Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

PLoS Pathogens

Volumn 12, Issue 12, 2016, Pages

  Adnan, Sama ^a,b   Reeves, R Keith ^b,c   Gillis, Jacqueline ^b   Wong, Fay E ^b   Yu, Yi ^b   Camp, Jeremy V ^d   Li, Qingsheng ^e   Connole, Michelle ^b   Li, Yuan ^f   Piatak, Michael ^f   Lifson, Jeffrey D ^f   Li, Wenjun ^g   Keele, Brandon F ^f   Kozlowski, Pamela A ^d   Desrosiers, Ronald C ^h   Haase, Ashley T ⁱ   Johnson, R Paul ^a,b,j  

^a EMORY UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^f FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^g UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^j MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 2; KI 67 ANTIGEN; NEUTRALIZING ANTIBODY; SIMIAN IMMUNODEFICIENCY VIRUS DELTA NEF VACCINE; SIMIAN IMMUNODEFICIENCY VIRUS MAC239 DELTA NEF VACCINE; SIMIAN IMMUNODEFICIENCY VIRUS MAC251 VACCINE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIRUS VACCINE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHESUS MONKEY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINATION; VAGINITIS; VIREMIA; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION; ANIMAL; CELLULAR IMMUNITY; HUMORAL IMMUNITY; IMMUNOLOGY; VAGINA; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MACACA MULATTA; REAL-TIME POLYMERASE CHAIN REACTION; SAIDS VACCINES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VAGINA; VIRAL LOAD;

EID: 85008224836     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006104     Document Type: Article

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