D., Newlin D.B., Villemagne V.L., Liu X., Contoreggi C., Phillips R.L., Kimes A.S., Margolin A. Activation of memory circuits during cue elicited cocaine craving. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:12040-12045.
62. Graybiel A.M. Habits, rituals, and the evaluative brain. Annu. Rev. Neurosci. 2008, 31:359-387.
63. Heath R.G., Dempesy C.W., Fontana C.J., Myers W.A. Cerebellar stimulation: effects on septal region, hippocampus, and amygdala of cats and rats. Biol. Psychiatry 1978, 13:501-529.
64. Heman P., Barcia C., Gómez A., Ros C.M., Ros-Bernal F., Yuste J.E., de Pablos V., Fernandez-Villalba E., Toledo-Cárdenas M.R., Herrero M.T. Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys. Histol. Histopathol. 2012, 27:89-94.
65. Herculano-Houzel S., Mota B.C., Lent R. Cellular scaling rules for rodent brains. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12138-12143.
66. Herrera-Meza G., Aguirre-Manzo L., Coria-Avila G.A., Lopez-Meraz M.L., Toledo-Cardenas R., Manzo J., Garcia L.I., Miquel M. Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterations. Neuroscience 2014, 267:219-231.
67. Hester R., Garavan H. Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. J. Neurosci. 2004, 24:11017-11022.
68. Hill S.Y., Wang S., Carter H., Tessner K., Holmes B., McDermott M., Zezza N., Stiffler S. Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF. Psychiatry Res. 2011, 194:304-313.
69. Holstege G., Huynh H.K. Brain circuits for mating behavior in cats and brain activations and de-activations during sexual stimulation and ejaculation and orgasm in humans. Horm. Behav. 2011, 59:702-707.
70. Holstege G., Georgiadis J.R., Paans A.M., Meiners L.C., van der Graaf F.H., Reinders A.A. Brain activation during human male ejaculation. J. Neurosci. 2003, 23:9185-9193.
71. Hutcheson D.M., Tzavara E.T., Smadja C., Valjent E., Roques B.P., Hanoune J., Maldonado R. Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. Br. J. Pharmacol. 1998, 125:1567-1577.
72. Hyman S.E. Can neuroscience be integrated into the DSM-V?. Nat. Rev. Neurosci. 2007, 8:725-732.
73. Hyman S.E., Malenka R.C., Nestler E.J. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci. 2006, 29:565-598.
74. Ikai Y., Takada M., Mizuno N. Single neurons in the ventral tegmental area that project to both the cerebral and cerebellar cortical areas by way of axon collaterals. Neuroscience 1994, 4:925-934.
75. Ikai Y., Takada M., Shinonaga Y., Mizuno N. Dopaminergic and nondopaminergic neurons in the ventral tegmental area of the rat project, respectively, to the cerebellar cortex and deep cerebellar nuclei. Neuroscience 1992, 51:719-728.
76. Ito M. The modifiable neuronal network of the cerebellum. Jpn. J. Physiol. 1984, 34:781-792.
77. Kalivas P., Volkow N.D., Seamans J. Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 2005, 45:647-650.
78. Klitenick M.A., Tham C.S., Fibiger H.C. Cocaine and d-amphetamine increase cfos expression in the rat cerebellum. Synapse 1995, 19:29-36.
79. Koehler S., Ovadia-Caro S., van der Meer E., Villringer A., Heinz A., Romanczuk-Seiferth N., Margulies D.S. Increased functional connectivity between prefrontal cortex and reward system in pathological gambling. PLoS ONE 2013, 8:e84565.
80. Konarski J.Z., McIntyre R.S., Grupp L.A., Kennedy S.H. Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?. J. Psychiatry Neurosci. 2005, 30:178-186.
81. Kotz S.A., Stockert A., Schwartze M. Cerebellum, temporal predictability and the updating of a mental model. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2014, 369:20130403.
82. Koziol L.F., Budding D., Andreasen N., D'Arrigo S., Bulgheroni S., Imamizu H., Ito M., Manto M., Marvel C., Parker K., Pezzulo G., Ramnani N., Riva D., Schmahmann J., Vandervert L., Yamazaki T. Consensus paper: the cerebellum's role in movement and cognition. Cerebellum 2014, 13:151-177.
83. Larsell O. The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat. J. Comp. Neurol. 1952, 97:281-356.
84. Leggio M., Molinari M. Cerebellar sequencing: a trick for predicting the future. Cerebellum 2015, 14:35-38.
85. Leiner H.C., Leiner A.L., Dow R.S. Cognitive and language functions of the human cerebellum. Trends Neurosci. 1993, 16:444-447.
86. Leiner H.C., Leiner A.L., Dow R.S. Does the cerebellum contribute to mental skills?. Behav. Neurosci. 1986, 100:443-454.
87. Lent R., Azevedo F.A., Andrade-Moraes C.H., Pinto A.V. How many neurons do you have? Some dogmas of quantitative neuroscience under revision. Eur. J. Neurosci. 2012, 35:1-9.
88. Levey D.F., Le-Niculescu H., Frank J., Ayalew M., Jain N., Kirlin B., Learman R., Winiger E., Rodd Z., Shekhar A., Schork N., Kiefer F., Wodarz N., Müller-Myhsok B., Dahmen N., Consortium GESGA., Nöthen M., Sherva R., Farrer L., Smith A.H., Kranzler H.R., Rietschel M., Gelernter J., Niculescu A.B. Genetic risk prediction and neurobiological understanding of alcoholism. Transl. Psychiatry 2014, 4:e391.
89. Leyton M., Vezina P. Striatal ups and downs: their roles in vulnerability to addictions in humans. Neurosci. Biobehav. Rev. 2013, 37:1999-2014.
90. Li Q., Li W., Wang H., Wang Y., Zhang Y., Zhu J., Zheng Y., Zhang D., Wang L., Li Y., Yan X., Chang H., Fan M., Li Z., Tian J., Gold M.S., Wang W., Liu Y. Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study. Addict. Biol. 2015, 20:968-978.
91. Limperopoulos C., Chilingaryan G., Sullivan N., Guizard N., Robertson R.L., du Plessis A.J. Injury to the premature cerebellum: outcome is related to remote cortical development. Cereb. Cortex 2014, 4:728-736.
92. Loweth J.A., Tseng K.Y., Wolf M.E. Adaptations in AMPA receptor transmission in the nucleus accumbens contributing to incubation of cocaine craving. Neuropharmacology 2014, 287-300.
93. Mandolesi L., Foti F., Cutuli D., Laricchiuta D., Gelfo F., De Bartolo P., Petrosini L. Features of sequential learning in hemicerebellectomized rats. J. Neurosci. Res. 2010, 88:478-486.
94. Manzo J., Miquel M., Toledo R., Mayor-Mar J.A., Garcia L.I., Aranda-Abreu G.E., Caba M., Hernandez M.E. Fos expression at the cerebellum following non-contact arousal and mating behavior in male rats. Physiol. Behav. 2008, 93:357-363.
95. Marr D. A theory of cerebellar cortex. J. Physiol. 1969, 202:437-470.
96. Martin-Sölch C., Magyar S., Künig G., Missimer J., Schultz W., Leendersw K.L. Changes in brain activation associated with reward processing in smoker and nonsmokers. A positron emission tomography study. Exp. Brain Res. 2001, 139:278-286.
97. Mazurek M.O., Engelhardt C.R. Video game use in boys with autism spectrum disorder, ADHD, or typical development. Pediatrics 2013, 132:260-266.
98. McFarland K., Kalivas P.W. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci. 2001, 21:8655-8663.
99. Medina K.L., Nagel B.J., Tapert S.F. Abnormal cerebellar morphometry in abstinent adolescent marijuana users. Psychiatry Res. 2010, 182:152-159.
100. Melchitzky D.S., Lewis D.A. Tyrosine hydroxylase and dopamine transporter-immunoreactivity axons in the primate cerebellum. Neuropsychopharmacology 2000, 22:466-472.
101. Miquel M., Toledo R., García L.I., Coria-Avila G.A., Manzo J. Why should we keep the cerebellum in mind when thinking about addiction?. Curr. Drug Abuse Rev. 2009, 2:26-40.
102. Moers-Hornikx V.M., Sesia T., Basar K., Lim L.W., Hoogland G., Steinbusch H.W., Gavilanes D.A., Temel Y., Vles J.S. Cerebellar nuclei are involved in impulsive behaviour. Behav. Brain Res. 2009, 203:256-263.
103. Moulton E.A., Elman I., Becerra L.R., Goldstein R.Z., Borsook D. The cerebellum and addiction: insights gained from neuroimaging research. Addict. Biol. 2014, 3:317-331.
104. Mulhern R.K., Merchant T.E., Gajjar A., Reddick W.E., Kun L.E. Late neurocognitive sequelae in survivors of brain tumors in childhood. Lancet Oncol. 2004, 5:399-408.
105. Murphy C.M., Christakou A., Daly E.M., Ecker C., Giampietro V., Brammer M., Smith A.B., Johnston P., Robertson D.M., Murphy D.G., Rubia K. Abnormal functional activation and maturation of fronto-striato-temporal and cerebellar regions during sustained attention in autism spectrum disorder. Am. J. Psychiatry 2014, 171:1107-1116.
106. Murray J.E., Dilleen R., Pelloux Y., Economidou D., Dalley J.W., Belin D., Everitt B.J. Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking. Biol. Psychiatry 2013, 76:15-22.
107. Netzeband J.G., Trotter C., Caguioa J.N., Gruol D.L. Chronic ethanol exposure enhances AMPA-elicited Ca2+ signals in the somatic and dendritic regions of cerebellar Purkinje neurons. Neurochem. Int. 1999, 35:163-174.
108. Nopoulos P.C., Ceilley J.W., Gailis E.A., Andreasen N.C. An MRI study of cerebellar vermis morphology in patients with schizophrenia: evidence in support of the cognitive dysmetria concept. Biol. Psychiatry 1999, 46:703-711.
109. Osipowicz K., Bosenbark D.D., Patrick K.E. Cortical changes across the autism lifespan. Autism Res. 2015, 2015.
110. Ostby Y., Tamnes C.K., Fjell A.M., Westlye L.T., Due-Tønnessen P., Walhovd K.B. Heterogeneity in subcortical brain development: a structural magnetic resonance imaging study of brain maturation from 8 to 30 years. J. Neurosci. 2009, 29:11772-117782.
111. Palomino A., Pavón F.J., Blanco-Calvo E., Serrano A., Arrabal S., Rivera P., Alén F., Vargas A., Bilbao A., Rubio L., Rodríguez de Fonseca F., Suárez J. Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling related proteins in the mouse cerebellum. Front. Integr. Neurosci. 2014, 8:22.
112. Paredes-Ramos P., Pfaus J.G., Miquel M., Manzo J., Coria-Avila G.A. Sexual reward induces Fos in the cerebellum of female rats. Physiol. Behav. 2011, 102:143-148.
113. Pastura G., Mattos P., Gasparetto E.L., Araújo A.P. Advanced techniques in magnetic resonance imaging of the brain in children with ADHD. Arq. Neuropsiquiatr. 2011, 69:242-252.
114. Peters J., Lalumiere R.T., Kalivas P.W. Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats. J. Neurosci. 2008, 28:6046-6053.
115. Picazio S., Koch G. Is motor inhibition mediated by cerebello-cortical interactions?. Cerebellum 2015, 14:47-49.
116. Ploghaus A., Tracey I., Gati J.S., Clare S., Menon R.S., Matthews P.M., Rawlins J.N. Dissociating pain from its anticipation in the human brain. Science 1999, 284:1979-1981.
117. Porter J.N., Minhas D., Lopresti B.J., Price J.C., Bradberry C.W. Altered cerebellar and prefrontal cortex function in rhesus monkeys that previously self-administered cocaine. Psychopharmacology (Berl.) 2014, 231:4211-4218.
118. Ramnani N. The primate cortico-cerebellar system: anatomy and function. Nat. Rev. Neurosci. 2006, 7:511-522.
119. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Brain Res. Rev. 1993, 18:247-291.
120. Robinson T.E., Berridge K.C. Incentive-sensitization and addiction. Addiction 2001, 96:103-114.
121. Robinson T.E., Berridge K.C. Review. The incentive sensitization theory of addiction: some current issues. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2008, 12:3137-3146.
122. Robinson T.E., Kolb B. Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats. Synapse 1999, 33:160-162.
123. Rogers T.D., Dickson P.E., Heck D.H., Goldowitz D., Mittleman G., Blaha C.D. Connecting the dots of the cerebro-cerebellar role in cognitive function: neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex. Synapse 2011, 65:1204-1212.
124. Rosenbloom M.H., Schmahmann J.D., Price B.H. The functional neuroanatomy of decision-making. J. Neuropsychiatry Clin. Neurosci. 2012, 24:266-277.
125. Rossi S., Mataluni G., De Bartolo P., Prosperetti C., Foti F., De Chiara V., Musella A., Mandolesi L., Bernardi G., Centonze D., Petrosini L. Cerebellar control of cortico-striatal LTD. Restor. Neurol. Neurosci. 2008, 6:475-480.
126. Rubino T., Forlani G., Viganò D., Zippel R., Parolaro D. Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment. Mol. Cell. Neurosci. 2004, 25:355-362.
127. Sacchetti B., Baldi E., Lorenzini C.A., Bucherelli C. Cerebellar role in fear-conditioning consolidation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:8406-8411.
128. Sacchetti B., Scelfo B., Strata P. The cerebellum: synaptic changes and fear conditioning. Neuroscientist 2005, 11:217-227.
129. Sacchetti B., Scelfo B., Tempia F., Strata P. Long-term synaptic changes induced in the cerebellar cortex by fear conditioning. Neuron 2004, 42:973-982.
130. Salin P.A., Malenka R.C., Nicoll R.A. Cyclic AMP mediates a pre-synaptic form of LTP at cerebellar parallel fiber synapses. Neuron 1996, 16:797-803.
131. Sanna P.P., Simpson C., Lutjens R., Koob G. ERK regulation in chronic ethanol and withdrawal. Brain Res. 2002, 948:186-191.
132. Schmahmann J.D. An emerging concept. The cerebellar contribution to higher function. Arch. Neurol. 1991, 48:1178-1187.
133. Schmahmann J.D., Sherman J.C. The cerebellar cognitive affective syndrome. Brain 1998, 121:561-579.
134. Schneider F., Habel U., Wagner M., Franke P., Salloum J.B., Shah N.J., Toni I., Sulzbach C., Hönig K., Maier W., Gaebel W., Zilles K. Subcortical correlates of craving in recently abstinent alcoholic patients. Am. J. Psychiatry 2001, 157:1075-1083.
135. Schutter D.J.L.G., van Honk J. An elecrophysiological link between the cerebellum, cognition and emotion: frontal theta EEG activity to single-pulse cerebellar TMS. Neuroimage 2006, 33:1227-1231.
136. Scott J.A., Schumann C.M., Goodlin-Jones B.L., Amaral D.G. A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder. Autism Res. 2009, 2:246-257.
137. Segobin S.H., Chételat G., Le Berre A.P., Lannuzel C., Boudehent C., Vabret F., Eustache F., Beaunieux H., Pitel A.L. Relationship between brain volumetric changes and interim drinking at six months in alcohol-dependent patients. Alcohol. Clin. Exp. Res. 2014, 38:739-748.
138. Skefos J., Cummings C., Enzer K., Holiday J., Weed K., Levy E., Yuce T., Kemper T., Bauman M. Regional alterations in Purkinje cell density in patients with autism. PLOS ONE 2014, 9:e81255.
139. Strata P., Scelfo B., Sacchetti B. Involvement of cerebellum in emotional behavior. Physiol. Res. 2011, 60:S39-S48.
140. Supple W.F., Leaton R.N. Lesions of the cerebellar vermis and cerebellar hemispheres: effects on heart rate conditioning in rats. Behav. Neurosci. 1990, 104:934-947.
141. Tanaka H., Harada M., Arai M., Hirata K. Cognitive dysfunction in cortical cerebellar atrophy correlates with impairment of the inhibitory system. Neuropsychobiology 2003, 47:206-211.
142. Thompson R.F., Steinmetz J.E. The role of the cerebellum in classical conditioning of discrete behavioral responses. Neuroscience 2009, 162:732-755.
143. Timmann D., Drepper J., Frings M., Maschke M., Richter S., Gerwig M., Kolb F.P. The human cerebellum contributes to motor, emotional and cognitive associative learning. A review. Cortex 2010, 46:845-857.
144. Tomasi D., Wang G.J., Wang R., Caparelli E.C., Logan J., Volkow N.D. Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: association to striatal D2/D3 receptors. Hum. Brain Mapp. 2015, 36:120-136.
145. Tronel S., Sara S.J. Mapping of olfactory memory circuits: region-specific c-fos activation after odor-reward associative learning or after its retrieval. Learn. Mem. 2002, 3:105-111.
146. Turner B.M., Paradiso S., Marvel C.L., Pierson R., Boles Ponto L.L., Hichwa R.D., Robinson R.G. The cerebellum and emotional experience. Neuropsychologia 2007, 45:1331-1341.
147. Vaidya J.G., Block R.I., O'Leary D.S., Ponto L.B., Ghoneim M.M., Bechara A. Effects of chronic marijuana use on brain activity during monetary decision-making. Neuropsychopharmacology 2012, 37:618-629.
148. Vazquez-Sanroman D., Carbo-Gas M., Leto K., Cerezo-Garcia M., Gil-Miravet I., Sanchis-Segura C., Carulli D., Rossi F., Miquel M. Cocaine-induced plasticity in the cerebellum of sensitised mice. Psychopharmacology 2015, 232:4455-4467.
149. Vazquez-Sanroman D., Leto K., Cerezo-Garcia M., Carbo-Gas M., Sanchis-Segura C., Carulli D., Rossi F., Miquel M. The cerebellum on cocaine: plasticity and metaplasticity. Addict. Biol. 2015, 10.1111/adb.12223.
150. Vezina P. Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci. Biobehav. Rev. 2004, 27:827-839.
151. Villanueva R. The cerebellum and neuropsychiatric disorders. Psychiatry Res. 2012, 198:527-532.
152. Vinod K.Y., Yalamanchili R., Xie S., Cooper T.B., Hungund B.L. Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system. Neurochem. Int. 2006, 49:619-625.
153. Volkow N.D., Wang G.J., Ma Y., Fowler J.S., Zhu W., Maynard L., Telang F., Vaska P., Ding Y.S., Wong C., Swanson J.M. Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. J. Neurosci. 2003, 23:11461-11468.
154. Voogd J., Glickstein M. The anatomy of the cerebellum. Trends Cogn. Sci. 1998, 9:307-313.
155. Wang S.S., Kloth A.D., Badura A. The cerebellum, sensitive periods, and autism. Neuron 2014, 83:518-532.
156. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 1987, 44:660-669.
157. Willuhn I., Burgeno L.M., Everitt B.J., Phillips P.E. Hierarchical recruitment of phasic dopamine signalling in the striatum during the progression of cocaine use. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:20703-20708.
158. Yalachkov Y., Kaiser J., Naumer M.J. Brain regions related to tool use and action knowledge reflect nicotine dependence. J. Neurosci. 2009, 29:4922-4929.
159. Yalachkov Y., Kaiser J., Naumer M.J. Sensory and motor aspects of addiction. Behav. Brain Res. 2010, 207:215-222.
160. Yeganeh-Doost P., Gruber O., Falkai P., Schmitt A. The role of the cerebellum in schizophrenia: from cognition to molecular pathways. Clinics 2011, Suppl.:71-77.
161. Yin H.H., Knowlton B.J. The role of the basal ganglia in habit formation. Nat. Rev. Neurosci. 2006, 7:464-476.
162. Yin H.S., Lai C.C., Tien T.W., Han S.K., Pu X.L. Differential changes in cerebellar transmitter content and expression of calcium binding proteins and transcription factors in mouse administered with amphetamine. Neurochem. Int. 2010, 57:288-296.
163. Yu H., Sternad D., Corcos D.M., Vaillancourt D.E. Role of hyperactive cerebellum and motor cortex in Parkinson's disease. Neuroimage 2007, 35:222-233.
164. Yu R., Zhao L., Lu L. Regional grey and white matter changes in heavy male smokers. PLoS ONE 2011, 6:e27440.