The potential role of vitamin D in the link between obesity and asthma severity/control in children

Expert Review of Respiratory Medicine

Volumn 9, Issue 3, 2015, Pages 309-325

  Vo, Phuong ^a   Bair Merritt, Megan ^a   Camargo, Carlos A ^b  

^a BOSTON MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

acute respiratory infection; asthma; children; corticosteroid responsiveness; obesity; vitamin D

Indexed keywords

CORTICOSTEROID; VITAMIN D;

ARTICLE; ASTHMA; CLINICAL TRIAL (TOPIC); CORTICOSTEROID THERAPY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; HUMAN; META ANALYSIS (TOPIC); NUTRITIONAL STATUS; OBESITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT INFECTION; RISK ASSESSMENT; TREATMENT RESPONSE; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; BLOOD; CHILD; COMPLICATION; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; ASTHMA; CHILD; HUMANS; OBESITY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VITAMIN D;

EID: 84930370682     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/17476348.2015.1042457     Document Type: Article

References (81)

1. National Surveillance of Asthma: United States, 2001-2010. In: Vital and Health Statistics. Centers for Disease Control and Prevention, November 2012
2. Ogden C CM. Prevalence of Obesity Among Children and Adolescents: United States, Trends 1963-1965 Through 2007-2008:CDC: National Center for Health Statistics, June 2010
3. Brüske I, Flexeder C, Heinrich J. Body mass index and the incidence of asthma in children. Curr Opin Allergy Clin Immunol 2014;14(2):155-60
4. Egan K, Ettinger A, Bracken M. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr 2013;13(1):121
5. Rzehak P, Wijga AH, Keil T, et al. Body mass index trajectory classes and incident asthma in childhood: Results from 8 European Birth Cohorts-a Global Allergy and Asthma European Network initiative. J Allergy Clin Immunol 2013; 131(6):1528-36; e1513
6. Suglia S, Chambers E, Rosario A, Duarte C. Asthma and obesity in three-year-old urban children: role of sex and home environment. J Pediatr 2011;159(1):14-20
7. Black MH, Zhou H, Takayanagi M, et al. Increased asthma risk and asthma-related health care complications associated with childhood obesity. Am J Epidemiol 2013; 178(7):1120-8
8. Cocoros NM, Lash TL, DeMaria A Jr, Klompas M. Obesity as a risk factor for severe influenza-like illness. Influenza Other Respir Viruses 2014;8(1):25-32
9. Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis 2006;6(7): 438-46
10. Camargo CA Jr, Boulet LP, Sutherland ER, et al. Body mass index and response to asthma therapy: fluticasone propionate/salmeterol versus montelukast. J Asthma 2010;47(1):76-82
11. Boulet L-P, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med 2007;101(11):2240-7
12. Forno E, Lescher R, Strunk R, et al. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol 2011;127(3):741-9
13. Peters-Golden M, Swern A, Bird SS, et al. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006;27(3):495-503
14. Sutherland ER, Camargo CA Jr, Busse WW, et al. Comparative effect of body mass index on response to asthma controller therapy. Allergy Asthma Proc 2010;31(1):20-5
15. Brehm JM, Schuemann B, Fuhlbrigge AL, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 2010;126(1):52-8; e55
16. Matheu V, Back O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 2003;112(3):585-92
17. Wang T-T, Nestel FP, Bourdeau V, et al. Cutting edge: 1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004;173(5): 2909-12
18. Bosse Y, Maghni K, Hudson TJ. 1 a, 25-Dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Physiol Genomics 2007;29(2): 161-8
19. Litonjua AA, Lange NE, Carey VJ, et al. The Vitamin D. Antenatal Asthma Reduction Trial (VDAART): Rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children. Contemp Clin Trials 2014; 38(1):37-50
20. Belamarich PF, Luder E, Kattan M, et al. Do obese inner-city children with asthma have more symptoms than nonobese children with asthma? Pediatrics 2000; 106(6):1436-41
21. Han Y-Y, Forno E, Celedon JC. Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children. Am J Respir Crit Care Med 2014;190(1):32-9
22. Luder E, Melnik TA, DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr 1998;132(4): 699-703
23. Michelson PH, Williams LW, Benjamin DK, Barnato AE. Obesity, inflammation, and asthma severity in childhood: data from the National Health and Nutrition Examination Survey 2001-2004. Ann Allergy Asthma Immunol 2009;103(5):381-5
24. Quinto KB, Zuraw BL, Poon K-YT, et al. The association of obesity and asthma severity and control in children. J Allergy Clin Immunol 2011;128(5):964-9
25. Kattan M, Kumar R, Bloomberg GR, et al. Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol 2010;125(3):584-92
26. Chu Y-T, Chen W-Y, Wang T-N, et al. Extreme BMI predicts higher asthma prevalence and is associated with lung function impairment in school-aged children. Pediatr Pulmonol 2009;44(5): 472-9
27. Tantisira KG, Litonjua AA, Weiss ST, Fuhlbrigge AL. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 2003;58(12):1036-41
28. Vo P, Makker K, Matta-Arroyo E, et al. The association of overweight and obesity with spirometric values in minority children referred for asthma evaluation. J Asthma 2013;50(1):56-63
29. Lang JE, Holbrook JT, Wise RA, et al. Obesity in children with poorly controlled asthma: sex differences. Pediatr Pulmonol 2013;48(9):847-56
30. Ginde AA, Santillan AA, Clark S, Camargo Jr CA. Body mass index and acute asthma severity among children presenting to the emergency department. Pediatr Allergy Immunol 2010;21(3):480-8
31. Lang JE, Hossain MJ, Lima JJ. Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures. J Allergy Clin Immunol 2015; 135(4):886-93
32. O'Shea D, Cawood TJ, O'Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One 2010;5(1):e8660
33. Lynch LA, O'Connell JM, Kwasnik AK, et al. Are natural killer cells protecting the metabolically healthy obese patient? Obesity 2009;17(3):601-5
34. O'Rourke R, Kay T, Scholz M, et al. Alterations in T-cell subset frequency in peripheral blood in obesity. Obes Surg 2005;15(10):1463-8
35. Tanaka SI, Isoda F, Ishihara Y, et al. T lymphopaenia in relation to body mass index and TNF-a in human obesity: adequate weight reduction can be corrective. Clin Endocrinol 2001;54(3):347-54
36. Baik I, Curhan GC, Rimm EB, et al. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in us men and women. Arch Intern Med 2000;160(20):3082-8
37. Morgan OW, Bramley A, Fowlkes A, et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease. PLoS One 2010;5(3):e9694
38. Campitelli MA, Rosella LC, Kwong JC. The association between obesity and outpatient visits for acute respiratory infections in Ontario, Canada. Int J Obes 2014;38(1):113-19
39. Tracey VV, De NC, Harper JR. Obesity and respiratory infection in infants and young children. BMJ 1971;1(5739):16-18
40. Jedrychowski W, Maugeri U, Flak E, et al. Predisposition to acute respiratory infections among overweight preadolescent children: an epidemiologic study in Poland. Public Health 1998;112(3):189-95
41. Chen W-H, Lu C-Y, Shao P-L, et al. Risk factors of severe novel influenza A (H1N1) infections in hospitalized children. J Formos Med Assoc 2012;111(8):421-6
42. Bateman ED, Reddel HK, Eriksson G, et al. Overall asthma control: The relationship between current control and future risk. J Allergy Clin Immunol 2010; 125(3):600-8; e606
43. Olenec JP, Kim WK, Lee W-M, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 2010; 125(5):1001-6; e1001
44. Heymann PW, Carper HT, Murphy DD, et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol 2004;114(2):239-47
45. de Blic J, Boucot I, Pribil C, et al. Control of asthma in children: still unacceptable? A French cross-sectional study. Respir Med 2009;103(9):1383-91
46. Schatz M, Zeiger RS, Zhang F, et al. Overweight/obesity and risk of seasonal asthma exacerbations. J Allergy Clin Immunol Pract 2013;1(6):618-22
47. Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics 2013;131(1): e152-61
48. Liel Y, Ulmer E, Shary J, et al. Low circulating vitamin D in obesity. Calcif Tissue Int 1988;43(4):199-201
49. Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72(3):690-3
50. Menon J, Maranda L, Nwosu BU. Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents. J Pediatr Endocrinol Metab 2012;25(7-8):673-9
51. Hewison M. Vitamin D and immune function: an overview. Proc Nutr Soc 2012; 71(01):50-61
52. Chun RF, Liu PT, Modlin RL, et al. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol 2014;5:151
53. Barlow PG, Findlay EG, Currie SM, Davidson DJ. Antiviral potential of cathelicidins. Future Microbiol 2013;9(1): 55-73
54. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006;311(5768):1770-3
55. Roth DE, Shah R, Black RE, Baqui AH. Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh. Acta Paediatr 2010; 99(3):389-93
56. Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis 2013;57(3):392-7
57. McNally JD, Leis K, Matheson LA, et al. Vitamin D deficiency in young children with severe acute lower respiratory infection. Pediatr Pulmonol 2009;44(10):981-8
58. Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5y. Eur J Clin Nutr 2004;58(4): 563-7
59. Lambert AA, Kirk GD, Astemborski J, et al. A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort. PLoS One 2014;9(4):e95099
60. Sutherland ER, Goleva E, Jackson LP, et al. Vitamin levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med 2010;181(7):699-704
61. Searing DA, Zhang Y, Murphy JR, et al. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010;125(5):995-1000
62. Wu AC, Tantisira K, Li L, et al. Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med 2012;186(6):508-13
63. Nanzer AM, Chambers ES, Ryanna K, et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1a, 25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol 2013;132(2): 297-304.e293
64. Dixon AE, Johnson SE, Griffes LV, et al. Relationship of adipokines with immune response and lung function in obese asthmatic and non-asthmatic women. J Asthma 2011;48(8):811-17
65. Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178(3):218-24
66. Magrone T, Simone M, Altamura M, Munno I. Characterization of the immune inflammatory profile in obese asthmatic children. Endocr Metab Immune Disord Drug Targets 2014;14(3):187-95
67. Rastogi D, Canfield SM, Andrade A, et al. Obesity-associated asthma in children: a distinct entity. Chest 2012;141(4): 895-905
68. Telenga ED, Tideman SW, Kerstjens HAM, et al. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy 2012; 67(8):1060-8
69. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010;91(5):1255-60
70. Manaseki-Holland S, Qader G, Isaq Masher M, et al. Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial. Trop Med Int Health 2010; 15(10):1148-55
71. Manaseki-Holland S, Maroof Z, Bruce J, et al. Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomised controlled superiority trial. Lancet 2012;379(9824):1419-27
72. Camargo CA, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics 2012;130(3):e561-7
73. Laaksi I, Ruohola J-P, Mattila V, et al. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis 2010;202(5):809-14
74. Bergman P, Norlin A-C, Hansen S, et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open 2012;2:6
75. Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. J Steroid Biochem Mol Biol 2013;136(0):321-9
76. Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol 2011;127(5): 1294-6
77. Arshi S, Fallahpour M, Nabavi M, et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol 2014;113(4):404-9
78. Pojsupap S, Iliriani K, Sampaio TZ, et al. Efficacy of high-dose vitamin D in pediatric asthma: a systematic review and meta-analysis. J Asthma 2014;1-9. [Epub ahead of print]
79. Lewis E, Fernandez C, Nella A, et al. Relationship of 25-hydroxyvitamin D and asthma control in children. Ann Allergy Asthma Immunol 2012;108(4):281-2
80. Jensen ME, Gibson PG, Collins CE, et al. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy 2013;43(7):775-84
81. Eneli IU, Skybo T, Camargo CA. Weight loss and asthma: a systematic review. Thorax 2008;63(8):671-6