Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention

Journal of Immunology

Volumn 194, Issue 5, 2015, Pages 2059-2063

  Mackay, Laura K ^a   Braun, Asolina ^a   Macleod, Bethany L ^a   Collins, Nicholas ^a   Tebartz, Christina ^a   Bedoui, Sammy ^a   Carbone, Francis R ^a   Gebhardt, Thomas ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; INTERFERON RECEPTOR; INTERFERON RECEPTOR TYPE 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; INTERFERON; LECTIN; LEUKOCYTE ANTIGEN; T LYMPHOCYTE ANTIGEN; VIRUS ANTIGEN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; FEMALE; GENETIC TRANSCRIPTION; IMMUNOLOGICAL MEMORY; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE TISSUE RETENTION; ANIMAL; C57BL MOUSE; COCULTURE; DENDRITIC CELL; GENE EXPRESSION REGULATION; GENETICS; HERPES SIMPLEX VIRUS 1; IMMUNOLOGY; IMMUNOPHENOTYPING; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; PATHOLOGY; SKIN; VIROLOGY;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; HERPESVIRUS 1, HUMAN; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERFERON TYPE I; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SKIN;

EID: 84924386358     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402256     Document Type: Article

References (24)

1. Woodland, D. L., and J. E. Kohlmeier. 2009. Migration, maintenance and recall of memory T cells in peripheral tissues. Nat. Rev. Immunol. 9: 153-161.
2. Gebhardt, T., L. M. Wakim, L. Eidsmo, P. C. Reading, W. R. Heath, and F. R. Carbone. 2009. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat. Immunol. 10: 524-530.
3. Mackay, L. K., A. Rahimpour, J. Z. Ma, N. Collins, A. T. Stock, M. L. Hafon, J. Vega-Ramos, P. Lauzurica, S. N. Mueller, T. Stefanovic, et al. 2013. The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat. Immunol. 14: 1294-1301.
4. Sheridan, B. S., Q. M. Pham, Y. T. Lee, L. S. Cauley, L. Puddington, and L. Lefrançois. 2014. Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function. Immunity 40: 747-757.
5. Jiang, X., R. A. Clark, L. Liu, A. J. Wagers, R. C. Fuhlbrigge, and T. S. Kupper. 2012. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 483: 227-231.
6. Mackay, L. K., A. T. Stock, J. Z. Ma, C. M. Jones, S. J. Kent, S. N. Mueller, W. R. Heath, F. R. Carbone, and T. Gebhardt. 2012. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc. Natl. Acad. Sci. USA 109: 7037-7042.
7. Casey, K. A., K. A. Fraser, J. M. Schenkel, A. Moran, M. C. Abt, L. K. Beura, P. J. Lucas, D. Artis, E. J. Wherry, K. Hogquist, et al. 2012. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J. Immunol. 188: 4866-4875.
8. Bromley, S. K., S. Y. Thomas, and A. D. Luster. 2005. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol. 6: 895-901.
9. Debes, G. F., C. N. Arnold, A. J. Young, S. Krautwald, M. Lipp, J. B. Hay, and E. C. Butcher. 2005. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat. Immunol. 6: 889-894.
10. Brown, M. N., S. R. Fintushel, M. H. Lee, S. Jennrich, S. A. Geherin, J. B. Hay, E. C. Butcher, and G. F. Debes. 2010. Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation. J. Immunol. 185: 4873-4882.
11. Jennrich, S., M. H. Lee, R. C. Lynn, K. Dewberry, and G. F. Debes. 2012. Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung. J. Virol. 86: 3436-3445.
12. Skon, C. N., J. Y. Lee, K. G. Anderson, D. Masopust, K. A. Hogquist, and S. C. Jameson. 2013. Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat. Immunol. 14: 1285-1293.
13. Ledgerwood, L. G., G. Lal, N. Zhang, A. Garin, S. J. Esses, F. Ginhoux, M. Merad, H. Peche, S. A. Lira, Y. Ding, et al. 2008. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat. Immunol. 9: 42-53.
14. Spiegel, S., and S. Milstien. 2011. The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 11: 403-415.
15. Carlson, C. M., B. T. Endrizzi, J. Wu, X. Ding, M. A. Weinreich, E. R. Walsh, M. A. Wani, J. B. Lingrel, K. A. Hogquist, and S. C. Jameson. 2006. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442: 299-302.
16. Bankovich, A. J., L. R. Shiow, and J. G. Cyster. 2010. CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. J. Biol. Chem. 285: 22328-22337.
17. Shiow, L. R., D. B. Rosen, N. Brdicková, Y. Xu, J. An, L. L. Lanier, J. G. Cyster, and M. Matloubian. 2006. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440: 540-544.
18. Alari-Pahissa, E., L. Notario, E. Lorente, J. Vega-Ramos, A. Justel, D. López, J. A. Villadangos, and P. Lauzurica. 2012. CD69 does not affect the extent of T cell priming. PLoS ONE 7: e48593.
19. Lee, Y. T., J. E. Suarez-Ramirez, T. Wu, J. M. Redman, K. Bouchard, G. A. Hadley, and L. S. Cauley. 2011. Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes. J. Virol. 85: 4085-4094.
20. Shinoda, K., K. Tokoyoda, A. Hanazawa, K. Hayashizaki, S. Zehentmeier, H. Hosokawa, C. Iwamura, H. Koseki, D. J. Tumes, A. Radbruch, and T. Nakayama. 2012. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl. Acad. Sci. USA 109: 7409-7414.
21. Macleod, B. L., S. Bedoui, J. L. Hor, S. N. Mueller, T. A. Russell, N. A. Hollett, W. R. Heath, D. C. Tscharke, A. G. Brooks, and T. Gebhardt. 2014. Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1. PLoS Pathog. 10: e1004303.
22. Testi, R., D. D'Ambrosio, R. De Maria, and A. Santoni. 1994. The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol. Today 15: 479-483.
23. Kohlmeier, J. E., S. C. Miller, and D. L. Woodland. 2007. Cutting edge: Antigen is not required for the activation and maintenance of virus-specific memory CD8+ T cells in the lung airways. J. Immunol. 178: 4721-4725.
24. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360.