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Volumn 138, Issue 5, 2016, Pages 1309-1318.e11

Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity

Author keywords

allergy; asthma; high fat diet; house dust mite; Innate lymphoid cells; obesity; TH17; TH2

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; CYTOKINE; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E;

EID: 84975125294     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.03.019     Document Type: Article
Times cited : (90)

References (60)
  • 1
    • 18144391936 scopus 로고    scopus 로고
    • The epidemiology of obesity and asthma
    • 1 Ford, E.S., The epidemiology of obesity and asthma. J Allergy Clin Immunol 115 (2005), 897–909.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 897-909
    • Ford, E.S.1
  • 2
    • 34047214102 scopus 로고    scopus 로고
    • Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies
    • 2 Beuther, D.A., Sutherland, E.R., Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 175 (2007), 661–666.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 661-666
    • Beuther, D.A.1    Sutherland, E.R.2
  • 4
    • 84871705836 scopus 로고    scopus 로고
    • Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial
    • 4 Scott, H.A., Gibson, P.G., Garg, M.L., Pretto, J.J., Morgan, P.J., Callister, R., et al. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial. Clin Exp Allergy 43 (2013), 36–49.
    • (2013) Clin Exp Allergy , vol.43 , pp. 36-49
    • Scott, H.A.1    Gibson, P.G.2    Garg, M.L.3    Pretto, J.J.4    Morgan, P.J.5    Callister, R.6
  • 5
    • 80053091650 scopus 로고    scopus 로고
    • Airway inflammation is augmented by obesity and fatty acids in asthma
    • 5 Scott, H.A., Gibson, P.G., Garg, M.L., Wood, L.G., Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J 38 (2011), 594–602.
    • (2011) Eur Respir J , vol.38 , pp. 594-602
    • Scott, H.A.1    Gibson, P.G.2    Garg, M.L.3    Wood, L.G.4
  • 6
    • 84863845758 scopus 로고    scopus 로고
    • Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response
    • 6 Telenga, E.D., Tideman, S.W., Kerstjens, H.A., Hacken, N.H., Timens, W., Postma, D.S., et al. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy 67 (2012), 1060–1068.
    • (2012) Allergy , vol.67 , pp. 1060-1068
    • Telenga, E.D.1    Tideman, S.W.2    Kerstjens, H.A.3    Hacken, N.H.4    Timens, W.5    Postma, D.S.6
  • 7
    • 84884653018 scopus 로고    scopus 로고
    • Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma
    • 7 Desai, D., Newby, C., Symon, F.A., Haldar, P., Shah, S., Gupta, S., et al. Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med 188 (2013), 657–663.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 657-663
    • Desai, D.1    Newby, C.2    Symon, F.A.3    Haldar, P.4    Shah, S.5    Gupta, S.6
  • 8
    • 84884610145 scopus 로고    scopus 로고
    • Type 2 immune responses in obese individuals with asthma
    • 8 Peters, M.C., Fahy, J.V., Type 2 immune responses in obese individuals with asthma. Am J Respir Crit Care Med 188 (2013), 633–634.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 633-634
    • Peters, M.C.1    Fahy, J.V.2
  • 11
    • 78649274468 scopus 로고    scopus 로고
    • Obesity, insulin resistance and the prevalence of atopy and asthma in US adults
    • 11 Ma, J., Xiao, L., Knowles, S.B., Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy 65 (2010), 1455–1463.
    • (2010) Allergy , vol.65 , pp. 1455-1463
    • Ma, J.1    Xiao, L.2    Knowles, S.B.3
  • 12
  • 15
    • 77949743206 scopus 로고    scopus 로고
    • Obesity, airway hyperresponsiveness, and inflammation
    • 15 Shore, S.A., Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol (1985) 108 (2010), 735–743.
    • (2010) J Appl Physiol (1985) , vol.108 , pp. 735-743
    • Shore, S.A.1
  • 17
    • 33746516349 scopus 로고    scopus 로고
    • Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
    • 17 Shore, S.A., Terry, R.D., Flynt, L., Xu, A., Hug, C., Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118 (2006), 389–395.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 389-395
    • Shore, S.A.1    Terry, R.D.2    Flynt, L.3    Xu, A.4    Hug, C.5
  • 22
    • 76449095106 scopus 로고    scopus 로고
    • Obesity enhances eosinophilic inflammation in a murine model of allergic asthma
    • 22 Calixto, M.C., Lintomen, L., Schenka, A., Saad, M.J., Zanesco, A., Antunes, E., Obesity enhances eosinophilic inflammation in a murine model of allergic asthma. Br J Pharmacol 159 (2010), 617–625.
    • (2010) Br J Pharmacol , vol.159 , pp. 617-625
    • Calixto, M.C.1    Lintomen, L.2    Schenka, A.3    Saad, M.J.4    Zanesco, A.5    Antunes, E.6
  • 23
    • 84869501433 scopus 로고    scopus 로고
    • Obesity lowers the threshold of allergic sensitization and augments airway eosinophilia in a mouse model of asthma
    • 23 Dietze, J., Bocking, C., Heverhagen, J.T., Voelker, M.N., Renz, H., Obesity lowers the threshold of allergic sensitization and augments airway eosinophilia in a mouse model of asthma. Allergy 67 (2012), 1519–1529.
    • (2012) Allergy , vol.67 , pp. 1519-1529
    • Dietze, J.1    Bocking, C.2    Heverhagen, J.T.3    Voelker, M.N.4    Renz, H.5
  • 24
    • 64649088382 scopus 로고    scopus 로고
    • High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia
    • 24 de Vries, A., Hazlewood, L., Fitch, P.M., Seckl, J.R., Foster, P., Howie, S.E., High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia. Clin Exp Allergy 39 (2009), 731–739.
    • (2009) Clin Exp Allergy , vol.39 , pp. 731-739
    • de Vries, A.1    Hazlewood, L.2    Fitch, P.M.3    Seckl, J.R.4    Foster, P.5    Howie, S.E.6
  • 25
    • 84886780778 scopus 로고    scopus 로고
    • High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice
    • 25 Ge, X.N., Greenberg, Y., Hosseinkhani, M.R., Long, E.K., Bahaie, N.S., Rao, A., et al. High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice. Exp Lung Res 39 (2013), 365–378.
    • (2013) Exp Lung Res , vol.39 , pp. 365-378
    • Ge, X.N.1    Greenberg, Y.2    Hosseinkhani, M.R.3    Long, E.K.4    Bahaie, N.S.5    Rao, A.6
  • 26
    • 65549163320 scopus 로고    scopus 로고
    • IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
    • 26 Wood, I.S., Wang, B., Trayhurn, P., IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem Biophys Res Commun 384 (2009), 105–109.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 105-109
    • Wood, I.S.1    Wang, B.2    Trayhurn, P.3
  • 28
    • 84877582160 scopus 로고    scopus 로고
    • Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue
    • 28 Zeyda, M., Wernly, B., Demyanets, S., Kaun, C., Hammerle, M., Hantusch, B., et al. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue. Int J Obes (Lond) 37 (2013), 658–665.
    • (2013) Int J Obes (Lond) , vol.37 , pp. 658-665
    • Zeyda, M.1    Wernly, B.2    Demyanets, S.3    Kaun, C.4    Hammerle, M.5    Hantusch, B.6
  • 30
    • 84906822605 scopus 로고    scopus 로고
    • Enhanced innate type 2 immune response in peripheral blood from patients with asthma
    • 30 Bartemes, K.R., Kephart, G.M., Fox, S.J., Kita, H., Enhanced innate type 2 immune response in peripheral blood from patients with asthma. J Allergy Clin Immunol 134 (2014), 671–678.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 671-678
    • Bartemes, K.R.1    Kephart, G.M.2    Fox, S.J.3    Kita, H.4
  • 31
    • 84455202426 scopus 로고    scopus 로고
    • Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity
    • 31 Barlow, J.L., Bellosi, A., Hardman, C.S., Drynan, L.F., Wong, S.H., Cruickshank, J.P., et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol 129 (2012), 191–198.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 191-198
    • Barlow, J.L.1    Bellosi, A.2    Hardman, C.S.3    Drynan, L.F.4    Wong, S.H.5    Cruickshank, J.P.6
  • 32
    • 84863011729 scopus 로고    scopus 로고
    • IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs
    • 32 Bartemes, K.R., Iijima, K., Kobayashi, T., Kephart, G.M., McKenzie, A.N., Kita, H., IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J Immunol 188 (2012), 1503–1513.
    • (2012) J Immunol , vol.188 , pp. 1503-1513
    • Bartemes, K.R.1    Iijima, K.2    Kobayashi, T.3    Kephart, G.M.4    McKenzie, A.N.5    Kita, H.6
  • 33
    • 84858775590 scopus 로고    scopus 로고
    • Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation
    • 33 Halim, T.Y., Krauss, R.H., Sun, A.C., Takei, F., Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36 (2012), 451–463.
    • (2012) Immunity , vol.36 , pp. 451-463
    • Halim, T.Y.1    Krauss, R.H.2    Sun, A.C.3    Takei, F.4
  • 34
    • 84860343753 scopus 로고    scopus 로고
    • Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma
    • 34 Klein Wolterink, R.G., Kleinjan, A., van Nimwegen, M., Bergen, I., de Bruijn, M., Levani, Y., et al. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol 42 (2012), 1106–1116.
    • (2012) Eur J Immunol , vol.42 , pp. 1106-1116
    • Klein Wolterink, R.G.1    Kleinjan, A.2    van Nimwegen, M.3    Bergen, I.4    de Bruijn, M.5    Levani, Y.6
  • 35
    • 84897130315 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures
    • 35 Gold, M.J., Antignano, F., Halim, T.Y., Hirota, J.A., Blanchet, M.R., Zaph, C., et al. Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures. J Allergy Clin Immunol 133 (2014), 1142–1148.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 1142-1148
    • Gold, M.J.1    Antignano, F.2    Halim, T.Y.3    Hirota, J.A.4    Blanchet, M.R.5    Zaph, C.6
  • 36
    • 84896343916 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
    • 36 Halim, T.Y., Steer, C.A., Matha, L., Gold, M.J., Martinez-Gonzalez, I., McNagny, K.M., et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40 (2014), 425–435.
    • (2014) Immunity , vol.40 , pp. 425-435
    • Halim, T.Y.1    Steer, C.A.2    Matha, L.3    Gold, M.J.4    Martinez-Gonzalez, I.5    McNagny, K.M.6
  • 38
    • 84907370454 scopus 로고    scopus 로고
    • MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion
    • 38 Oliphant, C.J., Hwang, Y.Y., Walker, J.A., Salimi, M., Wong, S.H., Brewer, J.M., et al. MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity 41 (2014), 283–295.
    • (2014) Immunity , vol.41 , pp. 283-295
    • Oliphant, C.J.1    Hwang, Y.Y.2    Walker, J.A.3    Salimi, M.4    Wong, S.H.5    Brewer, J.M.6
  • 39
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • 39 Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463 (2010), 540–544.
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3    Takeuchi, T.4    Ikawa, T.5    Kawamoto, H.6
  • 40
    • 84888346690 scopus 로고    scopus 로고
    • Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
    • 40 Hams, E., Locksley, R.M., McKenzie, A.N., Fallon, P.G., Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol 191 (2013), 5349–5353.
    • (2013) J Immunol , vol.191 , pp. 5349-5353
    • Hams, E.1    Locksley, R.M.2    McKenzie, A.N.3    Fallon, P.G.4
  • 41
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • 41 Molofsky, A.B., Nussbaum, J.C., Liang, H.E., Van Dyken, S.J., Cheng, L.E., Mohapatra, A., et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med 210 (2013), 535–549.
    • (2013) J Exp Med , vol.210 , pp. 535-549
    • Molofsky, A.B.1    Nussbaum, J.C.2    Liang, H.E.3    Van Dyken, S.J.4    Cheng, L.E.5    Mohapatra, A.6
  • 43
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • 43 Buonocore, S., Ahern, P.P., Uhlig, H.H., Ivanov, I.I., Littman, D.R., Maloy, K.J., et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464 (2010), 1371–1375.
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1    Ahern, P.P.2    Uhlig, H.H.3    Ivanov, I.I.4    Littman, D.R.5    Maloy, K.J.6
  • 44
    • 84891889644 scopus 로고    scopus 로고
    • Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
    • 44 Kim, H.Y., Lee, H.J., Chang, Y.J., Pichavant, M., Shore, S.A., Fitzgerald, K.A., et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med 20 (2014), 54–61.
    • (2014) Nat Med , vol.20 , pp. 54-61
    • Kim, H.Y.1    Lee, H.J.2    Chang, Y.J.3    Pichavant, M.4    Shore, S.A.5    Fitzgerald, K.A.6
  • 46
    • 84901757490 scopus 로고    scopus 로고
    • CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin
    • 46 Staumont-Salle, D., Fleury, S., Lazzari, A., Molendi-Coste, O., Hornez, N., Lavogiez, C., et al. CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. J Exp Med 211 (2014), 1185–1196.
    • (2014) J Exp Med , vol.211 , pp. 1185-1196
    • Staumont-Salle, D.1    Fleury, S.2    Lazzari, A.3    Molendi-Coste, O.4    Hornez, N.5    Lavogiez, C.6
  • 47
    • 78149360636 scopus 로고    scopus 로고
    • CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
    • 47 Mionnet, C., Buatois, V., Kanda, A., Milcent, V., Fleury, S., Lair, D., et al. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med 16 (2010), 1305–1312.
    • (2010) Nat Med , vol.16 , pp. 1305-1312
    • Mionnet, C.1    Buatois, V.2    Kanda, A.3    Milcent, V.4    Fleury, S.5    Lair, D.6
  • 50
    • 84882239266 scopus 로고    scopus 로고
    • Eosinophils in the spotlight: finding the link between obesity and asthma
    • 50 Lloyd, C.M., Saglani, S., Eosinophils in the spotlight: finding the link between obesity and asthma. Nat Med 19 (2013), 976–977.
    • (2013) Nat Med , vol.19 , pp. 976-977
    • Lloyd, C.M.1    Saglani, S.2
  • 51
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is essential for the function of human type 2 innate lymphoid cells
    • 51 Mjosberg, J., Bernink, J., Golebski, K., Karrich, J.J., Peters, C.P., Blom, B., et al. The transcription factor GATA-3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37 (2012), 649–659.
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjosberg, J.1    Bernink, J.2    Golebski, K.3    Karrich, J.J.4    Peters, C.P.5    Blom, B.6
  • 52
    • 84900872494 scopus 로고    scopus 로고
    • Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines
    • 52 Makki, K., Froguel, P., Wolowczuk, I., Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm, 2013, 2013, 139239.
    • (2013) ISRN Inflamm , vol.2013 , pp. 139239
    • Makki, K.1    Froguel, P.2    Wolowczuk, I.3
  • 53
    • 84866362664 scopus 로고    scopus 로고
    • IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells
    • 53 Coccia, M., Harrison, O.J., Schiering, C., Asquith, M.J., Becher, B., Powrie, F., et al. IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med 209 (2012), 1595–1609.
    • (2012) J Exp Med , vol.209 , pp. 1595-1609
    • Coccia, M.1    Harrison, O.J.2    Schiering, C.3    Asquith, M.J.4    Becher, B.5    Powrie, F.6
  • 54
    • 84866130874 scopus 로고    scopus 로고
    • Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
    • 54 Willart, M.A., Deswarte, K., Pouliot, P., Braun, H., Beyaert, R., Lambrecht, B.N., et al. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 209 (2012), 1505–1517.
    • (2012) J Exp Med , vol.209 , pp. 1505-1517
    • Willart, M.A.1    Deswarte, K.2    Pouliot, P.3    Braun, H.4    Beyaert, R.5    Lambrecht, B.N.6
  • 55
    • 84907953760 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice
    • 55 Drake, L.Y., Iijima, K., Kita, H., Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice. Allergy 69 (2014), 1300–1307.
    • (2014) Allergy , vol.69 , pp. 1300-1307
    • Drake, L.Y.1    Iijima, K.2    Kita, H.3
  • 56
    • 84878737123 scopus 로고    scopus 로고
    • Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
    • 56 Hepworth, M.R., Monticelli, L.A., Fung, T.C., Ziegler, C.G., Grunberg, S., Sinha, R., et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature 498 (2013), 113–117.
    • (2013) Nature , vol.498 , pp. 113-117
    • Hepworth, M.R.1    Monticelli, L.A.2    Fung, T.C.3    Ziegler, C.G.4    Grunberg, S.5    Sinha, R.6
  • 58
    • 84899442976 scopus 로고    scopus 로고
    • Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice
    • Makki, K., Taront, S., Molendi-Coste, O., Bouchaert, E., Neve, B., Eury, E., et al. Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. PLoS One, 9, 2014, e92684.
    • (2014) PLoS One , vol.9 , pp. e92684
    • Makki, K.1    Taront, S.2    Molendi-Coste, O.3    Bouchaert, E.4    Neve, B.5    Eury, E.6
  • 59
    • 0034885812 scopus 로고    scopus 로고
    • Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung
    • Takeda, K., Haczku, A., Lee, J.J., Irvin, C.G., Gelfand, E.W., Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung. Am J Physiol Lung Cell Mol Physiol 281 (2001), L394–L402.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L394-L402
    • Takeda, K.1    Haczku, A.2    Lee, J.J.3    Irvin, C.G.4    Gelfand, E.W.5
  • 60
    • 84866132321 scopus 로고    scopus 로고
    • Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer
    • Bossard, C., Busson, M., Vindrieux, D., Gaudin, F., Machelon, V., Brigitte, M., et al. Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer. PLoS One, 7, 2012, e44787.
    • (2012) PLoS One , vol.7 , pp. e44787
    • Bossard, C.1    Busson, M.2    Vindrieux, D.3    Gaudin, F.4    Machelon, V.5    Brigitte, M.6


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