Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese

Journal of Allergy and Clinical Immunology: In Practice

Volumn 3, Issue 5, 2015, Pages 765-771.e2

  Strunk, Robert C ^a   Colvin, Ryan ^a   Bacharier, Leonard B ^a   Fuhlbrigge, Anne ^b   Forno, Erick ^c   Arbelaez, Ana Maria ^a   Tantisira, Kelan G ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Childhood asthma; Childhood obesity; Obese asthma; Pulmonary function

Indexed keywords

BRONCHODILATING AGENT; BUDESONIDE; NEDOCROMIL; PLACEBO; PREDNISONE;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BODY MASS; CHILD; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FUNCTIONAL ASSESSMENT; HEALTH PROGRAM; HUMAN; HUMAN CELL; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBESITY; POST HOC ANALYSIS; PREDICTION; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; SPIROMETRY; SYMPTOM; YOUNG ADULT; ADOLESCENT; COMPLICATION; DISEASE COURSE; FOLLOW UP; LUNG FUNCTION TEST; RISK;

ADOLESCENT; ADULT; AIRWAY OBSTRUCTION; ASTHMA; BODY MASS INDEX; BUDESONIDE; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; NEDOCROMIL; OBESITY; RESPIRATORY FUNCTION TESTS; RISK; YOUNG ADULT;

EID: 84941260396     PISSN: 22132198     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaip.2015.05.009     Document Type: Article

References (41)

1. Ford E. The epidemiology of obesity. J Allergy Clin Immunol 2005, 115:897-909.
2. Boulet L.-P. Asthma and obesity. Clin Exp Allergy 2013, 43:8-21.
3. Litonjua A., Gold D. Asthma and obesity: common early-life influences in the inception of disease. J Allergy Clin Immunol 2008, 121:1075-1084.
4. Dixon A., Holguin F., Sood A., et al. An official American Thoracic Society Workshop Report: obesity and asthma. Proc Am Thorac Soc 2010, 7:325-335.
5. Castro-Rodriguez J.A., Holberg C.J., Morgan W.J., Wright A.L., Martinez F.D. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001, 163:1344-1349.
6. Gilliland F., Berhane K., Islam T., Salome C.M., Pratley R.E., Buether D.A., et al. Obesity and the risk of newly diagnonosed asthma in school-age children. Am J Epidemiol 2003, 158:406-415.
7. Gold D., Damokosh A., Dockery D., Kerkey C. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr Pulmonol 2003, 36:514-521.
8. Forno E., Lescher R., Strunk R., Weiss S., Fuhlbrigge A.L., Celedon J.C., et al. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol 2011, 127:741-749.
9. Quinto K., Zuraw B., Poon K.-T., Chen W., Schatz M., Christiansen S. The association of obesity and asthma severity and control in children. J Allergy Clin Immunol 2011, 128:964-969.
10. Mosen D., Schatz M., Magid D., Carmargo C. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 2008, 122:507-511.
11. Borrell L., Nguyen E., Roth A., Oh S.S., Tcheurekdjian H., Sen S., et al. Childhood obesity and asthma control in the GALA II and SAGE II studies. Am J Respir Crit Care Med 2013, 187:697-702.
12. Holguin F., Bleecker E., Busse W., et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol 2011, 127:1486-1493.
13. Haselkorn T., Fish J., Chipps B., Miller D., Chen H., Weiss S. Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma. Respir Med 2009, 103:274-283.
14. Stenius-Aarrniala B., Poulton R., Kvarnstrom J., Gronlund E., Ylikahri M., Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomized controlled study. BMJ 2000, 320:827-832.
15. Dixon A., Pratley R., Forgione P., Kaminsky D.A., Whittaker-Leclair L.A., Griffes L.A., et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol 2011, 128:508-515.
16. Jensen M., Gibson P., Collins C., Hilton J., Wood L. Diet-induced weight loss in obese chidlren with assthma: a randomized controlled trial. Clin Exp Allergy 2013, 43:775-784.
17. Sah P., Teague W., Demuth K., Whitlock D., Brown S., Fitzpatrick A. Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea. J Allergy Clin Immunol Pract 2013, 1:39-45.
18. Scott S., Currie J., Albert P., Calverley P., Wilding J. Risk of misdiagnosis, health-related qualtiy of life, and BMI in patients who are overweight with doctor-diagnosed asthma. Chest 2012, 141:616-624.
19. Tantisira K., Litonjua A., Weiss S., Fuhlbrigge A.L. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 2003, 58:1036-1041.
20. Vo P., Makker K., Matta-arroyo E., Hall C., Arend R., Rastogi D. The association of overweight and obesity with spirometry values in minority children referred for asthma evaluation. J Asthma 2013, 50:56-63.
21. Chu Y.-T., Chen W.-Y., Wang T.-N., Tseng H.-I., Wu J.-R., Ko Y.-C. Extreme BMI predicted higher asthma prevalence and is associated with lung function impairment in school-ages children. Pediatr Pulmonol 2009, 44:472-479.
22. Marcon A., Corsico A., Cazzoletti L., Bugiani M., Accordini S., Almar E., et al. Body mass index, weight gain, and other determinants of lung function decline in adult asthma. J Allergy Clin Immunol 2009, 123:1069-1074.
23. The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Control Clin Trials 1999, 20:91-120. Childhood Asthma Management Program Research Group.
24. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000, 343:1054-1063. Childhood Asthma Management Program Research Group.
25. Centers for Disease Control. Division of Nutrition, Physical Activity, and Nutrition. A SAS Program for the 2000 CDC Growth Charts (ages 0 to <20 years). 2015. Available from: Accessed June 30, 2015. http://www.cdc.gov/nccdphp/dnpao/growthcharts/resources/sas.htm.
26. Barlow S. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007, 120(Suppl 4):S164-S192.
27. Centers for Disease Control. Division of Nutrition, Physical Activity, and Nutrition. Defining Adult Overweight and Obesity. 2012. Available from: Accessed June 30, 2015. http://cdc.gov/obesity/adult/defining.html.
28. Wang X., Dockery D., Wypij D., Fay M., Ferris B. Pulmonary function between 6 and 18 years of age. Pediatr Pulmonol 1993, 15:75-88.
29. Hankinson J., Odencrantz J., Fedan K. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999, 159:179-187.
30. Childhood Asthma Management Program for Methacholine Challenge Testing, Version 3.0 1994, Childhood Asthma Management Program Research Group, National Technical Information Service, Springfield, Va.
31. Peters J., McKinney J., Smith B., Wood P., Forkner E., Galbreath A. Impact of obesity in asthma: evidence from a large prospective disease management study. Ann Allergy Asthma Immunol 2011, 106:30-35.
32. Tzelepes G., McColl F. The lungs and ches wall disease. Murray and Nadel's Textbook of Respiratory Medicine, 4th edn 2005, 2311-2334. Elsevier Saunders, Philadelphia, PA. R. Mason, V. Broaddus, F. Murray, J. Nadel (Eds.).
33. Chen Y., Horne S., Dosman J. Body weight and weight gain related to pulmonary funcntion decline in adults: a six year follow up study. Thorax 1993, 48:375-380.
34. Thyagarajan B., Jacobs D.J., Apostol G., Smith L.J., Jensen R.L., Crapo R.O., et al. Longitudinal association of body mass index with lung function: the CARDIA study. Respir Res 2008, 9:31.
35. Pistelli F., Bottai M., Carrozzi L., DePede F., Baldacci S., Maio S., et al. Changes in obesity status and lung functino decline in a genertal population sample. Respir Med 2008, 102:674-680.
36. Fantuzzi G. Adipose tissue, adipokines, and inflammation. Molecular mechanisms in allergy and clinical immunology. J Allergy Clin Immunol 2005, 115:911-919.
37. Shore S., Schwartzman I., Mellema M., Flynt L., Imrich A. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005, 115:103-109.
38. Sood A., Camargo D., Ford E. Association between leptin and asthma in adults. Thorax 2006, 61:300-305.
39. Sood A., Qualls D., Schuyler M., Thyagarajan B., Steffesm M.W., Smith L.J., et al. Low serum adiponectin predicts future risk for asthma in women. Am J Respir Crit Care Med 2012, 186:41-47.
40. Forno E., Acosta-Perez E., Brehm J., Han Y.-Y., Alvarez M., Colon-Semidey A., et al. Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children. J Allergy Clin Immunol 2014, 133:1308-1314.
41. Al-Alwan A., Bates J., Chapman D., Kaminsky D.A., DeSarno M.J., Irvin C.G., et al. The nonallergic asthma of obesity. A matter of distal lung compliance. Am J Respir Crit Care Med 2014, 189:1494-1502.