The effect of obesity, weight gain, and weight loss on asthma inception and control

Current Opinion in Allergy and Clinical Immunology

Volumn 17, Issue 2, 2017, Pages 123-130

  Forno, Erick ^a   Celedón, Juan C ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Adipokines and asthma; Airway dysanapsis; Diet and asthma; Insulin resistance; Metabolic syndrome microbiome and asthma; Obese asthma; Obesity induced asthma

Indexed keywords

ADIPOCYTOKINE; GLUCOSE;

ASTHMA; CHILDHOOD OBESITY; CYTOKINE PRODUCTION; DIET; DISEASE CONTROL; EPIGENETICS; GENOMICS; GLUCOSE METABOLISM; HUMAN; INFLAMMATION; INSULIN METABOLISM; INSULIN RESISTANCE; INTESTINE FLORA; MATERNAL OBESITY; METABOLIC SYNDROME X; NUTRIENT; PERINATAL PERIOD; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TREATMENT RESPONSE; WEIGHT GAIN; WEIGHT REDUCTION; ANIMAL; CHILD; FEMALE; GENOTYPE ENVIRONMENT INTERACTION; METABOLISM; OBESITY;

ANIMALS; ASTHMA; CHILD; FEMALE; GENE-ENVIRONMENT INTERACTION; GLUCOSE; HUMANS; OBESITY; PREGNANCY; QUALITY OF LIFE; WEIGHT GAIN; WEIGHT LOSS;

EID: 85007439482     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000339     Document Type: Review

References (107)

1. CDC. Asthma data, statistics, and surveillance 2016 [updated 4/14/2016; cited 10/18/2016]. Most recent asthma data. Available from: http://www.cdc.gov/asthma/most-recent-data.htm
2. CDC. Childhood obesity 2016 [updated 11/09/2015; cited 10/18/2016]. Available from: https://www.cdc.gov/obesity/childhood/index.html
3. Weinmayr G, Forastiere F, Buchele G, et al. Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two. PLoS One 2014; 9:e113996
4. Mebrahtu TF, Feltbower RG, Greenwood DC, Parslow RC. Childhood body mass index and wheezing disorders: a systematic review and meta-analysis. Pediatr Allergy Immunol 2015; 26:62-72
5. Granell R, Henderson AJ, Evans DM, et al. Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med 2014; 11:e1001669
6. Wood LG. Metabolic dysregulation. Driving the obese asthma phenotype in adolescents? Am J Respir Crit Care Med 2015; 191:121-122
7. Lang JE, Hossain J, Dixon AE, et al. Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. Chest 2011; 140:1524-1533
8. Borrell LN, Nguyen EA, Roth LA, et al. Childhood obesity and asthma control in the GALA II and SAGE II studies. Am J Respir Crit Care Med 2013; 187:697-702
9. Ahmadizar F, Vijverberg SJ, Arets HG, et al. Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis. Eur Respir J 2016; 48:1063-1073
10. Denlinger LC, Phillips BR, Ramratnam S, et al. Inflammatory and co-morbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med 2016. DOI: 10.1164/rccm.201602-0419OC. [Epub ahead of print]
11. Okubo Y, Nochioka K, Hataya H, et al. Burden of obesity on pediatric inpatients with acute asthma exacerbation in the United States. J Allergy Clin Immunol Pract 2016; 4:1227-1231
12. Aragona E, El-Magbri E, Wang J, et al. Impact of obesity on clinical outcomes in urban children hospitalized for status asthmaticus. Hosp Pediatr 2016; 6:211-218
13. Forno E, Lescher R, Strunk R, et al. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol 2011; 127:741-749
14. van Gent R, van der Ent CK, Rovers MM, et al. Excessive body weight is associated with additional loss of quality of life in children with asthma. J Allergy Clin Immunol 2007; 119:591-596
15. Lu KD, Billimek J, Bar-Yoseph R, et al. Sex differences in the relationship between fitness and obesity on risk for asthma in adolescents. J Pediatr 2016; 176:36-42
16. Maltz L, Matz EL, Gordish-Dressman H, et al. Sex differences in the association between neck circumference and asthma. Pediatr Pulmonol 2016; 51:893-900
17. Castro-Rodriguez JA. A new childhood asthma phenotype: obese with early menarche. Paediatr Respir Rev 2016; 18:85-89
18. Willeboordse M, van den Bersselaar DL, van de Kant KD, et al. Sex differences in the relationship between asthma and overweight in Dutch children: a survey study. PLoS One 2013; 8:e77574
19. Forno E, Young OM, Kumar R, et al. Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma. Pediatrics 2014; 134:e535-e546
20. Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy 2016; 71:1295-1304
21. Harskamp-van Ginkel MW, London SJ, Magnus MC, et al. A study on mediation by offspring bmi in the association between maternal obesity and child respiratory outcomes in the amsterdam born and their development study cohort. PLoS One 2015; 10:e0140641
22. Wilson RM, Marshall NE, Jeske DR, et al. Maternal obesity alters immune cell frequencies and responses in umbilical cord blood samples. Pediatr Allergy Immunol 2015; 26:344-351. In this study, umbilical cord blood from babies born to obese mothers had lower eosinophil and CD4 T-helper cells, altered monocyte and dendritic cell responses, and higher IL-6
23. Dosch NC, Guslits EF, Weber MB, et al. Maternal obesity affects inflammatory and iron indices in umbilical cord blood. J Pediatr 2016; 172:20-28
24. Costa SM, Isganaitis E, Matthews TJ, et al. Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells. Int J Obes (Lond) 2016; 40:1627-1634
25. Malti N, Merzouk H, Merzouk SA, et al. Oxidative stress and maternal obesity: feto-placental unit interaction. Placenta 2014; 35:411-416
26. Catalano PM, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 2009; 32:1076-1080
27. Popovic M, Pizzi C, Rusconi F, et al. Infant weight trajectories and early childhood wheezing: the NINFEA birth cohort study. Thorax 2016; pii: thoraxjnl-2015-208208. DOI: 10.1136/thoraxjnl-2015-208208. [Epub ahead of print]
28. Casas M, den Dekker HT, Kruithof CJ, et al. Early childhood growth patterns and school-age respiratory resistance, fractional exhaled nitric oxide and asthma. Pediatr Allergy Immunol 2016; 27:854-860
29. Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit Care Med 2006; 174:112-119
30. Wei YF, Wu HD, Chang CY, et al. The impact of various anthropometric measurements of obesity on pulmonary function in candidates for surgery. Obes Surg 2010; 20:589-594
31. Cibella F, Bruno A, Cuttitta G, et al. An elevated body mass index increases lung volume but reduces airflow in Italian schoolchildren. PLoS One 2015; 10:e0127154
32. Chih AH, Chen YC, Tu YK, et al. Mediating pathways from central obesity to childhood asthma: a population-based longitudinal study. Eur Respir J 2016; 48:748-757
33. Strunk RC, Colvin R, Bahcarier LB, et al. Airway obstruction worsens in young adults with asthma who become obese. J Allergy Clin Immunol Pract 2015; 3:765-771
34. Del Rio-Navarro BE, Blandon-Vijil V, Escalante-Dominguez AJ, et al. Effect of obesity on bronchial hyperreactivity among Latino children. Pediatr Pulmonol 2013; 48:1201-1205
35. Chen YC, Huang YL, Ho WC, et al. Gender differences in effects of obesity and asthma on adolescent lung function: results from a population-based study. J Asthma 2016: 1-7. 2016 doi: 10.1080/02770903.2016.1212367. [Epub ahead of print]
36. Forno E, Weiner DJ, Mullen J, et al. Obesity and airway dysanapsis in children with and without asthma. Am J Respir Crit Care Med 2016. DOI: 10.1164/rccm.201605-1039OC. [Epub ahead of print]
37. McGarry ME, Castellanos E, Thakur N, et al. Obesity and bronchodilator response in black and Hispanic children and adolescents with asthma. Chest 2015; 147:1591-1598
38. da Rosa GJ, Schivinski CI. Assessment of respiratory muscle strength in children according to the classification of body mass index. Rev Paul Pediatr 2014; 32:250-255
39. Forno E, Acosta-Perez E, Brehm JM, et al. Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children. J Allergy Clin Immunol 2014; 133:1308-1314
40. Murray CS, Canoy D, Buchan I, et al. Body mass index in young children and allergic disease: gender differences in a longitudinal study. Clin Exp Allergy 2011; 41:78-85
41. Nordlund B, Melen E, Schultz ES, et al. Risk factors and markers of asthma control differ between asthma subtypes in children. Pediatr Allergy Immunol 2014; 25:558-564
42. Kattan M, Kumar R, Bloomberg GR, et al. Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol 2010; 125:584-592
43. Visness CM, London SJ, Daniels JL, et al. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006. J Asthma 2010; 47:822-829
44. Han YY, Forno E, Celedon JC. Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children. Am J Respir Crit Care Med 2014; 190:32-39
45. Rastogi D, Fraser S, Oh J, et al. Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma. Am J Respir Crit Care Med 2015; 191:149-160
46. Sood A, Shore SA. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J Allergy 2013; 2013:785835
47. Everaere L, Ait-Yahia S, Molendi-Coste O, et al. Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity. J Allergy Clin Immunol 2016; 138:1309-1318.e11; DOI: 10.1016/j.jaci.2016.03.019
48. Kim HY, Lee HJ, Chang YJ, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med 2014; 20:54-61. This study looks at the role of innate lymphoid cells and IL-17 in asthma. High-fat fed mice developed airway hyper-reactivity, which was dependent on IL-17 producing innate lymphoid cells (ILC3)
49. Periyalil HA, Wood LG, Scott HA, et al. Macrophage activation, age and sex effects of immunometabolismin obese asthma. Eur Respir J 2015; 45:388-395
50. Berentzen NE, van Stokkom VL, Gehring U, et al. Associations of sugarcontaining beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort. Eur J Clin Nutr 2015; 69:303-308
51. Dogaru CM, Nyffenegger D, Pescatore AM, et al. Breastfeeding and childhood asthma: systematic review and meta-analysis. Am J Epidemiol 2014; 179:1153-1167
52. Yan J, Liu L, Zhu Y, et al. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health 2014; 14:1267
53. Rice JL, Romero KM, Galvez Davila RM, et al. Association between adherence to the Mediterranean diet and asthma in peruvian children. Lung 2015; 193:893-899
54. Lv N, Xiao L, Ma J. Dietary pattern and asthma: a systematic review and metaanalysis. J Asthma Allergy 2014; 7:105-121
55. Han YY, Forno E, Brehm J, et al. Diet, interleukin-17, and childhood asthma in Puerto Ricans. Ann Allergy Asthma Immunol 2015; 115:288-293.e1
56. Wood LG, Garg ML, Gibson PG. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma. J Allergy Clin Immunol 2011; 127:1133-1140
57. Vo P, Bair-Merritt M, Camargo CA. The potential role of vitamin D in the link between obesity and asthma severity/control in children. Expert Rev Respir Med 2015; 9:309-325
58. Lautenbacher LA, Jariwala SP, Markowitz ME, Rastogi D. Vitamin D and pulmonary function in obese asthmatic children. Pediatr Pulmonol 2016; 51:1276-1283
59. Arikoglu T, Kuyucu S, Karaismailoglu E, et al. The association of vitamin D, cathelicidin, and vitamin D binding protein with acute asthma attacks in children. Allergy Asthma Proc 2015; 36:51-58
60. Li J, Xun P, Zamora D, et al. Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study. Am J Clin Nutr 2013; 97:173-178
61. D'Vaz N, Meldrum SJ, Dunstan JA, et al. Fish oil supplementation in early infancy modulates developing infant immune responses. Clin Exp Allergy 2012; 42:1206-1216
62. Forno E, Han YY, Muzumdar RH, Celedon JC. Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma. J Allergy Clin Immunol 2015; 136:304-311
63. Karampatakis N, Karampatakis T, Galli-Tsinopoulou A, et al. Impaired glucose metabolism and bronchial hyperresponsiveness in obese prepubertal asthmatic children. Pediatr Pulmonol 2016. DOI: 10.1002/ppul.23516. [Epub ahead of print]
64. Cottrell L, Neal WA, Ice C, et al. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med 2011; 183:441-448
65. Del-Rio-Navarro BE, Castro-Rodriguez JA, Garibay Nieto N, et al. Higher metabolic syndrome in obese asthmatic compared to obese nonasthmatic adolescent males. J Asthma 2010; 47:501-506
66. Chen YC, Tung KY, Tsai CH, et al. Lipid profiles in children with and without asthma: interaction of asthma and obesity on hyperlipidemia. Diabetes Metab Syndr 2013; 7:20-25
67. Sanchez Jimenez J, Herrero Espinet FJ, Mengibar Garrido JM, et al. Asthma and insulin resistance in obese children and adolescents. Pediatr Allergy Immunol 2014; 25:699-705
68. Singh VP, Aggarwal R, Singh S, et al. Metabolic syndrome is associated with increased oxo-nitrative stress and asthma-like changes in lungs. PLoS One 2015; 10:e0129850
69. Dekkers BG, Schaafsma D, Tran T, et al. Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype. Am J Respir Cell Mol Biol 2009; 41:494-504
70. Agrawal A, Mabalirajan U, Ahmad T, Ghosh B. Emerging interface between metabolic syndrome and asthma. Am J Respir Cell Mol Biol 2011; 44: 270-275
71. Melen E, Granell R, Kogevinas M, et al. Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin Exp Allergy 2013; 43:463-474
72. Murphy A, Tantisira KG, Soto-Quiros ME, et al. PRKCA: a positional candidate gene for body mass index and asthma. Am J Hum Genet 2009; 85:87-96
73. Kuo NW, Tung KY, Tsai CH, et al. beta3-Adrenergic receptor gene modifies the association between childhood obesity and asthma. J Allergy Clin Immunol 2014; 134:731-733
74. Butsch Kovacic M, Martin LJ, Biagini Myers JM, et al. Genetic approach identifies distinct asthma pathways in overweight vs normal weight children. Allergy 2015; 70:1028-1032
75. Rastogi D, Suzuki M, Greally JM. Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep 2013; 3:2164
76. Ahangari F, Sood A, Ma B, et al. Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med 2015; 191:746-757
77. Pitter G, Ludvigsson JF, Romor P, et al. Antibiotic exposure in the first year of life and later treated asthma, a population based birth cohort study of 143,000 children. Eur J Epidemiol 2016; 31:85-94
78. Bailey LC, Forrest CB, Zhang P, et al. Association of antibiotics in infancy with early childhood obesity. JAMA Pediatr 2014; 168:1063-1069
79. Depner M, Ege MJ, Cox MJ, et al. Bacterial microbiota of the upper respiratory tract and childhood asthma. J Allergy Clin Immunol 2016; Jul 27. pii: S0091- 6749(16)30710-2. DOI: 10.1016/j.jaci.2016.05.050. [Epub ahead of print]
80. Khan MJ, Gerasimidis K, Edwards CA, Shaikh MG. Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature. J Obesity 2016; 15:353642
81. Forno E, Onderdonk AB, McCracken J, et al. Diversity of the gut microbiota and eczema in early life. Clin Mol Allergy 2008; 6:11
82. Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med 2016; 22:1187-1191
83. Dzidic M, Abrahamsson TR, Artacho A, et al. Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development. J Allergy Clin Immunol 2016; pii: S0091-6749(16)30786-2. DOI: 10.1016/j.jaci.2016.06.047. [Epub ahead of print]
84. Elazab N, Mendy A, Gasana J, et al. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics 2013; 132:e666-e676
85. Perez-Losada M, Crandall KA, Freishtat RJ. Two sampling methods yield distinct microbial signatures in the nasopharynges of asthmatic children. Microbiome 2016; 4:25
86. Shore SA, Cho Y. Obesity and asthma: microbiome-metabolome interactions. Am J Respir Cell Mol Biol 2016; 54:609-617
87. Lang JE, Hossain J, Holbrook JT, et al. Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution? Thorax 2016; 71:238-246
88. Lang JE, Hossain MJ, Lima JJ. Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures. J Allergy Clin Immunol 2015; 135:886-893
89. Westergren T, Berntsen S, Ldrup Carlsen KC, et al. Perceived exercise limitation in asthma: the role of disease severity, overweight, and physical activity in children. Pediatr Allergy Immunol 2016; doi: 10.1111/pai.12670. [Epub ahead of print]
90. Sah PK, Gerald Teague W, Demuth KA, et al. Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea. J Allergy Clin Immunol Pract 2013; 1:39-45
91. Leinaar E, Alamian A, Wang L. A systematic review of the relationship between asthma, overweight, and the effects of physical activity in youth. Ann Epidemiol 2016; 26:504-510
92. den Dekker HT, Ros KP, de Jongste JC, et al. Body fat mass distribution and interrupter resistance, fractional exhaled nitric oxide, and asthma at schoolage. J Allergy Clin Immunol 2016; pii: S0091-6749(16)30625-X. doi: 10.1016/j.jaci.2016.06.022. [Epub ahead of print]
93. Forno E. Childhood obesity and asthma: to BMI or not to BMI? J Allergy Clin Immunol 2016; pii: S0091-6749(16)30972-1. doi: 10.1016/j.jaci.2016.08.020. [Epub ahead of print]
94. Hacihamdioglu B, Arslan M, Yesilkaya E, et al. Wider neck circumference is related to severe asthma in children. Pediatr Allergy Immunol 2015; 26:456-460
95. Wisner E, Shah H, Sorenson R. The obesity-asthma link in different ages and the role of body mass index in its investigation: findings from the genesis and healthy growth studies. Pediatrics 2014; 134 (Suppl 3): S168-S169
96. Egan KB, Ettinger AS, DeWan AT, et al. General, but not abdominal, overweight increases odds of asthma among Norwegian adolescents: the Young-HUNT study. Acta Paediatr 2014; 103:1270-1276
97. Borgmeyer A, Ercole PM, Niesen A, Strunk RC. Lack of recognition, diagnosis, and treatment of overweight/obesity in children hospitalized for asthma. Hosp Pediatr 2016; 6:667-676
98. Jensen ME, Gibson PG, Collins CE, et al. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy 2013; 43:775-784
99. van Leeuwen JC, Hoogstrate M, Duiverman EJ, Thio BJ. Effects of dietary induced weight loss on exercise-induced bronchoconstriction in overweight and obese children. Pediatr Pulmonol 2014; 49:1155-1161
100. Willeboordse M, Kant KD, Tan FE, et al. A multifactorial weight reduction programme for children with overweight and asthma: a randomized controlled trial. PLoS One 2016; 11:e0157158
101. Luna-Pech JA, Torres-Mendoza BM, Luna-Pech JA, et al. Normocaloric diet improves asthma-related quality of life in obese pubertal adolescents. Int Arch Allergy Immunol 2014; 163:252-258
102. LiCY, Erickson SR, Wu CH. Metformin use and asthmaoutcomesamong patients with concurrent asthma and diabetes. Respirology 2016; 21:1210-1218
103. Calixto MC, Lintomen L, Andre DM, et al. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. PLoS One 2013; 8:e76786
104. Ratnovsky A, Mellema M, An SS, et al. Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists. Mol Cell Biomech 2007; 4:143-157
105. McDonagh MS, Selph S, Ozpinar A, Foley C. Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger. JAMA Pediatr 2014; 168:178-184
106. Marques P, Limbert C, Oliveira L, et al. Metformin effectiveness and safety in the management of overweight/obese nondiabetic children and adolescents: metabolic benefits of the continuous exposure to metformin at 12 and 24 months. Int J Adolesc Med Health 2016; pii: /j/ijamh.ahead-of-print/ijamh-2015-0110/ijamh-2015-0110.xml. doi: 10.1515/ijamh-2015-0110. [Epub ahead of print]
107. Peters-Golden M, Swern A, Bird SS, et al. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006; 27: 495-503